The cannabinoid receptor 2 agonist, β-caryophyllene, reduced voluntary alcohol intake and attenuated ethanol-induced place preference and sensitivity in mice

Pharmacology Biochemistry and Behavior

Volumn 124, Issue , 2014, Pages 260-268

  Al Mansouri, Shamma ^a   Ojha, Shreesh ^a   Al Maamari, Elyazia ^a   Al Ameri, Mouza ^a   Nurulain, Syed M ^a   Bahi, Amine ^a  

^a UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

Author keywords

AM630; Conditioned place preference; LORR; Two bottle choice; Caryophyllene

Indexed keywords

6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; ALCOHOL; CANNABINOID 2 RECEPTOR; CANNABINOID 2 RECEPTOR AGONIST; CARYOPHYLLENE; QUININE; SACCHARIN; SESQUITERPENE;

ADULT; ALCOHOL CONSUMPTION; ALCOHOLISM; ANIMAL EXPERIMENT; APPETITE; ARTICLE; BITTER TASTE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOSE RESPONSE; FLUID INTAKE; MALE; MOUSE; NONHUMAN; PLACE PREFERENCE; PRIORITY JOURNAL; REWARD; SENSITIVITY ANALYSIS; SWEETNESS; TASTE ACUITY; AGONISTS; ANIMAL; C57BL MOUSE; CONDITIONED REFLEX; DRINKING BEHAVIOR; PREVENTION AND CONTROL;

ALCOHOL DRINKING; ANIMALS; CONDITIONING, CLASSICAL; ETHANOL; MALE; MICE; MICE, INBRED C57BL; RECEPTOR, CANNABINOID, CB2; SESQUITERPENES;

EID: 84904160427     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2014.06.025     Document Type: Article

References (46)

