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Volumn 142, Issue 4, 2014, Pages 594-602

VGX-1027 modulates genes involved in lipopolysaccharide-induced Toll-like receptor 4 activation and in a murine model of systemic lupus erythematosus

Author keywords

Autoimmunity; Bioinformatics; Cell activation

Indexed keywords

3 PHENYL 4,5 DIHYDRO 5 ISOXAZOLE ACETIC ACID; IMMUNOMODULATING AGENT; ISOXAZOLINE DERIVATIVE; LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; VGX 1027;

EID: 84904048838     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/imm.12267     Document Type: Article
Times cited : (32)

References (26)
  • 1
    • 34249686065 scopus 로고    scopus 로고
    • In vitro, ex vivo and in vivo immunopharmacological activities of the isoxazoline compound VGX-1027: modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models
    • Stojanovic I, Cuzzocrea S, Mangano K et al. In vitro, ex vivo and in vivo immunopharmacological activities of the isoxazoline compound VGX-1027: modulation of cytokine synthesis and prevention of both organ-specific and systemic autoimmune diseases in murine models. Clin Immunol 2007; 123:311-23.
    • (2007) Clin Immunol , vol.123 , pp. 311-323
    • Stojanovic, I.1    Cuzzocrea, S.2    Mangano, K.3
  • 2
    • 33847110804 scopus 로고    scopus 로고
    • A potent immunomodulatory compound, (S,R)-3-Phenyl-4,5-dihydro-5-isoxazole acetic acid, prevents spontaneous and accelerated forms of autoimmune diabetes in NOD mice and inhibits the immunoinflammatory diabetes induced by multiple low doses of streptozotocin in CBA/H mice
    • Stosic-Grujicic S, Cvetkovic I, Mangano K et al. A potent immunomodulatory compound, (S, R)-3-Phenyl-4, 5-dihydro-5-isoxazole acetic acid, prevents spontaneous and accelerated forms of autoimmune diabetes in NOD mice and inhibits the immunoinflammatory diabetes induced by multiple low doses of streptozotocin in CBA/H mice. J Pharmacol Exp Ther 2007; 320:1038-49.
    • (2007) J Pharmacol Exp Ther , vol.320 , pp. 1038-1049
    • Stosic-Grujicic, S.1    Cvetkovic, I.2    Mangano, K.3
  • 3
    • 43749093434 scopus 로고    scopus 로고
    • + CD25- T cells and suppression of immunoinflammatory colitis in mice by the novel immunomodulatory agent VGX-1027
    • + CD25- T cells and suppression of immunoinflammatory colitis in mice by the novel immunomodulatory agent VGX-1027. Eur J Pharmacol 2008; 586:313-21.
    • (2008) Eur J Pharmacol , vol.586 , pp. 313-321
    • Mangano, K.1    Sardesai, N.2    D'Alcamo, M.3
  • 4
    • 77954339096 scopus 로고    scopus 로고
    • Babelomics: an integrative platform for the analysis of transcriptomics, proteomics and genomic data with advanced functional profiling
    • Medina I, Carbonell J, Pulido L et al. Babelomics: an integrative platform for the analysis of transcriptomics, proteomics and genomic data with advanced functional profiling. Nucleic Acids Res 2010; 38:W210-3.
    • (2010) Nucleic Acids Res , vol.38
    • Medina, I.1    Carbonell, J.2    Pulido, L.3
  • 5
    • 0037311919 scopus 로고    scopus 로고
    • TM4: a free, open-source system for microarray data management and analysis
    • Saeed AI, Sharov V, White J et al. TM4: a free, open-source system for microarray data management and analysis. Biotechniques 2003; 34:374-8.
    • (2003) Biotechniques , vol.34 , pp. 374-378
    • Saeed, A.I.1    Sharov, V.2    White, J.3
  • 6
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang DW, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009; 4:44-57.
    • (2009) Nat Protoc , vol.4 , pp. 44-57
