Hesperidin, nobiletin, and tangeretin are collectively responsible for the anti-neuroinflammatory capacity of tangerine peel (Citri reticulatae pericarpium)

Food and Chemical Toxicology

Volumn 71, Issue , 2014, Pages 176-182

  Ho, Su Chen ^a   Kuo, Chun Ting ^a  

^a YUANPEI UNIVERSITY   (Taiwan)

Author keywords

Anti neuroinflammatory activity; BV2 microglia; Flavanone glycoside; Polymethoxy flavone; Tangerine peel

Indexed keywords

ALCOHOL; ANTIINFLAMMATORY AGENT; AURANTIIN; CITRI RETICULATAE EXTRACT; DIDYMIN; ERIOCITRIN; FLAVONOID; HESPERIDIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; NARIRUTIN; NEOHESPERIDIN; NITRIC OXIDE; NOBILETIN; PLANT EXTRACT; TANGERETIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; TANGERINE EXTRACT; FLAVONE DERIVATIVE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL VIABILITY; CITRI RETICULATAE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG EFFECT; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INOS GENE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MICROGLIAL CELL CULTURE; NERVOUS SYSTEM INFLAMMATION; PERICARP; PROTEIN EXPRESSION; TANGERINE; ANTINEUROINFLAMMATORY ACTIVITY; DOWN REGULATION; DRUG CYTOTOXICITY; ENZYME ACTIVE SITE; IN VITRO STUDY; MICROGLIA; PROTEIN DETERMINATION; ANIMAL; CELL LINE; CHEMISTRY; CITRUS; DRUG EFFECTS; ELECTROSPRAY MASS SPECTROMETRY;

CITRUS RETICULATA;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CITRUS; FLAVONES; HESPERIDIN; MICROGLIA; PLANT EXTRACTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84904025173     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2014.06.014     Document Type: Article

References (32)

