Gap-junctional communication in normal and neoplastic prostate epithelial cells and its regulation by cAMP

Molecular Carcinogenesis

Volumn 15, Issue 1, 1996, Pages 18-32

  Mehta, Parmender P ^a,b   Lokeshwar, Balakrishna L ^a,b   Schiller, Paul C ^a,b   Bendix, Marcelo V ^a,b   Ostenson, Richard C ^c   Howard, Guy A ^a,b   Roos, Bernard A ^a,b  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Connexin; Cyclic AMP; Gap junction; Prostate cancer

Indexed keywords

CYCLIC AMP; FORSKOLIN; GAP JUNCTION PROTEIN; LUCIFER YELLOW; MESSENGER RNA;

ARTICLE; CELL COMMUNICATION; CELL JUNCTION; CONTROLLED STUDY; EPITHELIUM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE CARCINOMA;

CALCIUM-BINDING PROTEINS; CALNEXIN; CELL COMMUNICATION; CELL COMPARTMENTATION; CYCLIC AMP; EPITHELIAL CELLS; FORSKOLIN; GAP JUNCTIONS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; PROSTATE; PROSTATIC NEOPLASMS; RNA, MESSENGER; RNA, NEOPLASM; SOLUBILITY; TUMOR CELLS, CULTURED;

EID: 0029865182     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199601)15:1<18::AID-MC4>3.0.CO;2-O     Document Type: Article

References (87)

