Practical value of identifying antibodies to cryptic HLA epitopes in cardiac transplantation

Journal of Heart and Lung Transplantation

Volumn 33, Issue 7, 2014, Pages 713-720

  Oaks, Martin ^a   Michel, Karen ^a   Sulemanjee, Nasir Z ^b   Thohan, Vinay ^b   Downey, Francis X ^a  

^a ST LUKE S MEDICAL CENTER   (United States)

^b UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

heart transplant; HLA antibodies; PRA; single antigen beads; unacceptable antigens; virtual crossmatch

Indexed keywords

COMPLEMENT COMPONENT C1Q ANTIBODY; HLA ANTIBODY; HLA ANTIGEN; HLA ANTIGEN CLASS 1; PANEL REACTIVE ANTIBODY; ANTIBODY; EPITOPE;

ADULT; AGE; AGED; ALGORITHM; ANTIBODY DETECTION; ANTIBODY RESPONSE; ANTIGEN BINDING; ARTICLE; ASSAY; ASSISTED CIRCULATION; B LYMPHOCYTE; BLOOD TRANSFUSION; COMPLEMENT FIXATION TEST; CONTROLLED STUDY; DENATURATION; FALSE POSITIVE RESULT; FEMALE; FLOW CYTOMETRY; GENDER; HEART TRANSPLANTATION; HOSPITAL ADMISSION; HUMAN; IMMUNOLOGY TEST KIT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SINGLE ANTIGEN BEAD ARRAY; T LYMPHOCYTE; VIRTUAL CROSSMATCHING; ADOLESCENT; ANTIBODY SPECIFICITY; BLOOD; HISTOCOMPATIBILITY TEST; IMMUNOLOGY; MIDDLE AGED; PROCEDURES; VALIDATION STUDY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; ANTIBODIES; ANTIBODY SPECIFICITY; COMPLEMENT FIXATION TESTS; EPITOPES; FEMALE; FLOW CYTOMETRY; HEART TRANSPLANTATION; HISTOCOMPATIBILITY TESTING; HLA ANTIGENS; HUMANS; MALE; MIDDLE AGED; WAITING LISTS; YOUNG ADULT;

EID: 84904260462     PISSN: 10532498     EISSN: 15573117     Source Type: Journal    
DOI: 10.1016/j.healun.2014.02.013     Document Type: Article

References (26)

1. J. Kobashigawa, M.G. Crespo-Leiro, and S.M. Ensminger et al. Report from a consensus conference on antibody-mediated rejection in heart transplantation J Heart Lung Transplant 30 2011 252 269
2. J. Stehlik, N. Islam, and D. Hurst et al. Utility of virtual crossmatch in sensitized patients awaiting heart transplantation J Heart Lung Transplant 28 2009 1129 1134
3. R. Pei, J.H. Lee, and N.J. Shih et al. Single human leukocyte antigen flow cytometry beads for accurate identification of human leukocyte antigen antibody specificities Transplantation 75 2003 43 49
4. L.E. Morales-Buenrostro, P.I. Terasaki, and L.A. Marino-Vázquez et al. Natural human leukocyte antigen antibodies found in nonalloimmunized healthy males Transplantation 86 2008 1111 1115
5. N. El-Awar, P.I. Terasaki, and A. Nguyen et al. Epitopes of human leukocyte antigen class I antibodies found in sera of normal healthy males and cord blood Hum Immunol 70 2009 844 853
6. S. Pereira, S. Perkins, and J.H. Lee et al. Donor-specific antibody against denatured HLA-A1: clinically nonsignificant? Hum Immunol 72 2011 492 498
7. J. Cai, P.I. Terasaki, and N. Anderson et al. Intact HLA not beta2m-free heavy chain-specific HLA class I antibodies are predictive of graft failure Transplantation 88 2009 226 230
8. J. Cai, and P.I. Terasaki Post-transplantation antibody monitoring and HLA antibody epitope identification Curr Opin Immunol 20 2008 602 606
9. A. Nikaein, N. El-Awar, and J. Hunt et al. Clinically irrelevant circulating human leukocyte antigen antibodies in the presence of ventricular assist devices J Heart Lung Transplant 31 2012 443 447
10. A. Loupy, C. Lefaucheur, and D. Vernerey et al. Complement-binding anti-HLA antibodies and kidney-allograft survival N Engl J Med 369 2013 1215 1226
11. B.D. Tait, F. Hudson, and L. Cantwell et al. Review article: Luminex technology for HLA antibody detection in organ transplantation Nephrology (Carlton) 14 2009 247 254
12. J.A. Kobashigawa, J.K. Patel, and M.M. Kittleson et al. The long-term outcome of treated sensitized patients who undergo heart transplantation Clin Transplant 25 2011 E61 E67
13. P. Stastny, B. Lavingia, and D.E. Fixler et al. Antibodies against donor human leukocyte antigens and the outcome of cardiac allografts in adults and children Transplantation 84 2007 738 745
14. G. Opelz, B. Döhler, and C. Süsal Analysis of positive kidney, heart, and liver transplant crossmatches reported to the Collaborative Transplant Study Hum Immunol 70 2009 627 630
15. M.R. Costanzo, A. Dipchand, and R. Starling et al. The International Society of Heart and Lung Transplantation guidelines for the care of heart transplant recipients J Heart Lung Transplant 29 2010 914 956
16. F. Poli, E. Benazzi, and A. Innocente et al. Heart transplantation with donor-specific antibodies directed toward denatured HLA-A*02:01: a case report Hum Immunol 72 2011 1045 1048
17. E.K. Jacob, S.R. De Goey, and M.J. Gandhi Positive virtual crossmatch with negative flow crossmatch results in two cases Transpl Immunol 25 2011 77 81
18. P. Gombos, G. Opelz, and S. Scherer et al. Influence of test technique on sensitization status of patients on the kidney transplant waiting list Am J Transplant 13 2013 2075 2082
19. L.D. Cornell, R.N. Smith, and R.B. Colvin Kidney transplantation: mechanisms of rejection and acceptance Annu Rev Pathol 3 2008 189 220
20. J. Hodoniczky, Y.Z. Zheng, and D.C. James Control of recombinant monoclonal antibody effector functions by Fc N-glycan remodeling in vitro Biotechnol Prog 21 2005 1644 1652
21. C. Lawrence, M. Willicombe, and P.A. Brookes et al. Preformed complement-activating low-level donor-specific antibody predicts early antibody-mediated rejection in renal allografts Transplantation 95 2013 341 346
22. C. Chin, G. Chen, and F. Sequeria et al. Clinical usefulness of a novel C1q assay to detect immunoglobulin G antibodies capable of fixing complement in sensitized pediatric heart transplant patients J Heart Lung Transplant 30 2011 158 163
23. M.L. Rose, and J.D. Smith Clinical relevance of complement-fixing antibodies in cardiac transplantation Hum Immunol 70 2009 605 609
24. A. Zeevi, J. Lunz, and B. Feingold et al. Persistent strong anti-HLA antibody at high titer is complement binding and associated with increased risk of antibody-mediated rejection in heart transplant recipients J Heart Lung Transplant 32 2013 98 105
25. J.J. Neefjes, and H.L. Ploegh Allele and locus-specific differences in cell surface expression and the association of HLA class I heavy chain with beta 2-microglobulin: differential effects of inhibition of glycosylation on class I subunit association Eur J Immunol 18 1988 801 810
26. A. Hill, M. Takiguchi, and A. McMichael Different rates of HLA class I molecule assembly which are determined by amino acid sequence in the alpha 2 domain Immunogenetics 37 1993 95 101