    • Huang, D.W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 7
    • 0033976316 scopus 로고    scopus 로고
    • Dichotomic effects of IFN-gamma on the development of systemic lupus erythematosus-like syndrome in MRL-lpr/lpr mice
    • Nicoletti F, Di Marco R, Zaccone P et al. Dichotomic effects of IFN-gamma on the development of systemic lupus erythematosus-like syndrome in MRL-lpr/lpr mice. Eur J Immunol 2000; 30:438-47.
    • (2000) Eur J Immunol , vol.30 , pp. 438-447
    • Nicoletti, F.1    Di Marco, R.2    Zaccone, P.3
  • 8
    • 84858983547 scopus 로고    scopus 로고
    • KEGG for integration and interpretation of large-scale molecular data sets
    • Kanehisa M, Goto S, Sato Y et al. KEGG for integration and interpretation of large-scale molecular data sets. Nucleic Acids Res 2012; 40:D109-14.
    • (2012) Nucleic Acids Res , vol.40
    • Kanehisa, M.1    Goto, S.2    Sato, Y.3
  • 9
    • 82055197518 scopus 로고    scopus 로고
    • Killer cell immunoglobulin-like receptor workshop: insights into evolution, genetics, function, and translation
    • Malmberg KJ, Michaëlsson J, Parham P et al. Killer cell immunoglobulin-like receptor workshop: insights into evolution, genetics, function, and translation. Immunity 2011; 35:653-7.
    • (2011) Immunity , vol.35 , pp. 653-657
    • Malmberg, K.J.1    Michaëlsson, J.2    Parham, P.3
  • 10
    • 0034597824 scopus 로고    scopus 로고
    • Structural basis for the activation of 20S proteasomes by 11S regulators
    • Whitby FG, Masters EI, Kramer L et al. Structural basis for the activation of 20S proteasomes by 11S regulators. Nature 2000; 408:115-20.
    • (2000) Nature , vol.408 , pp. 115-120
    • Whitby, F.G.1    Masters, E.I.2    Kramer, L.3
  • 11
    • 84868355027 scopus 로고    scopus 로고
    • The spliceosome as a target of novel antitumour drugs
    • Bonnal S, Vigevani L, Valcárcel J. The spliceosome as a target of novel antitumour drugs. Nat Rev Drug Discov 2012; 11:847-59.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 847-859
    • Bonnal, S.1    Vigevani, L.2    Valcárcel, J.3
  • 12
    • 0033997355 scopus 로고    scopus 로고
    • MAGOH interacts with a novel RNA-binding protein
    • Zhao XF, Nowak NJ, Shows TB et al. MAGOH interacts with a novel RNA-binding protein. Genomics 2000; 63:145-8.
    • (2000) Genomics , vol.63 , pp. 145-148
    • Zhao, X.F.1    Nowak, N.J.2    Shows, T.B.3
  • 13
    • 0032454018 scopus 로고    scopus 로고
    • Reassignment of peptidyl prolyl isomerase-like 1 gene (PPIL1) to human chromosome region 6p21.1 by radiation hybrid mapping and fluorescence in situ hybridization
    • Mann SS, Pettenati MJ, von Kap-herr C et al. Reassignment of peptidyl prolyl isomerase-like 1 gene (PPIL1) to human chromosome region 6p21.1 by radiation hybrid mapping and fluorescence in situ hybridization. Cytogenet Cell Genet 1999; 83:228-9.
    • (1999) Cytogenet Cell Genet , vol.83 , pp. 228-229
    • Mann, S.S.1    Pettenati, M.J.2    von Kap-herr, C.3
  • 14
    • 0036909093 scopus 로고    scopus 로고
    • The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci
    • Ingelfinger D, Arndt-Jovin DJ, Luhrmann R et al. The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci. RNA 2003; 8:1489-501.
    • (2003) RNA , vol.8 , pp. 1489-1501
    • Ingelfinger, D.1    Arndt-Jovin, D.J.2    Luhrmann, R.3
  • 15
    • 0033179986 scopus 로고    scopus 로고
    • A human nuclear-localized chaperone that regulates dimerization, DNA binding, and transcriptional activity of bZIP proteins