1. Gilula NB, Reeves OR, Steinbach A Metabolic coupling, ionic coupling and cell contacts Nature 235:262-265, 1972
2. Loewenstein WR. Junctional intercellular communication. The cell-to-cell membrane channel Physiol Rev 61:829-913, 1981.
3. Bennett MVL, Barrio LC, Bargiello DC, Spray DC, Hertzberg E, Saez JC. Gap junctions Newtools, new answers, new questions. Neuron 6:305-320, 1991.
4. Loewenstein WR. Junctional intercellular communication and the control of growth. Biochim Biophys Acta 560:1-65, 1979.
5. Trosko JE, Chang CC Rote of intercellular communication in tumor promotion. In. Slaga TJ (ed), Mechanism of Tumor Promotion, Vol 4, Cellular Responses to Tumor Promoters. CRC Press, Boca Raton, FL, 1984, pp. 119-145.
6. Sheridan JD, Atkinson MM. Physiological roles of permeable junctions: Some possibilities Am J Physiol 47 337-353, 1985.
7. Yamasaki H Gap junctional intercellular communication and carcinogenesis Carcinogenesis 7:1051-1058, 1990.
8. Loewenstein WR, Rose B. The cell-cell channel in the control of growth. Semin Cell Biol 3.59-79, 1992
9. Caveney S. The role of gap junctions in development. Annu Rev Physiol 47:319-335, 1985
10. Guthrie SC, Gilula NB. Gap junctional communication and development. Trends Neurosci 12 12-16, 1989.
11. Lo CW Communication compartments A conserved role in pattern formation? In: Sperelakis N, Cole WC (eds), Cell Interactions and Gap Junctions CRC Press, Boca Raton, FL, 1989, pp 86-96.
12. Hossain MJ, Wilkens LR, Mehta PP, Loewenstein WR, Bertram JS. Enhancement of gap junctional communication by retinoids correlates with their ability to inhibit neoplastic transformation Carcinogenesis 10:1743-1748, 1989.
13. Mehta PP, Bertram JS, Loewenstein WR. The actions of retinoids on cellular growth correlate with their actions on gap junctional communication. J Cell Biol 108:1053-1065, 1989.
14. Atkinson MM, Anderson SK, Sheridan JD. Modification of gap junctions in cells transformed by a temperature-sensitive mutant of Rous sarcoma virus J Membr Biol 91:53-64, 1986
15. Lee SW, Tomasetto C, Paul D, Keyomarsi K, Sager R Transcriptional downregulatton of gap-junction proteins blocks junctional communication in human mammary tumor cell lines. J Cell Biol 118:1213-1221, 1992
16. Mehta PP, Bertram JS, Loewenstein WR. Growth inhibition of transformed cells correlates with their junctional communication with normal cells Cell 44 187-196, 1986.
17. Yamasaki H, Hollstein M, Mesnil M, Martel N, Aguelon A-M. Selective lack of intercellular communication between transformed and nontransformed cells as a common property of chemical and oncogene transformation of Balb/c3T3 cells. Cancer Res 47:5658-5664, 1987
18. Bignami M, Rosa S, Falcone G, Tato F, Katoh F, Yamasaki H. Specific viral oncogenes cause differential effects on cell-to-cell communication. Mol Carcinog 1:67-75, 1988.
19. Tomasetto C, Neveu MJ, Daley J, Horan PK, Sager R. Specificity of gap junction communication among human mammary cells and connexin transfectants in culture. J Cell Biol 122 157-167, 1993.
20. Mehta PP, Hotz-Wagenblatt A, Rose B, Shalloway D, Loewenstein WR. Incorporation of the gene for a cell-cell channel protein into transformed cells leads to normalization of growth J Membr Biol 124:207-225, 1991.
21. Beyer EC, Paul DL, Goodenough DA. Connexin family of gap junction proteins J Membr Biol 116:187-194, 1990.
22. Willecke K, Hennemann H, Dahl E, Jungbluth S, Heynkes R The diversity of connexin genes encoding gap junctional proteins. Eur J Cell Biol 56:1-7, 1991.
23. Kumar NM, Gilula NB Molecular biology and genetics of gap junctional channels. Semin Cell Biol 3:3-16, 1992.
24. Seamon KB, Daly JW. Forskolin: A unique diterpine activator of cyclic AMP-generating systems. Journal of Cyclic Nucleotide Research 7:201-224, 1981
25. Mehta PP, Yamamoto M, Rose B Transcription of the gene for gap junctional protein connexin 43 and expression of functional cell-to-cell channels are regulated by cAMP. Mol Biol Cell 3:839-850, 1992.
26. Cunha GR. Epithelial-stromal interactions in development of the urogenital tract. Int Rev Cytol 47.137-194, 1976.
27. Morris DW, Cardiff RD. Multistep model of mouse mammary tumor development. Adv Viral Oncol 7:123-139, 1987.
28. Thompson TC, Cunha GR, Shannon JM, Chung LWK. Androgen-induced biochemical responses in epithelium lacking androgen receptors Characterization of androgen receptors in the mesenchymal derivative of urogenital sinus. J Steroid Biochem 25:627-634, 1986
29. Merz VW, Miller GJ, Krebs T, et al Elevated TGF-beta1 and beta3 mRNA levels are associated with the ras + myc-induced carcinomas in reconstituted mouse prostate Evidence for a paracrine role during progression. Mol Endocrinol 5.503-513, 1991
