메뉴 건너뛰기




Volumn 29, Issue 7, 2014, Pages 1449-1457

Effect of carnitine-orotate complex on glucose metabolism and fatty liver: A double-blind, placebo-controlled study

Author keywords

Carnitine orotate; Fatty liver; Insulin resistance; Metformin; Oxidative stress

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; AGENTS AFFECTING LIPID METABOLISM; ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CARNITINE DERIVATIVE; CARNITINE OROTATE COMPLEX; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; GODEX; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; MITOCHONDRIAL DNA; OROTIC ACID DERIVATIVE; PLACEBO; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; CARNITINE; DRUG COMBINATION; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN; OROTIC ACID;

EID: 84904311408     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/jgh.12536     Document Type: Article
Times cited : (32)

References (50)
  • 2
    • 0035084699 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities
    • Sanyal AJ, Campbell-Sargent C, Mirshahi F etal. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001; 120: 1183-1192.
    • (2001) Gastroenterology , vol.120 , pp. 1183-1192
    • Sanyal, A.J.1    Campbell-Sargent, C.2    Mirshahi, F.3
  • 4
    • 48649110854 scopus 로고    scopus 로고
    • The role of fatty acids in the development and progression of nonalcoholic fatty liver disease
    • Gentile CL, Pagliassotti MJ. The role of fatty acids in the development and progression of nonalcoholic fatty liver disease. J. Nutr. Biochem. 2008; 19: 567-576.
    • (2008) J. Nutr. Biochem. , vol.19 , pp. 567-576
    • Gentile, C.L.1    Pagliassotti, M.J.2
  • 5
    • 34548306770 scopus 로고    scopus 로고
    • The effects of discontinuing pioglitazone in patients with nonalcoholic steatohepatitis
    • Lutchman G, Modi A, Kleiner DE etal. The effects of discontinuing pioglitazone in patients with nonalcoholic steatohepatitis. Hepatology 2007; 46: 424-429.
    • (2007) Hepatology , vol.46 , pp. 424-429
    • Lutchman, G.1    Modi, A.2    Kleiner, D.E.3
  • 6
    • 34648828532 scopus 로고    scopus 로고
    • AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
    • Hardie DG. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat. Rev. Mol. Cell Biol. 2007; 8: 774-785.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 774-785
    • Hardie, D.G.1
  • 7
    • 0034773404 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in mechanism of metformin action
    • Zhou G, Myers R, Li Y etal. Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Invest. 2001; 108: 1167-1174.
    • (2001) J. Clin. Invest. , vol.108 , pp. 1167-1174
    • Zhou, G.1    Myers, R.2    Li, Y.3
  • 8
    • 79955446251 scopus 로고    scopus 로고
    • Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial
    • Lavine JE, Schwimmer JB, Van Natta ML etal. Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial. JAMA 2011; 305: 1659-1668.
    • (2011) JAMA , vol.305 , pp. 1659-1668
    • Lavine, J.E.1    Schwimmer, J.B.2    Van Natta, M.L.3
  • 9
    • 84862517200 scopus 로고    scopus 로고
    • Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials
    • Musso G, Cassader M, Rosina F, Gambino R. Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials. Diabetologia 2012; 55: 885-904.
    • (2012) Diabetologia , vol.55 , pp. 885-904
    • Musso, G.1    Cassader, M.2    Rosina, F.3    Gambino, R.4
  • 10
    • 19144365586 scopus 로고    scopus 로고
    • A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease
    • Bugianesi E, Gentilcore E, Manini R etal. A randomized controlled trial of metformin versus vitamin E or prescriptive diet in nonalcoholic fatty liver disease. Am. J. Gastroenterol. 2005; 100: 1082-1090.
    • (2005) Am. J. Gastroenterol. , vol.100 , pp. 1082-1090
    • Bugianesi, E.1    Gentilcore, E.2    Manini, R.3
  • 12
    • 70350662659 scopus 로고    scopus 로고
    • Metformin in patients with non-alcoholic fatty liver disease: a randomized, controlled trial
    • Haukeland JW, Konopski Z, Eggesbo HB etal. Metformin in patients with non-alcoholic fatty liver disease: a randomized, controlled trial. Scand. J. Gastroenterol. 2009; 44: 853-860.
