Replicon system for Lassa virus

Journal of Virology

Volumn 78, Issue 24, 2004, Pages 13793-13803

  Hass, Meike ^a   Gölnitz, Uta ^a,b   Müller, Stefanie ^a   Becker Ziaja, Beate ^a   Günther, Stephan ^a  

^a BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; DNA; FATTY ACID BINDING PROTEIN; LUCIFERASE; NUCLEOPROTEIN; PROTEIN L; RIBAVIRIN; RIBONUCLEOPROTEIN; RNA POLYMERASE; TRANSFER RNA; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; AFRICA; ANIMAL CELL; ARENAVIRUS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HEMORRHAGIC FEVER; INTERNAL RIBOSOME ENTRY SITE; LASSA VIRUS; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; REPLICON; REPORTER GENE; RNA REPLICATION; RNA TRANSCRIPTION; VIRUS GENOME; VIRUS STRAIN; VIRUS TRANSCRIPTION;

ANIMALS; ANTIVIRAL AGENTS; CERCOPITHECUS AETHIOPS; DNA-DIRECTED RNA POLYMERASES; GENOME, VIRAL; LASSA VIRUS; MOLECULAR SEQUENCE DATA; PLASMIDS; REPLICON; TRANSCRIPTION, GENETIC; VERO CELLS; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 10044221111     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.78.24.13793-13803.2004     Document Type: Article

References (59)

