-
1
-
-
84864367360
-
The ERBB network: At last, cancer therapy meets systems biology
-
Yarden Y, Pines G. The ERBB network: at last, cancer therapy meets systems biology. Nat Rev Cancer 2012;12: 553-63.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 553-563
-
-
Yarden, Y.1
Pines, G.2
-
2
-
-
33847718214
-
The EGF receptor family: Spearheading a merger of signaling and therapeutics
-
Bublil EM, Yarden Y. The EGF receptor family: spearheading a merger of signaling and therapeutics. Curr Opin Cell Biol 2007;19: 124-34.
-
(2007)
Curr Opin Cell Biol
, vol.19
, pp. 124-134
-
-
Bublil, E.M.1
Yarden, Y.2
-
3
-
-
68949201629
-
Activating and resistance mutations of EGFR in non-smallcell lung cancer: Role in clinical response to EGFR tyrosine kinase inhibitors
-
Gazdar AF. Activating and resistance mutations of EGFR in non-smallcell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors. Oncogene 2009;28(Suppl 1): S24-31.
-
(2009)
Oncogene
, vol.28
, Issue.SUPPL. 1
-
-
Gazdar, A.F.1
-
4
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004;350: 2129-39.
-
(2004)
N Engl J Med
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Brannigan, B.W.6
-
5
-
-
27744606737
-
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
-
Mellinghoff IK, Wang MY, Vivanco I, Haas-Kogan DA, Zhu S, Dia EQ, et al. Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N Engl J Med 2005;353: 2012-24.
-
(2005)
N Engl J Med
, vol.353
, pp. 2012-2024
-
-
Mellinghoff, I.K.1
Wang, M.Y.2
Vivanco, I.3
Haas-Kogan, D.A.4
Zhu, S.5
Dia, E.Q.6
-
6
-
-
77953930730
-
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
-
Maemondo M, Inoue A, Kobayashi K, Sugawara S, Oizumi S, Isobe H, et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med 2010;362: 2380-8.
-
(2010)
N Engl J Med
, vol.362
, pp. 2380-2388
-
-
Maemondo, M.1
Inoue, A.2
Kobayashi, K.3
Sugawara, S.4
Oizumi, S.5
Isobe, H.6
-
8
-
-
0038482086
-
Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells
-
Mansouri A, Ridgway LD, Korapati AL, Zhang Q, Tian L, Wang Y, et al. Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells. J Biol Chem 2003;278: 19245-56.
-
(2003)
J Biol Chem
, vol.278
, pp. 19245-19256
-
-
Mansouri, A.1
Ridgway, L.D.2
Korapati, A.L.3
Zhang, Q.4
Tian, L.5
Wang, Y.6
-
9
-
-
0242610903
-
P53 is a determinant of X-linked inhibitor of apoptosis protein/Akt-mediated chemoresistance in human ovarian cancer cells
-
Fraser M, Leung BM, Yan XJ, Dan HC, Cheng JQ, Tsang BK. p53 is a determinant of X-linked inhibitor of apoptosis protein/Akt-mediated chemoresistance in human ovarian cancer cells. Cancer Res 2003; 63: 7081-8.
-
(2003)
Cancer Res
, vol.63
, pp. 7081-7088
-
-
Fraser, M.1
Leung, B.M.2
Yan, X.J.3
Dan, H.C.4
Cheng, J.Q.5
Tsang, B.K.6
-
10
-
-
77956268839
-
Understanding resistance to EGFR inhibitors-impact on future treatment strategies
-
Wheeler DL, Dunn EF, Harari PM. Understanding resistance to EGFR inhibitors-impact on future treatment strategies. Nat Rev Clin Oncol 2010;7: 493-507.
-
(2010)
Nat Rev Clin Oncol
, vol.7
, pp. 493-507
-
-
Wheeler, D.L.1
Dunn, E.F.2
Harari, P.M.3
-
11
-
-
79551510855
-
EGFR nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatment
-
Liccardi G, Hartley JA, Hochhauser D. EGFR nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatment. Cancer Res 2011;71: 1103-14.
