PAX1 methylation as a potential biomarker for cervical cancer screening

International Journal of Gynecological Cancer

Volumn 24, Issue 5, 2014, Pages 928-934

  Kan, Yuen Yee ^a   Liou, Yu Ligh ^b   Wang, Huei Jen ^b   Chen, Chiao Ying ^a   Sung, Li Chi ^a   Chang, Chi Feng ^b   Liao, Cheng I ^c  

^a YUAN'S GENERAL HOSPITAL   (Taiwan)

^b ISTAT BIOMEDICAL CO LTD   (Taiwan)

^c KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Human papillomavirus (HPV); NK6 transcription factor related locus 1 (NKX6 1); Paired box gene 1 (PAX1); Papanicolaou test (Pap); Sex determining region Y box 1 (SOX1)

Indexed keywords

PHOSPHATE BUFFERED SALINE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NKX6.1; TRANSCRIPTION FACTOR PAX1; TRANSCRIPTION FACTOR SOX1; UNCLASSIFIED DRUG; HOMEODOMAIN PROTEIN; NKX6-1 PROTEIN, HUMAN; PAIRED BOX TRANSCRIPTION FACTOR; PAX1 TRANSCRIPTION FACTOR; SOX1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR SOX; TUMOR MARKER;

ADULT; ARTICLE; BIOPSY; CANCER SCREENING; COLPOSCOPY; CONTROLLED STUDY; DIAGNOSTIC KIT; DIAGNOSTIC TEST ACCURACY STUDY; DNA EXTRACTION; DNA METHYLATION; FEASIBILITY STUDY; FEMALE; GENERAL HOSPITAL; HUMAN; HUMAN TISSUE; INSTITUTIONAL REVIEW; LABORATORY; MAJOR CLINICAL STUDY; MAJOR SURGERY; PAPANICOLAOU TEST; PRIORITY JOURNAL; QUANTITATIVE ASSAY; SENSITIVITY AND SPECIFICITY; UTERINE CERVIX CANCER; UTERINE CERVIX CONIZATION; UTERINE CERVIX CYTOLOGY; VIRUS TYPING; WART VIRUS; ADENOCARCINOMA; AGED; CANCER GRADING; CARCINOMA, SQUAMOUS CELL; CERVICAL INTRAEPITHELIAL NEOPLASIA; CROSS-SECTIONAL STUDY; EARLY DIAGNOSIS; FOLLOW UP; GENETICS; MIDDLE AGED; POLYMERASE CHAIN REACTION; PROGNOSIS; SURVIVAL RATE; UTERINE CERVICAL NEOPLASMS; VAGINA SMEAR; VERY ELDERLY; YOUNG ADULT;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; CERVICAL INTRAEPITHELIAL NEOPLASIA; CROSS-SECTIONAL STUDIES; DNA METHYLATION; EARLY DETECTION OF CANCER; FEASIBILITY STUDIES; FEMALE; FOLLOW-UP STUDIES; HOMEODOMAIN PROTEINS; HUMANS; MIDDLE AGED; NEOPLASM GRADING; PAIRED BOX TRANSCRIPTION FACTORS; POLYMERASE CHAIN REACTION; PROGNOSIS; SOXB1 TRANSCRIPTION FACTORS; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL; UTERINE CERVICAL NEOPLASMS; VAGINAL SMEARS; YOUNG ADULT;

EID: 84904113570     PISSN: 1048891X     EISSN: 15251438     Source Type: Journal    
DOI: 10.1097/IGC.0000000000000155     Document Type: Article

References (27)

