Netrin-1 promotes medulloblastoma cell invasiveness and angiogenesis, and demonstrates elevated expression in tumor tissue and urine of patients with pediatric medulloblastoma

Cancer Research

Volumn 74, Issue 14, 2014, Pages 3716-3726

  Akino, Tomoshige ^a   Han, Xuezhe ^a,b   Nakayama, Hironao ^a   McNeish, Brendan ^a   Zurakowski, David ^a   Mammoto, Akiko ^a   Klagsbrun, Michael ^a   Smith, Edward ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE RECEPTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NEOGENIN; NETRIN; NETRIN 1; NETRIN 2; NETRIN 4; PROTEIN UNC5B; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VASCULOTROPIN A;

ANIMAL CELL; ARTICLE; BRAIN CAPILLARY ENDOTHELIAL CELL; CANCER DIAGNOSIS; CANCER PROGNOSIS; CANCER SURGERY; CELL PROLIFERATION; CELL STIMULATION; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MEDULLOBLASTOMA; MEDULLOBLASTOMA CELL LINE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PHENOTYPE; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN URINE LEVEL; TREATMENT RESPONSE; TUMOR INVASION; TUMOR VASCULARIZATION;

ADOLESCENT; BIOLOGICAL MARKERS; BRAIN; CELL LINE, TUMOR; CHILD; ENDOTHELIAL CELLS; ENZYME ACTIVATION; GENE EXPRESSION; HUMANS; MAGNETIC RESONANCE IMAGING; MEDULLOBLASTOMA; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASM INVASIVENESS; NEOVASCULARIZATION, PATHOLOGIC; NERVE GROWTH FACTORS; PROGNOSIS; RECEPTORS, CELL SURFACE; TUMOR SUPPRESSOR PROTEINS;

EID: 84904247223     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-13-3116     Document Type: Article

References (26)