1. Andrei, G., and E. De Clercq. 1990. Inhibitory effect of selected antiviral compounds on arenavirus replication in vitro. Antivir. Res. 14:287-299.
2. Asper, M., T. Sternsdorf, M. Hass, C. Drosten, A. Rhode, H. Schmitz, and S. Günther. 2004. Inhibition of different Lassa virus strains by alpha and gamma interferons and comparison with a less pathogenic arenavirus. J. Virol. 78:3162-3169.
3. Auperin, D. D., D. R. Sasso, and J. B. McCormick. 1986. Nucleotide sequence of the glycoprotein gene and intergenic region of the Lassa virus S genome RNA. Virology 154:155-167.
4. Auperin, D. D., V. Romanowski, M. Galinski, and D. H. Bishop. 1984. Sequencing studies of pichinde arenavirus S RNA indicate a novel coding strategy, an ambisense viral S RNA. J. Virol. 52:897-904.
5. Bausch, D. G., A. H. Demby, M. Coulibaly, J. Kanu, A. Goba, A. Bah, N. Conde, H. L. Wurtzel, K. F. Cavallaro, E. Lloyd, F. B. Baldet, S. D. Cisse, D. Fofona, I. K. Savane, R. T. Tolno, B. Mahy, K. D. Wagoner, T. G. Ksiazek, C. J. Peters, and P. E. Rollin. 2001. Lassa fever in Guinea. I. Epidemiology of human disease and clinical observations. Vector Borne Zoonotic Dis. 1:269-281.
6. Biebricher, C. K., and R. Luce. 1996. Template-free generation of RNA species that replicate with bacteriophage T7 RNA polymerase. EMBO J. 15:3458-3465.
7. Buchholz, U. J., S. Finke, and K. K. Conzelmann. 1999. Generation of bovine respiratory syncytial virus (BRSV) from cDNA: BRSV NS2 is not essential for virus replication in tissue culture, and the human RSV leader region acts as a functional BRSV genome promoter. J. Virol. 73:251-259.
8. Buchmeier, M. J., P. J. Southern, B. S. Parekh, M. K. Wooddell, and M. B. Oldstone. 1987. Site-specific antibodies define a cleavage site conserved among arenavirus GP-C glycoproteins. J. Virol. 61:982-985.
9. Carey, D. E., G. E. Kemp, H. A. White, L. Pinneo, R. F. Addy, A. L. Fom, G. Stroh, J. Casals, and B. E. Henderson. 1972. Lassa fever. Epidemiological aspects of the 1970 epidemic, Jos, Nigeria. Trans. R. Soc. Trop. Med. Hyg. 66:402-408.
10. Cazenave, C., and O. C. Uhlenbeck. 1994. RNA template-directed RNA synthesis by T7 RNA polymerase. Proc. Natl. Acad. Sci. USA 91:6972-6976.
11. Conzelmann, K. K. 1998. Nonsegmented negative-strand RNA viruses: genetics and manipulation of viral genomes. Annu. Rev. Genet. 32:123-162.
12. Cornu, T. I., and J. C. de la Torre. 2001. RING finger Z protein of lymphocytic choriomeningitis virus (LCMV) inhibits transcription and RNA replication of an LCMV S-segment minigenome. J. Virol. 75:9415-9426.
13. Cornu, T. I., and J. C. de la Torre. 2002. Characterization of the arenavirus RING finger Z protein regions required for Z-mediated inhibition of viral RNA synthesis. J. Virol. 76:6678-6688.
14. Crotty, S., C. E. Cameron, and R. Andino. 2001. RNA virus error catastrophe: direct molecular test by using ribavirin. Proc. Natl. Acad. Sci. USA 98:6895-6900.
15. Crotty, S., D. Maag, J. J. Arnold, W. Zhong, J. Y. Lau, Z. Hong, R. Andino, and C. E. Cameron. 2000. The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Nat. Med. 6:1375-1379.
16. Elroy-Stein, O., and B. Moss. 1990. Cytoplasmic expression system based on constitutive synthesis of bacteriophage T7 RNA polymerase in mammalian cells. Proc. Natl. Acad. Sci. USA 87:6743-6747.
17. Fisher-Hoch, S. P., O. Tomori, A. Nasidi, G. I. Perez-Oronoz, Y. Fakile, L. Hutwagner, and J. B. McCormick. 1995. Review of cases of nosocomial Lassa fever in Nigeria: the high price of poor medical practice. BMJ 311:857-859.
18. Fuerst, T. R., and B. Moss. 1989. Structure and stability of mRNA synthesized by vaccinia virus-encoded bacteriophage T7 RNA polymerase in mammalian cells. Importance of the 5′ untranslated leader. J. Mol. Biol. 206:333-348.
19. Fuerst, T. R., E. G. Niles, F. W. Studier, and B. Moss. 1986. Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase. Proc. Natl. Acad. Sci. USA 83:8122-8126.
20. Fuller-Pace, F. V., and P. J. Southern. 1989. Detection of virus-specific RNA-dependent RNA polymerase activity in extracts from cells infected with lymphocytic choriomeningitis virus: in vitro synthesis of full-length viral RNA species. J. Virol. 63:1938-1944.