1. Benavente-Garcia O., Castillo J. Update on uses and properties of citrus flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory activity. J. Agric. Food Chem. 2008, 56:6185-6205.
2. China Pharmacopoeia Committee. 2010. Chinese Pharmacopoeia (II). Beijing: China Medical Science and Technology Press (in Chinese).
3. Choi S.Y., Ko H.C., Ko S.Y., Hwang J.H., Park J.G., Kang S.H., Han S.H., Yun S.H., Kim S.J. Correlation between flavonoid content and the NO production inhibitory activity of peel extracts from various citrus fruits. Biol. Pharm. Bull. 2007, 30:772-778.
4. Choi D.K., Koppula S., Suk K. Inhibitors of microglial neurotoxicity: focus on natural products. Molecules 2011, 16:1021-1043.
5. Cui Y., Wu J., Jung S.C., Park D.B., Maeng Y.H., Hong J.Y., Kim S.J., Lee S.R., Kim S.J., Kim S.J., Eun S.Y. Anti-neuroinflammatory activity of nobiletin on suppression of microglial activation. Biol. Pharm. Bull. 2010, 33:1814-1821.
6. Datla K.P., Christidou M., Widmer W.W., Rooprai H.K., Dexter D.T. Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease. NeuroReport 2001, 12:3871-3875.
7. Datla K.P., Zbarsky V., Rai D., Parkar S., Osakabe N., Aruoma O.I., Dexter D.T. Short-term supplementation with plant extracts rich in flavonoids protect nigrostriatal dopaminergic neurons in a rat model of Parkinson's disease. J. Am. Coll. Nutr. 2007, 26(4):341-349.
8. Glass C.K., Saijo K., Winner B., Marchetto M.C., Gage F.H. Mechanisms underlying inflammation in neurodegeneration. Cell 2010, 140:918-934.
9. Huang Y.S., Ho S.C. Polymethoxy flavones are responsible for the anti-inflammatory activity of citrus fruit peel. Food Chem. 2010, 119:868-873.
10. Hwang S.L., Shih P.H., Yen G.C. Neuroprotective effects of citrus flavonoids. J. Agric. Food Chem. 2012, 60:877-885.
11. Lee H., Kim Y.O., Kim H., Kim S.Y., Noh H.S., Kang S.S., Cho G.J., Choi W.S., Suk K. Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia. Faseb J. 2003, 17:1943-1944.
12. Li S., Sang S., Pan M.H., Lai C.S., Lo C.Y., Yang C.S., Ho C.T. Anti-inflammatory property of the urinary metabolites of nobiletin in mouse. Bioorg. Med. Chem. Lett. 2007, 17:5177-5181.
13. Liu B., Hong J.S. Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. J. Pharmacol. Exp. Ther. 2003, 304:1-7.
14. Liu E.H., Zhao P., Duan L., Zheng G.D., Guo L., Yang H., Li P. Simultaneous determination of six bioactive flavonoids in Citri Reticulatae Pericarpium by rapid resolution liquid chromatography coupled with triple quadrupole electrospray tandem mass spectrometry. Food Chem. 2013, 141:3977-3983.
15. Londono-Londono J., de Lima V.R., Lara O., Gil A., Pasa T.B.C., Arango G.J., Pineda J.R.R. Clean recovery of antioxidant flavonoids from citrus peel: optimizing an aqueous ultrasound-assisted extraction method. Food Chem. 2010, 119:81-87.
16. Manthey J.A., Guthrie N. Antiproliferative activities of citrus flavonoids against six human cancer cell lines. J. Agric. Food Chem. 2002, 50:5837-5843.
17. McGeer E.G., McGeer P.L. Inflammatory processes in Alzheimer's disease. Prog. Neuro-Psychoph. 2003, 27:741-749.
18. Nakajima A., Yamakuni T., Haraguchi M., Omae N., Song S.Y., Kato C., Nakagawasai O., Tadano T., Yokosuka A., Mimaki Y., Sashida Y., Ohizumi Y. Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice. J. Pharmacol. Sci. 2007, 105:122-126.
19. Onozuka H., Nakajima A., Matsuzaki K., Shin R.W., Ogino K., Saigusa D., Tetsu N., Yokosuka A., Sashida Y., Mimaki Y., Yamakuni T., Ohizumi Y. Nobiletin, a citrus flavonoid, improves memory impairment and Aβ pathology in a transgenic mouse model of Alzheimer's disease. J. Pharmacol. Exp. Ther. 2008, 326:739-744.
20. Pan X.D., Chen X.C., Zhu Y.G., Zhang J., Huang T.W., Chen L.M., Ye Q.Y., Huang H.P. Neuroprotective role of tripchlorolide on inflammatory neurotoxicity induced by lipopolysaccharide-activated microglia. Biochem. Pharmacol. 2008, 76:362-372.
21. Raza S.S., Khan M.M., Ahmad A., Ashafag M., Khuwaja G., Tabassum R., Javed H., Siddiqui M.S., Safhi M.M., Islam F. Hesperidin ameliorates functional and histological outcome and reduces neuroinflammation in experimental stroke. Brain Res. 2011, 1420:93-105.
22. Singh M., Arseneault M., Sanderson T., Murthy V., Ramassamy C. Challenges for research on polyphenols from foods in Alzheimer's disease: bioavailability, metabolism, and cellular and molecular mechanisms. J. Agric. Food Chem. 2008, 56:4855-4873.
23. Singh S.P., Wahajuddin, Tewari D., Patel K., Jain G.K. Permeability determination and pharmacokinetic study of nobiletin in rat plasma and brain by validated high-performance liquid chromatography method. Fitoterapia 2011, 82:1206-1214.
24. Spencer J.P.E. Flavonoids and brain health: multiple effects underpinned by common mechanisms. Genes Nutr. 2009, 4:243-250.
25. Tistaert C., Thierry L., Szandrach A., Dejaegher B., Fan G., Frederich M., Heyden Y.V. Quality control of Citri reticulatae pericarpium: exploratory analysis and discrimination. Anal. Chim. Acta 2011, 705:111-122.
26. Tripoli E., Guardia M.L., Giammanco S., Majo D.D., Giammanco M. Citrus flavonoids: molecular structure, biological activity and nutritional properties: a review. Food Chem. 2007, 104:466-479.
27. VafeiAdou K., Vauzour D., Lee H.Y., Rodriguez-Mateos A., Williams R.J., Spencer J.P.E. The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury. Arch. Biochem. Biophys. 2009, 484:100-109.
28. Vauzour D., Vafeiadou K., Rodriguez-Mateos A., Rendeiro C., Spencer J.P.E. The neuroprotective potential of flavonoids: a multiplicity of effects. Genes Nutr. 2008, 3:115-126.
29. Yang H.L., Chen S.C., Senthil Kumar K.J., Yu K.N., Lee Chao P.D., Tsai S., Hou Y.C., Hseu Y.C. Antioxidant and anti-inflammatory potential of hesperetin metabolites obtained from hesperetin-administered rat serum: an ex vivo approach. J. Agric. Food Chem. 2012, 60:522-532.
30. Ye X.Q., Chen J.C., Liu D.H., Jiang P., Shi J., Xue S., Wu D., Xu J.G., Kakuda Y. Identification of bioactive composition and antioxidant activity in young mandarin fruits. Food Chem. 2011, 124:1561-1566.
31. Youdim K.A., Shukitt-Hale B., Joseph J.A. Flavonoids and the brain: interactions at the blood-brain barrier and their physiological effects on the central nervous system. Free Radic. Biol. Med. 2004, 37:1683-1693.
32. Zheng L.T., Ryu G.M., Kwon M., Lee W.H., Suk K. Anti-inflammatory effects of cathecols in lipopolysaccharide-stimulated microglia cells: inhibition of microglia neurotoxicity. Eur. J. Pharmacol. 2008, 588:106-113.