1. Dolecek TA, Propp JM, Stroup NE, Kruchko C. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2005-2009. Neuro Oncol 2012;14Suppl 5:v1-49.
2. Zeltzer PM, Boyett JM, Finlay JL, Albright AL, Rorke LB, Milstein JM, et al. Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: conclusions from the Children's Cancer Group 921 randomized phase III study. J Clin Oncol 1999;17:832-45. (Pubitemid 29109313)
3. Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, et al. Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol 2012;123:465-72.
4. Milla LA, Arros A, Espinoza N, Remke M, Kool M, Taylor MD, et al. Neogenin1 is a Sonic Hedgehog target in medulloblastoma and is necessary for cell cycle progression. Int J Cancer 2014;134:21-31.
5. Snuderl M, Batista A, Kirkpatrick ND, Ruiz de Almodovar C, Riedemann L, Walsh EC, et al. Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell 2013;152:1065-76.
6. Shimizu A, Nakayama H, Wang P, Konig C, Akino T, Sandlund J, et al. Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein. J Biol Chem 2013;288:2210-22.
7. Lai W, Sun K, Correia JP, Kennedy TE. Netrins: versatile extracellular cues with diverse functions. Development 2011;138:2153-69.
8. Mehlen P, Delloye-Bourgeois C, Chedotal A. Novel roles for slits and netrins: axon guidance cues as anticancer targets? Nat Rev Cancer 2011;11:188-97.
9. Tadagavadi RK, Wang W, Ramesh G. Netrin-1 regulates Th1/Th2/Th17 cytokine production and inflammation through UNC5B receptor and protects kidney against ischemia-reperfusion injury. J Immunol 2010;185:3750-8.
10. Tsuchiya A, Hayashi T, Deguchi K, Sehara Y, Yamashita T, Zhang H, et al. Expression of netrin-1 and its receptors DCC and neogenin in rat brain after ischemia. Brain Res 2007;1159:1-7. (Pubitemid 47058023)
11. Wang W, Reeves WB, Pays L, Mehlen P, Ramesh G. Netrin-1 overexpression protects kidney from ischemia reperfusion injury by suppressing apoptosis. Am J Pathol 2009;175:1010-8.
12. Mazelin L, Bernet A, Bonod-Bidaud C, Pays L, Arnaud S, Gespach C, et al. Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. Nature 2004;431:80-4. (Pubitemid 39215111)
13. Delloye-Bourgeois C, Fitamant J, Paradisi A, Cappellen D, Douc-Rasy S, Raquin MA, et al. Netrin-1 acts as a survival factor for aggressive neuroblastoma. J Exp Med 2009;206:833-47.
14. Dumartin L, Quemener C, Laklai H, Herbert J, Bicknell R, Bousquet C, et al. Netrin-1 mediates early events in pancreatic adenocarcinoma progression, acting on tumor and endothelial cells. Gastroenterology 2010;138:1595-606, 606 e1-8.
15. Delloye-Bourgeois C, Brambilla E, Coissieux MM, Guenebeaud C, Pedeux R, Firlej V, et al. Interference with netrin-1 and tumor cell death in non-small cell lung cancer. J Natl Cancer Inst 2009;101:237-47.
16. Fitamant J, Guenebeaud C, Coissieux MM, Guix C, Treilleux I, Scoazec JY, et al. Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer. Proc Natl Acad Sci U S A 2008;105:4850-5. (Pubitemid 351753835)
17. Smith ER, Zurakowski D, Saad A, Scott RM, Moses MA. Urinary biomarkers predict brain tumor presence and response to therapy. Clin Cancer Res 2008;14:2378-86. (Pubitemid 351551071)
18. Bielenberg DR, Shimizu A, Klagsbrun M. Semaphorin-induced cytoskeletal collapse and repulsion of endothelial cells. Methods Enzymol 2008;443:299-314.
19. Chang CH, Housepian EM, Herbert C Jr. An operative staging system and a megavoltage radiotherapeutic technic for cerebellar medulloblastomas. Radiology 1969;93:1351-9.
20. Harisiadis L, Chang CH. Medulloblastoma in children: a correlation between staging and results of treatment. Int J Radiat Oncol Biol Phys 1977;2:833-41. (Pubitemid 8253089)
21. Taylor RE, Bailey CC, Robinson K, Weston CL, Ellison D, Ironside J, et al. Results of a randomized study of preradiation chemotherapy versus radiotherapy alone for nonmetastatic medulloblastoma: The International Society of Paediatric Oncology/United Kingdom Children's Cancer Study Group PNET-3 Study. J Clin Oncol 2003;21:1581-91. (Pubitemid 46594113)
22. Yao MS, Mehta MP, Boyett JM, Li H, Donahue B, Rorke LB, et al. The effect of M-stage on patterns of failure in posterior fossa primitive neuroectodermal tumors treated on CCG-921: a phase III study in a high-risk patient population. Int J Radiat Oncol Biol Phys 1997;38:469-76. (Pubitemid 27305005)
23. Park KW, Crouse D, Lee M, Karnik SK, Sorensen LK, Murphy KJ, et al. The axonal attractant Netrin-1 is an angiogenic factor. Proc Natl Acad Sci U S A 2004;101:16210-5. (Pubitemid 39552824)
24. Wilson BD, Ii M, Park KW, Suli A, Sorensen LK, Larrieu-Lahargue F, et al. Netrins promote developmental and therapeutic angiogenesis. Science 2006;313:640-4. (Pubitemid 44201136)
25. Larrivee B, Freitas C, Trombe M, Lv X, Delafarge B, Yuan L, et al. Activation of the UNC5B receptor by Netrin-1 inhibits sprouting angiogenesis. Genes Dev 2007;21:2433-47. (Pubitemid 47533561)
26. Lu X, Le Noble F, Yuan L, Jiang Q, De Lafarge B, Sugiyama D, et al. The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature 2004;432:179-86. (Pubitemid 39545842)