Ghrelin knockout mice show decreased voluntary alcohol consumption and reduced ethanol-induced conditioned place preference

Peptides

Volumn 43, Issue , 2013, Pages 48-55

  Bahi, Amine ^a   Tolle, Virginie ^b   Fehrentz, Jean Alain ^c   Brunel, Luc ^c   Martinez, Jean ^c   Tomasetto, Catherine Laure ^d   Karam, Sherif M ^a  

^a UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

^b INSERM   (France)

^c UNIVERSITÉ DE MONTPELLIER   (France)

^d INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Addiction; Conditioned place preference; Ethanol; Ghrelin; JMV2959; Locomotor activity; Two bottle choice

Indexed keywords

ALCOHOL; GHRELIN; GHRELIN RECEPTOR;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; GENE DELETION; KNOCKOUT MOUSE; LOCOMOTION; MOUSE; NEUROTRANSMISSION; NONHUMAN; NUCLEOTIDE SEQUENCE; PLACE PREFERENCE; PRIORITY JOURNAL; WILD TYPE;

ALCOHOL DRINKING; ANIMALS; CONDITIONING, OPERANT; ETHANOL; GHRELIN; GLYCINE; LOCOMOTION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, GHRELIN; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

MUS;

EID: 84875343182     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2013.02.008     Document Type: Article

References (55)

