Calmodulin mutations associated with long QT syndrome prevent inactivation of cardiac L-type Ca2+ currents and promote proarrhythmic behavior in ventricular myocytes

Journal of Molecular and Cellular Cardiology

Volumn 74, Issue , 2014, Pages 115-124

  Limpitikul, Worawan B ^a   Dick, Ivy E ^a   Joshi Mukherjee, Rosy ^a   Overgaard, Michael T ^b   George Jr , Alfred L ^c,d,e   Yue, David T ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b AALBORG UNIVERSITY   (Denmark)

^c VANDERBILT UNIVERSITY   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NORTHWESTERN UNIVERSITY   (United States)

Author keywords

APD prolongation; Calmodulin; Long QT syndrome

Indexed keywords

CALCIUM CHANNEL L TYPE; CALCIUM ION; CALMODULIN; CALCIUM;

ACTION POTENTIAL; ADULT; ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CALCIUM TRANSPORT; CONTROLLED STUDY; ELECTROPHYSIOLOGY; GENE EXPRESSION; GENETIC TRANSFECTION; GUINEA PIG; HEART MUSCLE CELL; HEART PROARRHYTHMIA; HEART VENTRICLE MUSCLE FIBER; HEK293 CELL LINE; LONG QT SYNDROME; MISSENSE MUTATION; MOLECULAR BIOLOGY; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; ANIMAL; GENE EXPRESSION REGULATION; GENETICS; HEART VENTRICLE; HUMAN; METABOLISM; MUTATION; PATCH CLAMP TECHNIQUE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ACTION POTENTIALS; ANIMALS; CALCIUM; CALCIUM CHANNELS, L-TYPE; CALMODULIN; GENE EXPRESSION REGULATION; GUINEA PIGS; HEART VENTRICLES; HEK293 CELLS; HUMANS; LONG QT SYNDROME; MUTATION; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; SIGNAL TRANSDUCTION;

EID: 84904258818     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2014.04.022     Document Type: Article

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