Antifilarial effect of ursolic acid from Nyctanthes arbortristis: Molecular and biochemical evidences

Parasitology International

Volumn 63, Issue 5, 2014, Pages 717-728

  Saini, Prasanta ^a   Gayen, Prajna ^a   Kumar, Deepak ^b   Nayak, Ananya ^a   Mukherjee, Niladri ^a   Mukherjee, Suprabhat ^a   Pal, Bikas C ^b   Babu, Santi P Sinha ^a  

^a VISVA BHARATI UNIVERSITY   (India)

^b NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH   (India)

Author keywords

Apoptosis; Nyctanthes arbortristis; Reactive oxygen species; Setaria cervi; Ursolic acid; Wuchereria bancrofti

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; ACETIC ACID ETHYL ESTER; GLUTATHIONE; GLUTATHIONE TRANSFERASE; IVERMECTIN; LIPOCORTIN 5; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; SUPEROXIDE DISMUTASE; URSOLIC ACID; ANTIFILARIAL AGENT; TRITERPENE;

AGAR GEL ELECTROPHORESIS; ANTHELMINTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA FRAGMENTATION; DNA FRAGMENTATION ASSAY; DNA SEQUENCE; ENZYME ACTIVITY; FLOW CYTOMETRY; FRACTIONATION; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VITRO STUDY; LAMIALES; MTT ASSAY; NICK END LABELING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NYCTANTHES ARBORTRISTIS; OXIDATIVE STRESS; PARASITE VIABILITY; PRIORITY JOURNAL; PURIFICATION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SETARIA CERVI; STAINING; WESTERN BLOTTING; WUCHERERIA BANCROFTI; ADULT; ANIMAL; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; FEMALE; GENETICS; MALE; MEDICINAL PLANT; METABOLISM; OLEACEAE; PLANT LEAF; SETARIA;

ADULT; ANIMALS; BLOTTING, WESTERN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FILARICIDES; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HUMANS; MALE; OLEACEAE; OXIDATIVE STRESS; PLANT LEAVES; PLANTS, MEDICINAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SETARIA NEMATODE; SUPEROXIDE DISMUTASE; SUPEROXIDES; TRITERPENES; WUCHERERIA BANCROFTI;

EID: 84904305481     PISSN: 13835769     EISSN: 18730329     Source Type: Journal    
DOI: 10.1016/j.parint.2014.06.008     Document Type: Article

References (44)

