Acquired macrolide-resistant Treponema pallidum after a human bite

Sexually Transmitted Diseases

Volumn 41, Issue 8, 2014, Pages 493-495

  Fanfair, Robyn Neblett ^a   Wallingford, Mark ^b   Long, Lana L ^c   Chi, Kai Hua ^a   Pillay, Allan ^a   Chen, Cheng Yen ^a   Workowski, Kimberly A ^a,d  

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^b Maysville Internal Medicine and Pediatric Associates   (United States)

^c City Dermatology and Laser   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZATHINE PENICILLIN; MACROLIDE; ANTIINFECTIVE AGENT;

ADULT; ARTICLE; BITE; CASE REPORT; CERVICAL LYMPHADENOPATHY; CHILL; CLINICAL FEATURE; CONTROLLED STUDY; ERYTHEMA; GENOTYPE; HERXHEIMER REACTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PUNCH BIOPSY; REAGIN TEST; REAL TIME POLYMERASE CHAIN REACTION; RIGOR; SEROLOGY; SYPHILIS; TREATMENT OUTCOME; TREPONEMA PALLIDUM; COMPLICATION; DRUG EFFECTS; INTRAMUSCULAR DRUG ADMINISTRATION; ISOLATION AND PURIFICATION; MICROBIOLOGY; MIDDLE AGED; MULTIDRUG RESISTANCE;

ANTI-BACTERIAL AGENTS; BITES, HUMAN; DRUG RESISTANCE, MULTIPLE, BACTERIAL; HUMANS; INJECTIONS, INTRAMUSCULAR; MACROLIDES; MALE; MIDDLE AGED; PENICILLIN G BENZATHINE; SYPHILIS; TREATMENT OUTCOME; TREPONEMA PALLIDUM;

EID: 84904414517     PISSN: 01485717     EISSN: 15374521     Source Type: Journal    
DOI: 10.1097/OLQ.0000000000000156     Document Type: Article

References (12)

1. Centers for Disease Control and Prevention. Sexually Transmitted Disease Surveillance 2011. Atlanta: U.S. Department of Health and Human Services; 2012.
2. Long FQ, Wang QQ, Jiang J, et al. Acquired secondary syphilis in preschool children by nonsexual close contact. Sex Transm Dis 2012; 39:588-590.
3. Zhou P, Qian Y, Lu H, et al. Nonvenereal transmission of syphilis in infancy by mouth-to-mouth transfer of prechewed food. Sex Transm Dis 2009; 36:216-217.
4. Chen CY, Chi KH, George RW, et al. Diagnosis of gastric syphilis by direct immunofluorescence staining and real-time PCR testing. J Clin Microbiol 2006; 44:3452-3456.
5. Liu H, Rodes B, Chen CY, et al. New tests for syphilis: rational design of a PCR method for detection of Treponema pallidum in clinical specimens using unique regions of the DNA polymerase I gene. J Clin Microbiol 2001; 39:1941-1946.
6. Chen CY, Chi KH, Pillay A, et al. Detection of the A2058G and A2059G 23S rRNA gene point mutations associated with azithromycin resistance in Treponema pallidum by use of a TaqMan real-time multiplex PCR assay. J Clin Microbiol 2013; 51:908-913.
7. Oh Y, Ahn SY, Hong SP, et al. A case of extragenital chancre on a nipple from a human bite during sexual intercourse. Int J Dermatol 2008; 47:978-980.
8. Chiu H, Tsai T. A crusted plaque on the right nipple. JAMA 2012; 308:403-404.
9. CDC. Sexually transmitted diseases treatment guidelines, 2010. MMWR Morbid Mortal Wkly Rep 2010; 59.
10. Stamm LV, Bergen HL. A point mutation associated with bacterial macrolide resistance is present in both 23S rRNA genes of an erythromycin-resistant Treponema pallidum clinical isolate. Antimicrob Agents Chemother 2000; 44:806-807.
11. Matejkova P, Flasarova M, Zakoucka H, et al. Macrolide treatment failure in a case of secondary syphilis: A novel A2059G mutation in the 23S rRNA gene of Treponema pallidum subsp. pallidum. J Med Microbiol 2009; 58(pt 6):832-836.
12. Workgroup AGP. Prevalence of the 23S rRNA A2058G point mutation and molecular subtypes in Treponema pallidum in the United States, 2007 to 2009. Sex Transm Dis 2012; 39:794-798.