    • (2009) Scand. J. Gastroenterol. , vol.44 , pp. 853-860
    • Haukeland, J.W.1    Konopski, Z.2    Eggesbo, H.B.3
  • 13
    • 34948893001 scopus 로고    scopus 로고
    • A combination of caffeine, arginine, soy isoflavones, and L-carnitine enhances both lipolysis and fatty acid oxidation in 3T3-L1 and HepG2 cells in vitro and in KK mice in vivo
    • Murosaki S, Lee TR, Muroyama K etal. A combination of caffeine, arginine, soy isoflavones, and L-carnitine enhances both lipolysis and fatty acid oxidation in 3T3-L1 and HepG2 cells in vitro and in KK mice in vivo. J. Nutr. 2007; 137: 2252-2257.
    • (2007) J. Nutr. , vol.137 , pp. 2252-2257
    • Murosaki, S.1    Lee, T.R.2    Muroyama, K.3
  • 14
    • 77951720920 scopus 로고    scopus 로고
    • Carnitine palmitoyltransferase I control of acetogenesis, the major pathway of fatty acid {beta}-oxidation in liver of neonatal swine
    • Lin X, Shim K, Odle J. Carnitine palmitoyltransferase I control of acetogenesis, the major pathway of fatty acid {beta}-oxidation in liver of neonatal swine. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2010; 298: R1435-R1443.
    • (2010) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.298
    • Lin, X.1    Shim, K.2    Odle, J.3
  • 15
    • 43249091827 scopus 로고    scopus 로고
    • Short- and medium-chain carnitine acyltransferases and acyl-CoA thioesterases in mouse provide complementary systems for transport of beta-oxidation products out of peroxisomes
    • Westin MA, Hunt MC, Alexson SE. Short- and medium-chain carnitine acyltransferases and acyl-CoA thioesterases in mouse provide complementary systems for transport of beta-oxidation products out of peroxisomes. Cell. Mol. Life Sci. 2008; 65: 982-990.
    • (2008) Cell. Mol. Life Sci. , vol.65 , pp. 982-990
    • Westin, M.A.1    Hunt, M.C.2    Alexson, S.E.3
  • 16
    • 33847646640 scopus 로고    scopus 로고
    • Carnitine revisited: potential use as adjunctive treatment in diabetes
    • Power RA, Hulver MW, Zhang JY etal. Carnitine revisited: potential use as adjunctive treatment in diabetes. Diabetologia 2007; 50: 824-832.
    • (2007) Diabetologia , vol.50 , pp. 824-832
    • Power, R.A.1    Hulver, M.W.2    Zhang, J.Y.3
  • 17
    • 69249113803 scopus 로고    scopus 로고
    • Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control
    • Noland RC, Koves TR, Seiler SE etal. Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control. J. Biol. Chem. 2009; 284: 22840-22852.
    • (2009) J. Biol. Chem. , vol.284 , pp. 22840-22852
    • Noland, R.C.1    Koves, T.R.2    Seiler, S.E.3
  • 18
    • 73349102478 scopus 로고    scopus 로고
    • Carnitine and type 2 diabetes
    • Mynatt RL. Carnitine and type 2 diabetes. Diabetes Metab. Res. Rev. 2009; 25 (Suppl. 1): S45-S49.
    • (2009) Diabetes Metab. Res. Rev. , vol.25 , Issue.SUPPL. 1
    • Mynatt, R.L.1
  • 19
    • 84860668300 scopus 로고    scopus 로고
    • Role of carnitine in the regulation of glucose homeostasis and insulin sensitivity: evidence from in vivo and in vitro studies with carnitine supplementation and carnitine deficiency
    • Ringseis R, Keller J, Eder K. Role of carnitine in the regulation of glucose homeostasis and insulin sensitivity: evidence from in vivo and in vitro studies with carnitine supplementation and carnitine deficiency. Eur. J. Nutr. 2012; 51: 1-18.
    • (2012) Eur. J. Nutr. , vol.51 , pp. 1-18
    • Ringseis, R.1    Keller, J.2    Eder, K.3
  • 20
    • 0031661865 scopus 로고    scopus 로고
    • Metabolic supplementation with orotic acid and magnesium orotate
    • Rosenfeldt FL. Metabolic supplementation with orotic acid and magnesium orotate. Cardiovasc. Drugs Ther. 1998; 12 (Suppl. 2): 147-152.
    • (1998) Cardiovasc. Drugs Ther. , vol.12 , Issue.SUPPL. 2 , pp. 147-152
    • Rosenfeldt, F.L.1
  • 21
    • 84859107103 scopus 로고    scopus 로고
    • Improvement of the energy supply and contractile function in normal and ischemic rat hearts by dietary orotic acid
    • Porto LC, de Castro CH, Savergnini SS etal. Improvement of the energy supply and contractile function in normal and ischemic rat hearts by dietary orotic acid. Life Sci. 2012; 90: 476-483.