30. McKeehan WL Growth factor receptors and prostate cell growth. Cancer Surv 11:165-175, 1991.
31. Story MT Polypeptide modulators of prostatic growth. Cancer Surv 11:123-146, 1991
32. Wilding G. Response of prostate cancer cells to peptide growth factors Cancer Surv 11 147-163, 1991.
33. Taylor-Papdimitriou J, Berdichevsky F, D'Souza B, Burchell J Human models of breast cancer Cancer Surv 7:59-78, 1993
34. Edwards PAW Tissue reconstitution models of breast cancer. Cancer Surv 16.79-96, 1993.
35. Thompson TC, Southgate J, Kitchner G, Land H. Multistage carcinogenesis induced by ras and myc oncogenes in a reconstituted organ. Cell 56:917-930, 1989.
36. Hayashi N, Cunha GR, Wong YC Influence of male genital mesenchymes on differentiation of Dunning prostatic adenocarcinoma Cancer Res 50:4747-4754, 1990.
37. Cunha GR, Hayashi N, Wong YC. Regulation of differentiation and growth of normal adult and neoplastic epithelia by inductive mesenchyme. Cancer Surv 11:73-90, 1991
38. Chang SM, Chung LWK. Interaction between prostatic fibroblast and epithelial cells in culture: Role of androgen. Endocrinology 125 2719-2727, 1989
39. Djakiew D, Pflug B, Onoda M. Stromal-epithelial paracrine interactions in the neoplastic rat and human prostate. In: Yang SS, Warner HE (eds), The Underlying Molecular, Cellular and Immunological Factors in Cancer and Aging. Plenum Press, New York, 1993, pp 185-202
40. Schiller PC, Mehta PP, Roos BA, Howard GA Hormonal regulation of intercellular communication Parathyroid hormone increases connexin43 gene expression and gap-junctional communication in osteoblastic cells Mol Endocrinol 6:1433-1440, 1992.
41. Stagg RB, Fletcher WH The hormone-induced regulation of contact-dependent cell-cell communication by phosphorylation. Endocr Rev 11:302-325, 1990.
42. Loop SM, RozanskyTA, Ostenson RC. Human primary tumor cell line, ALVA-31. A new model for studying the hormonal regulation of tumor cell growth Prostate 22.93-108, 1993
43. 3 Prostate 26:72-79, 1995.
44. Loop SM, Gorder CA, Lewis SM, Drivdahl RH, Ostenson RC. Growth inhibition of human prostate tumor cells by an agonist of gonadotrophin-releasmg hormone. Prostate 26:179-188, 1995.
45. Hedlund TE, Miller GJ A serum-free defined medium capable of supporting growth of four established human prostate cancer cell lines Prostate 24:221-228, 1994.
46. Plymate SR, Loop SM, Hoop RC, et al. Effects of sex hormone binding globulin (SHBG) on human prostatic carcinoma. J Steroid Biochem Mol Biol 40:833-839, 1991.
47. Lie X-H, Wiley HS, Meikle AW. Androgens regulate proliferation of human prostate cancer cells in culture by increasing transforming growth factor-α (TGF-α) and epidermal growth factor (EGF)/ TGF-α receptor. J Clin Endocrinol Metab 77:1472-1478, 1993
48. Lokeshwar BL, Selzer MG, Block NL, Gunja-Smith Z. Secretion of matrix metalloproteinases and their tissue inhibitors (tissue inhibitor of metalloproteinases) by human prostate in explant cultures. Reduced tissue inhibitor of metalloproteinase secretion by malignant tissues. Cancer Res 53:4493-4498, 1993
49. Wang Y, Mehta PP Facilitation of gap-junctional communication and gap-junction formation in mammalian cells by inhibition of glycosylation Eur J Cell Biol, 67:285-296, 1995.
50. Beyer EC, Paul DL, Goodenough DE. Connexin43: A protein from rat heart homologous to a gap junction protein from liver J Cell Biol 105 2621-2629, 1987
51. Zhang J-T, Nicholson BJ Sequence and tissue distribution of a second protein of hepatic gap junctions, Cx26, as deduced from its CDNA J Cell Biol 109 3391-3401, 1989
52. Haefliger J-A, Bruzzone R, Jenkins NA, Gilbert DJ, Copeland NG, Paul DL. Four novel members of the connexin family of gap junction proteins. J Biol Chem 267:2057-2064, 1992
53. Ho JH, Scott JA, Revel J-P Molecular cloning and characterization of a new member of the gap junction gene family, connexin-31 J Biol Chem 266 6524-6531, 1991
54. Hennemann H, Suchyna T, Lichtenberg-Frate H, et al. Molecular cloning and functional expression of mouse connexin40, a second gap junction gene preferentially expressed in lung J Cell Biol 117.1299-1310, 1992
55. Hennemann H, Dahl E, White JB, et al Two gap junction genes, connexin 31.1 and 30.3, are closely linked on mouse chromosome 4 and preferentially expressed in skin. J Biol Chem 267:17225-17233, 1992.
56. Hennemann H, Schwarz HJ, Willecke K. Characterization of gap junction genes expressed in F9 embryonic carcinoma cells: Molecular cloning of mouse connexin31 and -45 cDNAs. Eur J Cell Biol 57:51-58, 1992.
57. Willecke K, Heynkes R, Dahl E, et al Mouse connexin37: Cloning and functional expression of a gap junction gene highly expressed in lung. J Cell Biol 114:1049-1057, 1991
