Multilayer spheroids to quantify drug uptake and diffusion in 3D

Molecular Pharmaceutics

Volumn 11, Issue 7, 2014, Pages 2071-2081

  Achilli, Toni Marie ^a,b   McCalla, Stephanie ^b,c   Meyer, Julia ^a,b   Tripathi, Anubhav ^b,c   Morgan, Jeffrey R ^a,b  

^a Department of Molecular Pharmacology Physiology and Biotechnology   (United States)

^b Center for Biomedical Engineering   (United States)

^c Brown University   (United States)

Author keywords

ABC transporters; drug diffusion; drug transport; gap junctions

Indexed keywords

CALCEIN; CARBENOXOLONE; CYCLOSPORIN A; LOPERAMIDE; MULTIDRUG RESISTANCE PROTEIN; VERAPAMIL; CYCLOSPORIN; DRUG; FLUORESCEIN DERIVATIVE;

ARTICLE; CALCIUM CELL LEVEL; CELL COMMUNICATION; CELL SUSPENSION; CONTROLLED STUDY; DRUG DIFFUSION; DRUG TRANSPORT; DRUG UPTAKE; FLUORESCENCE; FLUORESCENT LIGHTING; GAP JUNCTION; HUMAN; HUMAN CELL; IMAGE ANALYSIS; MULTICELLULAR SPHEROID; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR SPHEROID; CELL LINE; DIFFUSION; HEK293 CELL LINE; MCF-7 CELL LINE; METABOLISM; TUMOR CELL LINE;

CARBENOXOLONE; CELL LINE; CELL LINE, TUMOR; CYCLOSPORINE; DIFFUSION; FLUORESCEINS; HEK293 CELLS; HUMANS; LOPERAMIDE; MCF-7 CELLS; P-GLYCOPROTEINS; PHARMACEUTICAL PREPARATIONS; SPHEROIDS, CELLULAR; VERAPAMIL;

EID: 84903977872     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp500002y     Document Type: Article

References (44)