1. A. Abizaid Ghrelin and dopamine: new insights on the peripheral regulation of appetite J Neuroendocrinol 21 2009 787 793
2. A. Abizaid, Y.S. Mineur, R.H. Roth, J.D. Elsworth, M.W. Sleeman, and M.R. Picciotto Reduced locomotor responses to cocaine in ghrelin-deficient mice Neuroscience 192 2011 500 506
3. G. Addolorato, L. Leggio, T. Hillemacher, T. Kraus, E. Jerlhag, and S. Bleich Hormones and drinking behaviour: new findings on ghrelin, insulin, leptin and volume-regulating hormones. An ESBRA symposium report Drug Alcohol Rev 28 2009 160 165
4. Z. Atcha, W.S. Chen, A.B. Ong, F.K. Wong, A. Neo, and E.R. Browne Cognitive enhancing effects of ghrelin receptor agonists Psychopharmacology (Berl) 206 2009 415 427
5. A. Badaoui, C. De Saeger, J. Duchemin, D. Gihousse, P. de Timary, and P. Starkel Alcohol dependence is associated with reduced plasma and fundic ghrelin levels Eur J Clin Invest 38 2008 397 403
6. A. Bahi The selective metabotropic glutamate receptor 7 allosteric agonist AMN082 prevents reinstatement of extinguished ethanol-induced conditioned place preference in mice Pharmacol Biochem Behav 101 2012 193 200
7. A. Bahi, and J.L. Dreyer Involvement of nucleus accumbens dopamine D1 receptors in ethanol drinking, ethanol-induced conditioned place preference, and ethanol-induced psychomotor sensitization in mice Psychopharmacology (Berl) 222 2012 141 153
8. D.A. Blizard Sweet and bitter taste of ethanol in C57BL/6J and DBA2/J mouse strains Behav Genet 37 2007 146 159
9. E. Carboni, E. Acquas, R. Frau, and G. Di Chiara Differential inhibitory effects of a 5-HT3 antagonist on drug-induced stimulation of dopamine release Eur J Pharmacol 164 1989 515 519
10. V.P. Carlini, M. Ghersi, H.B. Schioth, and S.R. de Barioglio Ghrelin and memory: differential effects on acquisition and retrieval Peptides 31 2010 1190 1193
11. V.P. Carlini, M.F. Perez, E. Salde, H.B. Schioth, O.A. Ramirez, and S.R. de Barioglio Ghrelin induced memory facilitation implicates nitric oxide synthase activation and decrease in the threshold to promote LTP in hippocampal dentate gyrus Physiol Behav 101 2010 117 123
12. P.S. Clifford, J. Rodriguez, D. Schul, S. Hughes, T. Kniffin, and N. Hart Attenuation of cocaine-induced locomotor sensitization in rats sustaining genetic or pharmacologic antagonism of ghrelin receptors Addict Biol. 17 Nov (6) 2012 956 963
13. S. Clifford, R.A. Zeckler, S. Buckman, J. Thompson, N. Hart, and P.J. Wellman Impact of food restriction and cocaine on locomotion in ghrelin- and ghrelin-receptor knockout mice Addict Biol 16 2011 386 392
14. G. Di Chiara Alcohol and dopamine Alcohol Health Res World 21 1997 108 114
15. G. Di Chiara, and A. Imperato Ethanol preferentially stimulates dopamine release in the nucleus accumbens of freely moving rats Eur J Pharmacol 115 1985 131 132
16. G. Di Chiara, and A. Imperato Preferential stimulation of dopamine release in the nucleus accumbens by opiates, alcohol, and barbiturates: studies with transcerebral dialysis in freely moving rats Ann NY Acad Sci 473 1986 367 381
17. S. Diano, S.A. Farr, S.C. Benoit, E.C. McNay, I. da Silva, and B. Horvath Ghrelin controls hippocampal spine synapse density and memory performance Nat Neurosci 9 2006 381 388
18. S.L. Dickson, E. Egecioglu, S. Landgren, K.P. Skibicka, J.A. Engel, and E. Jerlhag The role of the central ghrelin system in reward from food and chemical drugs Mol Cell Endocrinol 340 2011 80 87
19. E. Disse, A.L. Bussier, C. Veyrat-Durebex, N. Deblon, P.T. Pfluger, and M.H. Tschop Peripheral ghrelin enhances sweet taste food consumption and preference, regardless of its caloric content Physiol Behav 101 2010 277 281
20. V.B. Duffy, A.C. Davidson, J.R. Kidd, K.K. Kidd, W.C. Speed, and A.J. Pakstis Bitter receptor gene (TAS2R38), 6-n-propylthiouracil (PROP) bitterness and alcohol intake Alcohol Clin Exp Res 28 2004 1629 1637
21. X.M. Guan, H. Yu, O.C. Palyha, K.K. McKee, S.D. Feighner, and D.J. Sirinathsinghji Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues Brain Res Mol Brain Res 48 1997 23 29
22. E. Jerlhag, E. Egecioglu, S.L. Dickson, and J.A. Engel Ghrelin receptor antagonism attenuates cocaine- and amphetamine-induced locomotor stimulation, accumbal dopamine release, and conditioned place preference Psychopharmacology (Berl) 211 2010 415 422
23. E. Jerlhag, E. Egecioglu, S. Landgren, N. Salome, M. Heilig, and D. Moechars Requirement of central ghrelin signaling for alcohol reward Proc Natl Acad Sci USA 106 2009 11318 11323
24. E. Jerlhag, and J.A. Engel Ghrelin receptor antagonism attenuates nicotine-induced locomotor stimulation, accumbal dopamine release and conditioned place preference in mice Drug Alcohol Depend 117 2011 126 131
25. E. Jerlhag, S. Landgren, E. Egecioglu, S.L. Dickson, and J.A. Engel The alcohol-induced locomotor stimulation and accumbal dopamine release is suppressed in ghrelin knockout mice Alcohol 45 2012 341 347
26. A. Ju, Y.H. Cheon, K.S. Lee, S.S. Lee, W.Y. Lee, and W.Y. Won The change of plasma ghrelin and leptin levels by the development of type 2 diabetes mellitus in patients with alcohol dependence Alcohol Clin Exp Res 35 2011 905 911
