New clues to understanding HIV nonprogressors: Low cholesterol blocks HIV trans infection

mBio

Volumn 5, Issue 3, 2014, Pages

  Prasad, Vinayaka R ^a   Bukrinsky, Michael I ^b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER A1; CHOLESTEROL; NEF PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; STEROL REGULATORY ELEMENT BINDING PROTEIN 2;

ABCA1 GENE; ANTIGEN PRESENTING CELL; ARTICLE; CD4+ T LYMPHOCYTE; CELL MEMBRANE FLUIDITY; CHOLESTEROL METABOLISM; CHOLESTEROL TRANSPORT; DENDRITIC CELL; GENE EXPRESSION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION CONTROL; LIPID RAFT; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; TRANSCRIPTION INITIATION; VIRUS ASSEMBLY; VIRUS CELL INTERACTION; VIRUS REPLICATION; VIRUS TRANSMISSION; HUMAN IMMUNODEFICIENCY VIRUS 1; METABOLISM; PHYSIOLOGY; VIROLOGY;

CHOLESTEROL; HIV INFECTIONS; HIV-1; HUMANS;

EID: 84903954201     PISSN: 21612129     EISSN: 21507511     Source Type: Journal    
DOI: 10.1128/mBio.01396-14     Document Type: Article

References (26)

