Notoginsenoside R1 attenuates hypoxia and hypercapnia-induced vasoconstriction in isolated rat pulmonary arterial rings by reducing the expression of ERK

American Journal of Chinese Medicine

Volumn 42, Issue 4, 2014, Pages 799-816

  Xu, Yixiao ^a   Lin, Lina ^b   Tang, Lanlan ^a   Zheng, Mengxiao ^a   Ma, Yingchun ^a   Huang, Linjing ^a   Meng, Wei ^c   Wang, Wantie ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

^c SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

ERK; Hypercapnia; Hypoxia; Pulmonary Hypertension

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; NOTOGINSENOSIDE R1; PANAX NOTOGINSENG EXTRACT; UNCLASSIFIED DRUG; GINSENOSIDE; MITOGEN ACTIVATED PROTEIN KINASE 3;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; HEART MUSCLE CONTRACTILE FORCE; HYPERCAPNIA; HYPOXIA; LUNG VASOCONSTRICTION; MALE; NONHUMAN; PULMONARY ARTERY; RAT; SMOOTH MUSCLE FIBER; SPRAGUE DAWLEY RAT; VASODILATATION; ANIMAL; ANOXIA; CELL CULTURE; DRUG EFFECTS; IN VITRO STUDY; METABOLISM; PANAX NOTOGINSENG; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION; ARTERY MUSCLE; ENZYME INHIBITION; PROTEIN EXPRESSION; PULMONARY ARTERIAL RING; SURGICAL EQUIPMENT;

ANIMALS; ANOXIA; CELLS, CULTURED; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GINSENOSIDES; HYPERCAPNIA; IN VITRO TECHNIQUES; MALE; MAP KINASE SIGNALING SYSTEM; MUSCLE, SMOOTH, VASCULAR; PANAX NOTOGINSENG; PULMONARY ARTERY; RATS, SPRAGUE-DAWLEY; VASOCONSTRICTION;

EID: 84904363175     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X14500517     Document Type: Article

References (44)

