New strategy for reversible modulation of protein activity through site-specific conjugation of small molecule and polymer

Bioconjugate Chemistry

Volumn 25, Issue 7, 2014, Pages 1252-1260

  Wang, Lei ^a   Yuan, Lin ^a   Wang, Hongwei ^a   Liu, Xiaoli ^a   Li, Xinming ^a   Chen, Hong ^a  

^a SOOCHOW UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYST ACTIVITY; CONFORMATIONS; ESCHERICHIA COLI; MODULATION; PROTEINS; SULFUR COMPOUNDS;

CYS RESIDUES; FUNCTIONALIZED; POLY(2-HYDROXYETHYL METHACRYLATE); PROTEIN ACTIVITY; PYRIDYL DISULFIDE; SIMPLE++; SITE-SPECIFIC; SMALL MOLECULE AND POLYMER; SPECIFIC CONJUGATIONS; SULFHYDRYL;

MOLECULES;

4 CHLOROMERCURIBENZOIC ACID; BACTERIAL PROTEIN; CYSTEINE; DITHIOTHREITOL; INORGANIC PYROPHOSPHATASE; PHOSPHATE; POLYMACON; POLYMER; PROTEIN VARIANT; PYROPHOSPHATE; THIOL GROUP; 2 HYDROXYETHYL METHACRYLATE; METHACRYLIC ACID DERIVATIVE; THIOL DERIVATIVE;

AFFINITY CHROMATOGRAPHY; ARTICLE; ATOM TRANSFER RADICAL POLYMERIZATION; BACTERIAL STRAIN; BIOLOGICAL ACTIVITY; CATALYSIS; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CONJUGATION; CONTROLLED STUDY; DISSOCIATION; DNA SEQUENCE; ENZYME ACTIVITY; ESCHERICHIA COLI; GEL PERMEATION CHROMATOGRAPHY; HYDRODYNAMICS; HYDROLYSIS; MOLECULAR WEIGHT; MOLECULE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN SECONDARY STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; SITE DIRECTED MUTAGENESIS; WILD TYPE; BINDING SITE; CHEMISTRY; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM; MUTATION;

BINDING SITES; CIRCULAR DICHROISM; ESCHERICHIA COLI; KINETICS; METHACRYLATES; MUTAGENESIS, SITE-DIRECTED; MUTATION; P-CHLOROMERCURIBENZOIC ACID; POLYHYDROXYETHYL METHACRYLATE; POLYMERS; PROTEIN CONFORMATION; PYROPHOSPHATASES; SULFHYDRYL COMPOUNDS;

EID: 84904433762     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc5000934     Document Type: Article

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