MiR-195 affects cell migration and cell proliferation by down-regulating DIEXF in Hirschsprung's Disease

BMC Gastroenterology

Volumn 14, Issue 1, 2014, Pages

  Lei, Hao ^a,b   Tang, Junwei ^a,b   Li, Hongxing ^a,b   Zhang, Hongwei ^c   Lu, Changgui ^a,b   Chen, Huan ^a,b   Li, Wei ^a,b   Xia, Yankai ^a   Tang, Weibing ^a,b  

^a NANJING MEDICAL UNIVERSITY   (China)

^b CHILDREN S HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^c XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Congenital diseases; Gastroenterology; HSCR; MicroRNA; Migration

Indexed keywords

DIGESTIVE ORGAN EXPANSION FACTOR; FIBROBLAST GROWTH FACTOR 2; MEMBRANE PROTEIN; MESSENGER RNA; MICRORNA; MICRORNA 195; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; MIRN195 MICRORNA, HUMAN;

3' UNTRANSLATED REGION; ANO3 GENE; APOPTOSIS; ARTICLE; BIOINFORMATICS; CELL MIGRATION; CELL PROLIFERATION; COMPARATIVE STUDY; CONTROLLED STUDY; DIEXF GENE; DOWN REGULATION; ENTERIC NEURAL CREST CELL; FGF2 GENE; FLOW CYTOMETER; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HIRSCHSPRUNG DISEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INFANT; MAJOR CLINICAL STUDY; MIGRATION INHIBITION; NEURAL CREST CELL; PATHOGENESIS; PROTEIN EXPRESSION; SLC11A2 GENE; UPREGULATION; CASE CONTROL STUDY; CELL MOTION; COLON; FEMALE; GENE EXPRESSION PROFILING; GENETICS; MALE; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

BLOTTING, WESTERN; CASE-CONTROL STUDIES; CELL MOVEMENT; CELL PROLIFERATION; COLON; DOWN-REGULATION; FEMALE; GENE EXPRESSION PROFILING; HIRSCHSPRUNG DISEASE; HUMANS; INFANT; MALE; MICRORNAS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84903861774     PISSN: None     EISSN: 1471230X     Source Type: Journal    
DOI: 10.1186/1471-230X-14-123     Document Type: Article

References (23)