1. Baliga, R.S., R.J. Macallister and A.J. Hobbs. Vasoactive peptides and the pathogenesis of pulmonary hypertension: Role and potential therapeutic application. Handb. Exp. Pharmacol. 218: 477-511, 2013.
2. Boeck, L., M. Tamm, P. Grendelmeier and D. Stolz. Acute effects of aerosolized iloprost in COPD related pulmonary hypertension-A randomized controlled crossover trial. PLoS One. 7: e52248, 2012.
3. Brimioulle, S., P. Lejeune, J.L. Vachiery, M. Leeman, C. Melot and R. Naeije. Effects of acidosis and alkalosis on hypoxic pulmonary vasoconstriction in dogs. Am. J. Physiol. 258: H347-H353, 1990.
4. Chaouat, A., R. Naeije and E. Weitzenblum. Pulmonary hypertension in COPD. Eur. Respir. J. 32: 1371-1385, 2008.
5. d extracted from Panax notoginseng saponins on microcirculation and blood coagulation. J. West China Univ. Med. Sci. 33: 550-552, 2002.
6. D'Angelo, G., P. Graceffa, C.A. Wang, J. Wrangle and L.P. Adam. Mammal-specific, ERK-de-pendent, caldesmon phosphorylation in smooth muscle. Quantitation using novel anti-phos-phopeptide antibodies. J. Biol. Chem. 274: 30115-30121, 1999.
7. Franco-Obregon, A. and J. Lopez-Bameo. Differential oxygen sensitivity of calcium channels in rabbit smooth muscle cells of conduit and resistance pulmonary arteries. J. Physiol. 491: 511-518, 1996.
8. Gologanu, D., C. Stanescu and M.A. Bogdan. Pulmonary hypertension secondary to chronic obstructive pulmonary disease. Rom. J. Intern. Med. 50: 259-268, 2012.
9. Guo, J., L. Li, Y.J. Wu, Y. Yan, X.N. Xu, S.B. Wang, T.Y. Yuan, L.H. Fang and G.H. Du. Inhibitory effects of Brazilin on the vascular smooth muscle cell proliferation and migration induced by PDGF-BB. Am. J. Chin. Med. 41: 1283-1296, 2013.
10. Guo, L., Z.P. Qiu, L. Zhang, S. Chen and D. Zhu. Hypoxia suppresses Kv 2.1 channel expression through endogenous 15-hydroxyeicosatetraenoic acid in rat pulmonary artery. J. Physiol. Sci. 60: 373-381, 2010.
11. Han, W., X. Tang, H. Wu, Y. Liu and D. Zhu. Role of ERK1/2 signaling pathways in 4-amino-pyridine-induced rat pulmonary vasoconstriction. Eur. J. Pharmacol. 569: 138-144, 2007.
12. Jacob, T., E. Ascher, D. Alapat, Y. Olevskaia and A. Hingorani. Activation of p38MAPK signaling cascade in a VSMC injury model: Role of p38MAPK inhibitors in limiting VSMC proliferation. Eur. J. Vasc. Endovasc. Surg. 29: 470-478, 2005.
13. Knock, G.A., V.A. Snetkov, Y. Shaifta, S. Drndarski, J.P. Ward and P.I. Aaronson. Role of src-family kinases in hypoxic vasoconstriction of rat pulmonary artery. Cardiovasc. Res. 80: 453-462, 2008.
14. Lee, S.J., S.S. Park, W.J. Kim and S.K. Moon. Gleditsia sinensis thorn extract inhibits proliferation and TNF-alpha-induced MMP-9 expression in vascular smooth muscle cells. Am. J. Chin. Med. 40: 373-386, 2012.
15. Liu, S.H.Y. and N. Wang. Effects of total Panax notoginseng saponin on proliferation and JNK phosphorylation of rat vascular smooth muscle cells. J. Sun Yat-Sen Univ. Med. Sci. 29: 393-397, 2008.
16. Lu, C., Y. Liu, X. Tang, H. Ye and D. Zhu. Role of 15- hydroxyeicosatetraenoic acid in phosphor-ylation of ERK1/2 and caldesmon in pulmonary arterial smooth muscle cells. Can. J. Physiol. Pharmacol. 84: 1061-1069, 2006.
17. Maddaluno, M., M. Di Lauro, A. Di Pascale, R. Santamaria, A. Guglielmotti, G. Grassia and A. Ialenti. Monocyte chemotactic protein-3 induces human coronary smooth muscle cell proliferation. Atherosclerosis. 217: 113-119, 2011.
18. Madden, J.A., C.A. Dawson and D.R. Harder. Hypoxia-induced activation in small isolated pulmonary arteries from the cat. J. Appl. Physiol. 59: 113-118, 1985.
19. 2+, cyanide and monocrotaline. J. Appl. Physiol. 71: 30-36, 1991.
20. Ma, W.P., Y.N. Yang, D.B. Zhou and W.Q. Zhou. The preventive effect of Panax notoginseng saponins (PNS) on chronic hypoxic pulmonary hypertension in rats. Chinese J. Pathophysiol. 20: 1074-1077, 2004.
21. McNee, W. Pathophysiology of cor pulmonale in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 150: 833-852, 1994.
22. Minai, O.A., A. Chaouat and S. Adnot. Pulmonary hypertension in COPD: Epidemiology, significance, and management: pulmonary vascular disease: the global perspective. Chest. 137: 39S-51S, 2010.
23. Moon, P.D., I.S. Choi, J.H. Go, B.J. Lee, S.W. Kang, S. Yoon, S.J. Han, S.Y. Nam, H.A. Oh, N.R. Han, Y.S. Kim, J.S. Kim, M.J. Kim, H.J. Jeong and H.M. Kim. Inhibitory effects of BiRyuChe-bang on mast cell-mediated allergic reactions and inflammatory cytokines production. Am. J. Chin. Med. 41: 1267-1282, 2013.