27. A.B. Kampov-Polevoy, M.V. Tsoi, E.E. Zvartau, N.G. Neznanov, and E. Khalitov Sweet liking and family history of alcoholism in hospitalized alcoholic and non-alcoholic patients Alcohol Alcohol 36 2001 165 170
28. S. Kaur, and A.E. Ryabinin Ghrelin receptor antagonism decreases alcohol consumption and activation of perioculomotor urocortin-containing neurons Alcohol Clin Exp Res 34 2010 1525 1534
29. M. Kojima, H. Hosoda, Y. Date, M. Nakazato, H. Matsuo, and K. Kangawa Ghrelin is a growth-hormone-releasing acylated peptide from stomach Nature 402 1999 656 660
30. G.F. Koob, and F. Weiss Pharmacology of drug self-administration Alcohol 7 1990 193 197
31. A. Koopmann, C. von der Goltz, M. Grosshans, C. Dinter, M. Vitale, and K. Wiedemann The association of the appetitive peptide acetylated ghrelin with alcohol craving in early abstinent alcohol dependent individuals Psychoneuroendocrinology 37 2012 980 986
32. S. Landgren, J.A. Engel, P. Hyytia, H. Zetterberg, K. Blennow, and E. Jerlhag Expression of the gene encoding the ghrelin receptor in rats selected for differential alcohol preference Behav Brain Res 221 2011 182 188
33. S. Landgren, E. Jerlhag, J. Hallman, L. Oreland, L. Lissner, and E. Strandhagen Genetic variation of the ghrelin signaling system in females with severe alcohol dependence Alcohol Clin Exp Res 34 2010 1519 1524
34. S. Landgren, J.A. Simms, P. Hyytia, J.A. Engel, S.E. Bartlett, and E. Jerlhag Ghrelin receptor (GHS-R1A) antagonism suppresses both operant alcohol self-administration and high alcohol consumption in rats Addict Biol 17 2012 86 94
35. L. Leggio Role of the ghrelin system in alcoholism: acting on the growth hormone secretagogue receptor to treat alcohol-related diseases Drug News Perspect 23 2010 157 166
36. L. Leggio, A. Ferrulli, S. Cardone, A. Nesci, A. Miceli, and N. Malandrino Ghrelin system in alcohol-dependent subjects: role of plasma ghrelin levels in alcohol drinking and craving Addict Biol 17 2012 452 464
37. A.I. Leshner, and G.F. Koob Drugs of abuse and the brain Proc Assoc Am Physicians 111 1999 99 108
38. C. Luscher, and C. Bellone Cocaine-evoked synaptic plasticity: a key to addiction Nat Neurosci 11 2008 737 738
39. W.J. McBride, and T.K. Li Animal models of alcoholism: neurobiology of high alcohol-drinking behavior in rodents Crit Rev Neurobiol 12 1998 339 369
40. A. Moulin, L. Demange, G. Berge, D. Gagne, J. Ryan, and D. Mousseaux Toward potent ghrelin receptor ligands based on trisubstituted 1,2,4-triazole structure.2. Synthesis and pharmacological in vitro and in vivo evaluations J Med Chem 50 2007 5790 5806
41. M. Nakazato, N. Murakami, Y. Date, M. Kojima, H. Matsuo, and K. Kangawa A role for ghrelin in the central regulation of feeding Nature 409 2001 194 198
42. E.J. Nestler Cellular responses to chronic treatment with drugs of abuse Crit Rev Neurobiol 7 1993 23 39
43. E.J. Nestler Genes and addiction Nat Genet 26 2000 277 281
44. M. Nisell, G.G. Nomikos, and T.H. Svensson Nicotine dependence, midbrain dopamine systems and psychiatric disorders Pharmacol Toxicol 76 1995 157 162
45. P.T. Pfluger, H. Kirchner, S. Gunnel, B. Schrott, D. Perez-Tilve, and S. Fu Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure Am J Physiol Gastrointest Liver Physiol 294 2008 G610 G618
46. P. Poitras, and C. Tomasetto The potential of ghrelin as a prokinetic Regul Pept 155 2009 24 27
47. M. Rosicka, M. Krsek, Z. Jarkovska, J. Marek, and V. Schreiber Ghrelin-a new endogenous growth hormone secretagogue Physiol Res 51 2002 435 441
48. A. Scinska, E. Koros, B. Habrat, A. Kukwa, W. Kostowski, and P. Bienkowski Bitter and sweet components of ethanol taste in humans Drug Alcohol Depend 60 2000 199 206
49. B. Söderpalm, and M. Ericson Neurocircuitry involved in the development of alcohol addiction: the dopamine system and its access points Curr Top Behav Neurosci. 13 2013 127 161
50. R. Spanagel, and M. Heilig Addiction and its brain science Addiction 100 2005 1813 1822
51. M. Tessari, A. Catalano, M. Pellitteri, C. Di Francesco, F. Marini, and P.A. Gerrard Correlation between serum ghrelin levels and cocaine-seeking behaviour triggered by cocaine-associated conditioned stimuli in rats Addict Biol 12 2007 22 29
52. C. Tomasetto, S.M. Karam, S. Ribieras, R. Masson, O. Lefebvre, and A. Staub Identification and characterization of a novel gastric peptide hormone: the motilin-related peptide Gastroenterology 119 2000 395 405
53. P.J. Wellman, P.S. Clifford, J. Rodriguez, S. Hughes, S. Eitan, and L. Brunel Pharmacologic antagonism of ghrelin receptors attenuates development of nicotine induced locomotor sensitization in rats Regul Pept 172 2011 77 80
54. P.J. Wellman, K.W. Davis, and J.R. Nation Augmentation of cocaine hyperactivity in rats by systemic ghrelin Regul Pept 125 2005 151 154
55. P.J. Wellman, C.N. Hollas, and A.E. Elliott Systemic ghrelin sensitizes cocaine-induced hyperlocomotion in rats Regul Pept 146 2008 33 37