Increase of gap junction activities in SW480 human colorectal cancer cells

BMC Cancer

Volumn 14, Issue 1, 2014, Pages

  Bigelow, Kristina ^a   Nguyen, Thu A ^a  

^a KANSAS STATE UNIVERSITY   (United States)

Author keywords

Gap junction intercellular communication; Kinase activity; PQ1

Indexed keywords

6 METHOXY 8 [(3 AMINOPROPYL)AMINO] 4 METHYL 5 (3 TRIFLUOROMETHYLPHENLOXY)QUINOLONE; CONNEXIN 43; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PQ 1; PROTEIN KINASE B; QUINOLONE DERIVATIVE; UNCLASSIFIED DRUG; AMINOQUINOLINE DERIVATIVE; PQ1 COMPOUND;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL ASSAY; CELL COMMUNICATION; CELL PROLIFERATION; CELL VIABILITY; CELLULAR DISTRIBUTION; COLORECTAL CANCER CELL LINE; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; GAP JUNCTION ACTIVITY ASSAY; GAP JUNCTIONAL INTERCELLULAR COMMUNICATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING; COLORECTAL TUMOR; GAP JUNCTION; METABOLISM; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

AMINOQUINOLINES; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; CONNEXIN 43; GAP JUNCTIONS; HUMANS; SIGNAL TRANSDUCTION;

EID: 84903877349     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-14-502     Document Type: Article

References (31)

1. Haggar FA, Boushey RP. Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors. Clin Colon Rectal Surg 2009, 22(4):191-197.
2. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin 2013, 63(1):11-30.
3. Siegel R, Desantis C, Jemal A. Colorectal cancer statistics, 2014. CA Cancer J Clin 2014, 64(2):104-117.
4. Laird DW, Fistouris P, Batist G, Alpert L, Huynh HT, Carystinos GD, Alaoui-Jamali MA. Deficiency of connexin43 gap junctions is an independent marker for breast tumors. Cancer Res 1999, 59(16):4104-4110.
5. Mehta PP, Lokeshwar BL, Schiller PC, Bendix MV, Ostenson RC, Howard GA, Roos BA. Gap-junctional communication in normal and neoplastic prostate epithelial cells and its regulation by cAMP. Mol Carcinog 1996, 15(1):18-32.
6. Söhl G, Willecke K. An update on connexin genes and their nomenclature in mouse and man. Cell Commun Adhes 2003, 10(4-6):173-180.
7. Loewenstein WR, Kanno Y. Intercellular communication and the control of tissue growth: lack of communication between cancer cells. Nature 1966, 209(5029):1248-1249.
8. Spray DC, Rozental R, Srinivas M. Prospects for rational development of pharmacological gap junction channel blockers. Curr Drug Targets 2002, 3(6):455-464.
9. Segretain D, Falk MM. Regulation of connexin biosynthesis, assembly, gap junction formation, and removal. Biochim Biophys Acta 2004, 1662(1-2):3-21.
10. Oyamada M, Oyamada Y, Takamatsu T. Regulation of connexin expression. Biochim Biophys Acta - Biomembr 2005, 1719(1-2):6-23.
11. Lampe PD, Lau AF. The effects of connexin phosphorylation on gap junctional communication. Int J Biochem Cell Biol 2004, 36(7):1171-1186.
12. Dunn CA, Lampe PD. Injury-triggered Akt phosphorylation of Cx43: a ZO-1-driven molecular switch that regulates gap junction size. J Cell Sci 2014, 127(Pt 2):455-464.
13. Hossain MZ, Jagdale AB, Ao P, Kazlauskas A, Alton L. Disruption of gap junctional communication by the platelet-derived growth factor is mediated via multiple signaling pathways. J Biol Chem 1999, 274:10489-10496.
14. Warn-Cramer BJ. Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase. J Biol Chem 1998, 273(15):9188-9196.
15. Dunn CA, Su V, Lau AF, Lampe PD. Activation of AKT, but not connexin43 ubiquitination, regulates gap junction stability. J Biol Chem 2012, 287(4):2600-2607.
16. Solan JL, Marquez-Rosado L, Sorgen PL, Thornton PJ, Gafken PR, Lampe PD. Phosphorylation at S365 is a gatekeeper event that changes the structure of Cx43 and prevents down-regulation by PKC. J Cell Biol 2007, 179(6):1301-1309.
17. Srisakuldee W, Jeyaraman MM, Nickel BE, Tanguy S, Jiang ZS, Kardami E. Phosphorylation of connexin-43 at serine 262 promotes a cardiac injury-resistant state. Cardiovasc Res 2009, 83(4):672-681.
18. Solan JL, Lampe PD. Key connexin43 phosphorylation events regulate the gap junction life cycle. J Membr Biol 2008, 217(206):35-41.
19. Doble BW, Dang X, Ping P, Fandrich RR, Nickel BE, Jin Y, Cattini PA, Kardami E. Phosphorylation of serine 262 in the gap junction protein connexin-43 regulates DNA synthesis in cell-cell contact forming cardiomyocytes. J Cell Sci 2004, 117(3):507-514.
20. Leithe E, Rivedal E. Ubiquitination and down-regulation of gap junction protein connexin-43 in response to 12-O-tetradecanoylphorbol 13-acetate treatment. J Biol Chem 2004, 279(48):50089-50096.
21. Gakhar G, Ohira T, Shi A, Hua DH, Nguyen TA. Antitumor effect of substituted quinolines in breast cancer cells. Drug Dev Res 2008, 69(8):526-534.
22. Ding Y, Nguyen TA. PQ1, a quinoline derivative, induces apoptosis in T47D breast cancer cells through activation of caspase-8 and caspase-9. Apoptosis 2013, 18:1071-1082.
23. Ding Y, Prasain K, Nguyen TDT, Hua DH, Nguyen TA. The effect of the PQ1 anti-breast cancer agent on normal tissues. Anticancer Drugs 2012, 23(9):897-905.
24. Kanczuga-Koda L, Koda M, Sulkowski S, Wincewicz A, Zalewski B, Sulkowska M. Gradual loss of functional gap junction within progression of colorectal cancer - a shift from membranous CX32 and CX43 expression to cytoplasmic pattern during colorectal carcinogenesis. In Vivo 2010, 24(1):101-107.
25. Banerjee D, Das S, Molina SA, Madgwick D, Katz MR, Jena S, Bossmann LK, Pal D, Takemoto DJ. Investigation of the reciprocal relationship between the expression of two gap junction connexin proteins, connexin46 and connexin43. J Biol Chem 2011, 286(27):24519-24533.
26. Brokamp C, Todd J, Montemagno C, Wendell D. Electrophysiology of single and aggregate Cx43 hemichannels. PLoS One 2012, 7(10):e47775.
27. Oh SY, Dupont E, Madhukar BV, Briand JP, Chang CC, Beyer E, Trosko JE. Characterization of gap junctional communication-deficient mutants of a rat liver epithelial cell line. Eur J Cell Biol 1993, 60(2):250-255.
28. Laird DW. Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation. Biochim Biophys Acta 2005, 1711(2):172-182.
29. Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC. Plasma membrane channels formed by connexins: their regulation and functions. Physiol Rev 2003, 83(4):1359-1400.
30. Söhl G, Willecke K. Gap junctions and the connexin protein family. Cardiovasc Res 2004, 62(2):228-232.
31. Sáez JC, Martínez AD, Brañes MC, González HE. Regulation of gap junctions by protein phosphorylation. Brazilian J Med Biol Res 1998, 31(5):593-600.