Antioxidant effects of the highly-substituted carbazole alkaloids and their related carbazoles

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 15, 2014, Pages 3530-3533

  Hieda, Yuhzo ^a   Anraku, Makoto ^b   Choshi, Tominari ^a   Tomida, Hisao ^a   Fujioka, Haruto ^a   Hatae, Noriyuki ^c   Hori, Osamu ^d   Hirose, Junzo ^a   Hibino, Satoshi ^a  

^a FUKUYAMA UNIVERSITY   (Japan)

^b SOJO UNIVERSITY   (Japan)

^c HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

^d KANAZAWA UNIVERSITY   (Japan)

Author keywords

Antioxidant activity; Carbazole alkaloid; DPPH radical; PAO SO

Indexed keywords

ALKALOID DERIVATIVE; ANTIOXIDANT; CARAZOSTATIN; CARBAZOLE DERIVATIVE; CARBAZOMADURIN A; CARBAZOMADURIN B; CARQUINOSTATIN A; UNCLASSIFIED DRUG; 3 HYDROXYCARBAZOLE ALKALOID CARAZOSTATIN; 3 MONOHYDROXYCARBAZOLES CARAZOSTATIN; 3,8 DIHYDROXYCARBAZOLES CARBAZOMADURIN A; NORPHENAZONE; ALKALOID;

ANTIOXIDANT ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL VIABILITY; DPPH RADICAL SCAVENGING ASSAY; DRUG DESIGN; DRUG SYNTHESIS; IC 50; PROTON NUCLEAR MAGNETIC RESONANCE; DRUG SCREENING; CHEMICAL STRUCTURE; CHEMISTRY;

ALKALOIDS; ANTIOXIDANTS; CARBAZOLES; MOLECULAR STRUCTURE;

EID: 84904038007     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.05.050     Document Type: Article

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34. ++ solution (50 μL) was added to each well, mixed gentry, and incubated at room temperature for 3 min. Stop solution (60 μL) was added and mixed gentry, and absorbance at 490 nm was read again (B). Standard curbs were plotted with the difference between the absorbance readings [(B) - (A)] on the vertical axis, and the concentrations of the uric acid standards on the horizontal axis. The uric acid concentration was calculated using this curve. The oxidant power (copper reducing power) was estimated by multiplying the uric acid concentration by 1938 and was expressed as μmol/L.
35. 2 for 24 h to allow the cells to attach to the wells. The cells were then treated with the indicated concentrations of the test agents in culture medium without FBS. Following a further 48 h incubation, 10 μL of MTT (5 mg/mL in PBS buffer) were added to each well, and the plate was incubated for 4 h to allow the MTT to be metabolized by cellular mitochondrial dehydrogenases. The excess MTT was aspirated, and the resultant formazan crystals were dissolved by addition of 100 μL of DMSO. The absorbance of purple formazan was read at 570 nm a microplate reader