EGCG decreases the expression of HIF-1α and VEGF and cell growth in MCF-7 breast cancer cells

Journal of B.U.ON.

Volumn 19, Issue 2, 2014, Pages 435-439

  Luo, Hai Qing ^a   Xu, Meng ^b   Zhong, Wang Tao ^a   Cui, Zhong Yi ^a   Liu, Fu Mei ^a   Zhou, Ke Yan ^a   Li, Xiang Yong ^a  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

^b JINAN UNIVERSITY   (China)

Author keywords

Breast cancer; Epigallocatechin 3 gallate (EGCG); HIF 1a; Vascular endothelial growth factor (VEGF)

Indexed keywords

EPIGALLOCATECHIN GALLATE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; TRYPAN BLUE; VASCULOTROPIN;

ARTICLE; BREAST CANCER; CELL CULTURE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; CULTURE MEDIUM; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; MCF 7 CELL LINE; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN SECRETION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STAINING; SUPERNATANT; WESTERN BLOTTING;

CATECHIN; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MCF-7 CELLS; RNA, MESSENGER; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84904210320     PISSN: 11070625     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Ahmad N, Feyes DK, Nieminen AL, Agarwal R, Mukhtar H. Green tea constituent epigallocatechin-3 gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells. Natl Cancer Inst 1997;89:1881-1886. (Pubitemid 28009824)
2. Zhang Y, Yang ND, Zhou F et al. (-)-Epigallocatechin-3-Gallate Induces Non-Apoptotic Cell Death in Human Cancer Cells via ROS-Mediated Lysosomal Membrane Permeabilization. PLoS One 2012;7:e46749. doi:10.1371/journal.pone. 0046749.
3. Wang H, Bian S, Yang CS. Green tea polyphenol EGCG suppresses lung cancer cell growth through upregulating miR-210 expression caused by stabilizing HIF-1α Carcinogenesis 2011;32:1881-1889.
4. Lin CH, Shen YA. Hung PH, Yu YB, Chen YJ. Epigallocathechin gallate, polyphenol present in green tea, inhibits stem-like characteristics and epithelial-mesenchymal transition innasopharyngeal cancer cell lines. BMC Complement Altern Med 2012;12:201-213.
5. Zhang Q, Fu H. Pan J et al. Effect of dietary Polyphenol E and EGCG on lung tumorigenesis in A/J Mice. Pharm Res 2010;27:1066-1071.
6. Shankar S, Suthakar G, Srivastava RK. Epigallocatechin-3-gallate inhibits cell cycle and induces apoptosis in pancreatic cancer. Front Biosci 2007;1:5039-5051.
7. Kang SU, Lee BS, Lee SH, Baek SJ, Shin YS, Kim CH. Expression of NSAID-activated gene-1 by EGCG in head and neck cancer: involvement of ATM-dependent p53 expression.) Nutr Biochem 2012 Sep 24. pii: S0955-2863(12)00196-9. doi: 10.1016/j.jnutbio.2012.07.003.
8. Lu X, Kang Y. Hypoxia and hypoxia-inducible factors: master regulators of metastasis. Clin Cancer Res 2010;16:5928-5935.
9. Hung JJ, Yang MH, Hsu HS, Hsu WH. Liu JS, Wu KJ. Prognostic significance of hypoxia-inducible factor-1 alpha, TWIST1 and Snail expression in resectable non-small cell lung cancer. Thorax 2009;12:1082-1089.
10. Dai CX, Gao Q, Qiu SJ et al. Hypoxia-inducible factor-1 alpha, in association with inflammation, angiogenesis and MYC, is a critical prognostic factor in patients with HCC after surgery. BMC Cancer 2009;9:418-429.
11. Ellis L, Hammers H, Pili R. Targeting tumor angiogenesis with histone deacetylase inhibitors. Cancer Lett 2009;280:145-153.
12. Semenza GL. Expression of hypoxia-inducible factor 1: mechanisms and consequences. Biochem Pharmacol 2000;59:47-53.
13. Li G, He L, Zhang E, Shi J et al. Overexpression of human papillomavirus (HPV) type 16 oncoproteins promotes angiogenesis via enhancing HIF-1α and VEGF expression in non-small cell lung cancer cells. Cancer Lett 2011;311:160-170.
14. Zhang Q, Tang X, Lu Q, Zhang Z, Rao J, Le AD. Green tea extract and (-)-epigallocatechin-3-gallate inhibit hypoxia- and serum-induced HIF-1 alpha protein accumulation and VEGF expression in human cervical carcinoma and hepatoma cells. Mol Cancer Ther 2006;5:1227-1238. (Pubitemid 43881315)
15. Shirakami Y, Shimizu M, Adachi S et al. (-)-Epigallocatechin gallate suppresses the growth of human hepatocellular carcinoma cells by inhibiting activation of the vascular endothelial growth factor-vascular endothelial growth factor receptor axis. Cancer Sci 2009;100:1957-1962.