The association of alcohol and alcohol metabolizing gene variants with diabetes and coronary heart disease risk factors in a white population

PLoS ONE

Volumn 5, Issue 8, 2010, Pages

  Husemoen, Lise Lotte N ^a   Jørgensen, Torben ^a,b   Borch Johnsen, Knut ^c   Hansen, Torben ^c,f   Pedersen, Oluf ^c,d,e   Linneberg, Allan ^a  

^a Research Centre for Prevention and Health   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c STENO DIABETES CENTER   (Denmark)

^d AARHUS UNIVERSITY   (Denmark)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

^f UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ALCOHOL DEHYDROGENASE; ALCOHOL DEHYDROGENASE 1B; ALCOHOL DEHYDROGENASE 1C; ALCOHOL DEHYDROGENASE 7; ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE 1B1; ALDEHYDE DEHYDROGENASE ISOENZYME 1; ALDEHYDE DEHYDROGENASE ISOENZYME 2; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HOMOCYSTEINE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ALCOHOL DERIVATIVE;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; CAUCASIAN; CONTROLLED STUDY; DENMARK; DIABETES MELLITUS; DIASTOLIC BLOOD PRESSURE; ENZYME METABOLISM; FEMALE; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; INSULIN SENSITIVITY; ISCHEMIC HEART DISEASE; MALE; METABOLIC SYNDROME X; ORAL GLUCOSE TOLERANCE TEST; RISK FACTOR; SYSTOLIC BLOOD PRESSURE; AGED; CORONARY ARTERY DISEASE; DRINKING BEHAVIOR; ENZYMOLOGY; GENETIC PREDISPOSITION; GENETICS; METABOLISM; MIDDLE AGED;

ADULT; AGED; ALCOHOL DEHYDROGENASE; ALCOHOL DRINKING; ALCOHOLS; ALDEHYDE DEHYDROGENASE; CORONARY DISEASE; DIABETES MELLITUS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HUMANS; MALE; MIDDLE AGED; RISK FACTORS;

EID: 77957759707     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011735     Document Type: Article

References (53)