1. Jang, S. H.; Wientjes, M. G.; Lu, D.; Au, J. L. Drug delivery and transport to solid tumors Pharm. Res. 2003, 20, 1337-1350
2. Minchinton, A. I.; Tannock, I. F. Drug penetration in solid tumours Nat. Rev. Cancer 2006, 6, 583-592
3. Elliott, N. T.; Yuan, F. A review of three-dimensional in vitro tissue models for drug discovery and transport studies J. Pharm. Sci. 2011, 100, 59-74
4. Szakacs, G.; Varadi, A.; Ozvegy-Laczka, C.; Sarkadi, B. The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME-Tox) Drug Discovery Today 2008, 13, 379-393
5. Shugarts, S.; Benet, L. Z. The role of transporters in the pharmacokinetics of orally administered drugs Pharm. Res. 2009, 26, 2039-2054
6. Varma, M. V.; Ashokraj, Y.; Dey, C. S.; Panchagnula, R. P-glycoprotein inhibitors and their screening: a perspective from bioavailability enhancement Pharmacol. Res. 2003, 48, 347-359
7. Giacomini, K. M. Membrane transporters in drug development Nat. Rev. Drug Discovery 2010, 9, 215-236
8. Borst, P.; Oude Elferink, R. Mammalian ABC transporters in health and disease Annu. Rev. Biochem. 2002, 71, 537-592
9. Ambudkar, S. V. Biochemical, cellular, and pharmacological aspects of the multidrug transporter Annu. Rev. Pharmacol. Toxicol. 1999, 39, 361-398
10. Fojo, A. T. Expression of a multidrug-resistance gene in human tumors and tissues Proc. Natl. Acad. Sci. U.S.A. 1987, 84, 265-269
11. Szakacs, G.; Paterson, J. K.; Ludwig, J. A.; Booth-Genthe, C.; Gottesman, M. M. Targeting multidrug resistance in cancer Nat. Rev. Drug Discovery 2006, 5, 219-234
12. Cecchelli, R. Modelling of the blood-brain barrier in drug discovery and development Nat. Rev. Drug Discovery 2007, 6, 650-661
13. Fellner, S. Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo J. Clin. Invest. 2002, 110, 1309-1318
14. Fromm, M. F. Importance of P-glycoprotein at blood-tissue barriers Trends Pharmacol. Sci. 2004, 25, 423-429
15. Letrent, S. P. P-glycoprotein-mediated transport of morphine in brain capillary endothelial cells Biochem. Pharmacol. 1999, 58, 951-957
16. Sikic, B. I. Modulation and prevention of multidrug resistance by inhibitors of P-glycoprotein Cancer Chemother. Pharmacol. 1997, 40 (Suppl.) S13-S19
17. Aszalos, A. Drug-drug interactions affected by the transporter protein, P-glycoprotein (ABCB1, MDR1) II. Clinical aspects Drug Discovery Today 2007, 12, 838-843
18. Polli, J. W. Rational use of in vitro P-glycoprotein assays in drug discovery J. Pharmacol. Exp. Ther. 2001, 299, 620-628
19. Rautio, J. In vitro p-glycoprotein inhibition assays for assessment of clinical drug interaction potential of new drug candidates: a recommendation for probe substrates Drug Metab. Dispos. 2006, 34, 786-792
20. Keogh, J. P.; Kunta, J. R. Development, validation and utility of an in vitro technique for assessment of potential clinical drug-drug interactions involving P-glycoprotein Eur. J. Pharm. Sci. 2006, 27, 543-554
21. Szeremy, P. Comparison of 3 assay systems using a common probe substrate, calcein AM, for studying P-gp using a selected set of compounds J. Biomol. Screening 2011, 16, 112-119
22. Nederman, T. Effects of vinblastine and 5-fluorouracil on human glioma and thyroid cancer cell monolayers and spheroids Cancer Res. 1984, 44, 254-258
23. Nederman, T.; Carlsson, J. Penetration and binding of vinblastine and 5-fluorouracil in cellular spheroids Cancer Chemother. Pharmacol. 1984, 13, 131-135
24. Risberg, B.; Grontoft, O.; Westholm, B. Origin of carcinoma in secretory endometrium - a study using a whole-organ sectioning technique Gynecol. Oncol. 1983, 15, 32-41
25. Hwang, C. W.; Wu, D.; Edelman, E. R. Physiological transport forces govern drug distribution for stent-based delivery Circulation 2001, 104, 600-605
26. Youssef, J.; Nurse, A. K.; Freund, L. B.; Morgan, J. R. Quantification of the forces driving self-assembly of three-dimensional microtissues Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 6993-6998
27. Napolitano, A. P.; Chai, P.; Dean, D. M.; Morgan, J. R. Dynamics of the Self-Assembly of Complex Cellular Aggregates on Micro-Molded Non-Adhesive Hydrogels Tissue Eng. 2007, 13, 2087-2094
28. Nishi, Y. Establishment and characterization of a steroidogenic human granulosa-like tumor cell line, KGN, that expresses functional follicle-stimulating hormone receptor Endocrinology 2001, 142, 437-445
29. Ford, J. M; Bruggemann, E. P.; Pastan, I.; Gottesman, M. M.; Hait, W. N. Cellular and biochemical characterization of thioxanthenes for reversal of multidrug resistance in human and murine cell lines Cancer Res. 1990, 50, 1748-1756
30. Robey, R. W.; Lin, B.; Qiu, J.; Chan, L. L. Y.; Bates, S. E. Rapid detection of ABC transporter interaction: Potential utility in pharmacology J. Pharmacol. Toxicol. Methods 2011, 63, 217-222
31. Hanna, E. A. Gap junctional intercellular comunication and connexin-43 expression in human ovarian surface epithelial cells and ovarian carcinoms in vivo and in vitro Carcinogenesis 1999, 20, 1369-1373
32. Davidson, J. S.; Baumgarten, I. M.; Harley, E. H. Reverisible inhibition of intercellular junctional communication by glycyrrhetinic acid Biochem. Biophys. Res. Commun. 1986, 134, 29-36
33. Gregor, T.; Bialek, W.; de Ruyter van Steveninck, R. R.; Tank, D. W.; Wieschaus, E. F. Diffusion and scaling during early embryonic pattern formation Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 18403-18407
34. Kirkpatrick, J. P.; Brizel, D. M.; Dewhirst, M. W. A mathematical model of tumor oxygen and glucose mass transport and metabolism with complex reaction kinetics Radiat. Res. 2003, 159, 336-344
35. Abbaci, M.; Barberi-Heyob, M.; Blondel, W.; Guillemin, F.; Didelon, J. Advantages and limitations of commonly used methods to assay the molecular permeability of gap junctional intercellular communication Biotechniques 2008, 45, 33-61
36. Bao, B.; Jiang, J.; Yanase, T.; Nishi, Y.; Morgan, J. R. Connexon-mediated Cell Adhesion Drives Microtissue Self-assembly FASEB J. 2011, 25, 255-264
37. Lee, K. S.; Tsien, R. W. Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells Nature 1983, 302, 790-794
38. Ferry, D. R.; Traunecker, H.; Kerr, D. J. Clinical trials of P-glycoprotein reversal in solid tumours Eur. J. Cancer 1996, 32A, 1070-1081
39. Tolcher, A. W. Phase I crossover study of paclitaxel with r-verapamil in patients with metastatic breast cancer J. Clin. Oncol. 1996, 14, 1173-1184
40. Bao, B.; Jiang, J.; Yanase, T.; Nishi, Y.; Morgan, J. R. Connexon-mediated cell adhesion drives microtissue self-assembly FASEB J. 2011, 25, 255-264
41. Chan, H. S. Combining cyclosporin with chemotherapy controls intraocular retinoblastoma without requiring radiation Clin. Cancer Res. 1996, 2, 1499-1508
42. Fracasso, P. M. Phase II study of paclitaxel and valspodar (PSC 833) in refractory ovarian carcinoma: a gynecologic oncology group study J. Clin. Oncol. 2001, 19, 2975-2982
43. Desroches, B. R.; Zhang, P.; Choi, B.; Maldonado, A. E.; Rago, A.; Liu, G. X.; Nath, N.; King, M. E.; Hartmann, K. M.; Yang, B.; Koren, G.; Morgan, J. R.; Mende, U. Functional Scaffold-free Cardiac Microtissues: A Novel Model for the Investigation of Heart Cells Am. J. Physiol. 2012, 302, H22031-H220442
44. Achilli, T. M.; McCalla, S.; Tripathi, A.; Morgan, J. R. Quantification of the kinetics and extent of self-sorting in three dimensional spheroids Tissue Eng., Part C 2012, 18, 302-309