FOLFOX 4 combined with herbal medicine for advanced colorectal cancer: A systematic review

Phytotherapy Research

Volumn 28, Issue 7, 2014, Pages 976-991

  Chen, Menghua ^a   May, Brian H ^a   Zhou, Iris W ^a   Xue, Charlie C L ^a,b   Zhang, Anthony L ^a  

^a RMIT UNIVERSITY   (Australia)

^b GUANGDONG PROVINCIAL HOSPITAL OF CHINESE MEDICINE   (China)

Author keywords

colorectal cancer; FOLFOX; herbal medicine; meta analysis; quality of life; tumor response

Indexed keywords

FLUOROURACIL; FOLINIC ACID; HERBACEOUS AGENT; OXALIPLATIN;

ADJUVANT THERAPY; ADVANCED CANCER; ANEMIA; ASTRAGALUS MEMBRANACEUS; ATRACTYLODES MACROCEPHALA; BODY WEIGHT; BONE MARROW SUPPRESSION; CANCER GROWTH; CANCER SURVIVAL; COIX LACRYMA JOBI; COLORECTAL CANCER; CONSTIPATION; DIARRHEA; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG EFFICACY; GINSENG; HERBAL MEDICINE; HUMAN; IMMUNITY; KARNOFSKY PERFORMANCE STATUS; MEDICINAL PLANT; META ANALYSIS; NAUSEA AND VOMITING; NEUROTOXICITY; NEUTROPENIA; NONHUMAN; OVERALL SURVIVAL; PORIA COCOS; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SOPHORA FLAVESCENS; STOMATITIS; SYSTEMATIC REVIEW; THROMBOCYTOPENIA;

ASTRAGALUS MEMBRANACEUS; ATRACTYLODES MACROCEPHALA; COIX LACRYMA-JOBI; PANAX GINSENG; PORIA COCOS; SOPHORA FLAVESCENS;

COLORECTAL CANCER; FOLFOX; HERBAL MEDICINE; META-ANALYSIS; QUALITY OF LIFE; TUMOR RESPONSE;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COLORECTAL NEOPLASMS; FLUOROURACIL; HUMANS; LEUCOVORIN; ORGANOPLATINUM COMPOUNDS; PHYTOTHERAPY; PLANTS, MEDICINAL; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84904268297     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5092     Document Type: Review

References (85)

