Secreted proteins from the helminth Fasciola hepatica inhibit the initiation of autoreactive T cell responses and prevent diabetes in the NOD mouse

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Lund, Maria E ^a   O'Brien, Bronwyn A ^a   Hutchinson, Andrew T ^a   Robinson, Mark W ^b   Simpson, Ann M ^a   Dalton, John P ^c   Donnelly, Sheila ^a  

^a UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ARGINASE 1; FASCIOLA HEPATICA EXCRETED SECRETED PROTEIN; GAMMA INTERFERON; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2A ANTIBODY; IMMUNOMODULATING AGENT; PROGRAMMED DEATH 1 LIGAND 1; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; DRUG MECHANISM; ENZYME REPRESSION; FASCIOLA HEPATICA; FEMALE; IMMUNOREGULATION; IN VITRO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; LYMPH NODE; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PANCREAS; PERITONEUM MACROPHAGE; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN SECRETION; REGULATORY T LYMPHOCYTE; SPLEEN CELL;

ANIMALS; ANTIGENS, CD274; AUTOANTIBODIES; AUTOIMMUNITY; BETA-N-ACETYLHEXOSAMINIDASES; CELL DIFFERENTIATION; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; FASCIOLA HEPATICA; FEMALE; HELMINTHS; INTERFERON-GAMMA; LECTINS; LYMPH NODES; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED NOD; PANCREAS; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA;

EID: 84904241398     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0086289     Document Type: Article

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