Cell-free urinary MicroRNA-99a and MicroRNA-125b are diagnostic markers for the non-invasive screening of bladder cancer

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Zhang, Ding Zuan ^a   Lau, Kin Mang ^a   Chan, Eddie S Y ^a   Wang, Gang ^a   Szeto, Cheuk Chun ^a   Wong, Kenneth ^a   Choy, Richard K W ^a   Ng, Chi Fai ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MICRORNA 125A; MICRORNA 99A; UNCLASSIFIED DRUG; MIRN125 MICRORNA, HUMAN; MIRN99 MICRORNA, HUMAN; TUMOR MARKER;

ARTICLE; BLADDER CANCER; CANCER GRADING; CANCER SCREENING; COHORT ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DISEASE MARKER; DOWN REGULATION; GENE EXPRESSION; GENE FUNCTION; GENE IDENTIFICATION; HUMAN; HUMAN TISSUE; MICROARRAY ANALYSIS; OUTCOME ASSESSMENT; PREDICTIVE VALUE; SENSITIVITY AND SPECIFICITY; TUMOR DIFFERENTIATION; ADULT; AGED; FEMALE; GENE EXPRESSION REGULATION; MALE; MIDDLE AGED; URINARY BLADDER NEOPLASMS; URINE; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICRORNAS; MIDDLE AGED; TUMOR MARKERS, BIOLOGICAL; URINARY BLADDER NEOPLASMS;

EID: 84904266675     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0100793     Document Type: Article

References (35)