-
(2011)
Cancer Res
, vol.71
, pp. 1103-1114
-
-
Liccardi, G.1
Hartley, J.A.2
Hochhauser, D.3
-
12
-
-
36849032852
-
Radiation-induced EGFR signaling and control of DNA-damage repair
-
Rodemann HP, Dittmann K, Toulany M. Radiation-induced EGFR signaling and control of DNA-damage repair. Int J Radiat Biol 2007; 83: 781-91.
-
(2007)
Int J Radiat Biol
, vol.83
, pp. 781-791
-
-
Rodemann, H.P.1
Dittmann, K.2
Toulany, M.3
-
13
-
-
84866128097
-
Nuclear EGFR suppresses ribonuclease activity of polynucleotide phosphorylase through DNAPK-mediated phosphorylation at serine 776
-
Yu YL, Chou RH, Wu CH, Wang YN, Chang WJ, Tseng YJ, et al. Nuclear EGFR suppresses ribonuclease activity of polynucleotide phosphorylase through DNAPK-mediated phosphorylation at serine 776. J Biol Chem 2012;287: 31015-26.
-
(2012)
J Biol Chem
, vol.287
, pp. 31015-31026
-
-
Yu, Y.L.1
Chou, R.H.2
Wu, C.H.3
Wang, Y.N.4
Chang, W.J.5
Tseng, Y.J.6
-
14
-
-
84867647937
-
Threonine 2609 phosphorylation of the DNA-dependent protein kinase is a critical prerequisite for epidermal growth factor receptor-mediated radiation resistance
-
Javvadi P, Makino H, Das AK, Lin YF, Chen DJ, Chen BP, et al. Threonine 2609 phosphorylation of the DNA-dependent protein kinase is a critical prerequisite for epidermal growth factor receptor-mediated radiation resistance. Mol Cancer Res 2012;10: 1359-68.
-
(2012)
Mol Cancer Res
, vol.10
, pp. 1359-1368
-
-
Javvadi, P.1
Makino, H.2
Das, A.K.3
Lin, Y.F.4
Chen, D.J.5
Chen, B.P.6
-
15
-
-
33751508862
-
Tyrosine phosphorylation controls PCNA function through protein stability
-
Wang SC, Nakajima Y, Yu YL, Xia W, Chen CT, Yang CC, et al. Tyrosine phosphorylation controls PCNA function through protein stability. Nat Cell Biol 2006;8: 1359-68.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 1359-1368
-
-
Wang, S.C.1
Nakajima, Y.2
Yu, Y.L.3
Xia, W.4
Chen, C.T.5
Yang, C.C.6
-
16
-
-
53349100168
-
Correlates and determinants of nuclear epidermal growth factor receptor content in an oropharyngeal cancer tissue microarray
-
Psyrri A, Egleston B, Weinberger P, Yu Z, Kowalski D, Sasaki C, et al. Correlates and determinants of nuclear epidermal growth factor receptor content in an oropharyngeal cancer tissue microarray. Cancer Epidemiol Biomarkers Prev 2008;17: 1486-92.
-
(2008)
Cancer Epidemiol Biomarkers Prev
, vol.17
, pp. 1486-1492
-
-
Psyrri, A.1
Egleston, B.2
Weinberger, P.3
Yu, Z.4
Kowalski, D.5
Sasaki, C.6
-
17
-
-
34248358971
-
Nuclear expression of phosphorylated EGFR is associated with poor prognosis of patients with esophageal squamous cell carcinoma
-
Hoshino M, Fukui H, Ono Y, Sekikawa A, Ichikawa K, Tomita S, et al. Nuclear expression of phosphorylated EGFR is associated with poor prognosis of patients with esophageal squamous cell carcinoma. Pathobiology 2007;74: 15-21.
-
(2007)
Pathobiology
, vol.74
, pp. 15-21
-
-
Hoshino, M.1
Fukui, H.2
Ono, Y.3
Sekikawa, A.4
Ichikawa, K.5
Tomita, S.6
-
18
-
-
20844442267
-
The XPF-ERCC1 endonuclease and homologous recombination contribute to the repair of minor groove DNA interstrand crosslinks in mammalian cells produced by the pyrrolo[2,1-c][1,4]benzodiazepine dimer SJG-136
-
Clingen PH, De Silva IU, McHugh PJ, Ghadessy FJ, Tilby MJ, Thurston DE, et al. The XPF-ERCC1 endonuclease and homologous recombination contribute to the repair of minor groove DNA interstrand crosslinks in mammalian cells produced by the pyrrolo[2,1-c][1,4]benzodiazepine dimer SJG-136. Nucleic Acids Res 2005;33: 3283-91.