1. Auyeung KK, Ko JK,. 2010. Novel herbal flavonoids promote apoptosis but differentially induce cell cycle arrest in human colon cancer cell. Invest New Drugs 28: 1-13. (Pubitemid 46274648)
2. Bensky D, Clavey S, Stoger E,. 2004. Chinese Herbal Medicine: Materia medica. Eastland Press: Seattle.
3. Boisdron-Celle M, Craipeau MC, Brienza S, et al,. 2002. Influence of oxaliplatin on 5-fluorouracil plasma clearance and clinical consequences. Cancer Chem Pharm 49: 235-243. (Pubitemid 34185597)
4. Cao Z, Liao L, Chen X, et al,. 2012. Enhancement of Antitumor Activity of Low-Dose 5-Fluorouracil by Combination With Fuzheng-Yiliu Granules in Hepatoma 22 Tumor-Bearing Mice. Integr Cancer Ther. DOI: 10.1177/1534735412450514.
5. Cassidy J, Clarke S, Diaz-Rubio E, et al,. 2008. Randomized phase III study of capecitabine plus oxaliplatin compared with fluorouracil/folinic acid plus oxaliplatin as first-line therapy for metastatic colorectal cancer. J Clin Oncol 26: 2006-2012.
6. Chen Y, Zhu B, Zhang L, et al,. 2009. Experimental study of the bone marrow protective effect of a traditional Chinese compound preparation. Phytother Res 23: 823-826.
7. Chung CP, Hsu HY, Huang DW, et al,. 2010. Ethyl acetate fraction of adlay bran ethanolic extract inhibits oncogene expression and suppresses DMH-induced preneoplastic lesions of the colon in F344 rats through an anti-inflammatory pathway. J Agric Food Chem 58: 7616-7623.
8. De Gramont A, Figer A, Seymour M, et al,. 2000. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol 18: 2938-2947. (Pubitemid 30644117)
9. Ding X, Xiao XY, Yang XY, et al,. 2010. Clinical observation of compound Kushen injection combined with FOLFOX4 regime for patients with advanced colorectal cancer. China Oncology 20 (11): 860-863.
10. Dobos G, Tan L, Cohen M, et al,. 2005. Are national quality standards for traditional Chinese herbal medicine sufficient?: Current governmental regulations for traditional Chinese herbal medicine in certain Western countries and China as the Eastern origin country. Complement Ther Med 13: 183-190. (Pubitemid 41258547)
11. Fang MZ, Li M,. 2008. The curative effect of the treatment for metastatic colorectal cancer by the FOLFOX4 scheme combining Javanica oil emulsion and the observation of adverse effects. Chinese Journal of Information on Traditional Chinese Medicine 15: 74-75.
12. Giantonio B, Catalano P, Meropol N, et al,. 2007. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol 25: 1539-1544. (Pubitemid 46733080)
13. Goldberg R, Sargent D, Morton R, et al,. 2004. A Randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J Clin Oncol 22: 23-30. (Pubitemid 41095110)
14. Goldberg R, Sargent D, Morton R, et al,. 2006. Randomized controlled trial of reduced-dose bolus fluorouracil plus leucovorin and irinotecan or infused fluorouracil plus leucovorin and oxaliplatin in patients with previously untreated metastatic colorectal cancer: a North American Intergroup Trial. J Clin Oncol 24: 3347-3353. (Pubitemid 46638888)
15. Gong T,. 2010. Progress in Chinese medicine treatment of leucopenia after chemotherapy. Guiding Journal of Traditional Chinese Medicine and Pharmacy 16: 105-106.
16. Granda-Cameron C, Viola Sr, Lynch Mp, et al,. 2008. Measuring patient-oriented outcomes in palliative care: functionality and quality of life. Clin J Oncol Nurs 12: 65-77.
17. Guo LD, Chen XJ, Hu YH, et al,. 2013. Curcumin inhibits proliferation and induces apoptosis of human colorectal cancer cells by activating the mitochondria apoptotic pathway. Phytother Res 27: 422-430.
18. Guo Z, Jia X, Liu JP, et al,. 2012. Herbal medicines for advanced colorectal cancer. Cochrane Database Syst Rev 5: 1-74.
19. Han SY, Li PP,. 2009. Progress of research in antitumor mechanisms with Chinese medicine. Chin J Integr Med 15: 316-320.
20. He BC, Gao JL, Luo X, et al,. 2011. Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of Wnt/ß-catenin signaling. Int J Oncol 38: 437-445.
