Role of the C terminus of Lassa virus l protein in viral mRNA synthesis

Journal of Virology

Volumn 88, Issue 15, 2014, Pages 8713-8717

  Lehmann, Maria ^a   Pahlmann, Meike ^a   Jérôme, Hanna ^a   Busch, Carola ^a   Lelke, Michaela ^a   Günther, Stephan ^a  

^a BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ASPARAGINE; ASPARTIC ACID; CAP BINDING PROTEIN; GLUTAMINE; LASSA VIRUS L PROTEIN; LEUCINE; SERINE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; LASSA VIRUS; MUTAGENESIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; REPLICON; RNA SYNTHESIS; VIRUS GENOME;

CELL LINE; HUMANS; LASSA VIRUS; RNA, MESSENGER; RNA, VIRAL; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 84903897156     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00652-14     Document Type: Article

References (32)

1. Auperin DD, Romanowski V, Galinski M, Bishop DH. 1984. Sequencing studies of pichinde arenavirus S RNA indicate a novel coding strategy, an ambisense viral S RNA. J. Virol. 52:897-904.
2. Strecker T, Eichler R, Meulen J, Weissenhorn W, Klenk HD, Garten W, Lenz O. 2003. Lassa virus Z protein is a matrix protein sufficient for the release of virus-like particles. J. Virol. 77:10700-10705. http://dx.doi.org/10.1128/JVI.77.19.10700-10705.2003.
3. Perez M, Craven RC, de la Torre JC. 2003. The small RING finger protein Z drives arenavirus budding: implications for antiviral strategies. Proc. Natl. Acad. Sci. U.S.A. 100:12978-12983. http://dx.doi.org/10.1073/pnas.2133782100.
4. Singh MK, Fuller-Pace FV, Buchmeier MJ, Southern PJ. 1987. Analysis of the genomic L RNA segment from lymphocytic choriomeningitis virus. Virology 161:448-456. http://dx.doi.org/10.1016/0042-6822(87)90138-3.
5. Hass M, Gölnitz U, Müller S, Becker-Ziaja B, Günther S. 2004. Replicon system for Lassa virus. J. Virol. 78:13793-13803. http://dx.doi.org/10.1128/JVI.78.24.13793-13803.2004.
6. Lee KJ, Novella IS, Teng MN, Oldstone MB, de La Torre JC. 2000. NP and L proteins of lymphocytic choriomeningitis virus (LCMV) are sufficient for efficient transcription and replication of LCMV genomic RNA analogs. J. Virol. 74:3470-3477. http://dx.doi.org/10.1128/JVI.74.8.3470-3477.2000.
7. Lopez N, Jacamo R, Franze-Fernandez MT. 2001. Transcription and RNA replication of Tacaribe virus genome and antigenome analogs requireNand L proteins: Z protein is an inhibitor of these processes. J. Virol. 75:12241-12251. http://dx.doi.org/10.1128/JVI.75.24.12241-12251.2001.
8. Garcin D, Kolakofsky D. 1990. A novel mechanism for the initiation of Tacaribe arenavirus genome replication. J. Virol. 64:6196-6203.
9. Meyer BJ, Southern PJ. 1993. Concurrent sequence analysis of 5' and 3' RNA termini by intramolecular circularization reveals 5' nontemplated bases and 3' terminal heterogeneity for lymphocytic choriomeningitis virus mRNAs. J. Virol. 67:2621-2627.
10. Fuller-Pace FV, Southern PJ. 1989. Detection of virus-specific RNAdependent RNA polymerase activity in extracts from cells infected with lymphocytic choriomeningitis virus: in vitro synthesis of full-length viral RNA species. J. Virol. 63:1938-1944.
11. Garcin D, Kolakofsky D. 1992. Tacaribe arenavirus RNA synthesis in vitro is primer dependent and suggests an unusual model for the initiation of genome replication. J. Virol. 66:1370-1376.
12. Lukashevich IS, Djavani M, Shapiro K, Sanchez A, Ravkov E, Nichol ST, Salvato MS. 1997. The Lassa fever virus L gene: nucleotide sequence, comparison, and precipitation of a predicted 250 kDa protein with monospecific antiserum. J. Gen. Virol. 78(Part 3):547-551.
13. Vieth S, Torda AE, Asper M, Schmitz H, Günther S. 2004. Sequence analysis of L RNA of Lassa virus. Virology 318:153-168. http://dx.doi.org/10.1016/j.virol.2003.09.009.
14. Hass M, Lelke M, Busch C, Becker-Ziaja B, Günther S. 2008. Mutational evidence for a structural model of the Lassa virusRNApolymerase domain and identification of two residues, Gly1394 and Asp1395, that are critical for transcription but not replication of the genome. J. Virol. 82:10207-10217. http://dx.doi.org/10.1128/JVI.00220-08.