24. Oeckler, R.A., E. Arcuino, M. Ahmad, S.C. Olson and M.S. Wolin. Cytosolic NADH redox and thiol oxidation regulate pulmonary arterial force through ERK MAP kinase. Am J. Physiol. Lung Cell Mol. Physiol. 288: L1017-L1025, 2005.
25. Ohnishi, R., I. Matsui-Yuasa, Y. Deguchi, K. Yaku, M. Tabuchi, H. Munakata, Y. Akahoshi and A. Kojima-Yuasa. 1-acetoxychavicol acetate inhibits adipogenesis in 3T3-L1 adipocytes and in high fat-fed rats. Am. J. Chin. Med. 40: 1189-1204, 2012.
26. Pan, C., Y. Huo, X. An, G. Singh, M. Chen, Z. Yang, J. Pu and J. Li. Panax notoginseng and its components decreased hypertension via stimulation of endothelial-dependent vesseldilatation. Vasc. Pharmacol. 56: 150-158, 2012.
27. Paul, J., K. Maiti, M. Read, A. Hure, J. Smith, E.C. Chan and R. Smith. Phasic phosphorylation of caldesmon and ERK1/2 during contractions in human myometrium. PLoS One. 6: e21542, 2011.
28. Pichler Hefti, J., D. Sonntag, U. Hefti, L. Risch, O.D. Schoch, A.J. Turk, T. Hess, K.E. Bloch, M. Maggiorini, T.M. Merz, K.M. Weinberger and A.R. Huber. Oxidative stress in hypobaric hypoxia and influence on vessel-tone modifying mediators. High Alt. Med. Biol. 14: 273-279, 2013.
29. Qiang, H., C. Zhang, Z.B. Shi, H.Q. Yang and K.Z. Wang. Protective effects and mechanism of Panax notoginseng saponins on oxidative stress-induced damage and apoptosis of rabbit bone marrow stromal cells. Chin. J. Integr. Med. 16: 525-530, 2010.
30. Schreiber, M.D. and S.J. Soifer. Respiratory alkalosis attenuates thromboxane-induced pulmonary hypertension. Crit. Care Med. 16: 1225-1228, 1998.
31. Shaw, J.W. and G.R. Barer. Pulmonary vasodilator and vasoconstrictor actions of carbon dioxide. J. Physiol. 213: 633-645, 1971.
32. Si, Y.C., J.P. Zhang, C.E. Xie, L.J. Zhang and X.N. Jiang. Effects of Panax notoginseng saponins on proliferation and differentiation of rat hippocampal neural stem cells. Am. J. Chin. Med. 39: 999-1013, 2011.
33. Sun, H.X., H.J. Pan and Y.J. Pan. Heamolytic activities and immunologic aduvant effect of Panax notoginseng saponine. Acta Pharmacol. Sin. 2: 1150-1154, 2003.
34. Tantini, B., A. Manes, E. Fiumana, C. Pignatti, C. Guarnieri, R. Zannoli, A. Branzi and N. Galié. Antiproliferative effect of sildenafil on human pulmonary artery smooth muscle cells. Basic Res. Cardiol. 100: 131-138, 2005.
35. 2+/NFAT pathway is involved in the anti-proliferative effect of sildenafil on pulmonary artery smooth muscle cells. Resp. Res. 10: 123, 2009a.
36. Wang, C.Z., J.T. Xie, A. Fishbein, H.H. Aung, H. He, S.R. Mehendale, T.C. He, W. Du and C.S. Yuan. Antiproliferative effects of different plant parts of Panax notoginseng on SW480 human colorectal cancer cells. Phytother. Res. 23: 6-13, 2009b.
37. Ward, J.P., G.A. Knock, V.A. Snetkov and P.I. Aaronson. Protein kinases in vascular smooth muscle tone-role in the pulmonary vasculature and hypoxic pulmonary vasoconstriction. Pharmacol. Ther. 104: 207-231, 2004.
38. Ward, J.P. and I.F. McMurtry. Mechanisms of hypoxic pulmonary vasoconstriction and their roles in pulmonary hypertension: New findings for an old problem. Curr. Opin. Pharmacol. 9: 287-296, 2009.
39. Xu, L., J.T. Liu, N. Liu, P.P. Lu and X.M. Pang. Effects of Panax notoginseng saponins on proliferation and apoptosis of vascular smooth muscle cells. J. Ethnopharmacol. 137: 226-230, 2011.
40. Yao, Y., W.Y. Wu, A.H. Liu, S.S. Deng, K.S. Bi, X. Liu and D.A. Guo. Interaction of salvianolic acids and notoginsengnosides in inhibition of ADP-induced platelet aggregation. Am. J. Chin. Med. 36: 313-328, 2008.
41. Yue, Q.X., F.B. Xie, X.Y. Song, W.Y. Wu, B.H. Jiang, S.H. Guan, M. Yang, X. Liu and D.A. Guo. Proteomic studies on protective effects of salvianolic acids, notoginsengnosides and combination of salvianolic acids and notoginsengnosides against cardiac ischemic-reperfusion injury. J. Ethnopharmacol. 141: 659-667, 2012.
42. 1 inhibits TNF-alpha-induced fibronectin production in smooth muscle cells via the ROS/ERK pathway. Free Radic. Biol. Med. 40: 1664-1674, 2006.
43. Zhu, A.N., L.N. Lin, W.T. Wang, S.H.J. Wang, K.K. Jin, L.D. Jin, Y. Wang and Q. Wang. Effect of Panax notoginoside on the hypoxia hypercapnia induced pulmonary vasoconstriction. J. Wenzhou Med. Coll. 38: 29-32, 2008.
44. Zhu, A.N., Y.Y. Wang, S.H.J. Wang, K.K. Jin, Y. Wang and W.T. Wang. Role of ERK pathway and Panax notoginoside treatment in hypoxic hypercapnia pulmonary hypertension in rats. Chinese J. Pathophysiol. 27: 1796-1801, 2011.