A PET tracer for brain α2C adrenoceptors, 11C-ORM-13070: Radiosynthesis and preclinical evaluation in rats and knockout mice

Journal of Nuclear Medicine

Volumn 55, Issue 7, 2014, Pages 1171-1177

  Arponen, Eveliina ^a   Helin, Semi ^a   Marjamäki, Päivi ^a   Grönroos, Tove ^a   Holm, Patrik ^b   Löyttyniemi, Eliisa ^c   Någren, Kjell ^a   Scheinin, Mika ^c,d   Haaparanta Solin, Merja ^a   Sallinen, Jukka ^b   Solin, Olof ^a,e  

^a TURKU PET CENTRE   (Finland)

^b ORION CORPORATION   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

^d TURKU UNIVERSITY HOSPITAL   (Finland)

^e ÅBO AKADEMI UNIVERSITY   (Finland)

Author keywords

Autoradiography; PET; Radiosynthesis

Indexed keywords

1 [1 [2,3 DIHYDROBENZO(1,4)DIOXIN 2 YL]METHYL] 4 (3 CARBON METHOXYMETHYLPYRIDIN 2 YL) PIPERAZINE C 11; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2C ADRENERGIC RECEPTOR; DRUG METABOLITE; NEURONAL TRACT TRACER; ORM 13070; UNCLASSIFIED DRUG; 1-(1-(2,3-DIHYDROBENZO(1,4)DIOXIN-2-YL)METHYL)-4-(3-METHOXYMETHYLPYRIDIN-2-YL)PIPERAZINE; DIOXANE DERIVATIVE; PIPERAZINE DERIVATIVE; TRACER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; DOSIMETRY; DRUG BINDING; DRUG DISTRIBUTION; DRUG SCREENING; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; EX VIVO STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; MALE; MASS SPECTROMETRY; MOUSE; NEUROIMAGING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIATION DOSE; RAT; WILD TYPE; ANIMAL; BRAIN; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC USE; ENZYME SPECIFICITY; HUMAN; KNOCKOUT MOUSE; METABOLISM; PROCEDURES; RADIOCHEMISTRY; RADIOGRAPHY; SCINTISCANNING; SYNTHESIS;

ANIMALS; BRAIN; DIOXANES; HUMANS; MALE; MICE; MICE, KNOCKOUT; PIPERAZINES; POSITRON-EMISSION TOMOGRAPHY; RADIOACTIVE TRACERS; RADIOCHEMISTRY; RATS; RECEPTORS, ADRENERGIC, ALPHA-2; SUBSTRATE SPECIFICITY; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84904091319     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.113.135574     Document Type: Article

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