1. Behm C.A., Bendig M.M., McCarter J.P., Sluder A.E. WHO report - WHO/TDR Scientific Working Group on 'RNA interference as a means of identifying drug targets for filariasis' 2003, 1-15. WHO, Geneva, Switzerland.
2. Awadzi K., Boakye D.A., Edwards G., Opoku N.O., Attah S.K., Osei-Atweneboana M.Y., et al. An investigation of persistent microfilaridermias despite multiple treatments with ivermectin, in two onchocerciasis-endemic foci in Ghana. Ann Trop Med Parasitol 2004, 98:231-249.
3. Pichard R.K. Markers for benzimidezole resistance in human parasitic nematodes. Parasitology 2007, 134:1087-1092.
4. Schwab A.E., Boakye D.A., Kyelem D., Pichard R.K. Detection of benzimidazole resistance-associated mutations in the filarial nematode Wuchereria bancrofti and evidence for selection by albendazole and ivermectin combination treatment. Am J Trop Med Hyg 2005, 73:234-238.
5. Schwab A.E., Churcher T.S., Schwab A.J., Baasanez M.G., Pichard R.K. An analysis of the population genetics of potential multi drug resistance in Wuchereria bancrofti due to combination chemotherapy. Parasitology 2007, 134:1025-1040.
6. Kaushal N.A., Kaushal D.C., Ghatak S. Identification of antigenic proteins of Setaria cervi by immunoblotting technique. Immunol Invest 1987, 16:139-149.
7. Misra S., Verma M., Mishra S.K., Srivastava S., Lakshmi V., Misra-Bhattacharya S. Gedunin and photogedunin of Xylocarpus granatum possess antifilarial activity against human lymphatic filarial parasite Brugia malayi in experimental rodent host. Parasitol Res 2011, 109:1351-1360.
8. Ghosh M., Sinha Babu S.P., Sukul N.C., Mahato S.B. Antifilarial effect of two triterpenoid saponins isolated from Acacia auriculiformis. Indian J Exp Biol 1993, 31:604-606.
9. Chakraborty T., Sinha Babu S.P., Sukul N.C. Antifilarial effects of a plant Acacia auriculiformis on canine dirofilariasis. Trop Med 1995, 37:31-44.
10. Nayak A., Gayen P., Saini P., Mukherjee N., Sinha Babu S.P. Molecular evidence of curcumin-induced apoptosis in the filarial worm Setaria cervi. Parasitol Res 2012, 111:1173-1186.
11. Saini P., Gayen P., Nayak A., Kumar D., Mukherjee N., Pal B.C., et al. Effect of ferulic acid from Hibiscus mutabilis on filarial parasite Setaria cervi: molecular and biochemical approaches. Parasitol Int 2012, 61:520-531.
12. Rathore B., Paul B., Chaudhary B.P., Saxena A.K., Sahu A.P., Gupta Y.K. Comparative studies of different organs of Nyctanthes arbortristis in modulation of cytokines in murine model of arthritis. Biomed Environ Sci 2007, 20:154-159.
13. Sandhar H.K., Kaur M., Kumar B., Prasher S. An update on Nyctanthes arbortristis Linn. Int Pharm Sci 2011, 1:77-86.
14. Shukla A.K., Patra S., Dubey V.K. Iridoid glucosides from Nyctanthes arbortristis result in increased reactive oxygen species and cellular redox homeostasis imbalance in Leishmania parasite. Eur J Med Chem 2012, 54:49-58.
15. Saxena R.S., Gupta B., Saxena K.K., Prasad D.N. Study on anti-inflammatory activity in leaves of Nyctanthes arbortristis. J Ethnopharmacol 1984, 11:319-330.
16. Narendhirakannan R.T., Smeera T. In-vitro antioxidant studies on ethanolic extracts of leaves and stems of Nyctanthes arbortristis L. (night-flowering jasmine). Int J Biol Med Res 2010, 1:188-192.
17. Sasmal D., Das S., Basu S.P. Phytoconstituents and therapeutic potential of Nyctanthes arbortristis Linn. Pharmacogn Rev 2007, 1:344-349.
18. Kumar D., Kumar H., Vedasiromoni J.R., Pal B.C. Bio-assay guided isolation of α-glucosidase inhibitory constituents from Hibiscus mutabilis leaves. Phytochem Anal 2012, 23:421-425.
19. Ibrahim A., Khalifa S.I., Khafagi I., Youssef D.T., Khan S., Mesbah M., et al. Microbial metabolism of biologically active secondary metabolites from Nerium oleander L. Chem Pharm Bull (Tokyo) 2008, 56:1253-1258.
