A derivatization and validation strategy for determining the spatial localization of endogenous amine metabolites in tissues using MALDI imaging mass spectrometry

Journal of Mass Spectrometry

Volumn 49, Issue 8, 2014, Pages 665-673

  Manier, M Lisa ^a   Spraggins, Jeffrey M ^a   Reyzer, Michelle L ^a   Norris, Jeremy L ^a   Caprioli, Richard M ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

amine metabolites; amino acids; identification; in tissue derivatization; MALDI imaging; neurotransmitters; reagent precoated MALDI targets

Indexed keywords

AMINO ACIDS; BIOMOLECULES; CHEMICAL DETECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOLOGY; IDENTIFICATION (CONTROL SYSTEMS); METABOLITES; NEUROPHYSIOLOGY; SECONDARY ION MASS SPECTROMETRY; TISSUE;

CHEMICAL DERIVATIZATION; DERIVATIZATION REAGENT; DERIVATIZATIONS; IMAGING MASS SPECTROMETRY; MALDI TARGETS; MATRIX ASSISTED LASER DESORPTION/IONIZATION; NEUROTRANSMITTERS; SENSITIVITY AND SPECIFICITY;

TISSUE ENGINEERING;

2 AMINO 2 METHYLPROPIONIC ACID; 4 AMINOBUTYRIC ACID; 4 HYDROXY 3 METHOXYCINNAMALDEHYDE; 5 HYDROXYDOPAMINE; ADRENALIN; ALDEHYDE DERIVATIVE; AMINO ACID; DL 2 AMINOBUTYRIC ACID; DL 3 AMINOISOBUTYRIC ACID; DL NORMETANEPHRINE; DOPAMINE; FERULIC ACID; GLUTAMIC ACID; MELATONIN; N ETHYLGLYCINE; N METHYL LEVO ALANINE; NEUROTRANSMITTER; NORADRENALIN; OXIDOPAMINE; SEROTONIN; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG; ACROLEIN; CATECHOLAMINE; CONIFERALDEHYDE;

ADRENAL GLAND; ANIMAL EXPERIMENT; ANIMAL TISSUE; CEREBELLUM; CHEMICAL STRUCTURE; DERIVATIZATION; DIAGNOSTIC TEST ACCURACY STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOHISTOCHEMISTRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; METABOLITE; NONHUMAN; PRIORITY JOURNAL; RAT; REVIEW; SENSITIVITY AND SPECIFICITY; SEPARATION TECHNIQUE; TANDEM MASS SPECTROMETRY; TISSUE SECTION; ANALOGS AND DERIVATIVES; ANIMAL; CHEMISTRY; CYTOCHEMISTRY; MASS SPECTROMETRY; MOLECULAR IMAGING; PIG; PROCEDURES; REPRODUCIBILITY;

ACROLEIN; ADRENAL GLANDS; AMINO ACIDS; ANIMALS; CATECHOLAMINES; CEREBELLUM; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HISTOCYTOCHEMISTRY; MOLECULAR IMAGING; RATS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SWINE;

EID: 84904434852     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.3411     Document Type: Review

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