Effects of Panax notoginseng saponins on proliferation and differentiation of rat hippocampal neural stem cells

American Journal of Chinese Medicine

Volumn 39, Issue 5, 2011, Pages 999-1013

  Si, Yin Chu ^a   Zhang, Jian Ping ^b   Xie, Chun E ^a   Zhang, Li Juan ^c   Jiang, Xiang Ning ^d  

^a BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b JINGGANGSHAN UNIVERSITY   (China)

^c 307th Military Hospital   (China)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Fluorescent Immunocytochemistry; Hippocampal Neural Stem Cells; Ischemia Reperfusion; MTT; Panax notoginseng Saponins; RT PCR

Indexed keywords

BROXURIDINE; GLIAL FIBRILLARY ACIDIC PROTEIN; MESSENGER RNA; NESTIN; PANAX NOTOGINSENG EXTRACT; SAPONIN; VIMENTIN;

ANIMAL CELL; ARTICLE; BRAIN ISCHEMIA; CELL CLONE; CELL CULTURE; CELL ISOLATION; CELL PROLIFERATION; CELL RENEWAL; COLORIMETRY; CONTROLLED STUDY; CULTURE MEDIUM; DRUG EFFICACY; HIPPOCAMPUS; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; NERVE CELL DIFFERENTIATION; NERVE REGENERATION; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; OPTICAL DENSITY; PANAX NOTOGINSENG; PROTEIN EXPRESSION; RAT; REPERFUSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; DRUGS, CHINESE HERBAL; HIPPOCAMPUS; NEURAL STEM CELLS; PANAX NOTOGINSENG; RATS; RATS, SPRAGUE-DAWLEY; SAPONINS;

EID: 80052633822     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X11009366     Document Type: Article

References (17)

1. Adam, D., J. Jernberq, A. Schlunk, J.L. Vila, C. Hudson, M.J. Cole, R.D. Hytle, J. Tan, P.R. Sanberg, C.D. Sanberq, C. Borlonqan, Y. Kaneko, N. Tajiri, C. Gemma and P.C. Bickford. Spirulina promotes stem cell genesis and protects against LPS induced declines in neural stem cell proliferation. J. PloS One 5(5): E10496, 2010.
2. Brannen, C.L. and K. Sugaya. In vitro differentiation of multipotent human neural progenitors in serum-free medium. J. Neuroreport 11(57): 1123-1128, 2000. (Pubitemid 30235466)
3. Kim, J.J., H. Xiao, Y. Tan, Z.Z. Wang, J. Paul Seale and X. Qu. The effects and mechanism of saponins of Panax notoginseng on glucose metabolism in 3T3-L1 cells. Am. J. Chin. Med. 37: 1179-1189, 2009.
4. Kurokawa, M. Effects of nestin-antisense treatment in mice on memory-related performance. Int. J. Neurosci. 18(5): 693-704, 2008. (Pubitemid 351630882)
5. Lendahl, U., L.B. Zimmenrman and R.D. Mckay. CNS stem cell expresses a new class of intermediate filament protein. Cell 60: 585-595, 1990.
6. Ng, T.B. Pharmacological activity of sanchi ginseng (Panax notoginseng). J. Pharm. Pharmacol. 58: 1007-1019, 2006. (Pubitemid 44213633)
7. Reynolds, B.A., W. Tetzlaff and S. Weiss. A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes. J. Neurosci. 12(11): 4565-4574, 1992.
8. Si, Y.C., J.W. Li, L.J. Zhang, H.X. Wu, H. Xu and P.Ch. Zhu. Panax notoginseng saponins promote the proliferation and differentiation of neural stem cells in subependymal zone of the lateral ventricle in rat brain after intracerebral hemorrhage. J. Clin. Rehabil. Tissue Eng. Res. 12(8): 1414-1417, 2008. (Pubitemid 351578002)
9. Si, Y.C., X.G. Li, H.Y. Li, G.Y. Li, Q.H. Shen and Z.W. Shang. Effects of cortical devascularization on Vimentin, GFAP positive cells located on SVZ of adult rat and the role of Tongluojiunao injection. China J. Tradit. Chin. Med. Pharm. 24(6): 709-712, 2009.
10. Wang, H.S., W.X. Niu, L.J. Song and X.Y. Qin. Investigation and application of neural stem cells. Int. J. Surg. 33(1): 54-57, 2006.
11. Weiss, S., B.A. Reynolds, A.L. Vescovi, C. Morshead, C.G. Craig and D. Van der Kooy. Is there a neural stem cell in the mammalian forebrain? Trends Neurosci. 19: 387-393, 1996. (Pubitemid 26270517)
12. Yan, R., X.G. Luo, G.R. Bi, J. Hong and C.D. Zhang. Influence of astrocyte-conditioned medium on the formation of synapses in neural stem cells: The role of neurotrophin proteins. Natl. Med. J. China 88(35): 2508-2512, 2008.
13. Zeiger, S.L., J.R. Mckenzie, J.N. Stankowski, J.A. Martin, D.E. Cliffer and B. McLauqhlin. Neuron specific metabolic adaptations following multi-day exposures to oxygen glucose deprivation. Biochim. Biophys. Acta 1802(11): 1095-104, 2010.
14. Zhang, J.P., Y.C. Si, Y.H. Hu and D.W. Liu. Effects of ginsenoside Rgl on neural stem cells in hippocampus zone in adult rats after cerebral ischemia. J. Fourth Mil. Med. Univ. 29(24): 2225-2228, 2008a.
15. Zhang, Y.Q., G.H. Mo, M. Chen, X.F. Zeng and H. Lv. Effect of Panax notoginseng saponins on the expression of BDNF in rats with cerebral ischemia reperfusion. Chin. Tradit. Patent Med. 30(7): 958-961, 2008b.
16. Zhou, Y., H. Song, Z. Ning, L. Tian, L. Xu and N. Mo. Effects of Panax notoginseng saponins on long-term potentiation in the CA1 region of the rat hippocampus. Acta Pharm. Sin. 42(11): 1137-1141, 2007.
17. Zhu, H.X., G.H. Jin, M.L. Tian, J.B. Qin, X.F. Tan and S.Y. Jin. Expression of phosphoryl extracellular signal-regulated kinases in the differentiation of NSCs into neurons induced by the extracts of the fimbria-transected hippocampus in rat. Acta Anat. Sin. 40(6): 857-861, 2009.