    • (2012) Life Sci. , vol.90 , pp. 476-483
    • Porto, L.C.1    de Castro, C.H.2    Savergnini, S.S.3
  • 22
    • 80052543705 scopus 로고    scopus 로고
    • Prevention of free fatty acid-induced hepatic lipotoxicity by carnitine via reversal of mitochondrial dysfunction
    • Jun DW, Cho WK, Jun JH etal. Prevention of free fatty acid-induced hepatic lipotoxicity by carnitine via reversal of mitochondrial dysfunction. Liver Int. 2011; 31: 1315-1324.
    • (2011) Liver Int. , vol.31 , pp. 1315-1324
    • Jun, D.W.1    Cho, W.K.2    Jun, J.H.3
  • 23
    • 77955495426 scopus 로고    scopus 로고
    • Effects of carnitine on peripheral blood mitochondrial DNA copy number and liver function in non-alcoholic fatty liver disease
    • Lim CY, Jun DW, Jang SS, Cho WK, Chae JD, Jun JH. Effects of carnitine on peripheral blood mitochondrial DNA copy number and liver function in non-alcoholic fatty liver disease. Korean J. Gastroenterol. 2010; 55: 384-389.
    • (2010) Korean J. Gastroenterol. , vol.55 , pp. 384-389
    • Lim, C.Y.1    Jun, D.W.2    Jang, S.S.3    Cho, W.K.4    Chae, J.D.5    Jun, J.H.6
  • 24
    • 68049120181 scopus 로고    scopus 로고
    • Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance
    • Schwenzer NF, Springer F, Schraml C, Stefan N, Machann J, Schick F. Non-invasive assessment and quantification of liver steatosis by ultrasound, computed tomography and magnetic resonance. J. Hepatol. 2009; 51: 433-445.
    • (2009) J. Hepatol. , vol.51 , pp. 433-445
    • Schwenzer, N.F.1    Springer, F.2    Schraml, C.3    Stefan, N.4    Machann, J.5    Schick, F.6
  • 25
    • 0021813187 scopus 로고
    • Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985; 28: 412-419.
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3    Naylor, B.A.4    Treacher, D.F.5    Turner, R.C.6
  • 26
    • 54249095053 scopus 로고    scopus 로고
    • Neopterin, a marker of immune response, and 8-hydroxy-2′-deoxyguanosine, a marker of oxidative stress, correlate at high age as determined by automated simultaneous high-performance liquid chromatography analysis of human urine
    • Svoboda P, Ko SH, Cho B etal. Neopterin, a marker of immune response, and 8-hydroxy-2′-deoxyguanosine, a marker of oxidative stress, correlate at high age as determined by automated simultaneous high-performance liquid chromatography analysis of human urine. Anal. Biochem. 2008; 383: 236-242.
    • (2008) Anal. Biochem. , vol.383 , pp. 236-242
    • Svoboda, P.1    Ko, S.H.2    Cho, B.3
  • 27
    • 0036320413 scopus 로고    scopus 로고
    • Real-time PCR technology for cancer diagnostics
    • Bernard PS, Wittwer CT. Real-time PCR technology for cancer diagnostics. Clin. Chem. 2002; 48: 1178-1185.
    • (2002) Clin. Chem. , vol.48 , pp. 1178-1185
    • Bernard, P.S.1    Wittwer, C.T.2
  • 28
    • 21544436004 scopus 로고    scopus 로고
    • Liver enzymes, the metabolic syndrome, and incident diabetes: the Mexico City diabetes study
    • Nannipieri M, Gonzales C, Baldi S etal. Liver enzymes, the metabolic syndrome, and incident diabetes: the Mexico City diabetes study. Diabetes Care 2005; 28: 1757-1762.
    • (2005) Diabetes Care , vol.28 , pp. 1757-1762
    • Nannipieri, M.1    Gonzales, C.2    Baldi, S.3
  • 29
    • 0035431018 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: a feature of the metabolic syndrome
    • Marchesini G, Brizi M, Bianchi G etal. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 2001; 50: 1844-1850.
    • (2001) Diabetes , vol.50 , pp. 1844-1850
    • Marchesini, G.1    Brizi, M.2    Bianchi, G.3
  • 30
    • 0037342842 scopus 로고    scopus 로고
    • Effects of identical weight loss on body composition and features of insulin resistance in obese women with high and low liver fat content
    • Tiikkainen M, Bergholm R, Vehkavaara S etal. Effects of identical weight loss on body composition and features of insulin resistance in obese women with high and low liver fat content. Diabetes 2003; 52: 701-707.
