Neutrophil recruitment is critical for 5-fluorouracil-induced diarrhea and the decrease in aquaporins in the colon

Pharmacological Research

Volumn 87, Issue , 2014, Pages 71-79

  Sakai, Hiroyasu ^a   Sagara, Atsunobu ^a   Matsumoto, Kenjiro ^a,b,d   Jo, Ara ^a   Hirosaki, Akiko ^a   Takase, Kazuhide ^a   Sugiyama, Ryoto ^a   Sato, Ken ^a   Ikegami, Daigo ^a   Horie, Syunji ^b   Matoba, Motohiro ^c   Narita, Minoru ^a  

^a HOSHI UNIVERSITY   (Japan)

^b JOSAI INTERNATIONAL UNIVERSITY   (Japan)

^c NATIONAL CANCER CENTER HOSPITAL   (Japan)

^d KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

5 Fluorouracil; Aquaporin; Colon; Diarrhea; Neutrophil elastase; Neutrophil recruitment

Indexed keywords

1 (2 BROMOPHENYL) 3 (2 HYDROXY 4 NITROPHENYL)UREA; AQUAPORIN 4; AQUAPORIN 8; CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; CXCL3 CHEMOKINE; FLUOROURACIL; LEUKOCYTE ELASTASE; LYMPHOCYTE ANTIGEN; LYMPHOCYTE ANTIGEN 6G; MYELOPEROXIDASE; SIVELESTAT; UNCLASSIFIED DRUG; ALPHA CHEMOKINE; ANTINEOPLASTIC ANTIMETABOLITE; AQP4 PROTEIN, MOUSE; AQUAPORIN; CXCL1 PROTEIN, MOUSE; CXCL2 PROTEIN, MOUSE; CXCL3 PROTEIN, MOUSE; MESSENGER RNA; PEROXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLON; COLON MUCOSA; CONTROLLED STUDY; DIARRHEA; FLOW CYTOMETRY; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; LEUKOCYTE FUNCTION; MALE; MOUSE; NEUTROPHIL CHEMOTAXIS; NEUTROPHIL COUNT; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE LEVEL; WEIGHT REDUCTION; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; DRUG EFFECTS; GENETICS; IMMUNOLOGY; METABOLISM;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; AQUAPORIN 4; AQUAPORINS; CHEMOKINE CXCL1; CHEMOKINE CXCL2; CHEMOKINES, CXC; COLON; DIARRHEA; FLUOROURACIL; LEUKOCYTE ELASTASE; MALE; MICE, INBRED C57BL; NEUTROPHIL INFILTRATION; PEROXIDASE; RNA, MESSENGER;

EID: 84903834835     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2014.05.012     Document Type: Article

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