The role of the liver and kidneys in the pharmacokinetics of subcutaneously administered teriparatide acetate in rats

Xenobiotica

Volumn 42, Issue 4, 2012, Pages 398-407

  Serada, Masashi ^a   Sakurai Tanikawa, Aki ^a   Igarashi, Masayo ^a   Mitsugi, Koichi ^b   Takano, Toshie ^b   Shibusawa, Koichi ^b   Kohira, Terutomo ^a  

^a ASAHI KASEI PHARMA CORPORATION   (Japan)

^b SEKISUI CHEMICAL CO LTD   (Japan)

Author keywords

125I Nle8,18Tyr34 PTH(1 34); distribution; hepatic failure rat; metabolism; osteoporosis; PTH(1 34); renal failure rat

Indexed keywords

PARATHYROID HORMONE[1-34];

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG EXCRETION; DRUG HALF LIFE; DRUG METABOLISM; DRUG URINE LEVEL; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; KIDNEY FAILURE; KIDNEY FUNCTION; LIVER FUNCTION; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RADIOACTIVITY; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; CELLS, CULTURED; FEMALE; HUMANS; INJECTIONS, SUBCUTANEOUS; KIDNEY; LIVER; MALE; PARATHYROID HORMONE; RATS; RATS, SPRAGUE-DAWLEY; TERIPARATIDE;

RATTUS;

EID: 84858396477     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2011.622811     Document Type: Article

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