1. A. Asghari-Roodsari, A. Lesani, M. Javadi-Paydar, L. Tabatabaeefar, S.M. Tavangar, and A. Norouzi et al. Tocolytic effect of delta9-tetrahydrocannabinol in mice model of lipopolysaccharide-induced preterm delivery: role of nitric oxide Reprod Sci 17 2010 391 400
2. B.K. Atwood, and K. Mackie CB2: a cannabinoid receptor with an identity crisis Br J Pharmacol 160 2010 467 479
3. A. Bahi Individual differences in elevated plus-maze exploration predicted higher ethanol consumption and preference in outbred mice Pharmacol Biochem Behav 105 2013 83 88
4. A. Bahi The selective metabotropic glutamate receptor 7 allosteric agonist AMN082 prevents reinstatement of extinguished ethanol-induced conditioned place preference in mice Pharmacol Biochem Behav 101 2012 193 200
5. A. Bahi Viral-mediated knockdown of mGluR7 in the nucleus accumbens mediates excessive alcohol drinking and increased ethanol-elicited conditioned place preference in rats Neuropsychopharmacology 38 2013 2109 2119
6. A. Bahi, and J.L. Dreyer Involvement of nucleus accumbens dopamine D1 receptors in ethanol drinking, ethanol-induced conditioned place preference, and ethanol-induced psychomotor sensitization in mice Psychopharmacology 222 2012 141 153
7. A. Bahi, and J.L. Dreyer Involvement of tissue plasminogen activator "tPA" in ethanol-induced locomotor sensitization and conditioned-place preference Behav Brain Res 226 2012 250 258
8. A. Bahi, B. Sadek, S.J. Schwed, M. Walter, and H. Stark Influence of the novel histamine H(3) receptor antagonist ST1283 on voluntary alcohol consumption and ethanol-induced place preference in mice Psychopharmacology 228 2013 85 95
9. A. Bahi, V. Tolle, J.A. Fehrentz, L. Brunel, J. Martinez, and C.L. Tomasetto et al. Ghrelin knockout mice show decreased voluntary alcohol consumption and reduced ethanol-induced conditioned place preference Peptides 43 2013 48 55
10. B.S. Basavarajappa The endocannabinoid signaling system: a potential target for next-generation therapeutics for alcoholism Mini-Rev Med Chem 7 2007 769 779 (Pubitemid 47304939)
11. A.F. Bento, R. Marcon, R.C. Dutra, R.F. Claudino, M. Cola, and D.F. Leite et al. Beta-caryophyllene inhibits dextran sulfate sodium-induced colitis in mice through CB2 receptor activation and PPARgamma pathway Am J Pathol 178 2011 1153 1166
12. C.S. Breivogel, and S.R. Childers The functional neuroanatomy of brain cannabinoid receptors Neurobiol Dis 5 1998 417 431 (Pubitemid 29075842)
13. A. Brusco, P. Tagliaferro, T. Saez, and E.S. Onaivi Postsynaptic localization of CB2 cannabinoid receptors in the rat hippocampus 62 2008 Synapse New York, N.Y 944 949
14. A.M. Erdozain, and L.F. Callado Involvement of the endocannabinoid system in alcohol dependence: the biochemical, behavioral and genetic evidence Drug Alcohol Depend 117 2011 102 110
15. P.M. Galdino, M.V. Nascimento, I.F. Florentino, R.C. Lino, J.O. Fajemiroye, and B.A. Chaibub et al. The anxiolytic-like effect of an essential oil derived from Spiranthera odoratissima A. St. Hil. leaves and its major component, beta-caryophyllene, in male mice Prog Neuropsychopharmacol Biol Psychiatry 38 2012 276 284
16. J. Gertsch, M. Leonti, S. Raduner, I. Racz, J.Z. Chen, and X.Q. Xie et al. Beta-caryophyllene is a dietary cannabinoid Proc Natl Acad Sci U S A 105 2008 9099 9104
17. J. Gertsch, R.G. Pertwee, and V. Di Marzo Phytocannabinoids beyond the Cannabis plant - do they exist? Br J Pharmacol 160 2010 523 529
18. B. Horvath, P. Mukhopadhyay, M. Kechrid, V. Patel, G. Tanchian, and D.A. Wink et al. Beta-caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner Free Radic Biol Med 52 2012 1325 1333
19. A.L. Klauke, I. Racz, B. Pradier, A. Markert, A.M. Zimmer, and J. Gertsch et al. The cannabinoid CB2 receptor-selective phytocannabinoid beta-caryophyllene exerts analgesic effects in mouse models of inflammatory and neuropathic pain Eur Neuropsychopharmacol 24 2014 608 620
20. M. Klugmann, V. Klippenstein, F.M. Leweke, R. Spanagel, and M. Schneider Cannabinoid exposure in pubertal rats increases spontaneous ethanol consumption and NMDA receptor associated protein levels Int J Neuropsychopharmacol 14 4 2011 May 505 517
21. B. Le Foll, D.A. Gorelick, and S.R. Goldberg The future of endocannabinoid-oriented clinical research after CB1 antagonists Psychopharmacology 205 2009 171 174
22. P. Maccioni, G. Colombo, and M.A. Carai Blockade of the cannabinoid CB1 receptor and alcohol dependence: preclinical evidence and preliminary clinical data CNS Neurol Disord Drug Targets 9 2010 55 59
23. R. Maldonado, O. Valverde, and F. Berrendero Involvement of the endocannabinoid system in drug addiction Trends Neurosci 29 2006 225 232
