In vivo evaluation of limiting brain penetration of probes for α2C-adrenoceptor using small-animal positron emission tomography

ACS Chemical Neuroscience

Volumn 1, Issue 7, 2010, Pages 520-528

  Kawamura, Kazunori ^a   Akiyama, Megumi ^a   Yui, Joji ^a   Yamasaki, Tomoteru ^a   Hatori, Akiko ^a   Kumata, Katsushi ^a   Wakizaka, Hidekatsu ^a   Takei, Makoto ^a,b   Nengaki, Nobuki ^a,c   Yanamoto, Kazuhiko ^a,d   Fukumura, Toshimitsu ^a   Zhang, Ming Rong ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b Department of Engineering and Environment   (Japan)

^c 141 0032   (Japan)

^d OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

2C Adrenoceptor; 3,4 tetrahydroisoquinolin 2 yl)methyl 2 aryl 7 methoxybenzofuran (MBF); 11C, 4 (6,7 dimethoxy 1,2; acridin 9 yl 4 (4 methylpiperazin 1 yl)phenyl amine (JP 1302); breast cancer resistance protein (Bcrp); P glycoprotein (P gp)

Indexed keywords

4 (6,7 DIMETHOXY 1,2,3,4 TETRAHYDROISOQUINOLIN 2 YL)METHYL 2 ARYL 7 METHOXYBENZOFURAN C 11; 4 (6,7 DIMETHOXY 1,2,3,4 TETRAHYDROISOQUINOLINE 2 YLMETHYL) 2 PHENYLBENZOFURAN 7 OL; ACRIDIN 9 YL [4 (4 METHYLPIPERAZIN 1 YL)PHENYL]AMINE C 11; ACRIDIN 9 YL [4 (PIPERAZIN 1 YL)PHENYL]AMINE; ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2C ADRENERGIC RECEPTOR; BREAST CANCER RESISTANCE PROTEIN; ELACRIDAR; GLYCOPROTEIN P; RADIOISOTOPE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG PENETRATION; DRUG SYNTHESIS; DRUG UPTAKE; FEMALE; IN VIVO STUDY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN FUNCTION; RADIOACTIVITY; RADIOCHEMISTRY;

Α2C-ADRENOCEPTOR; 11C; 4-(6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLIN-2-YL)METHYL-2-ARYL-7-METHOXYBENZOFURAN (MBF); ACRIDIN-9-YL-[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINE (JP-1302); BREAST CANCER RESISTANCE PROTEIN (BCRP); P-GLYCOPROTEIN (P-GP);

ACRIDINES; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BENZOFURANS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; CARBON RADIOISOTOPES; ISOQUINOLINES; MALE; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; P-GLYCOPROTEIN; PIPERAZINES; QUINOLIZINES; RECEPTORS, ADRENERGIC, ALPHA-2; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

ANIMALIA; MUS;

EID: 77954899291     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn1000364     Document Type: Article

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