1. Forouzanfar MH, Foreman KJ, Delossantos AM, et al. Breast and cervical cancer in 187 countries between 1980 and 2010: a systematic analysis. Lancet. 2011;378:1461-1484.
2. Pak SC, Martens M, Bekkers R, et al. Pap smear screening history of women with squamous cell carcinoma and adenocarcinoma of the cervix. Aust N Z J Obstet Gynaecol. 2007;47:504-507.
3. Mahlck CG, Jonsson H, Lenner P. Pap smear screening and changes in cervical cancer mortality in Sweden. Int J Gynaecol Obstet. 1994;44:267-272.
4. Geldenhuys L, Murray ML. Sensitivity and specificity of the Pap smear for glandular lesions of the cervix and endometrium. Acta Cytol. 2007;51:47-50.
5. Brinton LA, Hamman RF, Huggins GR, et al. Sexual and reproductive risk factors for invasive squamous cell cervical cancer. J Natl Cancer Inst. 1987;79:23-30.
6. Nanda K, McCrory DC, Myers ER, et al. Accuracy of the Papanicolaou test in screening for and follow-up of cervical cytologic abnormalities: a systematic review. Ann Intern Med. 2000;132:810-819.
7. Myers ER, McCrory DC, Subramanian S, et al. Setting the target for a better cervical screening test: characteristics of a cost-effective test for cervical neoplasia screening. Obstet Gynecol. 2000;96:645-652.
8. Loiudice L, Abbiati R, Boselli F, et al. Improvement of Pap smear sensitivity using a visual adjunctive procedure: a co-operative Italian study on speculoscopy (GISPE). Eur J Cancer Prev. 1998;7:295-304.
9. Priebe AM. 2012 cervical cancer screening guidelines and the future role of HPV testing. Clin Obstet Gynecol. 2013;56:44-50.
10. Chelimo C, Wouldes TA, Cameron LD, et al. Risk factors for and prevention of human papillomaviruses (HPV), genital warts and cervical cancer. J Infect. 2013;66:207-217.
11. Ding DC, Hsu HC, Huang RL, et al. Type-specific distribution of HPV along the full spectrum of cervical carcinogenesis in Taiwan: an indication of viral oncogenic potential. Eur J Obstet Gynecol Reprod Biol. 2008;140:245-251.
12. Eide ML, Debaque H. HPV detection methods and genotyping techniques in screening for cervical cancer. Ann Pathol. 2012;32:e15-e23, 401-409.
13. Fukushige S, Horii A. DNA methylation in cancer: a gene silencing mechanism and the clinical potential of its biomarkers. Tohoku J Exp Med. 2013;229:173-185.
14. Venkatachalam R, Ligtenberg MJ, Hoogerbrugge N, et al. The epigenetics of (hereditary) colorectal cancer. Cancer Genet Cytogenet. 2010;203:1-6.
15. Schmidt B, Liebenberg V, Dietrich D, et al. SHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer based on bronchial aspirates. BMC Cancer. 2010;10:600.
16. Gupta AK, Brenner DE, Turgeon DK. Early detection of colon cancer: new tests on the horizon. Mol Diagn Ther. 2008;12:77-85.
17. Huang RL, Chang CC, Su PH, et al. Methylomic analysis identifies frequent DNA methylation of zinc finger protein 582 (ZNF582) in cervical neoplasms. PLoS One. 2012;7:e41060.
18. Wang KL, Chang TC, Jung SM, et al. Primary treatment and prognostic factors of small cell neuroendocrine carcinoma of the uterine cervix: a Taiwanese Gynecologic Oncology Group study. Eur J Cancer. 2012;48:1484-1494.
19. Chung MT, Lai HC, Sytwu HK, et al. SFRP1 and SFRP2 suppress the transformation and invasion abilities of cervical cancer cells through Wnt signal pathway. Gynecol Oncol. 2009;112:646-653.
20. Lai HC, Lin YW, Chang CC, et al. Hypermethylation of two consecutive tumor suppressor genes, BLU and RASSF1A, located at 3p21.3 in cervical neoplasias. Gynecol Oncol. 2007;104:629-635.
21. Chao TK, Ke FY, Liao YP, et al. Triage of cervical cytological diagnoses of atypical squamous cells by DNA methylation of paired boxed gene 1 (PAX1). Diagn Cytopathol. 2013;41:41-46.
22. Lai HC, Lin YW, Huang RL, et al. Quantitative DNA methylation analysis detects cervical intraepithelial neoplasms type 3 and worse. Cancer. 2010;116:4266-4274.
23. Lai HC, Lin YW, Huang TH, et al. Identification of novel DNA methylation markers in cervical cancer. Int J Cancer. 2008;123:161-7.
24. Lin H, Moh JS, Ou YC, et al. A simple method for the detection and genotyping of high-risk human papillomavirus using seminested polymerase chain reaction and reverse hybridization. Gynecol Oncol. 2005;96:84-91.
25. Lai HC, Ou YC, Chen TC, et al. PAX1/SOX1 DNA methylation and cervical neoplasia detection: a Taiwanese Gynecologic Oncology Group (TGOG) study. Cancer Medicine. 2014 (accepted).
26. Holowaty P, Miller AB, Rohan T, et al. Natural history of dysplasia of the uterine cervix. J Natl Cancer Inst. 1999;91:252-258.
27. Mandelblatt JS, Lawrence WF, Gaffikin L, et al. Costs and benefits of different strategies to screen for cervical cancer in less-developed countries. J Natl Cancer Inst. 2002;94:1469-1483.