21. Garcin, D., and D. Kolakofsky. 1990. A novel mechanism for the initiation of Tacaribe arenavirus genome replication. J. Virol. 64:6196-6203.
22. Goswami, B. B., E. Borek, O. K. Sharma, J. Fujitaki, and R. A. Smith. 1979. The broad spectrum antiviral agent ribavirin inhibits capping of mRNA. Biochem. Biophys. Res. Commun. 89:830-336.
23. Günther, S., O. Kühle, D. Render, G. N. Odaibo, D. O. Olaleye, P. Emmerich, J. ter Meulen, and H. Schmitz. 2001. Antibodies to Lassa virus Z protein and nucleoprotein co-occur in human sera from Lassa fever endemic regions. Med. Microbiol. Immunol. (Berlin) 189:225-229.
24. Günther, S., P. Emmerich, T. Laue, O. Kühle, M. Asper, A. Jung, T. Grewing, J. ter Meulen, and H. Schmitz. 2000. Imported Lassa fever in Germany: molecular characterization of a new Lassa virus strain. Emerg. Infect. Dis. 6:466-476.
25. Günther, S., M. Asper, C. Röser, L. K. S. Luna, C. Drosten, B. Becker-Ziaja, P. Borowski, H.-M. Chen, and R. S. Hosmane. 2004. Application of real-time PCR for testing antiviral compounds against Lassa virus, SARS coronavirus, and Ebola virus in vitro. Antivir. Res. 63:209-215.
26. Imburgio, D., M. Rong, K. Ma, and W. T. McAllister. 2000. Studies of promoter recognition and start site selection by T7 RNA polymerase using a comprehensive collection of promoter variants. Biochemistry 39:10419-10430.
27. Jacamo, R., N. Lopez, M. Wilda, and M. T. Franze-Fernandez. 2003. Tacaribe virus Z protein interacts with the L polymerase protein to inhibit viral RNA synthesis. J. Virol. 77:10383-10393.
28. Kao, C., M. Zheng, and S. Rudisser. 1999. A simple and efficient method to reduce nontemplated nucleotide addition at the 3 terminus of RNAs transcribed by T7 RNA polymerase. RNA 5:1268-1272.
29. Katz, E., E. Margalith, and B. Winer. 1976. Inhibition of vaccinia virus growth by the nucleoside analogue 1-beta-D-ribofuranosyl-1,2,4-triazole-3- carboxamide (virazole, ribavirin). J. Gen. Virol. 32:327-330.
30. Lee, K. J., M. Perez, D. D. Pinschewer, and J. C. de la Torre. 2002. Identification of the lymphocytic choriomeningitis virus (LCMV) proteins required to rescue LCMV RNA analogs into LCMV-like particles. J. Virol. 76:6393-6397.
31. Lee, K. J., I. S. Novella, M. N. Teng, M. B. Oldstone, and J. C. de La Torre. 2000. NP and L proteins of lymphocytic choriomeningitis virus (LCMV) are sufficient for efficient transcription and replication of LCMV genomic RNA analogs. J. Virol. 74:3470-3477.
32. Lopez, N., R. Jacamo, and M. T. Franze-Fernandez. 2001. Transcription and RNA replication of tacaribe virus genome and antigenome analogs require N and L proteins: Z protein is an inhibitor of these processes. J. Virol. 75:12241-12251.
33. Lukashevich, I. S., T. A. Stelmakh, V. P. Golubev, E. P. Stchesljenok, and N. N. Lemeshko. 1984. Ribonucleic acids of Machupo and Lassa viruses. Arch. Virol. 79:189-203.
34. Lukashevich, I. S., M. Djavani, K. Shapiro, A. Sanchez, E. Ravkov, S. T. Nichol, and M. S. Salvato. 1997. The Lassa fever virus L gene: nucleotide sequence, comparison, and precipitation of a predicted 250 kDa protein with monospecific antiserum. J. Gen. Virol. 78:547-551.
35. McCormick, J. B., I. J. King, P. A. Webb, C. L. Scribner, R. B. Craven, K. M. Johnson, L. H. Elliott, and R. Belmont-Williams. 1986. Lassa fever. Effective therapy with ribavirin. N. Engl. J. Med. 314:20-26.
36. McCormick, J. B., I. J. King, P. A. Webb, K. M. Johnson, R. O'Sullivan, E. S. Smith, S. Trippel, and T. C. Tong. 1987. A case-control study of the clinical diagnosis and course of Lassa fever. J. Infect. Dis. 155:445-455.
37. Meyer, B. J., and P. J. Southern. 1993. Concurrent sequence analysis of 5′ and 3′ RNA termini by intramolecular circularization reveals 5′ nontemplated bases and 3′ terminal heterogeneity for lymphocytic choriomeningitis virus mRNAs. J. Virol. 67:2621-2627.
38. Meyer, B. J., and P. J. Southern. 1994. Sequence heterogeneity in the termini of lymphocytic choriomeningitis virus genomic and aritigenomic RNAs. J. Virol. 68:7659-7664.