20. Gayen P., Nayak A., Saini P., Mukherjee N., Maitra S., Sarkar P., et al. A double-blind controlled field trial of doxycycline and albendazole in combination for the treatment of bancroftian filariasis in India. Acta Trop 2013, 125:150-156.
21. Rao R., Weil G.J. In vitro effects of antibiotics on Brugia malayi worm survival and reproduction. J Parasitol 2002, 88:605-611.
22. Comley J.C.W., Rees M.J., Turner C.H., Jenkins D. Colorimetric quantitation of filarial viability. Int J Parasitol 1989, 19:77-83.
23. Nayak A., Gayen P., Saini P., Maitra S., Sinha Babu S.P. Albendazole induces apoptosis in adults and microfilariae of Setaria cervi. Exp Parasitol 2011, 128:236-242.
24. Habig W.H., Pabst M.J., Jakoby W.B. Glutathione S-transferases: the first enzymatic step in mercapturic acid formation. J Biol Chem 1974, 249:7130-7139.
25. Choi H.S., Kim J.W., Cha Y.N., Kim C. A quantitative nitroblue tetrazolium assay for determining intracellular superoxide anion production in phagocytic cells. J Immunoassay Immunochem 2006, 27:31-44.
26. Liu J. Pharmacology of oleanolic acid and ursolic acid. J Ethnopharmacol 1995, 49:57-68.
27. Agrawal J., Pal A. Nyctanthes arbortristis Linn.-a critical ethnopharmacological review. J Ethnopharmacol 2013, 146:645-658.
28. Cimanga R.K., Tona G.L., Mesia G.K., Kambu O.K., Bakana D.P., Kalenda P.D.T., et al. Bioassay guided isolation of antimalarial triterpenoid acids from the leaves of Morinda lucida. Pharm Biol 2006, 44:677-681.
29. Abe F., Yamauchi T., Nagao T., Kinjo J., Okabe H., Higo H., et al. Ursolic acid as a trypanocidal constituent in rosemary. Biol Pharm Bull 2002, 25:1485-1487.
30. Molyneux D.H., Bradley M., Hoerauf A., Kyelem D., Taylor M.J. Mass drug treatment for lymphatic filariasis and onchocerciasis. Trends Parasitol 2003, 19:516-522.
31. 1. Cancer Res 2003, 63:4375-4383.
32. Danial N.N., Korsmeyer S.J. Cell death: critical control points. Cell 2004, 116:205-219.
33. Wyllie A. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 1980, 284:555-556.
34. Ahmad R., Srivastava A.K. Cytosolic and microsomal glutathione-S-transferases from bovine filarial worms Setaria cervi. J Parasitol 2007, 93:1285-1290.
35. Rossum A.J.V., Jefferies J., Young C.J., Barrett J., Tait A., Brophy P.M. Glutathione S-transferase (GST) functional genomics: role of Caenorhabditis elegans in investigating GST expression in parasitic nematodes. Chem Biol Interact 2001, 133:274-277.
36. Ahmad R., Srivastava A.K., Walter R.D. Purification and biochemical characterization of cytosolic glutathione-S-transferase from filarial worms Setaria cervi. Comp Biochem Physiol B 2008, 151:237-245.
37. Rathaur S., Yadav M., Singh N., Singh A. Effect of diethylcarbamazine, butylated hydroxy anisole and methyl substituted chalcone on filarial parasite Setaria cervi: proteomic and biochemical approaches. J Proteomics 2011, 74:1595-1606.
38. Ou X., Tang L., McCrossan M., Henkle-Dührsen K., Selkirk M.E. Brugia malayi: localisation and differential expression of extracellular and cytoplasmic CuZn superoxide dismutases in adults and microfilariae. Exp Parasitol 1995, 80:515-529.
39. Tang L., Ou X., Henkle-Dührsen K., Selkirk M.E. Extracellular and cytoplasmic CuZn superoxide dismutases from Brugia lymphatic filarial nematode parasites. Infect Immun 1994, 62:961-967.
40. Batra S., Chatterjee R.K., Srivastava V.M. Antioxidant system of Litomosoides carinii and Setaria cervi: effect of a macrofilaricidal agent. Vet Parasitol 1992, 43:93-103.
41. Beckman K.B., Ames B.N. The free radical theory of aging matures. Physiol Rev 1998, 78:574-581.
42. Henkle-Dührsen K., Kampkötter A. Antioxidant enzyme families in parasitic nematodes. Mol Biochem Parasitol 2001, 114:129-142.
43. Gupta S., Rathaur S. Filarial glutathione S-transferase: its induction by xenobiotics and potential as drug target. Acta Biochim Pol 2005, 52:493-500.
44. Gorman A., McGowan A., Cotter T.G. Role of peroxide and superoxide anion during tumour cell apoptosis. FEBS Lett 1997, 404:27-33.