15. Morin B, Coutard B, Lelke M, Ferron F, Kerber R, Jamal S, Frangeul A, Baronti C, Charrel R, de Lamballerie X, Vonrhein C, Lescar J, Bricogne G, Günther S, Canard B. 2010. The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription. PLoS Pathog. 6:e1001038. http://dx.doi.org/10.1371/journal.ppat.1001038.
16. Lelke M, Brunotte L, Busch C, Günther S. 2010. An N-terminal region of Lassa virus L protein plays a critical role in transcription but not replication of the virus genome. J. Virol. 84:1934-1944. http://dx.doi.org/10.1128/JVI.01657-09.
17. Polyak SJ, Zheng S, Harnish DG. 1995. 5' Termini of Pichinde arenavirus S RNAs and mRNAs contain nontemplated nucleotides. J. Virol. 69:3211-3215.
18. Raju R, Raju L, Hacker D, Garcin D, Compans R, Kolakofsky D. 1990. Nontemplated bases at the 5' ends of Tacaribe virus mRNAs. Virology 174:53-59. http://dx.doi.org/10.1016/0042-6822(90)90053-T.
19. Guilligay D, Tarendeau F, Resa-Infante P, Coloma R, Crepin T, Sehr P, Lewis J, Ruigrok RW, Ortin J, Hart DJ, Cusack S. 2008. The structural basis for cap binding by influenza virus polymerase subunit PB2. Nat. Struct. Mol. Biol. 15:500-506. http://dx.doi.org/10.1038/nsmb.1421.
20. Dias A, Bouvier D, Crepin T, McCarthy AA, Hart DJ, Baudin F, Cusack S, Ruigrok RW. 2009. The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit. Nature 458:914-918. http://dx.doi.org/10.1038/nature07745.
21. Yuan P, Bartlam M, Lou Z, Chen S, Zhou J, He X, Lv Z, Ge R, Li X, Deng T, Fodor E, Rao Z, Liu Y. 2009. Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site. Nature 458:909-913. http://dx.doi.org/10.1038/nature07720.
22. Li M, Diehl F, Dressman D, Vogelstein B, Kinzler KW. 2006. BEAMing up for detection and quantification of rare sequence variants. Nat. Methods 3:95-97. http://dx.doi.org/10.1038/nmeth850.
23. Gunther S, Sommer G, Von Breunig F, Iwanska A, Kalinina T, Sterneck M, Will H. 1998. Amplification of full-length hepatitis B virus genomes from samples from patients with low levels of viremia: frequency and functional consequences of PCR-introduced mutations. J. Clin. Microbiol. 36:531-538.
24. Buchholz UJ, Finke S, Conzelmann KK. 1999. Generation of bovine respiratory syncytial virus (BRSV) from cDNA: BRSV NS2 is not essential for virus replication in tissue culture, and the human RSV leader region acts as a functional BRSV genome promoter. J. Virol. 73:251-259.
25. Sutter G, Ohlmann M, Erfle V. 1995. Non-replicating vaccinia vector efficiently expresses bacteriophage T7 RNA polymerase. FEBS Lett. 371: 9-12. http://dx.doi.org/10.1016/0014-5793(95)00843-X.
26. Fechter P, Brownlee GG. 2005. Recognition of mRNA cap structures by viral and cellular proteins. J. Gen. Virol. 86:1239-1249. http://dx.doi.org/10.1099/vir.0.80755-0.
27. Fechter P, Mingay L, Sharps J, Chambers A, Fodor E, Brownlee GG. 2003. Two aromatic residues in the PB2 subunit of influenza A RNA polymerase are crucial for cap binding. J. Biol. Chem. 278:20381-20388. http://dx.doi.org/10.1074/jbc.M300130200.
28. Qi X, Lan S, Wang W, Schelde LM, Dong H, Wallat GD, Ly H, Liang Y, Dong C. 2010. Cap binding and immune evasion revealed by Lassa nucleoprotein structure. Nature 468:779-783. http://dx.doi.org/10.1038/nature09605.
29. Mir MA, Duran WA, Hjelle BL, Ye C, Panganiban AT. 2008. Storage of cellular 5' mRNA caps in P bodies for viral cap-snatching. Proc. Natl. Acad. Sci. U.S.A. 105:19294-19299. http://dx.doi.org/10.1073/pnas.0807211105.
30. Cheng E, Mir MA. 2012. Signatures of host mRNA 5' terminus for efficient hantavirus cap snatching. J. Virol. 86:10173-10185. http://dx.doi.org/10.1128/JVI.05560-11.
31. Simossis VA, Heringa J. 2005. PRALINE: a multiple sequence alignment toolbox that integrates homology-extended and secondary structure information. Nucleic Acids Res. 33:W289-W294. http://dx.doi.org/10.1093/nar/gki390.
32. Cuff JA, Barton GJ. 2000. Application of multiple sequence alignment profiles to improve protein secondary structure prediction. Proteins 40: 502-511. http://dx.doi.org/10.1002/1097-0134(20000815)40:3<502::AID-PROT170>3.0.CO;2-Q.