39. Meyer, B. J., and P. J. Southern. 1997. A novel type of defective viral genome suggests a unique strategy to establish and maintain persistent lymphocytic choriomeningitis virus infections. J. Virol. 71:6757-6764.
40. Meyer, H., G. Sutter, and A. Mayr. 1991. Mapping of deletions in the genome of the highly attenuated vaccinia virus MVA and their influence on virulence. J. Gen. Virol. 72:1031-1038.
41. Milligan, J. F., D. R. Groebe, G. W. Witherell, and O. C. Uhlenbeck. 1987. Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates. Nucleic Acids Res. 15:8783-8798.
42. Monath, T. P., M. Maher, J. Casals, R. E. Kissling, and A. Cacciapuoti. 1974. Lassa fever in the Eastern Province of Sierra Leone, 1970-1972. II. Clinical observations and virological studies on selected hospital cases. Am. J. Trop. Med. Hyg. 23:1140-1149.
43. Monath, T. P., V. F. Newhouse, G. E. Kemp, H. W. Setzer, and A. Cacciapuoti. 1974. Lassa virus isolation from Mastomys natalensis rodents during an epidemic in Sierra Leone. Science 185:263-265.
44. Monath, T. P., P. E. Merteus, R. Patton, C. R. Moser, J. J. Baum, L. Pinneo, G. W. Gary, and R. E. Kissling. 1973. A hospital epidemic of Lassa fever in Zorzor, Liberia, March-April 1972. Am. J. Trop. Med. Hyg. 22:773-779.
45. Mühlberger, E., B. Lotfering, H. D. Klenk, and S. Becker. 1998. Three of the four nucleocapsid proteins of Marburg virus, NP, VP35, and L, are sufficient to mediate replication and transcription of Marburg virus-specific monocistronic minigenomes. J. Virol. 72:8756-8764.
46. Perez, M., and J. C. de la Torre. 2003. Characterization of the genomic promoter of the prototypic arenavirus lymphocytic choriomeningitis virus. J. Virol. 77:1184-1194.
47. Perez, M., R. C. Craven, and J. C. de la Torre. 2003. The small RING finger protein Z drives arenavirus budding: implications for antiviral strategies. Proc. Natl. Acad. Sci. USA 100:12978-12983.
48. Pinschewer, D. D., M. Perez, and J. C. de la Torre. 2003. Role of the virus nucleoprotein in the regulation of lymphocytic choriomeningitis virus transcription and RNA replication. J. Virol. 77:3882-3887.
49. Pinschewer, D. D., M. Perez, A. B. Sanchez, and J. C. de la Torre. 2003. Recombinant lymphocytic choriomeningitis virus expressing vesicular stomatitis virus glycoprotein. Proc. Natl. Acad. Sci. USA 100:7895-7900.
50. Polyak, S. J., S. Zheng, and D. G. Harnish. 1995. 5′ termini of Pichinde arenavirus S RNAs and mRNAs contain nontemplated nucleotides. J. Virol. 69:3211-3215.
51. Raju, R., L. Raju, D. Hacker, D. Garcin, R. Compans, and D. Kolakofsky. 1990. Nontemplated bases at the 5′ ends of Tacaribe virus mRNAs. Virology 174:53-59.
52. Ruiz-Jarabo, C. M., C. Ly, E. Domingo, and J. C. de la Torre. 2003. Lethal mutagenesis of the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV). Virology 308:37-47.
53. Sänger, C., E. Mühlberger, H. D. Klenk, and S. Becker. 2001. Adverse effects of MVA-T7 on the transport of Marburg virus glycoprotein. J. Virol. Methods 91:29-35.
54. Schmitz, H., B. Köhler, T. Laue, C. Drosten, P. J. Veldkamp, S. Günther, P. Emmerich, H. P. Geisen, K. Fleischer, M. F. Beersma, and A. Hoerauf. 2002. Monitoring of clinical and laboratory data in two cases of imported Lassa fever. Microbes Infect. 4:43-50.
55. Strecker, T., R. Eichler, J. ter Meulen, W. Weissenhorn, H. D. Klenk, W. Garten, and O. Lenz. 2003. Lassa virus Z protein is a matrix protein sufficient for the release of virus-like particles. J. Virol. 77:10700-10705.
56. Streeter, D. G., J. T. Witkowski, G. P. Khare, R. W. Sidwell, R. J. Bauer, R. K. Robins, and L. N. Simon. 1973. Mechanism of action of 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent. Proc. Natl. Acad. Sci. USA 70:1174-1178.
57. Sutter, G., M. Ohlmann, and V. Erfle. 1995. Non-replicating vaccinia vector efficiently expresses bacteriophage T7 RNA polymerase. FEBS Lett. 371:9-12.
58. Vieth, S., A. E. Torda, M. Asper, H. Schmitz, and S. Günther. 2004. Sequence analysis of L RNA of Lassa virus. Virology 318:153-168.
59. Weber, F., E. F. Dunn, A. Bridgen, and R. M. Elliott. 2001. The Bunyamwera virus nonstructural protein NSs inhibits viral RNA synthesis in a minireplicon system. Virology 281:67-74.