Overexpression of integrin αv correlates with poor prognosis in colorectal cancer

Journal of Clinical Pathology

Volumn 67, Issue 7, 2014, Pages 576-581

  Ha, Sang Yun ^a   Shin, Juyoun ^b   Kim, Jeong Hoon ^a,c   Kang, Myung Soo ^a,c   Yoo, Hae Yong ^a,c   Kim, Hyeon Ho ^a,c   Um, Sung Hee ^a   Kim, Seok Hyung ^a,c  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b National Cancer Center   (South Korea)

^c Samsung Medical Center   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CD51 ANTIGEN;

ADULT; ADVANCED CANCER; ANGIOGENESIS; ARTICLE; CANCER PATIENT; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; COLORECTAL CANCER; COLORECTAL CARCINOMA; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

CANCER; CELL-ADHESION MOLECULES; COLORECTAL CANCER;

ADENOCARCINOMA; CELL DIFFERENTIATION; COLONIC POLYPS; COLORECTAL NEOPLASMS; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTEGRIN ALPHAV; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; NEOPLASM STAGING; PREDICTIVE VALUE OF TESTS; RETROSPECTIVE STUDIES; RISK FACTORS; TIME FACTORS; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 84904368110     PISSN: 00219746     EISSN: 14724146     Source Type: Journal    
DOI: 10.1136/jclinpath-2013-202163     Document Type: Article

References (32)