24. C. Manzanedo, M.A. Aguilar, M. Rodriguez-Arias, M. Navarro, and J. Minarro Cannabinoid agonist-induced sensitisation to morphine place preference in mice Neuroreport 15 2004 1373 1377 (Pubitemid 38757284)
25. D. Molina-Jasso, I. Alvarez-Gonzalez, and E. Madrigal-Bujaidar Clastogenicity of beta-caryophyllene in mouse Biol Pharm Bull 32 2009 520 522
26. F.A. Moreira, M. Grieb, and B. Lutz Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: focus on anxiety and depression Best Pract Res Clin Endocrinol Metab 23 2009 133 144
27. F.A. Moreira, and C.T. Wotjak Cannabinoids and anxiety Curr Top Behav Neurosci 2 2010 429 450
28. S. Moreno, S. Farioli-Vecchioli, and M.P. Ceru Immunolocalization of peroxisome proliferator-activated receptors and retinoid X receptors in the adult rat CNS Neuroscience 123 2004 131 145 (Pubitemid 37518482)
29. F. Navarrete, M. Rodriguez-Arias, E. Martin-Garcia, D. Navarro, M.S. Garcia-Gutierrez, and M.A. Aguilar et al. Role of CB2 cannabinoid receptors in the rewarding, reinforcing, and physical effects of nicotine Neuropsychopharmacology 38 2013 2515 2524
30. S.E. O'Sullivan, and D.A. Kendall Cannabinoid activation of peroxisome proliferator-activated receptors: potential for modulation of inflammatory disease Immunobiology 215 2010 611 616
31. E.S. Onaivi Cannabinoid receptors in brain: pharmacogenetics, neuropharmacology, neurotoxicology, and potential therapeutic applications Int Rev Neurobiol 88 2009 335 369
32. E.S. Onaivi Neuropsychobiological evidence for the functional presence and expression of cannabinoid CB2 receptors in the brain Neuropsychobiology 54 2006 231 246
33. E.S. Onaivi, H. Ishiguro, J.P. Gong, S. Patel, P.A. Meozzi, and L. Myers et al. Brain neuronal CB2 cannabinoid receptors in drug abuse and depression: from mice to human subjects PLoS ONE 3 2008 e1640
34. E.S. Onaivi, H. Ishiguro, J.P. Gong, S. Patel, P.A. Meozzi, and L. Myers et al. Functional expression of brain neuronal CB2 cannabinoid receptors are involved in the effects of drugs of abuse and in depression Ann N Y Acad Sci 1139 2008 434 449
35. E.S. Onaivi, H. Ishiguro, J.P. Gong, S. Patel, A. Perchuk, and P.A. Meozzi et al. Discovery of the presence and functional expression of cannabinoid CB2 receptors in brain Ann N Y Acad Sci 1074 2006 514 536 (Pubitemid 44532857)
36. A. Ortega-Álvaro, A. Ternianov, A. Aracil-Fernández, F. Navarrete, M.S. García-Gutiérrez, and J. Manzanares Role of cannabinoid CB(2) receptor in the reinforcing actions of ethanol Addict Biol. 2013 10.1111/adb.12076 (Epub ahead of print)
37. Y. Persidsky, W. Ho, S.H. Ramirez, R. Potula, M.E. Abood, and E. Unterwald et al. HIV-1 infection and alcohol abuse: neurocognitive impairment, mechanisms of neurodegeneration and therapeutic interventions Brain Behav Immun 25 Suppl. 1 2011 S61 S70
38. D.A. Sarruf, F. Yu, H.T. Nguyen, D.L. Williams, R.L. Printz, and K.D. Niswender et al. Expression of peroxisome proliferator-activated receptor-gamma in key neuronal subsets regulating glucose metabolism and energy homeostasis Endocrinology 150 2009 707 712
39. S. Stopponi, L. Somaini, A. Cippitelli, N. Cannella, S. Braconi, and M. Kallupi et al. Activation of nuclear PPARgamma receptors by the antidiabetic agent pioglitazone suppresses alcohol drinking and relapse to alcohol seeking Biol Psychiatry 69 2011 642 649
40. G. Tanda Modulation of the endocannabinoid system: therapeutic potential against cocaine dependence Pharmacol Res 56 2007 406 417 (Pubitemid 350030890)
41. M.D. Van Sickle, M. Duncan, P.J. Kingsley, A. Mouihate, P. Urbani, and K. Mackie et al. Identification and functional characterization of brainstem cannabinoid CB2 receptors Science 310 2005 329 332 (Pubitemid 41457202)
42. T. Vasiljevik, L.N. Franks, B.M. Ford, J.T. Douglas, P.L. Prather, and W.E. Fantegrossi et al. Design, synthesis, and biological evaluation of aminoalkylindole derivatives as cannabinoid receptor ligands with potential for treatment of alcohol abuse J Med Chem 56 2013 4537 4550
43. K.Y. Vinod, R. Yalamanchili, P.K. Thanos, C. Vadasz, T.B. Cooper, and N.D. Volkow et al. Genetic and pharmacological manipulations of the CB(1) receptor alter ethanol preference and dependence in ethanol preferring and nonpreferring mice 62 2008 Synapse New York, N.Y 574 581
44. M.P. Viveros, E.M. Marco, R. Llorente, and L. Lamota The role of the hippocampus in mediating emotional responses to nicotine and cannabinoids: a possible neural substrate for functional interactions Behav Pharmacol 18 2007 375 389 (Pubitemid 47356366)
45. WHO, 2004. http://www.who.int/whr/2004/en/report04-en.pdf?ua=1.
46. Z.X. Xi, X.Q. Peng, X. Li, R. Song, H.Y. Zhang, and Q.R. Liu et al. Brain cannabinoid CB(2) receptors modulate cocaine's actions in mice Nat Neurosci 14 2011 1160 1166