Undecaprenyl diphosphate synthase inhibitors: Antibacterial drug leads

Journal of Medicinal Chemistry

Volumn 57, Issue 13, 2014, Pages 5693-5701

  Sinko, William ^a   Wang, Yang ^b   Zhu, Wei ^b   Zhang, Yonghui ^b   Feixas, Ferran ^a   Cox, Courtney L ^b,c   Mitchell, Douglas A ^b,c   Oldfield, Eric ^b   McCammon, J Andrew ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ENZYME INHIBITOR; EPALRESTAT; METICILLIN; PYROPHOSPHATE; TRANSFERASE; UNCLASSIFIED DRUG; UNDECAPRENYL DIPHOSPHATE SYNTHASE INHIBITOR;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; BACILLUS ANTHRACIS; CELL WALL; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DETERMINATION; DRUG SCREENING; ESCHERICHIA COLI; FRACTIONAL INHIBITORY CONCENTRATION INDEX; GROWTH INHIBITION; IC 50; LISTERIA MONOCYTOGENES; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHARMACOLOGICAL PARAMETERS; PROTEIN EXPRESSION; PROTEIN PURIFICATION; STAPHYLOCOCCUS AUREUS; VALIDATION PROCESS; VANCOMYCIN RESISTANT ENTEROCOCCUS;

ALKYL AND ARYL TRANSFERASES; ANTI-BACTERIAL AGENTS; BARBITURATES; CELL WALL; ENTEROCOCCUS; ENZYME INHIBITORS; ESCHERICHIA COLI; INHIBITORY CONCENTRATION 50; METHICILLIN RESISTANCE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MOLECULAR DOCKING SIMULATION; RESORCINOLS; RHODANINE; SMALL MOLECULE LIBRARIES; TRANSFERASES; VANCOMYCIN RESISTANCE;

EID: 84904325067     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm5004649     Document Type: Article

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