Influence of test technique on sensitization status of patients on the kidney transplant waiting list

American Journal of Transplantation

Volumn 13, Issue 8, 2013, Pages 2075-2082

  Gombos, P ^a   Opelz, G ^a   Scherer, S ^a   Morath, C ^a   Zeier, M ^a   Schemmer, P ^a   Susal C ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Antibody screening; HLA antibodies; kidney transplantation; single antigen beads; unacceptable HLA antigen mismatches

Indexed keywords

HLA A11 ANTIGEN; HLA A24 ANTIGEN; HLA A25 ANTIGEN; HLA A30 ANTIGEN; HLA A31 ANTIGEN; HLA A43 ANTIGEN; HLA A66 ANTIGEN; HLA A80 ANTIGEN; HLA ANTIBODY; HLA ANTIGEN; HLA B15 ANTIGEN; HLA B37 ANTIGEN; HLA B44 ANTIGEN; HLA B45 ANTIGEN; HLA B49 ANTIGEN; HLA B8 ANTIGEN; HLA B82 ANTIGEN; HLA C17 ANTIGEN; HLA C18 ANTIGEN; HLA C3 ANTIGEN; HLA DP ANTIGEN; HLA DQA1 ANTIGEN; HLA DRB1 ANTIGEN; UNCLASSIFIED DRUG;

ALLELE; ALLOIMMUNIZATION; ARTICLE; COMPLEMENT DEPENDENT CYTOTOXICITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE; HUMAN; IMMUNIZATION; IMMUNOASSAY; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SENSITIZATION; SINGLE ANTIGEN BEAD TEST;

EID: 84881375871     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.12332     Document Type: Article

References (21)

1. Lee PC, Ozawa M, Hung CJ, Lin YJ, Chang SS, Chou TC., Reappraisal of HLA antibody analysis and crossmatching in kidney transplantation. Transplant Proc 2009; 41: 95-98.
2. van den Berg-Loonen EM, Billen EV, Voorter CE, et al. Clinical relevance of pretransplant donor-directed antibodies detected by single antigen beads in highly sensitized renal transplant patients. Transplantation 2008; 85: 1086-1090.
3. Süsal C, Ovens J, Mahmoud K, et al. No association of kidney graft loss with human leukocyte antigen antibodies detected exclusively by sensitive Luminex single-antigen testing: A Collaborative Transplant Study report. Transplantation 2011; 91: 883-887.
4. Roelen DL, Doxiadis II, Claas FH., Detection and clinical relevance of donor specific HLA antibodies: A matter of debate. Transpl Int 2012; 25: 604-610.
5. Morales-Buenrostro LE, Terasaki PI, Marino-Vázquez LA, Lee JH, El-Awar N, Alberú J., " Natural" human leukocyte antigen antibodies found in nonalloimmunized healthy males. Transplantation 2008; 86: 1111-1115.
6. Süsal C, Opelz G., Kidney graft failure and presensitization against HLA class I and class II antigens. Transplantation 2002; 73: 1269-1273.
7. Pereira S, Perkins S, Lee JH, et al. Donor-specific antibody against denatured HLA-A1: Clinically nonsignificant ? Human Immunol 2011; 72: 492-498.
8. Poli F, Benazzi E, Innocente A, et al. Heart transplantation with donor-specific antibodies directed toward denatured HLA-A*02:01: A case report. Human Immunol 2011; 72: 1045-1048.
9. Cai J, Terasaki PI, Anderson N, Lachmann N, Schönemann C., Intact HLA not beta2m-free heavy chain-specific HLA class I antibodies are predictive of graft failure. Transplantation 2009; 88: 226-230.
10. Raybourne RB, Bunning VK, Williams KM., Reaction of anti-HLA-B monoclonal antibodies with envelope proteins of Shigella species. Evidence for molecular mimicry in the spondyloarthropathies. J Immunol 1988; 140: 3489-3495.
11. Süsal C, Kröpelin M, Daniel V, Opelz G., Molecular mimicry between HIV-1 and antigen receptor molecules: A clue to the pathogenesis of AIDS. Vox Sang 1993; 65: 10-17.
12. Grassi F, Meneveri R, Gullberg M, et al. Human immunodeficiency virus type 1 gp120 mimics a hidden monomorphic epitope borne by class I major histocompatibility complex heavy chains. J Exp Med 1991; 174: 53-62.
13. D'Orsogna LJ, Roelen DL, Doxiadis II, Claas FH., Alloreactivity from human viral specific memory T-cells. Transpl Immunol 2010; 23: 149-155.
14. Issa N, Cosio FG, Gloor JM, et al. Transplant glomerulopathy: Risk and prognosis related to anti-human leukocyte antigen class II antibody levels. Transplantation 2008; 86: 681-685.
15. Amico P, Hönger G, Mayr M, Steiger J, Hopfer H, Schaub S., Clinical relevance of pretransplant donor-specific HLA antibodies detected by single-antigen flow-beads. Transplantation 2009; 87: 1681-1688.
16. Willicombe M, Brookes P, Santos-Nunez E, et al. Outcome of patients with preformed donor-specific antibodies following alemtuzumab induction and tacrolimus monotherapy. Am J Transplant 2011; 11: 470-477.
17. Otten HG, Verhaar MC, Borst HP, Hené RJ, van Zuilen AD., Pretransplant donor-specific HLA class-I and -II antibodies are associated with an increased risk for kidney graft failure. Am J Transplant 2012; 12: 1618-1623.
18. Caro-Oleas JL, González-Escribano MF, Gentil-Govantes MÁ, et al. Clinical relevance of anti-HLA donor-specific antibodies detected by Luminex assay in the development of rejection after renal transplantation. Transplantation 2012; 94: 338-344.
19. Dunn TB, Noreen H, Gillingham K, et al. Revisiting traditional risk factors for rejection and graft loss after kidney transplantation. Am J Transplant 2011; 11: 2132-2143.
20. Tait BD, Süsal C, Gebel HM, et al. Consensus guidelines on the testing and clinical management issues associated with HLA and non-HLA antibodies in transplantation. Transplantation 2013; 95: 19-47.
21. Available at: http://bioinformatics.nmdp.org/HLA/Haplotype-Frequencies/ High-Res-HLA-Alleles-US-Pop/High-Resolution HLA Alleles and Haplotypes in the US Population.aspx. Accessed October 25, 2012.