1. Walker BD, Yu XG. 2013. Unravelling the mechanisms of durable control of HIV-1. Nat. Rev. Immunol. 13: 487-498. http://dx. doi. org/10. 1038/nri3478.
2. Rappocciolo G, Jais M, Piazza P, Reinhart TA, Berendam SJ, Garcia-Exposito L, Gupta P, Rinaldo CR. 2014. Alterations in cholesterol metabolism restrict HIV-1 trans infection in nonprogressors. mBio 5(3): e01031-13. http://dx. doi. org/10. 1128/mBio. 01031-13.
3. Daya M, Cervin M, Anderson R. 1988. Cholesterol enhances mouse hepatitis virus-mediated cell fusion. Virology 163: 276-283. http://dx. doi. org/10. 1016/0042-6822(88)90267-X.
4. Vashishtha M, Phalen T, Marquardt MT, Ryu JS, Ng AC, Kielian M. 1998. A single point mutation controls the cholesterol dependence of Semliki Forest virus entry and exit. J. Cell Biol. 140: 91-99. http://dx. doi. org/10. 1083/jcb. 140. 1. 91.
5. Danthi P, Chow M. 2004. Cholesterol removal by methyl-betacyclodextrin inhibits poliovirus entry. J. Virol. 78: 33-41. http://dx. doi. org/10. 1128/JVI. 78. 1. 33-41. 2004.
6. Petersen J, Drake MJ, Bruce EA, Riblett AM, Didigu CA, Wilen CB, Malani N, Male F, Lee FH, Bushman FD, Cherry S, Doms RW, Bates P, Briley K, Jr. 2014. The major cellular sterol regulatory pathway is required for Andes virus infection. PLoS Pathog. 10(2): e1003911. http://dx. doi. org/10. 1371/journal. ppat. 1003911.
7. Ono A, Freed EO. 2001. Plasma membrane rafts play a critical role in HIV-1 assembly and release. Proc. Natl. Acad. Sci. U. S. A. 98: 13925-13930. http://dx. doi. org/10. 1073/pnas. 241320298.
8. Mañes S, del Real G, Lacalle RA, Lucas P, Gómez-Moutón C, Sánchez-Palomino S, Delgado R, Alcamí J, Mira E, Martinez AC. 2000. Membrane raft microdomains mediate lateral assemblies required for HIV-1 infection. EMBO Rep. 1: 190-196. http://dx. doi. org/10. 1093/embo-reports/kvd025.
9. Guyader M, Kiyokawa E, Abrami L, Turelli P, Trono D. 2002. Role for human immunodeficiency virus type 1 membrane cholesterol in viral internalization. J. Virol. 76: 10356-10364. http://dx. doi. org/10. 1128/JVI. 76. 20. 10356-10364. 2002.
10. Viard M, Parolini I, Sargiacomo M, Fecchi K, Ramoni C, Ablan S, Ruscetti FW, Wang JM, Blumenthal R. 2002. Role of cholesterol in human immunodeficiency virus type 1 envelope protein-mediated fusion with host cells. J. Virol. 76: 11584-11595. http://dx. doi. org/10. 1128/JVI. 76. 22. 11584-11595. 2002.
11. Liao Z, Cimakasky LM, Hampton R, Nguyen DH, Hildreth JE. 2001. Lipid rafts and HIV pathogenesis: host membrane cholesterol is required for infection by HIV type 1. AIDS Res. Hum. Retroviruses 17: 1009-1019. http://dx. doi. org/10. 1089/088922201300343690.
12. Nguyen DH, Hildreth JE. 2000. Evidence for budding of human immunodeficiency virus type 1 selectively from glycolipid-enriched membrane lipid rafts. J. Virol. 74: 3264-3272. http://dx. doi. org/10. 1128/JVI. 74. 7. 3264-3272. 2000.
13. Blanchette CD, Lin WC, Ratto TV, Longo ML. 2006. Galactosylceramide domain microstructure: impact of cholesterol and nucleation/growth conditions. Biophys. J. 90: 4466-4478. http://dx. doi. org/10. 1529/biophysj. 105. 072744.
14. van 't Wout AB, Swain JV, Schindler M, Rao U, Pathmajeyan MS, Mullins JI, Kirchhoff F. 2005. Nef induces multiple genes involved in cholesterol synthesis and uptake in human immunodeficiency virus type 1-infected T cells. J. Virol. 79: 10053-10058. http://dx. doi. org/10. 1128/JVI. 79. 15. 10053-10058. 2005.
15. Mujawar Z, Rose H, Morrow MP, Pushkarsky T, Dubrovsky L, Mukhamedova N, Fu Y, Dart A, Orenstein JM, Bobryshev YV, Bukrinsky M, Sviridov D. 2006. Human immunodeficiency virus impairs reverse cholesterol transport from macrophages. PLoS Biol. 4(11): e365. http://dx. doi. org/10. 1371/journal. pbio. 0040365.
16. Zheng YH, Plemenitas A, Fielding CJ, Peterlin BM. 2003. Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions. Proc. Natl. Acad. Sci. U. S. A. 100: 8460-8465. http://dx. doi. org/10. 1073/pnas. 1437453100.
17. Cui HL, Grant A, Mukhamedova N, Pushkarsky T, Jennelle L, Dubrovsky L, Gaus K, Fitzgerald ML, Sviridov D, Bukrinsky M. 2012. HIV-1 Nef mobilizes lipid rafts in macrophages through a pathway that competes with ABCA1-dependent cholesterol efflux. J. Lipid Res. 53: 696-708. http://dx. doi. org/10. 1194/jlr. M023119.
18. Morrow MP, Grant A, Mujawar Z, Dubrovsky L, Pushkarsky T, Kiselyeva Y, Jennelle L, Mukhamedova N, Remaley AT, Kashanchi F, Sviridov D, Bukrinsky M. 2010. Stimulation of the liver X receptor pathway inhibits HIV-1 replication via induction of ATP-binding cassette transporter A1. Mol. Pharmacol. 78: 215-225. http://dx. doi. org/10. 1124/mol. 110. 065029.
19. Dubrovsky L, Van Duyne R, Senina S, Guendel I, Pushkarsky T, Sviridov D, Kashanchi F, Bukrinsky M. 2012. Liver X receptor agonist inhibits HIV-1 replication and prevents HIV-induced reduction of plasma HDL in humanized mouse model of HIV infection. Biochem. Biophys. Res. Commun. 419: 95-98. http://dx. doi. org/10. 1016/j. bbrc. 2012. 01. 137.
20. Jiang H, Badralmaa Y, Yang J, Lempicki R, Hazen A, Natarajan V. 2012. Retinoic acid and liver X receptor agonist synergistically inhibit HIV infection in CD4+ T cells by up-regulating ABCA1-mediated cholesterol efflux. Lipids Health Dis. 11: 69. http://dx. doi. org/10. 1186/1476-511X-11-69.
21. Rinaldo CR. 2013. HIV-1 trans infection of CD4(_) T cells by professional antigen presenting cells. Scientifica (Cairo) 2013: 164203. http://dx. doi. org/10. 1155/2013/164203.
22. Hanley TM, Blay Puryear W, Gummuluru S, Viglianti GA. 2010. PPARgamma and LXR signaling inhibit dendritic cell-mediated HIV-1 capture and trans-infection. PLoS Pathog. 6: e1000981. http://dx. doi. org/10. 1371/journal. ppat. 1000981.
23. Jolly C, Sattentau QJ. 2005. Human immunodeficiency virus type 1 virological synapse formation in T cells requires lipid raft integrity. J. Virol. 79: 12088-12094. http://dx. doi. org/10. 1128/JVI. 79. 18. 12088-12094. 2005.
24. McDonald D. 2010. Dendritic cells and HIV-1 trans-infection. Viruses 2: 1704-1717. http://dx. doi. org/10. 3390/v2081704.
25. Rappocciolo G, Piazza P, Fuller CL, Reinhart TA, Watkins SC, Rowe DT, Jais M, Gupta P, Rinaldo CR. 2006. DC-SIGN on B lymphocytes is required for transmission of HIV-1 to T lymphocytes. PLoS Pathog. 2(7): e70. http://dx. doi. org/10. 1371/journal. ppat. 0020070.
26. Kumar A, Abbas W, Herbein G. 2014. HIV-1 latency in monocytes/macrophages. Viruses 6: 1837-1860. http://dx. doi. org/10. 3390/v6041837.