1. Stampfer MJ, Colditz GA, Willett WC, Speizer FE, Hennekens CH (1988) A prospective study of moderate alcohol consumption and the risk of coronary disease and stroke in women. N Engl J Med 319: 267-273.
2. Corrao G, Rubbiati L, Bagnardi V, Zambon A, Poikolainen K (2000) Alcohol and coronary heart disease: a meta-analysis. Addiction 95: 1505-1523.
3. Gronbaek M, Becker U, Johansen D, Gottschau A, Schnohr P, et al. (2000) Type of alcohol consumed and mortality from all causes, coronary heart disease, and cancer. Ann Intern Med 133: 411-419.
4. Rimm EB, Williams P, Fosher K, Criqui M, Stampfer MJ (1999) Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors. BMJ 319: 1523-1528.
5. Sesso HD, Gaziano JM (1999) Alcohol intake and cardiovascular morbidity and mortality. Curr Opin Nephrol Hypertens 8: 353-357.
6. Carlsson S, Hammar N, Grill V (2005) Alcohol consumption and type 2 diabetes Meta-analysis of epidemiological studies indicates a U-shaped relationship. Diabetologia 48: 1051-1054.
7. Koppes LL, Dekker JM, Hendriks HF, Bouter LM, Heine RJ (2005) Moderate alcohol consumption lowers the risk of type 2 diabetes: a meta-analysis of prospective observational studies. Diabetes Care 28: 719-725.
8. Cushman WC (2001) Alcohol consumption and hypertension. J Clin Hypertens (Greenwich) 3: 166-170.
9. Savolainen MJ, Kesaniemi YA (1995) Effects of alcohol on lipoproteins in relation to coronary heart disease. Curr Opin Lipidol 6: 243-250.
10. Davies MJ, Baer DJ, Judd JT, Brown ED, Campbell WS, et al. (2002) Effects of moderate alcohol intake on fasting insulin and glucose concentrations and insulin sensitivity in postmenopausal women: a randomized controlled trial. JAMA 287: 2559-2562.
11. Sierksma A, Patel H, Ouchi N, Kihara S, Funahashi T, et al. (2004) Effect of moderate alcohol consumption on adiponectin, tumor necrosis factor-alpha, and insulin sensitivity. Diabetes Care 27: 184-189.
12. Kannel WB, Ellison RC (1996) Alcohol and coronary heart disease: the evidence for a protective effect. Clin Chim Acta 246: 59-76.
13. Husemoen LL, Fenger M, Friedrich N, Tolstrup JS, Beenfeldt FS, et al. (2008) The association of ADH and ALDH gene variants with alcohol drinking habits and cardiovascular disease risk factors. Alcohol Clin Exp Res 32: 1984-1991.
14. Tolstrup JS, Nordestgaard BG, Rasmussen S, Tybjaerg-Hansen A, Gronbaek M (2008) Alcoholism and alcohol drinking habits predicted from alcohol dehydrogenase genes. Pharmacogenomics J 8: 220-227.
15. Eriksson CJ, Fukunaga T, Sarkola T, Chen WJ, Chen CC, et al. (2001) Functional relevance of human adh polymorphism. Alcohol Clin Exp Res 25: 157S-163S.
16. Bosron WF, Li TK (1987) Catalytic properties of human liver alcohol dehydrogenase isoenzymes. Enzyme 37: 19-28.
17. Hashibe M, McKay JD, Curado MP, Oliveira JC, Koifman S, et al. (2008) Multiple ADH genes are associated with upper aerodigestive cancers. Nat Genet 40: 707-709.
18. Homann N, Stickel F, Konig IR, Jacobs A, Junghanns K, et al. (2006) Alcohol dehydrogenase 1C*1 allele is a genetic marker for alcohol-associated cancer in heavy drinkers. Int J Cancer 118: 1998-2002.
19. Borras E, Coutelle C, Rosell A, Fernandez-Muixi F, Broch M, et al. (2000) Genetic polymorphism of alcohol dehydrogenase in europeans: the ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1. Hepatology 31: 984-989.
20. Gemma S, Vichi S, Testai E (2006) Individual susceptibility and alcohol effects:biochemical and genetic aspects. Ann Ist Super Sanita 42: 8-16.
21. Crabb DW, Matsumoto M, Chang D, You M (2004) Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology. Proc Nutr Soc 63: 49-63.
22. Yoshida A, Huang IY, Ikawa M (1984) Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals. Proc Natl Acad Sci U S A 81: 258-261.
23. Hempel J, Kaiser R, Jornvall H (1984) Human liver mitochondrial aldehyde dehydrogenase: a C-terminal segment positions and defines the structure corresponding to the one reported to differ in the Oriental enzyme variant. FEBS Lett 173: 367-373.
24. Brennan P, Lewis S, Hashibe M, Bell DA, Boffetta P, et al. (2004) Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review. Am J Epidemiol 159: 1-16.
25. Harada S, Okubo T, Nakamura T, Fujii C, Nomura F, et al. (1999) A novel polymorphism (2357 G/A) of the ALDH2 gene: linkage disequilibrium and an association with alcoholism. Alcohol Clin Exp Res 23: 958-962.
26. Chou WY, Stewart MJ, Carr LG, Zheng D, Stewart TR, et al. (1999) An A/G polymorphism in the promoter of mitochondrial aldehyde dehydrogenase (ALDH2): effects of the sequence variant on transcription factor binding and promoter strength. Alcohol Clin Exp Res 23: 963-968.
27. Stewart MJ, Malek K, Xiao Q, Dipple KM, Crabb DW (1995) The novel aldehyde dehydrogenase gene, ALDH5, encodes an active aldehyde dehydrogenase enzyme. Biochem Biophys Res Commun 211: 144-151.
28. Smith GD, Ebrahim S (2004) Mendelian randomization: prospects, potentials, and limitations. Int J Epidemiol 33: 30-42.
