Cross-section perimeter is a suitable parameter to describe the effects of different baffle geometries in shaken microtiter plates

Journal of Biological Engineering

Volumn 8, Issue 1, 2014, Pages

  Lattermann, Clemens ^a   Funke, Matthias ^b   Hansen, Sven ^c   Diederichs, Sylvia ^a   Büchs, Jochen ^a  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b LONZA AG   (Switzerland)

^c EVONIK INDUSTRIES AG   (Germany)

Author keywords

Degree of baffling; Out of phase phenomena; Relative perimeter; Shaken bioreactors

Indexed keywords

OXYGEN;

ARTICLE; BIOREACTOR; BIOREACTOR DESIGN; CHEMICAL PARAMETERS; CORRELATIONAL STUDY; EMPIRICAL RESEARCH; GEOMETRY; MICROTITER PLATE ASSAY; OXYGEN CONCENTRATION; OXYGEN TRANSFER CAPACITY; OXYGEN TRANSPORT; PRIORITY JOURNAL; REACTOR OPERATION; RELATIVE PERIMETER; REPRODUCIBILITY; CROSS SECTION PERIMETER; GENERAL DEVICE; LIQUID; MAXIMUM OXYGEN TRANSFER CAPACITY; MICROTITER PLATE; PERIMETER; SURFACE PROPERTY; SURFACE TENSION;

EID: 84904085456     PISSN: None     EISSN: 17541611     Source Type: Journal    
DOI: 10.1186/1754-1611-8-18     Document Type: Article

References (22)

1. Kirk TV, Szita N. Oxygen transfer characteristics of miniaturized bioreactor systems. Biotechnol Bioeng 2013, 110:1005-1019. 10.1002/bit.24824, 3790518, 23280578.
2. Klöckner W, Büchs J. Advances in shaking technologies. Trends Biotechnol 2012, 30:307-314. 10.1016/j.tibtech.2012.03.001, 22520242.
3. Schäpper D, Alam MNHZ, Szita N, Lantz AE, Gernaey KV. Application of microbioreactors in fermentation process development: a review. Anal Bioanal Chem 2009, 395:679-695. 10.1007/s00216-009-2955-x, 19649621.
4. Duetz WA. Microtiter plates as mini-bioreactors: miniaturization of fermentation methods. Trends Microbiol 2007, 15:469-475. 10.1016/j.tim.2007.09.004, 17920276.
5. Fernandes P, Cabral JMS. Microlitre/millilitre shaken bioreactors in fermentative and biotransformation processes - a review. Biocatal Biotransform 2006, 24:237-252.
6. Kumar S, Wittmann C, Heinzle E. Minibioreactors. Biotechnol Lett 2004, 26:1-10.
7. Büchs J. Introduction to advantages and problems of shaken cultures. Biochem Eng J 2001, 7:91-98. 10.1016/S1369-703X(00)00106-6, 11173295.
8. Bareither R, Pollard D. A review of advanced small-scale parallel bioreactor technology for accelerated process development: current state and future need. Biotechnol Progr 2011, 27:2-14.
9. Delgado G, Topete M, Galindo E. Interaction of cultural conditions and end-product distribution in Bacillus subtilis grown in shake flasks. Appl Microbiol Biotechnol 1989, 31:288-292.
10. McDaniel LE, Bailey EG, Zimmerli A. Effect of oxygen supply rates on growth of Escherichia coli - I: studies in unbaffled and baffled shake flasks. Appl Microbiol 1965, 13:13.
11. Henzler HJ, Schedel M. Suitability of the shaking flask for oxygen supply to microbial cultures. Bioprocess Eng 1991, 7:123-131.
12. Funke M, Diederichs S, Kensy F, Müller C, Büchs J. The baffled microtiter plate: increased oxygen transfer and improved online monitoring in small scale fermentations. Biotechnol Bioeng 2009, 103:1118-1128. 10.1002/bit.22341, 19449392.
13. Hermann R, Lehmann M, Büchs J. Characterization of gas-liquid mass transfer phenomena in microtiter plates. Biotechnol Bioeng 2003, 81:178-186. 10.1002/bit.10456, 12451554.
14. Maier U, Büchs J. Characterisation of the gas-liquid mass transfer in shaking bioreactors. Biochem Eng J 2001, 7:99-106. 10.1016/S1369-703X(00)00107-8, 11173296.
15. Büchs J, Lotter S, Milbradt C. Out-of-phase operating conditions, a hitherto unknown phenomenon in shaking bioreactors. Biochem Eng J 2001, 7:135-141. 10.1016/S1369-703X(00)00113-3, 11173302.
16. Büchs J, Maier U, Milbradt C, Zoels B. Power consumption in shaking flasks on rotary shaking machines: II: nondimensional description of specific power consumption and flow regimes in unbaffled flasks at elevated liquid viscosity. Biotechnol Bioeng 2000, 68:594-601. 10.1002/(SICI)1097-0290(20000620)68:6<594::AID-BIT2>3.0.CO;2-U, 10799984.
17. Kensy F, Zimmermann HF, Knabben I, Anderlei T, Trauthwein H, Dingerdissen U, Büchs J. Oxygen transfer phenomena in 48-well microtiter plates: determination by optical monitoring of sulfite oxidation and verification by real-time measurement during microbial growth. Biotechnol Bioeng 2005, 89:698-708. 10.1002/bit.20373, 15696519.
18. Samorski M, Müller-Newen G, Büchs J. Quasi-continuous combined scattered light and fluorescence measurements: a novel measurement technique for shaken microtiter plates. Biotechnol Bioeng 2005, 92:61-68. 10.1002/bit.20573, 15988771.
19. Hermann R, Walther N, Maier U, Büchs J. Optical method for the determination of the oxygen-transfer capacity of small bioreactors based on sulfite oxidation. Biotechnol Bioeng 2001, 74:355-363. 10.1002/bit.1126, 11427937.
20. Weisenberger S, Schumpe A. Estimation of gas solubilities in salt solutions at temperatures from 273 K to 363 K. Aiche J 1996, 42:298-300.
21. Hansen PC, O'Leary DP. The use of the L-curve in the regularization of discrete ill-posed problems. SIAM J Sci Comput 1993, 14:1487-1503.
22. Hansen PC. Analysis of discrete ill-posed problems by means of the L-curve. SIAM Rev 1992, 34:561-580.