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 3283-3291
-
-
Clingen, P.H.1
De Silva, I.U.2
McHugh, P.J.3
Ghadessy, F.J.4
Tilby, M.J.5
Thurston, D.E.6
-
19
-
-
77955889858
-
Multiple roles of ERCC1-XPF in mammalian interstrand crosslink repair
-
Rahn JJ, Adair GM, Nairn RS. Multiple roles of ERCC1-XPF in mammalian interstrand crosslink repair. Environ Mol Mutagen 2010;51: 567-81.
-
(2010)
Environ Mol Mutagen
, vol.51
, pp. 567-581
-
-
Rahn, J.J.1
Adair, G.M.2
Nairn, R.S.3
-
20
-
-
40249094603
-
ERCC1 protein expression predicts the response of cisplatin-based neoadjuvant chemotherapy in non-small-cell lung cancer
-
Fujii T, Toyooka S, Ichimura K, Fujiwara Y, Hotta K, Soh J, et al. ERCC1 protein expression predicts the response of cisplatin-based neoadjuvant chemotherapy in non-small-cell lung cancer. Lung Cancer 2008;59: 377-84.
-
(2008)
Lung Cancer
, vol.59
, pp. 377-384
-
-
Fujii, T.1
Toyooka, S.2
Ichimura, K.3
Fujiwara, Y.4
Hotta, K.5
Soh, J.6
-
21
-
-
34447534435
-
ERCC1-tailored chemotherapy in lung cancer: The first prospective randomized trial
-
Soria JC. ERCC1-tailored chemotherapy in lung cancer: the first prospective randomized trial. J Clin Oncol 2007;25: 2648-9.
-
(2007)
J Clin Oncol
, vol.25
, pp. 2648-2649
-
-
Soria, J.C.1
-
22
-
-
80052440005
-
Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair
-
Wang AT, Sengerova B, Cattell E, Inagawa T, Hartley JM, Kiakos K, et al. Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair. Genes Dev 2011;25: 1859-70.
-
(2011)
Genes Dev
, vol.25
, pp. 1859-1870
-
-
Wang, A.T.1
Sengerova, B.2
Cattell, E.3
Inagawa, T.4
Hartley, J.M.5
Kiakos, K.6
-
23
-
-
70450224524
-
The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links
-
Al-Minawi AZ, Lee YF, Hakansson D, Johansson F, Lundin C, Saleh-Gohari N, et al. The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links. Nucleic Acids Res 2009;37: 6400-13.
-
(2009)
Nucleic Acids Res
, vol.37
, pp. 6400-6413
-
-
Al-Minawi, A.Z.1
Lee, Y.F.2
Hakansson, D.3
Johansson, F.4
Lundin, C.5
Saleh-Gohari, N.6
-
24
-
-
49449084673
-
ERCC1-XPF endonuclease facilitates DNA double-strand break repair
-
Ahmad A, Robinson AR, Duensing A, van Drunen E, Beverloo HB, Weisberg DB, et al. ERCC1-XPF endonuclease facilitates DNA double-strand break repair. Mol Cell Biol 2008;28: 5082-92.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 5082-5092
-
-
Ahmad, A.1
Robinson, A.R.2
Duensing, A.3
Van Drunen, E.4
Beverloo, H.B.5
Weisberg, D.B.6
-
25
-
-
84934439164
-
Measurement of DNA damage in individual cells using the Single Cell Gel Electrophoresis (Comet) assay
-
Hartley JM, Spanswick VJ, Hartley JA. Measurement of DNA damage in individual cells using the Single Cell Gel Electrophoresis (Comet) assay. Methods Mol Biol 2011;731: 309-20.
-
(2011)
Methods Mol Biol
, vol.731
, pp. 309-320
-
-
Hartley, J.M.1
Spanswick, V.J.2
Hartley, J.A.3
-
26
-
-
33744521546
-
Characterization of interactions between ras family GTPases and their effectors
-
Rodriguez-Viciana P, McCormick F. Characterization of interactions between ras family GTPases and their effectors. Methods Enzymol 2006;407: 187-94.
