A phase II study of an herbal decoction that includes astragali radix for cancer-associated anorexia in patients with advanced cancer

Integrative Cancer Therapies

Volumn 9, Issue 1, 2010, Pages 24-31

  Lee, Jae Jin ^a   Lee, Jung Joo ^a  

^a Kyung Hee University College of Medicine   (South Korea)

Author keywords

Anorexia; Astragali Radix; Cachexia; Cancer; Herbal decoction

Indexed keywords

AGASTACHIS HERBA EXTRACT; ALANINE AMINOTRANSFERASE; ALISMATIS RHIZOMA EXTRACT; ANTINEOPLASTIC AGENT; ASTRAGALI RADIX EXTRACT; ATRACTYLODIS RHIZOMA ALBA EXTRACT; CITRI UNSHIU PERICARPIUM EXTRACT; CRATAEGI FRUCTUS EXTRACT; GALLI STOMACHICHUM CORIUM EXTRACT; HOELEN EXTRACT; INTERLEUKIN 1BETA; INTERLEUKIN 6; ISPAGULA; PINELLIAE TUBER EXTRACT; PLANT EXTRACT; RHYNCHOSIA NULUBILIS EXTRACT; SPATHOLOBI CAULIS EXTRACT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ZIZYPHI FRUCTUS EXTRACT; ASTRAGALI COMPOUND; CYTOKINE; HERBACEOUS AGENT; LACTIC ACID;

ADULT; ADVANCED CANCER; AGASTACHIS HERBA; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALISMATIS RHIZOMA; ANEMIA; ANOREXIA; ANTHROPOMETRY; APPETITE; ARTICLE; ASTRAGALI RADIX; ATRACTYLODIS RHIZOMA ALBA; BODY WEIGHT; BONE METASTASIS; CANCER ADJUVANT THERAPY; CANCER CHEMOTHERAPY; CITRI UNSHIU PERICARPIUM; CLINICAL ARTICLE; CLINICAL TRIAL; COLORECTAL CANCER; CRATAEGI FRUCTUS; DIARRHEA; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; DYSPEPSIA; FEMALE; GALLI STOMACHICHUM CORIUM; GASTROINTESTINAL OBSTRUCTION; GLYCYRRHIZA; HERBAL MEDICINE; HOELEN; HUMAN; HYPERCALCEMIA; LIVER METASTASIS; LUNG CANCER; MALE; MEDICINAL PLANT; NEUTROPENIA; PHASE 2 CLINICAL TRIAL; PINELLIA TUBER; PRIORITY JOURNAL; RHYNCHOSIA NULUBILIS; SCORING SYSTEM; SIDE EFFECT; SPATHOLOBI CAULIS; STOMACH CANCER; TREATMENT DURATION; VISUAL ANALOG SCALE; WEIGHT REDUCTION; ZIZYPHUS FRUIT; AGED; ASTRAGALUS PLANT; BLOOD; CHEMISTRY; DISEASE COURSE; DRUG EFFECT; MIDDLE AGED; NEOPLASM; PATHOLOGY;

AGED; ANOREXIA; ASTRAGALUS PLANT; BODY WEIGHT; CYTOKINES; DISEASE PROGRESSION; DRUGS, CHINESE HERBAL; FEMALE; HUMANS; LACTIC ACID; MALE; MIDDLE AGED; NEOPLASMS;

EID: 77953932843     PISSN: 15347354     EISSN: 1552695X     Source Type: Journal    
DOI: 10.1177/1534735409359180     Document Type: Article

References (48)