29. Jorgensen T, Borch-Johnsen K, Thomsen TF, Ibsen H, Glumer C, et al. (2003) A randomized non-pharmacological intervention study for prevention of ischaemic heart disease: baseline results Inter99. Eur J Cardiovasc Prev Rehabil 10: 377-386.
30. [Anonymous] (1999) Definition, diagnosis and classification of diabetes mellitus and its complications. Report of a WHO Consultation, Part 1: Diagnosis and classification of diabetes mellitus.
31. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, et al. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419.
32. Fischer M, Wetherill LF, Carr LG, You M, Crabb DW (2007) Association of the aldehyde dehydrogenase 2 promoter polymorphism with alcohol consumption and reactions in an American Jewish population. Alcohol Clin Exp Res 31: 1654-1659.
33. Hsu LC, Chang WC (1991) Cloning and characterization of a new functional human aldehyde dehydrogenase gene. J Biol Chem 266: 12257-12265.
34. Sherman D, Dave V, Hsu LC, Peters TJ, Yoshida A (1993) Diverse polymorphism within a short coding region of the human aldehyde dehydrogenase-5 (ALDH5) gene. Hum Genet 92: 477-480.
35. Balkau B, Charles MA (1999) Comment on the provisional report from the WHO consultation. European Group for the Study of Insulin Resistance (EGIR). Diabet Med 16: 442-443.
36. von Huth SL, Borch-Johnsen K, Jorgensen T (2007) Commuting physical activity is favourably associated with biological risk factors for cardiovascular disease. Eur J Epidemiol 22: 771-779.
37. Toft U, Kristoffersen LH, Lau C, Borch-Johnsen K, Jorgensen T (2007) The Dietary Quality Score: validation and association with cardiovascular risk factors: the Inter99 study. Eur J Clin Nutr 61: 270-278.
38. Husemoen LL, Thomsen TF, Fenger M, Jorgensen T (2004) Effect of lifestyle factors on plasma total homocysteine concentrations in relation to MTHFR(C677T) genotype. Inter99 (7). Eur J Clin Nutr 58: 1142-1150.
39. Husemoen LL, Thomsen TF, Fenger M, Jorgensen HL, Jorgensen T (2003) Contribution of thermolabile methylenetetrahydrofolate reductase variant to total plasma homocysteine levels in healthy men and women. Inter99 (2). Genet Epidemiol 24: 322-330.
40. Fagrell B, De Faire U, Bondy S, Criqui M, Gaziano M, et al. (1999) The effects of light to moderate drinking on cardiovascular diseases. J Intern Med 246: 331-340.
41. Beulens JW, Rimm EB, Hendriks HF, Hu FB, Manson JE, et al. (2007) Alcohol consumption and type 2 diabetes: influence of genetic variation in alcohol dehydrogenase. Diabetes 56: 2388-2394.
42. Hines LM, Stampfer MJ, Ma J, Gaziano JM, Ridker PM, et al. (2001) Genetic variation in alcohol dehydrogenase and the beneficial effect of moderate alcohol consumption on myocardial infarction. N Engl J Med 344: 549-555.
43. Younis J, Cooper JA, Miller GJ, Humphries SE, Talmud PJ (2005) Genetic variation in alcohol dehydrogenase 1C and the beneficial effect of alcohol intake on coronary heart disease risk in the Second Northwick Park Heart Study. Atherosclerosis 180: 225-232.
44. Djousse L, Levy D, Herbert AG, Wilson PW, D'Agostino RB, et al. (2005) Influence of alcohol dehydrogenase 1C polymorphism on the alcoholcardiovascular disease association (from the Framingham Offspring Study). Am J Cardiol 96: 227-232.
45. Hines LM, Hunter DJ, Stampfer MJ, Spiegelman D, Chu NF, et al. (2005) Alcohol consumption and high-density lipoprotein levels: the effect of ADH1C genotype, gender and menopausal status. Atherosclerosis 182: 293-300.
46. Whitfield JB, O'Brien ME, Nightingale BN, Zhu G, Heath AC, et al. (2003) ADH genotype does not modify the effects of alcohol on high-density lipoprotein. Alcohol Clin Exp Res 27: 509-514.
47. Hashimoto Y, Nakayama T, Futamura A, Omura M, Nakarai H, et al. (2002) Relationship between genetic polymorphisms of alcohol-metabolizing enzymes and changes in risk factors for coronary heart disease associated with alcohol consumption. Clin Chem 48: 1043-1048.
48. Nakamura Y, Amamoto K, Tamaki S, Okamura T, Tsujita Y, et al. (2002) Genetic variation in aldehyde dehydrogenase 2 and the effect of alcohol consumption on cholesterol levels. Atherosclerosis 164: 171-177.
49. Tsuritani I, Ikai E, Date T, Suzuki Y, Ishizaki M, et al. (1995) Polymorphism in ALDH2-genotype in Japanese men and the alcohol-blood pressure relationship. Am J Hypertens 8: 1053-1059.
50. Okayama A, Ueshima H, Yamakawa M, Kita Y (1994) Low-Km aldehyde dehydrogenase deficiency does not influence the elevation of blood pressure by alcohol. J Hum Hypertens 8: 205-208.
51. Linneberg A, Gonzalez-Quintela A, Vidal C, Jorgensen T, Fenger M, et al. (2009) Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians. Clin Exp Allergy 40: 123-130.
52. Peterson RJ, Goldman D, Long JC (1999) Effects of worldwide population subdivision on ALDH2 linkage disequilibrium. Genome Res 9: 844-852.
53. Linneberg A, Hertzum I, Husemoen LL, Johansen N, Jorgensen T (2006) Association between alcohol consumption and aeroallergen sensitization in Danish adults. Clin Exp Allergy 36: 714-721.