1. Timberg G, Rahu M, Gornoi K, Aareleid T, Baburin A. (1997) Bladder cancer in Estonia, 1968-1992: incidence, mortality, prevalence and survival. Scand J Urol Nephrol 31: 337-342. (Pubitemid 27364457)
2. Parker J, Spiess PE. (2011) Current and emerging bladder cancer urinary biomarkers. Sci World J 11: 1103-1112.
3. Fabbri M, Garzon R, Cimmino A, Liu Z, Zanesi N, et al. (2006) MicroRNA expression and function in cancer. Trends Mol Med 12: 580-587. (Pubitemid 44780201)
4. Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, et al. (2005) MicroRNA gene expression deregulation in human breast cancer. Cancer Res 65: 7065-7070. (Pubitemid 41161233)
5. Yanaihara N, Caplen N, Bowman E, Seike M, Kumamoto K, et al. (2006) Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 9: 189-198. (Pubitemid 43357945)
6. Chen X, Ba Y, Ma L, Cai X, Yin Y, et al. (2008) Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 18: 997-1006.
7. Weber JA, Baxter DH, Zhang S, Huang DY, Huang KH, et al. (2010) The microRNA spectrum in 12 body fluids. Clin Chem 56: 1733-1741.
8. Mraz M, Malinova K, Mayer J, Pospisilova S. (2009) MicroRNA isolation and stability in stored RNA samples. Biochem Biophys Res Commun 390: 1-4.
9. Yang H, Dinney CP, Ye Y, Zhu Y, Grossman HB, Wu X. (2008) Evaluation of genetic variants in microRNA-related genes and risk of bladder cancer. Cancer Res 68: 2530-2537. (Pubitemid 351521830)
10. Hanke M, Hoefig K, Merz H, Feller AC, Kausch I, et al. (2010) A robust methodology to study urine microRNA as tumor marker: microRNA-126 and microRNA-182 are related to urinary bladder cancer. Urol Oncol 28: 655-661.
11. Snowdon J, Boag S, Feilotter H, Izard J, Siemens DR. (2012) A pilot study of urinary microRNA as a biomarker for urothelial cancer. Can Urol Assoc J May 15: 1-5.
12. Schroeder GL, Lorenzo-Gomez MF, Hautmann SH, Friedrich MG, Ekici S, et al. (2004) A side by side comparison of cytology and biomarkers for bladder cancer detection. J Urol 172(3): 1123-1126. (Pubitemid 39096484)
13. Friedman GD, Carroll PR, Cattolica EV, Hiatt RA. (1996) Can hematuria be a predictor as well as a symptom or sign of bladder cancer? Cancer Epidemiol Biomarkers Prev 5(12): 993-996. (Pubitemid 26415872)
14. Szarvas T, Kovalszky I, Bedi K, Szendroi A, Majoros A, et al. (2007) Deletion analysis of tumor and urinary DNA to detect bladder cancer: urine supernatant versus urine sediment. Oncol Rep 18: 405-409.
15. Chang HW, Tsui KH, Shen LC, Huang HW, Wang SN, et al. (2007) Urinary cell-free DNA as a potential tumor marker for bladder cancer. Int J Biol Markers 22: 287-294. (Pubitemid 351256265)
16. Zancan M, Franceschini R, Mimmo C, Vianello M, Di Tonno F, et al. (2005) Free DNA in urine: a new marker for bladder cancer? Preliminary data. Int J Biol Markers 20: 134-136. (Pubitemid 41052460)
17. Mostofi FK, Davis CJ, Sesterhenn I. (1999) Histological typing of urinary bladder tumours. 2nd edition. Berlin, New York: Springer.
18. Yamada Y, Enokida H, Kojima S, Kawakami K, Chiyomaru T, et al. (2011) MiR-96 and miR-183 detection in urine serve as potential tumor markers of urothelial carcinoma: correlation with stage and grade, and comparison with urinary cytology. Cancer Sci 102(3): 522-529.
19. Lawrie CH, Gal S, Dunlop HM, Pushkaran B, Liggins AP, et al. (2008) Detection of elevated levels of tumor-associated microRNAs in serum of patients with diffuse large B-cell lymphoma. Br J Haematol 141: 672-675. (Pubitemid 351667616)
20. Ng EK, Chong WW, Jin H, Lam EK, Shin VY, et al. (2009) Differential expression of microRNAs in plasma of patients with colorectal cancer: a potential marker for colorectal cancer screening. Gut 58: 1375-1381.
21. Wang G, Tam LS, Li EK, Kwan BC, Chow KM, et al. (2010) Serum and urinary cell-free miR-146a and miR-155 in patients with systemic lupus erythematosus. J Rheumatol 37: 516-522.
22. Wang G, Chan ES, Kwan BC, Li PK, Yip SK, et al. (2012) Expression of microRNAs in the urine of patients with bladder cancer. Clin Genitourin Cancer 10(2): 106-113.
23. Wang G, Zhang H, He H, Tong W, Wang B, et al. (2010) Up-regulation of microRNA in bladder tumor tissue is not common. Int Urol Nephrol 42: 95-102.
24. Esquela-Kerscher A, Slack FJ. (2006) Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 6(4): 259-269.
25. Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, et al. (2008) Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA 105: 10513-10518.
26. Yoshino H, Enokida H, Chiyomaru T, Tatarano S, Hidaka H, et al. (2011) The tumor-suppressive function of miR-1 and miR-133a targeting TAGLN2 in bladder cancer. Br J Cancer 104: 808-818.
27. Tzai TS, Chen HH, Chan SH, Ho CL, Tsai YS, et al. (2003) Clinical significance of allelotype profiling for urothelial carcinoma. Urology 62(2): 378-384. (Pubitemid 36952110)
28. Satgé D, Sasco AJ, Day S, Culine S. (2009) A lower risk of dying from urological cancer in Down syndrome: clue for cancer protecting genes on chromosome 21. Urol Int 82: 296-300.
29. Sun D, Lee YS, Malhotra A, Kim HK, Matecic M, et al. (2011) MiR-99 family of microRNAs suppresses the expression of prostate-specific antigen and prostate cancer cell proliferation. Cancer Res 71: 1313-1324.
30. Hansel DE, Platt E, Orloff M, Harwalker J, Sethu S, et al. (2010) Mammalian target of rapamycin (mTOR) regulates cellular proliferation and tumor growth in urothelial carcinoma. Am J Pathol 176: 3062-3672.
31. Wszolek MF, Rieger-Christ KM, Kenney PA, Gould JJ, Silva Neto B, et al. (2011) A microRNA expression profile defining the invasive bladder tumor phenotype. Urol Oncol 29(6): 794-801.
32. Alpini G, Glaser SS, Zhang JP, Francis H, Han Y, et al. (2011) Regulation of placenta growth factor by microRNA-125b in hepatocellular cancer. J Hepatol 55(6): 1339-1345.
33. Liu LH, Li H, Li JP, Zhong H, Zhang HC, et al. (2011) MiR-125b suppresses the proliferation and migration of osteosarcoma cells through down-regulation of STAT3. Biochem Biophys Res Commun 416(1-2): 31-38.
34. Huang L, Luo J, Cai Q, Pan Q, Zeng H, et al. (2011) MicroRNA-125b suppresses the development of bladder cancer by targeting E2F3. Int J Cancer 128(8): 1758-1769.
35. Zhao A, Zeng Q, Xie X, Zhou J, Yue W, et al. (2012) MicroRNA-125b induces cancer cell apoptosis through suppression of Bcl-2 expression. J Genet Genomics 39(1): 29-35.