    • Virbasius CM, Wagner S, Green MR. A human nuclear-localized chaperone that regulates dimerization, DNA binding, and transcriptional activity of bZIP proteins. Mol Cell 1999; 4:219-28.
    • (1999) Mol Cell , vol.4 , pp. 219-228
    • Virbasius, C.M.1    Wagner, S.2    Green, M.R.3
  • 16
    • 84879887989 scopus 로고    scopus 로고
    • Simultaneous positivity for anti-DNA, anti-nucleosome and anti-histone antibodies is a marker for more severe lupus nephritis
    • Sui M, Lin Q, Xu Z et al. Simultaneous positivity for anti-DNA, anti-nucleosome and anti-histone antibodies is a marker for more severe lupus nephritis. J Clin Immunol 2013; 33:378-87.
    • (2013) J Clin Immunol , vol.33 , pp. 378-387
    • Sui, M.1    Lin, Q.2    Xu, Z.3
  • 17
    • 84887257597 scopus 로고    scopus 로고
    • Major pathogenic steps in human lupus can be effectively suppressed by nucleosomal histone peptide epitope-induced regulatory immunity
    • Zhang L, Bertucci AM, Ramsey-Goldman R et al. Major pathogenic steps in human lupus can be effectively suppressed by nucleosomal histone peptide epitope-induced regulatory immunity. Clin Immunol 2013; 149:365-78.
    • (2013) Clin Immunol , vol.149 , pp. 365-378
    • Zhang, L.1    Bertucci, A.M.2    Ramsey-Goldman, R.3
  • 18
    • 84863531764 scopus 로고    scopus 로고
    • Functional characterization of peripheral blood dendritic cells and monocytes in systemic lupus erythematosus
    • Henriques A, Inês L, Carvalheiro T et al. Functional characterization of peripheral blood dendritic cells and monocytes in systemic lupus erythematosus. Rheumatol Int 2012; 32:863-9.
    • (2012) Rheumatol Int , vol.32 , pp. 863-869
    • Henriques, A.1    Inês, L.2    Carvalheiro, T.3
  • 21
    • 67349258944 scopus 로고    scopus 로고
    • Why can't we find a new treatment for SLE?
    • Eisenberg R. Why can't we find a new treatment for SLE? J Autoimmun 2009; 32:223-30.
    • (2009) J Autoimmun , vol.32 , pp. 223-230
    • Eisenberg, R.1
  • 23
    • 84862176053 scopus 로고    scopus 로고
    • Belimumab for the management of systemic lupus erythematosus
    • Lutalo PM, D'Cruz DP. Belimumab for the management of systemic lupus erythematosus. Expert Opin Biol Ther 2012; 12:957-63.
    • (2012) Expert Opin Biol Ther , vol.12 , pp. 957-963
    • Lutalo, P.M.1    D'Cruz, D.P.2
  • 24
    • 0028962115 scopus 로고
    • Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus
    • Llorente L, Zou W, Levy Y et al. Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus. J Exp Med 1995; 181:839-44.
    • (1995) J Exp Med , vol.181 , pp. 839-844
    • Llorente, L.1    Zou, W.2    Levy, Y.3
  • 25
    • 0033066019 scopus 로고    scopus 로고
    • The roles of interleukin-6 and interleukin-10 in B cell hyperactivity in systemic lupus erythematosus
    • Cross JT, Benton HP. The roles of interleukin-6 and interleukin-10 in B cell hyperactivity in systemic lupus erythematosus. Inflamm Res 1999; 48:255-61.
    • (1999) Inflamm Res , vol.48 , pp. 255-261
    • Cross, J.T.1    Benton, H.P.2
  • 26
    • 0032192043 scopus 로고    scopus 로고
    • Role of IL-10 in the abnormalities of early cell activation events of lymphocytes from patients with systemic lupus erythematosus
    • González-Amaro R, Portales-Pérez D, Baranda L et al. Role of IL-10 in the abnormalities of early cell activation events of lymphocytes from patients with systemic lupus erythematosus. J Autoimmun 1998; 11:395-402.
    • (1998) J Autoimmun , vol.11 , pp. 395-402
    • González-Amaro, R.1    Portales-Pérez, D.2    Baranda, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.