Clotrimazole Protects the Liver Against Normothermic Ischemia-Reperfusion Injury in Rats

Transplantation Proceedings

Volumn 41, Issue 10, 2009, Pages 4099-4104

  Iannelli, A ^a,b   de Sousa, G ^b   Zucchini, N ^b   Peyre, L ^b   Gugenheim, J ^a   Rahmani, R ^b  

^a CENTRE HOSPITALIER UNIVERSITAIRE DE NICE   (France)

^b UNIVERSITÉ CÔTE D'AZUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CASPASE 3; CLOTRIMAZOLE; CYTOCHROME P450 3A; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PREGNANE X RECEPTOR;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD SAMPLING; BODY TEMPERATURE; CONTROLLED STUDY; CYTOCHROME P450 3A GENE; DRUG EFFICACY; GENE EXPRESSION; LIVER; LIVER ISCHEMIA; LIVER PROTECTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; TRANSACTIVATION;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; CLOTRIMAZOLE; CYTOCHROME P-450 CYP3A; GENE EXPRESSION REGULATION; HEAT-SHOCK PROTEINS; HSP27 HEAT-SHOCK PROTEINS; HSP70 HEAT-SHOCK PROTEINS; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; TRANSCRIPTIONAL ACTIVATION;

EID: 71249163508     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2009.08.074     Document Type: Article

References (12)

1. Farmer D.G., Amersi F., and Kupiec-Weglinski J.W. Current status of ischemia and reperfusion injury in the liver. Transplant Rev 14 (2000) 106
2. Cursio R., Gugenheim J., Ricci J.E., et al. A caspase inhibitor fully protects rats against lethal normothermic liver ischemia by inhibition of liver apoptosis. FASEB J13 (1999) 253
3. Kakizaki S., Yamazaki Y., Takizawa D., et al. New insights on the xenobiotic-sensing nuclear receptors in liver diseases: CAR and PXR. Curr Drug Metab 9 (2008) 614
4. Bailly-Maitre B., de Sousa G., Boulukos K., et al. Dexamethasone inhibits spontaneous apoptosis in primary cultures of human and rat hepatocytes via Bcl-2 and Bcl-xL induction. Cell Death Differ 8 (2001) 279
5. Bailly-Maitre B., de Sousa G., Zucchini N., et al. Spontaneous apoptosis in primary cultures of human and rat hepatocytes: molecular mechanisms and regulation by dexamethasone. Cell Death Differ 9 (2002) 945
6. Zucchini N., de Sousa G., Bailly-Maitre B., et al. Regulation of Bcl-2 and Bcl-xL anti-apoptotic protein expression by nuclear receptor PXR in primary cultures of human and rat hepatocytes. Biochim Biophys Acta 1745 (2005) 48
7. Chomczynski P., and Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162 (1987) 156
8. Cursio R., Filippa N., Miele C., et al. Involvement of protein kinase B and mitogen-activated protein kinases in experimental normothermic liver ischaemia-reperfusion injury. Br J Surg 93 (2006) 752
9. Beere H.M. Death versus survival: functional interaction between the apoptotic and stress-inducible heat shock protein pathways. J Clin Invest 115 (2005) 2633
10. Lazebnik Y.A., Kaufmann S.H., Desnoyers S., et al. Cleavage of poly(ADP-ribose)polymerase by a proteinase with properties like ICE. Nature 371 (1994) 346
11. Bertilsson G., Heidrich J., Svensson K., et al. Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc Natl Acad Sci U S A 95 (1998) 12208
12. Galea-Lauri J., Richardson A.J., Latchman D.S., et al. Increased heat shock protein 90 (hsp 90) expression leads to increased apoptosis in the monoblastoid cell line U937 following induction with TNF-alpha and cycloheximide: a possible role in immunopathology. J Immunol 157 (1996) 4109