    • (2003) Diabetes , vol.52 , pp. 701-707
    • Tiikkainen, M.1    Bergholm, R.2    Vehkavaara, S.3
  • 31
    • 0036263238 scopus 로고    scopus 로고
    • High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes
    • Vozarova B, Stefan N, Lindsay RS etal. High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes. Diabetes 2002; 51: 1889-1895.
    • (2002) Diabetes , vol.51 , pp. 1889-1895
    • Vozarova, B.1    Stefan, N.2    Lindsay, R.S.3
  • 32
    • 35148879097 scopus 로고    scopus 로고
    • Abnormal liver function test predicts type 2 diabetes: a community-based prospective study
    • Cho NH, Jang HC, Choi SH etal. Abnormal liver function test predicts type 2 diabetes: a community-based prospective study. Diabetes Care 2007; 30: 2566-2568.
    • (2007) Diabetes Care , vol.30 , pp. 2566-2568
    • Cho, N.H.1    Jang, H.C.2    Choi, S.H.3
  • 33
    • 10644229056 scopus 로고    scopus 로고
    • Kinetics, pharmacokinetics, and regulation of L-carnitine and acetyl-L-carnitine metabolism
    • Rebouche CJ. Kinetics, pharmacokinetics, and regulation of L-carnitine and acetyl-L-carnitine metabolism. Ann. N. Y. Acad. Sci. 2004; 1033: 30-41.
    • (2004) Ann. N. Y. Acad. Sci. , vol.1033 , pp. 30-41
    • Rebouche, C.J.1
  • 34
    • 30544455318 scopus 로고    scopus 로고
    • Antioxidant and antiradical activities of L-carnitine
    • Gulcin I. Antioxidant and antiradical activities of L-carnitine. Life Sci. 2006; 78: 803-811.
    • (2006) Life Sci. , vol.78 , pp. 803-811
    • Gulcin, I.1
  • 35
    • 77953229020 scopus 로고    scopus 로고
    • L-carnitine supplementation to diet: a new tool in treatment of nonalcoholic steatohepatitis-a randomized and controlled clinical trial
    • Malaguarnera M, Gargante MP, Russo C etal. L-carnitine supplementation to diet: a new tool in treatment of nonalcoholic steatohepatitis-a randomized and controlled clinical trial. Am. J. Gastroenterol. 2010; 105: 1338-1345.
    • (2010) Am. J. Gastroenterol. , vol.105 , pp. 1338-1345
    • Malaguarnera, M.1    Gargante, M.P.2    Russo, C.3
  • 37
    • 72449163629 scopus 로고    scopus 로고
    • Oxidative stress and mitochondrial dysfunction in atherosclerosis: mitochondria-targeted antioxidants as potential therapy
    • Victor VM, Apostolova N, Herance R, Hernandez-Mijares A, Rocha M. Oxidative stress and mitochondrial dysfunction in atherosclerosis: mitochondria-targeted antioxidants as potential therapy. Curr. Med. Chem. 2009; 16: 4654-4667.
    • (2009) Curr. Med. Chem. , vol.16 , pp. 4654-4667
    • Victor, V.M.1    Apostolova, N.2    Herance, R.3    Hernandez-Mijares, A.4    Rocha, M.5
  • 38
    • 80051820360 scopus 로고    scopus 로고
    • Role of the AMPK/SREBP-1 pathway in the development of orotic acid-induced fatty liver
    • Jung EJ, Kwon SW, Jung BH, Oh SH, Lee BH. Role of the AMPK/SREBP-1 pathway in the development of orotic acid-induced fatty liver. J. Lipid Res. 2011; 52: 1617-1625.
    • (2011) J. Lipid Res. , vol.52 , pp. 1617-1625
    • Jung, E.J.1    Kwon, S.W.2    Jung, B.H.3    Oh, S.H.4    Lee, B.H.5
  • 39
    • 79953281026 scopus 로고    scopus 로고
    • Study on possible mechanism of orotic acid-induced fatty liver in rats
    • Wang YM, Hu XQ, Xue Y, Li ZJ, Yanagita T, Xue CH. Study on possible mechanism of orotic acid-induced fatty liver in rats. Nutrition 2011; 27: 571-575.