1. Tisdale MJ Cancer anorexia and cachexia. Nutrition. 2001 ; 17: 438-442.
2. Chlebowski RT, Palomares MR, Lillington L., Grosvenor M. Recent implications of weight loss in lung cancer management. Nutrition. 1996 ; 12 (suppl 1). S43 - S47.
3. Nixon DW, Lawson DH, Kutner M., et al. Hyperalimentation of the cancer patient with protein-calorie undernutrition. Cancer Res. 1981 ; 41: 2038-2045.
4. Brennan MF Uncomplicated starvation versus cancer cachexia. Cancer Res. 1977 ; 37: 2359-2364.
5. Armes PJ, Plant HJ, Allbright A., Silverstone T., Slevin ML A study to investigate the incidence of early satiety in patients with advanced cancer. Br J Cancer. 1992 ; 65: 481-484.
6. Curtis EB, Krech R., Walsh TD Common symptoms in patients with advanced cancer. J Palliat Care. 1991 ; 7: 25-29.
7. Maltoni M., Amadori D. Prognosis in advanced cancer. Hematol Oncol Clin North Am. 2002 ; 16: 715-729.
8. Mullen JL, Gertner MH, Buzby GP, Goodhart GL, Rosato EF Implications of malnutrition in the surgical patient. Arch Surg. 1979 ; 114: 121-125.
9. Stanley KE Prognostic factors for survival in patients with inoperable lung cancer. J Natl Cancer Inst. 1980 ; 65: 25-32.
10. DeWys WD, Walters K. Abnormalities of taste sensation in cancer patients. Cancer. 1975 ; 36: 1888-1896.
11. Nielsen SS, Theologides A., Vickers ZM Influence of food odors on food aversion and preference in patients with cancer. Am J Clin Nutr. 1980 ; 33: 2253-2261.
12. Baile CA, Zinn WM, Mayer J. Effects of lactate and other metabolites on food intake of monkeys. Am J Physiol. 1970 ; 219: 1606-1613.
13. Bajorunas DR Clinical manifestations of cancer-related hypercalcemia. Semin Oncol. 1990 ; 17 (2 suppl 5). 16-25.
14. Cangiano C., Testa U., Muscaritoli M., et al. Cytokines, tryptophan and anorexia in cancer patients before and after surgical tumor ablation. Anticancer Res. 1994 ; 14: 1451-1455. (Pubitemid 24264205)
15. Krause R., Humphrey C., von Meyenfeldt M., James H., Fischer JE A central mechanism for anorexia in cancer: a hypothesis. Cancer Treat Res. 1981 ; 65 (suppl 5). 15-21.
16. Bodnar RJ, Pasternak GW, Mann PE, Paul D., Warren R., Donner DB Mediation of anorexia by human recombinant tumor necrosis factor through a peripheral action in the rat. Cancer Res. 1989 ; 49: 6280-6284.
17. Plata-Salaman CR, Oomura Y., Kai Y. Tumor necrosis factor and interleukin-1 beta: suppression of food intake by direct action in the central nervous system. Brain Res. 1988 ; 448: 106-114.
18. Socher SH, Friedman A., Martinez D. Recombinant human tumor necrosis factor induces acute reduction in food intake and body weight in mice. J Exp Med. 1988 ; 167: 1957-1962.
19. Maltoni M., Fabbri L., Nanni O., et al. Serum levels of tumour necrosis factor alpha and other cytokines do not correlate with weight loss and anorexia in cancer patients. Support Care Cancer. 1997 ; 5: 130-135.
20. Gold J. Cancer cachexia and gluconeogenesis. Ann N Y Acad Sci. 1974 ; 230: 103-110.
21. Lundholm K., Edström S., Karlberg I., Ekman L., Scherstén T. Glucose turnover, gluconeogenesis from glycerol and estimation of net glucose cycling in cancer patients. Cancer. 1982 ; 50: 1142-1150.
22. Bruera E., Roca E., Cedaro L., Carraro S., Chacon R. Action of oral methylprednisolone in terminal cancer patients: a prospective randomized double-blind study. Cancer Treat Rep. 1985 ; 69: 751-754.
23. Loprinzi CL, Kugler JW, Sloan JA, et al. Randomized comparison of megestrol acetate versus dexamethasone versus fluoxymesterone for the treatment of cancer anorexia/cachexia. J Clin Oncol. 1999 ; 17: 3299-3306.
24. Mantovani G., Macciò A., Bianchi A., et al. Megestrol acetate in neoplastic anorexia/cachexia: clinical evaluation and comparison with cytokine levels in patients with head and neck carcinoma treated with neoadjuvant chemotherapy. Int J Clin Lab Res. 1995 ; 25: 135-141.
25. Mantovani G., Macciò A., Esu S., et al. Medroxyprogesterone acetate reduces the in vitro production of cytokines and serotonin involved in anorexia/cachexia and emesis by peripheral blood mononuclear cells of cancer patients. Eur J Cancer. 1997 ; 33: 602-607. (Pubitemid 27223745)
