Nitric oxide induces apoptosis and autophagy; autophagy down-regulates NO synthesis in physalin A-treated A375-S2 human melanoma cells

Food and Chemical Toxicology

Volumn 71, Issue , 2014, Pages 128-135

  He, Hao ^a   Feng, Yong Sheng ^a   Zang, Ling He ^a   Liu, Wei Wei ^a   Ding, Li Qin ^b   Chen, Li Xia ^a   Kang, Ning ^b   Hayashi, Toshihiko ^a   Tashiro, Shin ichi ^c   Onodera, Satoshi ^d   Qiu, Feng ^a,b   Ikejima, Takashi ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^c Institute for Clinical and Biomedical Sciences   (Japan)

^d SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

A375 S2 cells; Apoptosis; Autophagy; MTOR; Nitric oxide; Physalin A

Indexed keywords

3 METHYLADENINE; INDUCIBLE NITRIC OXIDE SYNTHASE; MAMMALIAN TARGET OF RAPAMYCIN; NITRIC OXIDE; PHYSALIN A; RAPAMYCIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; WITHANOLIDE; REACTIVE NITROGEN SPECIES;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL PROTECTION; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG STRUCTURE; HUMAN; HUMAN CELL; MELANOMA CELL; NEGATIVE FEEDBACK; PROTEIN EXPRESSION; BIOSYNTHESIS; MELANOMA; METABOLISM; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE; A375 S2 CELL LINE; ANTINEOPLASTIC ACTIVITY; FLOW CYTOMETRY; GENETIC TRANSFECTION; MELANOMA CELL LINE; OXIDATIVE STRESS; PROTEIN ANALYSIS;

APOPTOSIS; AUTOPHAGY; CELL LINE, TUMOR; DOWN-REGULATION; HUMANS; MELANOMA; NITRIC OXIDE; REACTIVE OXYGEN SPECIES; WITHANOLIDES;

PHYSALIS ALKEKENGI;

EID: 84903905958     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2014.06.007     Document Type: Article

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