-
(2006)
Methods Enzymol
, vol.407
, pp. 187-194
-
-
Rodriguez-Viciana, P.1
McCormick, F.2
-
27
-
-
34247330161
-
The tumor suppressor neurofibromin confers sensitivity to apoptosis by Rasdependent and Ras-independent pathways
-
Shapira S, Barkan B, Friedman E, Kloog Y, Stein R. The tumor suppressor neurofibromin confers sensitivity to apoptosis by Rasdependent and Ras-independent pathways. Cell Death Differ 2007; 14: 895-906.
-
(2007)
Cell Death Differ
, vol.14
, pp. 895-906
-
-
Shapira, S.1
Barkan, B.2
Friedman, E.3
Kloog, Y.4
Stein, R.5
-
28
-
-
52749092194
-
Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK
-
Dittmann K, Mayer C, Kehlbach R, Rodemann HP. Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK. Mol Cancer 2008;7: 69.
-
(2008)
Mol Cancer
, vol.7
, pp. 69
-
-
Dittmann, K.1
Mayer, C.2
Kehlbach, R.3
Rodemann, H.P.4
-
29
-
-
74949108644
-
The complexity of phosphorylated H2AX foci formation and DNA repair assembly at DNA double-strand breaks
-
Nakamura AJ, Rao VA, Pommier Y, Bonner WM. The complexity of phosphorylated H2AX foci formation and DNA repair assembly at DNA double-strand breaks. Cell Cycle 2010;9: 389-97.
-
(2010)
Cell Cycle
, vol.9
, pp. 389-397
-
-
Nakamura, A.J.1
Rao, V.A.2
Pommier, Y.3
Bonner, W.M.4
-
30
-
-
72049089840
-
Cellular radiosensitivity: How much better do we understand it?
-
Jeggo P, Lavin MF. Cellular radiosensitivity: how much better do we understand it? Int J Radiat Biol 2009;85: 1061-81.
-
(2009)
Int J Radiat Biol
, vol.85
, pp. 1061-1081
-
-
Jeggo, P.1
Lavin, M.F.2
-
31
-
-
32144433159
-
Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
-
Bonner JA, Harari PM, Giralt J, Azarnia N, Shin DM, Cohen RB, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med 2006;354: 567-78.
-
(2006)
N Engl J Med
, vol.354
, pp. 567-578
-
-
Bonner, J.A.1
Harari, P.M.2
Giralt, J.3
Azarnia, N.4
Shin, D.M.5
Cohen, R.B.6
-
32
-
-
0034675930
-
Role of ERCC1 in removal of long non-homologous tails during targeted homologous recombination
-
Adair GM, Rolig RL, Moore-Faver D, Zabelshansky M, Wilson JH, Nairn RS. Role of ERCC1 in removal of long non-homologous tails during targeted homologous recombination. EMBO J 2000;19: 5552-61.
-
(2000)
EMBO J
, vol.19
, pp. 5552-5561
-
-
Adair, G.M.1
Rolig, R.L.2
Moore-Faver, D.3
Zabelshansky, M.4
Wilson, J.H.5
Nairn, R.S.6
-
33
-
-
38349098477
-
The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells
-
Al-Minawi AZ, Saleh-Gohari N, Helleday T. The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells. Nucleic Acids Res 2008;36: 1-9.
-
(2008)
Nucleic Acids Res
, vol.36
, pp. 1-9
-
-
Al-Minawi, A.Z.1
Saleh-Gohari, N.2
Helleday, T.3
-
34
-
-
0033532342
-
Action of DNA repair endonuclease ERCC1/XPF in living cells
-
Houtsmuller AB, Rademakers S, Nigg AL, Hoogstraten D, Hoeijmakers JH, Vermeulen W. Action of DNA repair endonuclease ERCC1/XPF in living cells. Science 1999;284: 958-61.
-
(1999)
Science
, vol.284
, pp. 958-961
-
-
Houtsmuller, A.B.1
Rademakers, S.2
Nigg, A.L.3
Hoogstraten, D.4
Hoeijmakers, J.H.5
Vermeulen, W.6
-
35
-
-
75749130671
-
Mechanism of elimination of phosphorylated histone H2AX from chromatin after repair of DNA double-strand breaks
-
Svetlova MP, Solovjeva LV, Tomilin NV. Mechanism of elimination of phosphorylated histone H2AX from chromatin after repair of DNA double-strand breaks. Mutat Res 2010;685: 54-60.
