TNF-α-mediated caspase-8 activation induces ROS production and TRPM2 activation in adult ventricular myocytes

Cardiovascular Research

Volumn 103, Issue 1, 2014, Pages 90-99

  Roberge, Stéphanie ^a   Roussel, Julien ^a   Andersson, Daniel C ^b,c   Meli, Albano C ^a   Vidal, Bastien ^a   Blandel, Florence ^a   Lanner, Johanna T ^b   Le Guennec, Jean Yves ^a   Katz, Abram ^d   Westerblad, Håkan ^b   Lacampagne, Alain ^a   Fauconnier, Jérémy ^a  

^a UNIVERSITY OF MONTPELLIER   (France)

^b KAROLINSKA INSTITUTE   (Sweden)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d ARIEL UNIVERSITY   (Israel)

Author keywords

Cardiac; Cell death; Ischaemia reperfusion; TNF ; TRPM2

Indexed keywords

3 AMINOBENZAMIDE; ACETYLCYSTEINE; ADENOSINE DIPHOSPHATE RIBOSE; ANTHRANILIC ACID; BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; CALCIUM; CASPASE 8; CLOTRIMAZOLE; FLUFENAMIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; REACTIVE OXYGEN METABOLITE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M2; TUMOR NECROSIS FACTOR ALPHA; BENZYLOXYCARBONYL-ISOLEUCYL-GLUTAMYL-THREONYL-ASPARTIC ACID FLUOROMETHYL KETONE; CASP8 PROTEIN, MOUSE; CYSTEINE PROTEINASE INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OLIGOPEPTIDE; PARP1 PROTEIN, MOUSE; TRANSIENT RECEPTOR POTENTIAL CHANNEL 3; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM2 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HEART MUSCLE CELL; HEART VENTRICLE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; C57BL MOUSE; CYTOLOGY; DRUG EFFECTS; HEART MITOCHONDRION; METABOLISM; PATCH CLAMP TECHNIQUE; SIGNAL TRANSDUCTION; ADENOSINE DIPHOSPHATE RIBOSYLATION; ADULT; CELL ISOLATION; EXPOSURE; INCUBATION TIME; MITOCHONDRIAL DYNAMICS; STEADY STATE; WHOLE CELL PATCH CLAMP;

ANIMALS; APOPTOSIS; CASPASE 8; CLOTRIMAZOLE; CYSTEINE PROTEINASE INHIBITORS; ENZYME ACTIVATION; MICE; MICE, INBRED C57BL; MITOCHONDRIA, HEART; MYOCYTES, CARDIAC; OLIGOPEPTIDES; PATCH-CLAMP TECHNIQUES; POLY(ADP-RIBOSE) POLYMERASES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRPC CATION CHANNELS; TRPM CATION CHANNELS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84903980623     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvu112     Document Type: Article

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