Nebulized hypertonic saline for bronchiolitis: A randomized clinical trial

JAMA Pediatrics

Volumn 168, Issue 7, 2014, Pages 657-663

  Wu, Susan ^a,b   Baker, Chris ^c   Lang, Michael E ^c   Schrager, Sheree M ^a   Liley, Fasha F ^a,b   Papa, Carmel ^c   Mira, Valerie ^a,b   Balkian, Ara ^a,b   Mason, Wilbert H ^a,b  

^a CHILDREN S HOSPITAL LOS ANGELES   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c CHILDREN S HOSPITAL OAKLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SALBUTAMOL SULFATE; SODIUM CHLORIDE;

ARTICLE; CONTROLLED STUDY; CONVENIENCE SAMPLE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; EMERGENCY WARD; FEMALE; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HUMAN; INFANT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; NEBULIZATION; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY DISTRESS ASSESSMENT INSTRUMENT SCORE; SCORING SYSTEM; VIRAL BRONCHIOLITIS;

ALBUTEROL; BRONCHIOLITIS, VIRAL; BRONCHODILATOR AGENTS; DOUBLE-BLIND METHOD; EMERGENCY MEDICAL SERVICES; FEMALE; HUMANS; INFANT; LENGTH OF STAY; MALE; NEBULIZERS AND VAPORIZERS; SALINE SOLUTION, HYPERTONIC; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; URBAN HEALTH;

EID: 84904202228     PISSN: 21686203     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamapediatrics.2014.301     Document Type: Article

References (39)