-
(2010)
Mutat Res
, vol.685
, pp. 54-60
-
-
Svetlova, M.P.1
Solovjeva, L.V.2
Tomilin, N.V.3
-
36
-
-
28844480409
-
The structure of the human ERCC1/XPF interaction domains reveals a complementary role for the two proteins in nucleotide excision repair
-
Tripsianes K, Folkers G, Ab E, Das D, Odijk H, Jaspers NG, et al. The structure of the human ERCC1/XPF interaction domains reveals a complementary role for the two proteins in nucleotide excision repair. Structure 2005;13: 1849-58.
-
(2005)
Structure
, vol.13
, pp. 1849-1858
-
-
Tripsianes, K.1
Folkers, G.2
Ab, E.3
Das, D.4
Odijk, H.5
Jaspers, N.G.6
-
37
-
-
80051820277
-
The knock-down of ERCC1 but not of XPF causes multinucleation
-
Rageul J, Fremin C, Ezan F, Baffet G, Langouet S. The knock-down of ERCC1 but not of XPF causes multinucleation. DNA Repair 2011;10: 978-90.
-
(2011)
DNA Repair
, vol.10
, pp. 978-990
-
-
Rageul, J.1
Fremin, C.2
Ezan, F.3
Baffet, G.4
Langouet, S.5
-
38
-
-
77958535871
-
Multiple roles of the ERCC1-XPF endonuclease in DNA repair and resistance to anticancer drugs
-
Kirschner K, Melton DW. Multiple roles of the ERCC1-XPF endonuclease in DNA repair and resistance to anticancer drugs. Anticancer Res. 2010;30: 3223-32.
-
(2010)
Anticancer Res.
, vol.30
, pp. 3223-3232
-
-
Kirschner, K.1
Melton, D.W.2
-
39
-
-
84874038196
-
Caspase-independent cell death is involved in the negative effect of EGF receptor inhibitors on cisplatin in non-small cell lung cancer cells
-
Yamaguchi H, Hsu JL, Chen CT, Wang YN, Hsu MC, Chang SS, et al. Caspase-independent cell death is involved in the negative effect of EGF receptor inhibitors on cisplatin in non-small cell lung cancer cells. Clin Cancer Res 2013;19: 845-54.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 845-854
-
-
Yamaguchi, H.1
Hsu, J.L.2
Chen, C.T.3
Wang, Y.N.4
Hsu, M.C.5
Chang, S.S.6
-
40
-
-
80052446021
-
Molecular characteristics of ERCC1-negative versus ERCC1-positive tumors in resected NSCLC
-
Friboulet L, Barrios-Gonzales D, Commo F, Olaussen KA, Vagner S, Adam J, et al. Molecular characteristics of ERCC1-negative versus ERCC1-positive tumors in resected NSCLC. Clin Cancer Res 2011; 17: 5562-72.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 5562-5572
-
-
Friboulet, L.1
Barrios-Gonzales, D.2
Commo, F.3
Olaussen, K.A.4
Vagner, S.5
Adam, J.6
-
41
-
-
68549140332
-
Somatic EGFR mutations and efficacy of tyrosine kinase inhibitors in NSCLC
-
Linardou H, Dahabreh IJ, Bafaloukos D, Kosmidis P, Murray S. Somatic EGFR mutations and efficacy of tyrosine kinase inhibitors in NSCLC. Nat Rev Clin Oncol 2009;6: 352-66.
-
(2009)
Nat Rev Clin Oncol
, vol.6
, pp. 352-366
-
-
Linardou, H.1
Dahabreh, I.J.2
Bafaloukos, D.3
Kosmidis, P.4
Murray, S.5
-
42
-
-
34249819963
-
ERCC1 as a risk stratifier in platinum-based chemotherapy for nonsmall-cell lung cancer
-
Olaussen KA, Mountzios G, Soria JC. ERCC1 as a risk stratifier in platinum-based chemotherapy for nonsmall-cell lung cancer. Curr Opin Pulm Med 2007;13: 284-9.
-
(2007)
Curr Opin Pulm Med
, vol.13
, pp. 284-289
-
-
Olaussen, K.A.1
Mountzios, G.2
Soria, J.C.3
|