1. International Agency for Research on Cancer. http://globocan.iarc.fr/old/ bar-sex-pop.asp?selection=225900&title=World&statistic=1&number= 10&window=1&grid=1&color1=5&color1e=&color2=4&color2e= &submit=%C2%A0Execute%C2%A0 (accessed 2 Jan 2014).
2. Sung JJ, Lau JY, Goh KL, et al. Increasing incidence of colorectal cancer in Asia: implications for screening. Lancet Oncol 2005;6:871-6. (Pubitemid 41614799)
3. Ng SC, Wong SH. Colorectal cancer screening in Asia. Br Med Bull 2013;105:29-42.
4. Humphries MJ. Integrin structure. Biochem Soc Trans 2000;28:311-39.
5. van der Flier A, Sonnenberg A. Function and interactions of integrins. Cell Tissue Res 2001;305:285-98. (Pubitemid 34212122)
6. Weis SM, Cheresh DA. alphaV integrins in angiogenesis and cancer. Cold Spring Harb Perspect Med 2011;1:a006478.
7. Stupack DG, Cheresh DA. Get a ligand, get a life: integrins, signaling and cell survival. J Cell Sci 2002;115:3729-38. (Pubitemid 35203599)
8. Guo W, Giancotti FG. Integrin signalling during tumour progression. Nat Rev Mol Cell Biol 2004;5:816-26. (Pubitemid 39336275)
9. Lu X, Lu D, Scully M, et al. The role of integrins in cancer and the development of anti-integrin therapeutic agents for cancer therapy. Perspect Medicin Chem 2008;2:57-73. (Pubitemid 351566493)
10. Jin H, Varner J. Integrins: roles in cancer development and as treatment targets. Br J Cancer 2004;90:561-5. (Pubitemid 38297190)
11. Plow EF, Haas TA, Zhang L, et al. Ligand binding to integrins. J Biol Chem 2000;275:21785-8. (Pubitemid 30621742)
12. Nemeth JA, Nakada MT, Trikha M, et al. Alpha-v integrins as therapeutic targets in oncology. Cancer Invest 2007;25:632-46. (Pubitemid 350135743)
13. Cooper CR, Chay CH, Pienta KJ. The role of alpha(v)beta(3) in prostate cancer progression. Neoplasia 2002;4:191-4. (Pubitemid 34525250)
14. Dingemans AM, van den Boogaart V, Vosse BA, et al. Integrin expression profiling identifies integrin alpha5 and beta1 as prognostic factors in early stage non-small cell lung cancer. Mol Cancer 2010;9:152.
15. Goldberg I, Davidson B, Reich R, et al. Alphav integrin expression is a novel marker of poor prognosis in advanced-stage ovarian carcinoma. Clin Cancer Res 2001;7:4073-9. (Pubitemid 34044630)
16. Hecht JL, Dolinski BM, Gardner HA, et al. Overexpression of the alphavbeta6 integrin in endometrial cancer. Appl Immunohistochem Mol Morphol 2008;16:543-7.
17. Huang Y, Lin Z, Zhuang J, et al. Prognostic significance of alpha V integrin and VEGF in osteosarcoma after chemotherapy. Onkologie 2008;31:535-40.
18. Kageshita T, Hamby CV, Hirai S, et al. Alpha(v)beta3 expression on blood vessels and melanoma cells in primary lesions: differential association with tumor progression and clinical prognosis. Cancer Immunol Immunother 2000;49:314-18. (Pubitemid 30615045)
19. Kawashima A, Tsugawa S, Boku A, et al. Expression of alphav integrin family in gastric carcinomas: increased alphavbeta6 is associated with lymph node metastasis. Pathol Res Pract 2003;199:57-64. (Pubitemid 36519495)
20. Li F, Liu Y, Kan X, et al. Elevated expression of integrin alphav and beta5 subunit in laryngeal squamous-cell carcinoma associated with lymphatic metastasis and angiogenesis. Pathol Res Pract 2013;209:105-9.
21. Liapis H, Adler LM, Wick MR, et al. Expression of alpha(v)beta3 integrin is less frequent in ovarian epithelial tumors of low malignant potential in contrast to ovarian carcinomas. Hum Pathol 1997;28:443-9. (Pubitemid 27175085)
22. Markovic-Lipkovski J, Brasanac D, Muller GA, et al. Cadherins and integrins in renal cell carcinoma: an immunohistochemical study. Tumori 2001;87:173-8. (Pubitemid 32655965)
23. Maubant S, Cruet-Hennequart S, Dutoit S, et al. Expression of alpha V-associated integrin beta subunits in epithelial ovarian cancer and its relation to prognosis in patients treated with platinum-based regimens. J Mol Histol 2005;36:119-29. (Pubitemid 40614388)
24. Nejjari M, Hafdi Z, Gouysse G, et al. Expression, regulation, and function of alpha V integrins in hepatocellular carcinoma: an in vivo and in vitro study. Hepatology 2002;36:418-26. (Pubitemid 34810362)
25. Nikkola J, Vihinen P, Vlaykova T, et al. Integrin chains beta1 and alphav as prognostic factors in human metastatic melanoma. Melanoma Res 2004;14:29-37. (Pubitemid 38392411)
26. Wechsel HW, Petri E, Feil G, et al. Renal cell carcinoma: immunohistological investigation of expression of the integrin alpha v beta 3. Anticancer Res 1999;19:1529-32. (Pubitemid 29255640)
27. Denadai MV, Viana LS, Affonso RJ Jr, et al. Expression of integrin genes and proteins in progression and dissemination of colorectal adenocarcinoma. BMC Clin Pathol 2013;13:16.
28. Enns A, Korb T, Schluter K, et al. Alphavbeta5-integrins mediate early steps of metastasis formation. Eur J Cancer 2005;41:1065-72. (Pubitemid 40602860)
29. Yoshioka T, Nishikawa Y, Ito R, et al. Significance of integrin alphavbeta5 and erbB3 in enhanced cell migration and liver metastasis of colon carcinomas stimulated by hepatocyte-derived heregulin. Cancer Sci 2010;101:2011-18.
30. Jia J, Starodub A, Cushman I, et al. Dual inhibition of alphaV integrins and Src kinase activity as a combination therapy strategy for colorectal cancer. Anticancer Drugs 2013;24:237-50.
31. Sinicrope FA, Ruan SB, Cleary KR, et al. bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis. Cancer Res 1995;55:237-41.
32. Bates RC, Bellovin DI, Brown C, et al. Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. J Clin Invest 2005;115:339-47. (Pubitemid 40385475)