1. Pelletier AJ, Mansbach JM, Camargo CA Jr. Direct medical costs of bronchiolitis hospitalizations in the United States. Pediatrics. 2006;118(6):2418-2423. (Pubitemid 46397582)
2. Shay DK, Holman RC, Newman RD, Liu LL, Stout JW, Anderson LJ. Bronchiolitis-associated hospitalizations among US children, 1980-1996. JAMA. 1999;282(15):1440-1446. (Pubitemid 29493797)
3. Viswanathan M, King VJ, Bordley C, et al. Management of bronchiolitis in infants and children. Evid Rep Technol Assess (Summ). 2003;69(69):1-5.
4. Hartling L, Fernandes RM, Bialy L, et al. Steroids and bronchodilators for acute bronchiolitis in the first two years of life: systematic review and meta-analysis. BMJ. 2011;342:d1714. doi:10.1136/bmj.d1714.
5. Fernandes RM, Bialy LM, Vandermeer B, et al. Glucocorticoids for acute viral bronchiolitis in infants and young children. Cochrane Database Syst Rev. 2010;(10):CD004878.
6. Gadomski AM, Brower M. Bronchodilators for bronchiolitis. Cochrane Database Syst Rev. 2010;(12):CD001266.
7. King VJ, Viswanathan M, Bordley WC, et al. Pharmacologic treatment of bronchiolitis in infants and children: a systematic review. Arch Pediatr Adolesc Med. 2004;158(2):127-137. (Pubitemid 38173966)
8. American Academy of Pediatrics Subcommittee on Diagnosis and Management of Bronchiolitis. Diagnosis and management of bronchiolitis. Pediatrics. 2006;118(4):1774-1793.
9. Donaldson SH, Bennett WD, Zeman KL, Knowles MR, Tarran R, Boucher RC. Mucus clearance and lung function in cystic fibrosis with hypertonic saline. N Engl J Med. 2006;354(3):241-250. (Pubitemid 43113029)
10. Wark PA, McDonald V, Jones AP. Nebulised hypertonic saline for cystic fibrosis. Cochrane Database Syst Rev. 2005;(3):001506.
11. Robinson M, Hemming AL, Regnis JA, et al. Effect of increasing doses of hypertonic saline on mucociliary clearance in patients with cystic fibrosis. Thorax. 1997;52(10):900-903. (Pubitemid 27473934)
12. Kellett F, Redfern J, Niven RM. Evaluation of nebulised hypertonic saline (7%) as an adjunct to physiotherapy in patients with stable bronchiectasis. Respir Med. 2005;99(1):27-31. (Pubitemid 40017380)
13. Wabnitz DA, Wormald PJ. A blinded, randomized, controlled study on the effect of buffered 0.9%and 3%sodium chloride intranasal sprays on ciliary beat frequency. Laryngoscope. 2005;115(5):803-805. (Pubitemid 40604683)
14. Homer JJ, Dowley AC, Condon L, El-Jassar P, Sood S. The effect of hypertonicity on nasal mucociliary clearance. Clin Otolaryngol Allied Sci. 2000;25(6):558-560. (Pubitemid 32002871)
15. Rabago D, Pasic T, Zgierska A, Mundt M, Barrett B, Maberry R. The efficacy of hypertonic saline nasal irrigation for chronic sinonasal symptoms. Otolaryngol Head Neck Surg. 2005;133(1):3-8. (Pubitemid 40980953)
16. Ciesla DJ, Moore EE, Biffl WL, Gonzalez RJ, Silliman CC. Hypertonic saline attenuation of the neutrophil cytotoxic response is reversed upon restoration of normotonicity and reestablished by repeated hypertonic challenge. Surgery. 2001;129(5):567-575. (Pubitemid 32374988)
17. Ciesla DJ, Moore EE, Musters RJ, Biffl WL, Silliman CA. Hypertonic saline alteration of the PMN cytoskeleton: implications for signal transduction and the cytotoxic response. J Trauma. 2001;50(2):206-212. (Pubitemid 32230140)
18. Das S, Palmer OP, Leight WD, et al. Cytokine amplification by respiratory syncytial virus infection in human nasal epithelial cells. Laryngoscope. 2005;115(5):764-768. (Pubitemid 40604676)
19. Miraglia Del Giudice M, Saitta F, Leonardi S, et al. Effectiveness of nebulized hypertonic saline and epinephrine in hospitalized infants with bronchiolitis. Int J Immunopathol Pharmacol. 2012;25(2):485-491.
20. Luo Z, Fu Z, Liu E, et al. Nebulized hypertonic saline treatment in hospitalized children with moderate to severe viral bronchiolitis. Clin Microbiol Infect. 2011;17(12):1829-1833.
21. Luo Z, Liu E, Luo J, et al. Nebulized hypertonic saline/salbutamol solution treatment in hospitalized children with mild to moderate bronchiolitis. Pediatr Int. 2010;52(2):199-202.
22. Kuzik BA, Al-Qadhi SA, Kent S, et al. Nebulized hypertonic saline in the treatment of viral bronchiolitis in infants. J Pediatr. 2007;151(3):266-270.e1. doi:10.1016/j.jpeds.2007.04.010.
23. Tal G, Cesar K, Oron A, Houri S, Ballin A, Mandelberg A. Hypertonic saline/epinephrine treatment in hospitalized infants with viral bronchiolitis reduces hospitalization stay: 2 years experience. Isr Med Assoc J. 2006;8(3):169-173.
24. Mandelberg A, Tal G, Witzling M, et al. Nebulized 3%hypertonic saline solution treatment in hospitalized infants with viral bronchiolitis. Chest. 2003;123(2):481-487. (Pubitemid 36269434)
25. Sarrell EM, Tal G, Witzling M, et al. Nebulized 3%hypertonic saline solution treatment in ambulatory children with viral bronchiolitis decreases symptoms. Chest. 2002;122(6):2015-2020. (Pubitemid 36051138)
26. Ipek IO, Yalcin EU, Sezer RG, Bozaykut A. The efficacy of nebulized salbutamol, hypertonic saline and salbutamol/hypertonic saline combination in moderate bronchiolitis. Pulm Pharmacol Ther. 2011;24(6):633-637.
27. Al-Ansari K, Sakran M, Davidson BL, El Sayyed R, Mahjoub H, Ibrahim K. Nebulized 5%or 3% hypertonic or 0.9%saline for treating acute bronchiolitis in infants. J Pediatr. 2010;157(4):630-634.e1. doi:10.1016/j.jpeds.2010.04.074.
28. Anil AB, Anil M, Saglam AB, Cetin N, Bal A, Aksu N. High volume normal saline alone is as effective as nebulized salbutamol-normal saline, epinephrine-normal saline, and 3% saline inmild bronchiolitis. Pediatr Pulmonol. 2010;45(1):41-47.
29. Kuzik BA, Flavin MP, Kent S, et al. Effect of inhaled hypertonic saline on hospital admission rate in children with viral bronchiolitis: a randomized trial. CJEM. 2010;12(6):477-484.
30. Grewal S, Ali S, McConnell DW, Vandermeer B, Klassen TP. A randomized trial of nebulized 3% hypertonic saline with epinephrine in the treatment of acute bronchiolitis in the emergency department. Arch Pediatr Adolesc Med. 2009;163(11):1007-1012.
31. Lowell DI, Lister G, Von Koss H, McCarthy P. Wheezing in infants: the response to epinephrine. Pediatrics. 1987;79(6):939-945. (Pubitemid 17079009)
32. Corneli HM, Zorc JJ, Mahajan P, et al Bronchiolitis Study Group of the Pediatric Emergency Care Applied Research Network (PECARN). A multicenter, randomized, controlled trial of dexamethasone for bronchiolitis. N Engl J Med. 2007;357(4):331-339. (Pubitemid 47124133)
33. Mull CC, Scarfone RJ, Ferri LR, et al. A randomized trial of nebulized epinephrine vs albuterol in the emergency department treatment of bronchiolitis. Arch Pediatr Adolesc Med. 2004;158(2):113-118. (Pubitemid 38173964)
34. Daviskas E, Anderson SD, Gonda I, et al. Inhalation of hypertonic saline aerosol enhances mucociliary clearance in asthmatic and healthy subjects. Eur Respir J. 1996;9(4):725-732. (Pubitemid 26167877)
35. Zhang L, Mendoza-Sassi RA, Wainwright C, Klassen TP. Nebulised hypertonic saline solution for acute bronchiolitis in infants. Cochrane Database Syst Rev. 2013;7:CD006458.
36. Sood N, Bennett WD, Zeman K, et al. Increasing concentration of inhaled saline with or without amiloride: effect on mucociliary clearance in normal subjects. Am J Respir Crit Care Med. 2003;167(2):158-163. (Pubitemid 36076074)
37. Destino L, Weisgerber MC, Soung P, et al. Validity of respiratory scores in bronchiolitis. Hosp Pediatr. 2012;2(4):202-209.
38. Plint AC, Johnson DW, Patel H, et al Pediatric Emergency Research Canada (PERC). Epinephrine and dexamethasone in children with bronchiolitis. N Engl J Med. 2009;360(20):2079-2089.
39. Ralston S, Hill V, Martinez M. Nebulized hypertonic saline without adjunctive bronchodilators for children with bronchiolitis. Pediatrics. 2010;126(3):e520-e525. doi:10.1542/peds.2009-3105.