26. Kardinal CG, Loprinzi CL, Schaid DJ, et al. A controlled trial of cyproheptadine in cancer patients with anorexia and/or cachexia. Cancer. 1990 ; 65: 2657-2662.
27. Nelson KA, Walsh TD Metoclopramide in anorexia caused by cancer-associated dyspepsia syndrome (CADS). J Palliat Care. 1993 ; 9: 14-18.
28. Ray PD, Hanson RL, Lardy HA Inhibition by hydrazine of glyconeogenesis in the rat. J Biol Chem. 1970 ; 245: 690-696.
29. Kosty MP, Fleishman SB, Herndon JE 2nd, et al. Cisplatin, vinblastine and hydrazine sulfate in advanced, non-small-cell lung cancer: a randomized placebo-controlled, double-blind phase III study of the Cancer and Leukemia Group B. J Clin Oncol. 1994 ; 12: 1113-1120.
30. Emilie D., Wijdenes J., Gisselbrecht C., et al. Administration of an anti-interleukin-6 monoclonal antibody to patients with acquired immunodeficiency syndrome and lymphoma: effect on lymphoma growth and on B clinical symptoms. Blood. 1994 ; 84: 2472-2479.
31. Fan Y., Wu DZ, Gong YQ, Zhou JY, Hu ZB Effects of calycosin on the impairment of barrier function induced by hypoxia in human umbilical vein endothelial cells. Eur J Pharmacol. 2003 ; 481: 33-40.
32. Wei JA, Sun LM, Chen YX Effects of ailing granule on immuno- reconstruction in HIV/AIDS patients [in Chinese]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 ; 26: 319-321.
33. Qun L., Luo Q., Zhang ZY, et al. Effects of astragalus on IL-2/ IL-2R system in patients with maintained hemodialysis. Clin Nephrol. 1999 ; 52: 333-334.
34. Kurashige S., Akuzawa Y., Endo F. Effects of astragali radix extract on carcinogenesis, cytokine production, and cytotoxicity in mice treated with a carcinogen, N-butyl-N'-butanolnitrosoamine. Cancer Invest. 1999 ; 17: 30-35.
35. Eum HA, Lee WY, Kim SH, et al. Anti-inflammatory activity of CML-1: an herbal formulation. Am J Chin Med. 2005 ; 33: 29-40.
36. Tai T., Akita Y., Kinoshita K., Koyama K., Takahashi K., Watanabe K. Anti-emetic principles of Poria cocos. Planta Med. 1995 ; 61: 527-530.
37. Hattori T., Hayashi K., Nagao T., Furuta K., Ito M., Suzuki Y. Studies on antinephritic effects of plant components(3): Effect of pachyman, a main component of Poria cocos Wolf on original-type anti-GBM nephritis in rats and its mechanisms. Jpn J Pharmacol. 1992 ; 59: 89-96.
38. Nukaya H., Yamashiro H., Fukazawa H., Ishida H., Tsuji K. Isolation of inhibitors of TPA-induced mouse ear edema from Hoelen, Poria cocos. Chem Pharm Bull (Tokyo). 1996 ; 44: 847-849.
39. Kim KS, Rhee HI, Park EK, et al. Anti-inflammatory effects of Radix Gentianae Macrophyllae (Qinjiao), Rhizoma Coptidis (Huanglian) and Citri Unshiu Pericarpium (Wenzhou migan) in animal models. Chin Med. 2008 ; 3: 10.
40. Oh HM, Kang YJ, Kim SH, et al. Agastache rugosa leaf extract inhibits the iNOS expression in ROS 17/2.8 cells activated with TNF-alpha and IL-1 beta. Arch Pharm Res. 2005 ; 28: 305-310.
41. Li H., Wang Q. Evaluation of free hydroxyl radical scavenging activities of some Chinese herbs by capillary zone electrophoresis with amperometric detection. Anal Bioanal Chem. 2004 ; 378: 1801-1805.
42. Li RW, Lin GD, Myers SP, Leach DN Anti-inflammatory activity of Chinese medicinal vine plants. J Ethnopharmacol. 2003 ; 85: 61-67.
43. Yamada K., Yagi G., Kanba S. Effectiveness of Gorei-san (TJ-17) for treatment of SSRI-induced nausea and dyspepsia: preliminary observations. Clin Neuropharmacol. 2003 ; 26: 112-114.
44. Zhao YJ, Ji ZQ, Zhang XN, et al. Effect of Rhizoma pinelliae on vomiting in minks [in Chinese]. Zhongguo Zhong Yao Za Zhi. 2005 ; 30: 277-279.
45. JY Yum, JS Eun. Effect of Aurantii nobilis pericarpium and Aurantii immaturi pericarpium on immunocytes in mice. Kor J Pharmacogn. 1998 ; 29: 173-178.
46. Matsuda H., Li YH, Taniguchi K., Yamahara J., Tamai Y. Imaging analysis of antiulcer action and the active constituent of Atractylodis rhizome [in Japanese]. Yakugaku Zasshi. 1991 ; 111: 36-39.
47. Strasser F., Luftner D., Possinger K., et al. Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled clinical trial from the Cannabis in Cachexia Study Group. J Clin Oncol. 2006 ; 24: 3394-3400.
48. Therasse P., Arbuck SG, Eisenhauer EA, et al. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst. 2000 ; 92: 205-216.