1. Kenny SE, Tam PK, Garcia-Barcelo M. Hirschsprung's disease. Semin Pediatr Surg 2010, 19(3):194-200.
2. Pan ZW, Li JC. Advances in molecular genetics of Hirschsprung's disease. Anat Rec (Hoboken) 2012, 295(10):1628-1638.
3. Borrego S, Ruiz-Ferrer M, Fernandez RM, Antinolo G. Hirschsprung's disease as a model of complex genetic etiology. Histol Histopathol 2013, 28(9):1117-1136.
4. Watanabe Y, Broders-Bondon F, Baral V, Paul-Gilloteaux P, Pingault V, Dufour S, Bondurand N. Sox10 and Itgb1 interaction in enteric neural crest cell migration. Dev Biol 2013, 379(1):92-106.
5. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004, 116(2):281-297.
6. Zhou Q, Haupt S, Prots I, Thummler K, Kremmer E, Lipsky PE, Schulze-Koops H, Skapenko A. miR-142-3p is involved in CD25+ CD4 T cell proliferation by targeting the expression of glycoprotein A repetitions predominant. J Immunol 2013, 190(12):6579-6588.
7. Wu W, Yang J, Feng X, Wang H, Ye S, Yang P, Tan W, Wei G, Zhou Y. MicroRNA-32 (miR-32) regulates phosphatase and tensin homologue (PTEN) expression and promotes growth, migration, and invasion in colorectal carcinoma cells. Mol Cancer 2013, 12:30.
8. Schug J, McKenna LB, Walton G, Hand N, Mukherjee S, Essuman K, Shi Z, Gao Y, Markley K, Nakagawa M, Kameswaran V, Vourekas A, Friedman JR, Kaestner KH, Greenbaum LE. Dynamic recruitment of microRNAs to their mRNA targets in the regenerating liver. BMC Genomics 2013, 14:264.
9. Hu JZ, Huang JH, Zeng L, Wang G, Cao M, Lu HB. Anti-apoptotic effect of microRNA-21 after contusion spinal cord injury in rats. J Neurotrauma 2013, 30(15):1349-1360.
10. Deng H, Guo Y, Song H, Xiao B, Sun W, Liu Z, Yu X, Xia T, Cui L, Guo J. MicroRNA-195 and microRNA-378 mediate tumor growth suppression by epigenetical regulation in gastric cancer. Gene 2013, 518(2):351-359.
11. Liu L, Chen L, Xu Y, Li R, Du X. microRNA-195 promotes apoptosis and suppresses tumorigenicity of human colorectal cancer cells. Biochem Biophys Res Commun 2010, 400(2):236-240.
12. Wang R, Zhao N, Li S, Fang JH, Chen MX, Yang J, Jia WH, Yuan Y, Zhuang SM. MicroRNA-195 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting the expression of VEGF, VAV2, and CDC42. Hepatology 2013, 58(2):642-653.
13. Mao JH, Zhou RP, Peng AF, Liu ZL, Huang SH, Long XH, Shu Y. microRNA-195 suppresses osteosarcoma cell invasion and migration in vitro by targeting FASN. Oncol Lett 2012, 4(5):1125-1129.
14. Tang W, Tang J, Qin J, Geng Q, Zhou Z, Li B, Zhang J, Chen H, Xia Y, Wang X. Involvement of down-regulated E2F3 in Hirschsprung's disease. J Pediatr Surg 2013, 48(4):813-817.
15. Fu MG, Li S, Yu TT, Qian LJ, Cao RS, Zhu H, Xiao B, Jiao CH, Tang NN, Ma JJ, Hua J, Zhang WF, Zhang HJ, Shi RH. Differential expression of miR-195 in esophageal squamous cell carcinoma and miR-195 expression inhibits tumor cell proliferation and invasion by targeting of Cdc42. FEBS Lett 2013, 587(21):3471-3479.
16. Furuta M, Kozaki K, Tanimoto K, Tanaka S, Arii S, Shimamura T, Niida A, Miyano S, Inazawa J. The tumor-suppressive miR-497-195 cluster targets multiple cell-cycle regulators in hepatocellular carcinoma. PLoS One 2013, 8(3):e60155.
17. Wang X, Wang J, Ma H, Zhang J, Zhou X. Downregulation of miR-195 correlates with lymph node metastasis and poor prognosis in colorectal cancer. Med Oncol 2012, 29(2):919-927.
18. Caramuta S, Lee L, Ozata DM, Akcakaya P, Xie H, Hoog A, Zedenius J, Backdahl M, Larsson C, Lui WO. Clinical and functional impact of TARBP2 over-expression in adrenocortical carcinoma. Endocr Relat Cancer 2013, 20(4):551-564.
19. Chen J, Ruan H, Ng SM, Gao C, Soo HM, Wu W, Zhang Z, Wen Z, Lane DP, Peng J. Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish. Genes Dev 2005, 19(23):2900-2911.
20. Raghavan S, Gilmont RR, Bitar KN. Neuroglial differentiation of adult enteric neuronal progenitor cells as a function of extracellular matrix composition. Biomaterials 2013, 34(28):6649-6658.
21. Lake JI, Heuckeroth RO. Enteric nervous system development: migration, differentiation, and disease. Am J Physiol Gastrointest Liver Physiol 2013, 305(1):G1-24.
22. Tang W, Li B, Tang J, Liu K, Qin J, Wu W, Geng Q, Zhang J, Chen H, Xu X, Xia Y. Methylation analysis of EDNRB in human colon tissues of Hirschsprung's disease. Pediatr Surg Int 2013, 29(7):683-688.
23. Tang W, Li B, Xu X, Zhou Z, Wu W, Tang J, Qin J, Geng Q, Jiang W, Zhang J, Sha J, Xia Y, Wang X. Aberrant high expression of NRG1 gene in Hirschsprung disease. J Pediatr Surg 2012, 47(9):1694-1698.