58. Chomezynski P, Sacchi N. Single-step method of RNA isolation by guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 162.156-159, 1987.
59. Mustl LS, Goodenough DA. Biochemical analysis of connexin43 transport, phosphorylation, and assembly into gap junctional plaques. J Cell Biol 115.1357-1374, 1991.
60. Meda P, Pepper MS, Traub O, et al. Differential expression of gap junction connexins in endocrine and exocrine glands. Endocrinology 133:2371-2378, 1993
61. Musil LS, Cunningham BA, Edelman GM, Goodenough DA Differential phosphorylation of the gap junction protein Cx43 in junctional communication-competent and -deficient cell lines. J Cell Biol 111:2077-2088, 1990.
62. Laird DW, Revel J-P. Biochemical and immunochemical analysis of the arrangement of connexin43 in rat heart gap junction membranes. J Cell Sci 97:109-117, 1990
63. Laird DW, Puranam KL, Revel J-P. Turnover and phosphorylation dynamics of connexin43 gap junction protein in cultured cardiac myocytes. Biochem J 273:67-72, 1991.
64. Lau AF, Kanemitsu MY, Kurata WE, Danesh S, Boynton AL. Epidermal growth factor disrupts gap-junctional communication and induces phosphorylation of connexin43 on serine Mol Biol Cell 3:865-874, 1992.
65. Brissette JL, Kumar NM, Gilulat NB, Dotto P. The tumor promoter 12-O-tetradecanoylphorbol-13-acetate and the ras oncogene modulate expression and phosphorylation of gap junction proteins. Mol Cell Biol 11:5364-5371, 1991
66. Dotto GP, El-Fouly MH, Nelson C, Trosko JE. Synergistic inhibition of gap-junctional communication by ras transformation and tumor promoter treatment. Oncogene 4:637-641, 1989
67. Kenne K, Franssib-Steen R, Honkasalo S, Warngard L Two inhibitors of gap junctional intercellular communication, TPA and endosulfan: Different effects on phosphorylation of connexin43 in the rat liver epithelial cell, line IAR 20 Carcinogenesis 15:1161-1165, 1994.
68. Oh SY, Grupen GS, Murray AW Phorbol ester induces phosphorylation and down-regulation of connexin43 in WB cells. Biochim Biophys Acta 1094:243-245, 1994
69. Filson AJ, Azarnia R, Beyer EC, Loewenstein WR, Brugge JS. Tyrosine phosphorylation correlates with inhibition of cell-to-cell communication Cell Growth Differ 1 661-668, 1990.
70. v-src-induced inhibition of communication. Cell Regul 1:989-1002, 1990
71. Crow DS, Beyer EC, Paul DL, Kobe SS, Lau AF Phosphorylation of Cx43 gap junction protein in uninfected and Rous sarcoma virus-transformed mammalian fibroblasts. Mol Cell Biol 10.1754-1763, 1990.
72. Crow DS, Kurata WE, Lau AF. Phosphorylation of connexin43 in cells containing mutant src oncogenes. Oncogene 7:999-1003, 1992.
73. Puranam KL, Laird DW, Revel J-P. Trapping an intermediate form of connexin43 in the Golgi. Exp Cell Res 206.85-92, 1993.
74. Gkonos PJ, Lokeshwar BL, Balkan W, Roos BA Neuroendocrine peptides stimulate adenyl cyclase in normal and malignant prostate cells. Regul Pept, 59:43-51, 1995.
75. Nicolson GL. Transmembrane control of receptors on normal and transformed cells Biochim Biophys Acta 458:2-72, 1976.
76. Pastan I, Willingham M. Cellular transformation and the "morphologic phenotype" of transformed cells. Nature 274.645-650, 1978.
77. Levine ER, Werner R, Dahl G. Cell-cell channel formation and lectins. Am J Physiol 261.C1025-C1032, 1991.
78. Wilding G. The importance of steroid hormones in prostate cancer Cancer Surv 14 113-130, 1992.
79. Chung LWK, Gleaver ME, Hsieh J-T, Hong S-J, Zhau HE. Reciprocal mesenchymal-epithelial interaction affecting prostate tumour growth and hormonal responsiveness. Cancer Surv 11:91-121, 1991
80. Decker RS. Hormonal regulation of gap junction differentiation. J Cell Biol 69:669-685, 1976.
81. Garfield RE, Sims S, Daniel EE. Gap junctions. The presence and necessity in myometrium during parturition. Science 198.958-960, 1977.
82. Dahl G, Berger W. Nexus formation in the myometrium during parturition and induced by oestrogen. Cell Biol Intern Rep 2:381-387, 1978
83. Risek B, Guthrie S, Kumar N, Gilula NB. Modulation of gap junction transcript and protein expression during pregnancy in the rat. J Cell Biol 110:269-282, 1990.
84. Yu W, Dahl G, Werner R. The connexin43 gene is responsive to oestrogen. Proc R Soc Lond B 255:125-132, 1994
85. Maldonado PE, Rose B, Loewenstein WR. Growth factors modulate junctional cell-to-cell communication. J Membr Biol 106:203-210, 1988
86. Madhukar BV, Oh SY, Chang CC, Wade M, Trosko JE. Altered regulation of intercellular communication by epidermal growth factor, transforming growth factor-beta and peptide hormones in normal human keratinocytes. Carcinogenesis 10:13-20, 1989
87. Wang Y, Mehta PP, Rose B Inhibition of gycosylation induces open connex 43 cell-cell channels and phosphorylation and Triton X-100 insolubility of connexin 43. J Biol Chem 270:26581-26585, 1995.