    • (2011) Nutrition , vol.27 , pp. 571-575
    • Wang, Y.M.1    Hu, X.Q.2    Xue, Y.3    Li, Z.J.4    Yanagita, T.5    Xue, C.H.6
  • 40
    • 0018951836 scopus 로고
    • Species specificity in the metabolic consequences of orotic acid consumption
    • Durschlag RP, Robinson JL. Species specificity in the metabolic consequences of orotic acid consumption. J. Nutr. 1980; 110: 822-828.
    • (1980) J. Nutr. , vol.110 , pp. 822-828
    • Durschlag, R.P.1    Robinson, J.L.2
  • 42
    • 0019519002 scopus 로고
    • Novel single-pass exchange of circulating uridine in rat liver
    • Gasser T, Moyer JD, Handschumacher RE. Novel single-pass exchange of circulating uridine in rat liver. Science 1981; 213: 777-778.
    • (1981) Science , vol.213 , pp. 777-778
    • Gasser, T.1    Moyer, J.D.2    Handschumacher, R.E.3
  • 44
    • 32844458032 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it
    • Begriche K, Igoudjil A, Pessayre D, Fromenty B. Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it. Mitochondrion 2006; 6: 1-28.
    • (2006) Mitochondrion , vol.6 , pp. 1-28
    • Begriche, K.1    Igoudjil, A.2    Pessayre, D.3    Fromenty, B.4
  • 45
    • 0038025371 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in the elderly: possible role in insulin resistance
    • Petersen KF, Befroy D, Dufour S etal. Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science 2003; 300: 1140-1142.
    • (2003) Science , vol.300 , pp. 1140-1142
    • Petersen, K.F.1    Befroy, D.2    Dufour, S.3
  • 46
    • 0033897367 scopus 로고    scopus 로고
    • Effect of exercise on the mitochondrial DNA content of peripheral blood in healthy women
    • Lim S, Kim SK, Park KS etal. Effect of exercise on the mitochondrial DNA content of peripheral blood in healthy women. Eur. J. Appl. Physiol. 2000; 82: 407-412.
    • (2000) Eur. J. Appl. Physiol. , vol.82 , pp. 407-412
    • Lim, S.1    Kim, S.K.2    Park, K.S.3
  • 47
    • 0035344913 scopus 로고    scopus 로고
    • Peripheral blood mitochondrial DNA content is related to insulin sensitivity in offspring of type 2 diabetic patients
    • Song J, Oh JY, Sung YA, Pak YK, Park KS, Lee HK. Peripheral blood mitochondrial DNA content is related to insulin sensitivity in offspring of type 2 diabetic patients. Diabetes Care 2001; 24: 865-869.
    • (2001) Diabetes Care , vol.24 , pp. 865-869
    • Song, J.1    Oh, J.Y.2    Sung, Y.A.3    Pak, Y.K.4    Park, K.S.5    Lee, H.K.6
  • 48
    • 0032429843 scopus 로고    scopus 로고
    • Decreased mitochondrial DNA content in peripheral blood precedes the development of non-insulin-dependent diabetes mellitus
    • Lee HK, Song JH, Shin CS etal. Decreased mitochondrial DNA content in peripheral blood precedes the development of non-insulin-dependent diabetes mellitus. Diabetes Res. Clin. Pract. 1998; 42: 161-167.
    • (1998) Diabetes Res. Clin. Pract. , vol.42 , pp. 161-167
    • Lee, H.K.1    Song, J.H.2    Shin, C.S.3
  • 49
    • 0028967724 scopus 로고
    • Increased expression of mitochondrial-encoded genes in skeletal muscle of humans with diabetes mellitus
    • Antonetti DA, Reynet C, Kahn CR. Increased expression of mitochondrial-encoded genes in skeletal muscle of humans with diabetes mellitus. J. Clin. Invest. 1995; 95: 1383-1388.
    • (1995) J. Clin. Invest. , vol.95 , pp. 1383-1388
    • Antonetti, D.A.1    Reynet, C.2    Kahn, C.R.3
  • 50
    • 17844385363 scopus 로고    scopus 로고
    • Pioglitazone induces mitochondrial biogenesis in human subcutaneous adipose tissue in vivo
    • Bogacka I, Xie H, Bray GA, Smith SR. Pioglitazone induces mitochondrial biogenesis in human subcutaneous adipose tissue in vivo. Diabetes 2005; 54: 1392-1399.
    • (2005) Diabetes , vol.54 , pp. 1392-1399
    • Bogacka, I.1    Xie, H.2    Bray, G.A.3    Smith, S.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.