21. Higgins JPT, Green S, (Editors). 2011. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011], The Cochrane Collaboration.
22. Hind D, Tappenden P, Tumur I, et al,. 2008. The use of irinotecan, oxaliplatin and raltitrexed for the treatment of advanced colorectal cancer: systematic review and economic evaluation. Health Technol Assess 12: 3-9: 11-162.
23. Huang F, Li S, Lu X, et al,. 2011. Two glutathione S-transferase inhibitors from Radix Angelicae sinensis. Phytother Res 25: 284-289.
24. Jeong JS, Ryu BH, Kim JS, et al,. 2010. Bojungikki-tang for cancer-related fatigue: a pilot randomized clinical trial. Integr Cancer Ther 9: 331-338.
25. Jeong SJ, Koh W, Lee EO, et al,. 2011. Antiangiogenic phytochemicals and medicinal herbs. Phytother Res 25: 1-10.
26. Jung HA, Jin SE, Choi RJ, et al,. 2011. Anti-tumorigenic activity of sophoflavescenol against Lewis lung carcinoma in vitro and in vivo. Arch Pharm Res 34: 2087-2099.
27. Law PC, Auyeung KK, Chan LY, et al,. 2012. Astragalus saponins downregulate vascular endothelial growth factor under cobalt chloride-stimulated hypoxia in colon cancer cells. BMC Complement Altern Med 12: 160.
28. Lee JC, Lee KY, Son YO, et al,. 2007. Stimulating effects on mouse splenocytes of glycoproteins from the herbal medicine Atractylodes macrocephala Koidz. Phytomedicine 14: 390-395.
29. Lee JJ, Chu E,. 2007. An update on treatment advances for the first-line therapy of metastatic colorectal cancer. Cancer J 13: 276-281.
30. Lee JJ, Lee JJ,. 2010. A phase II study of an herbal decoction that includes Astragali radix for cancer-associated anorexia in patients with advanced cancer. Integr Cancer Ther 9: 24-31.
31. Li CQ, He LC, Dong HY, et al,. 2007a. Screening for the anti-inflammatory activity of fractions and compounds from Atractylodes macrocephala koidz. J Ethnopharmacol 114: 212-217.
32. Li DP,. 2007. Progress in pharmacodynamics and clinical studies of active components of Coix Seed (Semen Coicis) and its preparation-Kanglaite Injection (KLT). Traditional Chinese Drug Research & Clinical Pharmacology 26 (10): 778-782.
33. Li HJ, Dong L, Fu SY,. 2007b. Comparative study on treatment of advanced colorectal cancer by Aidi injection combined with FOLFOX4 regimen and by FOLFOX4 regimen alone. Chinese Journal of Integrated Traditional and Western Medicine 27: 1086-1089.
34. Li SC, Chen CM, Lin SH, et al,. 2011. Effects of adlay bran and its ethanolic extract and residue on preneoplastic lesions of the colon in rats. J Sci Food Agric 91: 547-552.
35. Li YJ, Chen JZ, Huang WX, et al,. 2007c. Treatment of Wenshen Jianpi Fang combination with chemotherapy for advanced colorectal cancer. Fujian Journal Traditional Chinese Medicine 38: 13-14.
36. Liu J, Zhu Q,. 2009. The reduction of adverse drug reaction incidences of colorectal cancer patients receiving Jianpi herbs combined with chemotherapy: a systematic review Chin J Evid-based Med 9: 802-808.
37. Liu Y, Ye F, Qiu GQ, et al,. 2005. Effects of lactone I from Atractylodes macrocephala Koidz on cytokines and proteolysis-inducing factors in cachectic cancer patients. Academic Journal of The First Medical College of PLA 25: 1308-1311.
38. Lu XM, Zhu YJ, Gu Y, et al,. 2010. Chinese reports on the effect and safety of FOLFOX or FOLFIRI for advanced colorectal cancer. Journal of Liaoning University of Traditional Chinese Medicine 12: 91-93.
39. Mansky PJ, Wallerstedt DB,. 2006. Complementary medicine in palliative care and cancer symptom management. Cancer J 12: 425-431. (Pubitemid 44564825)
40. McCulloch M, See C, Shu XJ, et al,. 2006. Astragalus-based Chinese herbs and platinum-based chemotherapy for advanced non-small-cell lung cancer: meta-analysis of randomized trials. J Clin Oncol 24: 419-430. (Pubitemid 46655594)
41. Miller AB, Hoogstraten B, Staquet M, et al,. 1981. Reporting results of cancer treatment. Cancer 47: 207-214. (Pubitemid 11167383)
42. Ming Y, Chen Z, Chen L, et al,. 2011. Ginsenoside compound K attenuates metastatic growth of hepatocellular carcinoma, which is associated with the translocation of nuclear factor-kappaB p65 and reduction of matrix metalloproteinase-2/9. Planta Med 77: 428-433.
43. Moher D, Hopewell S, Schulz KF, et al,. 2010. CONSORT 2010 Explanation and Elaboration: updated guidelines for reporting parallel group randomised trials. BMJ 340: c 869. doi: 10.1136/bmj.c869.
44. Molassiotis A, Potrata B, Cheng K,. 2009. A systematic review of the effectiveness of Chinese herbal medication in symptom management and improvement of quality of life in adult cancer patients. Complement Ther Med 17: 92-120.
45. Nag SA, Qin JJ, Wang W, et al,. 2012. Ginsenosides as Anticancer Agents: In vitro and in vivo Activities, Structure-Activity Relationships, and Molecular Mechanisms of Action. Front Pharmacol 3: 25.
46. Nguyen HT, Du GJ, Wang CZ, et al,. 2013. Naphthoquinone components from alkanna tinctoria (l.) tausch show significant antiproliferative effects on human colorectal cancer cells. Phytother Res 27: 66-70.
47. National Cancer Institute. 1999. Common Toxicity Criteria. Version 2.0 National Cancer Institute.
48. Parekh HS, Liu G, Wei MQ,. 2009. A new dawn for the use of traditional Chinese medicine in cancer therapy. Mol Cancer 8: 1-8.
49. Park JO, Lee SI, Song SY, et al,. 2003. Measuring response in solid tumors: comparison of RECIST and WHO response criteria. Jpn J Clin Oncol 33: 533-537. (Pubitemid 43115248)
50. Prescrire Editorial Staff. 2010. Chemotherapy of metastatic colorectal cancer. Prescrire Int 19: 219-224.
51. Qiu ZC,. 2011. Kang'ai Injection combined with chemotherapy in treating advanced colorectal cancer. Shaanxi Journal of Traditional Chinese Medicine 32: 3-4.
52. Raftery L, Goldberg RM,. 2010. Optimal delivery of cytotoxic chemotherapy for colon cancer. Cancer J 16: 214-219.
53. Rios JL,. 2011. Chemical constituents and pharmacological properties of Poria cocos. Planta Med 77: 681-691.
54. Saif M, Lansigan F, Ruta S, et al,. 2010. Phase I study of the botanical formulation PHY906 with capecitabine in advanced pancreatic and other gastrointestinal malignancies. Phytomedicine 17: 161-169.
55. Sewitch M, Rajput Y,. 2010. A literature review of complementary and alternative medicine use by colorectal cancer patients. Complement Ther Clin Pract 16: 52-56.
56. Shergis JL, Zhang AL, Zhou W, et al. 2012. Panax ginseng in randomised controlled trials: a systematic review. Phytother Res 27: 949-965
57. Shu X, Mcculloch M, Xiao H, et al,. 2005. Chinese herbal medicine and chemotherapy in the treatment of hepatocellular carcinoma: a meta-analysis of randomized controlled trials. Integr Cancer Ther 4: 219-229. (Pubitemid 41153748)
58. Sun M, Cao H, Sun L, et al,. 2012. Antitumor activities of kushen: literature review. Evid Based Complement Alternat Med 2012: 373219.
59. Tin MM, Cho CH, Chan K, et al,. 2007. Astragalus saponins induce growth inhibition and apoptosis in human colon cancer cells and tumor xenograft. Carcinogenesis 28: 1347-1355. (Pubitemid 47062696)
60. Vapiwala N, Mick R, Hampshire MK, et al,. 2006. Patient initiation of complementary and alternative medical therapies (CAM) following cancer diagnosis. Cancer J 12: 467-474. (Pubitemid 46026195)
61. Waddell JA, Solimando DA,. 2005. Leucovorin, Fluorouracil, and Oxaliplatin (FOLFOX 6 and 7) regimens for colorectal cancer. Hosp Pharm 40: 662-670.
62. Wang CZ, Xie JT, Fishbein A, et al,. 2009a. Antiproliferative effects of different plant parts of Panax notoginseng on SW480 human colorectal cancer cells. Phytother Res 23: 6-13.
63. Wang J, Xia Y, Wang H, et al,. 2007. Chinese herbs of Shenghe Powder reverse multidrug resistance of gastric carcinoma SGC-7901. Integr Cancer Ther 6: 400-404.
64. Wang X, Zheng YL, Li K, et al,. 2009b. The effects of ginsenosides Rg3 on the expressions of VEGF and KDR in human lung squamous cancer cells. Journal of Chinese medicinal materials 32: 1708-1710.
65. Woo JH, Li D, Wilsbach K, et al,. 2007. Coix seed extract, a commonly used treatment for cancer in China, inhibits NFkappaB and protein kinase C signaling. Cancer Biol Ther 6: 2005-2011. (Pubitemid 351590416)
66. Wu G, Yu G, Li J, et al,. 2010. Short term therapeutic effect on treatment of postoperational large intestine carcinoma by Fupiyiwei decoction combined with chemotherapy and it's effect on immune function. Chin J Chin materia medica 35: 782-785.
67. Wu T, Li Y, Bian Z, et al,. 2009. Randomized trials published in some Chinese journals: how many are randomized? Trials 10: 46.
68. Wu T, Munro A, Guanjian L, et al,. 2005. Chinese medical herbs for chemotherapy side effects in colorectal cancer patients, Cochrane Database of Syst Rev. John Wiley & Sons, Ltd: Chichester, UK.
69. Xu L, Lao LX, Ge A, et al,. 2007. Chinese herbal medicine for cancer pain. Integ Cancer Ther 6: 208-234. (Pubitemid 47301116)
70. Xu YX, Wang SL,. 2010. Clinical observation of Jiangniling combined with chemotherapy treatment on advanced colorectal cancer. China Medical Herald 7: 84-85.
71. Yang C, Lao Y, Wu F, et al,. 2002. Advances in the study of Atractylodes macrocephala Koidz. Journal of Chinese Medicinal Materials 25: 206-208.
72. Yang S, Wang L, Wang S, et al,. 2011. Job's tears components and bioactivity. Journal of Chinese Medicinal Materials 34: 1306-1312.
73. Yang YF,. 2008. The comparative study of Kang'ai injection combined with FOLFOX4 regimen for advanced colorectal cancer. Master, Fujian University of Traditional Chinese Medicine, Fuzhou.
74. Ye Y, Wang H, Chu JH, et al,. 2011. Atractylenolide II induces G1 cell-cycle arrest and apoptosis in B16 melanoma cells. J Ethnopharmacol 136: 279-282.
75. Yu W, Li B, Ren RJ, et al,. 2006. The effects of matrine on cell proliferation and telomerase activity in retinoblastoma cells in vitro. Chinese journal of ophthalmology 42: 594-599. (Pubitemid 44382811)
76. Zeng D, Ling Y, Yang Q, et al,. 2009. GinsenosideRg3 capsules combined with FOLFOX4 regimen for treatment of advanced colon cancer: a report of 35 cases. Journal of Bengbu Medical College 34: 1092-1094.
77. Zeng JQ, Li ZP, Wang X,. 2008. Traditional Chinese medicine with chemotherapy treatment on advanced colorectal carcinoma: reported of 30 cases. Journal of Jiangxi University of Traditional Chinese Medicine 20: 39-41.
78. Zhang HT, Fang CT, Huang ZY, et al,. 2008. Clinical observation of integrated Chinese medicine and chemotherapy on 31 cases of advanced colon cancer. Journal of New Chinese Medicine 40: 22-23.
79. Zhang JF, He ML, Qi D, et al,. 2011. Aqueous extracts of Fructus Ligustri Lucidi enhance the sensitivity of human colorectal carcinoma DLD-1 cells to doxorubicin-induced apoptosis via Tbx3 suppression. Integr Cancer Ther 10: 85-91.
80. Zhang Q, Wang XM, Yang GW,. 2010a. Clinical research of Guben Xiaoliu Capsule combined with FOLFOX4 plan for treatment of advanced colorectal cancer. Beijing Journal of Traditional Chinese Medicine 14: 255-257.
81. Zhang Y, Xu J, Sun J,. 2010b. Clinical study of Jianpi Jiedu decoction plus FOLFOX4 regimen in the treatment of advanced colorectal cancer. Global Traditional Chinese Medicine 3: 117-120.
82. Zhong LL, Chen HY, Cho WC, et al,. 2012. The efficacy of Chinese herbal medicine as an adjunctive therapy for colorectal cancer: a systematic review and meta-analysis. Complement Ther Med 20: 240-252.
83. Zhu XL, Zhu BD,. 2007. Mechanisms by which Astragalus membranaceus injection regulates hematopoiesis in myelosuppressed mice. Phytother Res 21: 663-667.
84. Zhuang SR, Chen SL, Tsai JH, et al,. 2009. Effect of citronellol and the Chinese medical herb complex on cellular immunity of cancer patients receiving chemotherapy/radiotherapy. Phytother Res 23: 785-790.
85. Zong A, Cao H, Wang F,. 2012. Anticancer polysaccharides from natural resources: A review of recent research. Carbohydr Polym 90: 1395-1410.