The knock-down of ERCC1 but not of XPF causes multinucleation

DNA Repair

Volumn 10, Issue 9, 2011, Pages 978-990

  Rageul, Julie ^a   Frëmin, Christophe ^a,b   Ezan, Frédéric ^a   Baffet, Georges ^a   Langouët, Sophie ^a  

^a UNIVERSITÉ DE RENNES 1   (France)

^b INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

Author keywords

ERCC1; Hepatocyte; Mitosis; Multinucleation; XPF

Indexed keywords

EXCISION REPAIR CROSS COMPLEMENTING PROTEIN 1; RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CELL CYCLE PROGRESSION; CELL GROWTH; CONTROLLED STUDY; CYTOKINESIS; DNA REPAIR; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL CARCINOMA; METAPHASE; MOUSE; MULTINUCLEAR CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA INTERFERENCE;

CELL LINE, TUMOR; CELL NUCLEUS DIVISION; DNA-BINDING PROTEINS; ENDONUCLEASES; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; HELA CELLS; HUMANS; MITOSIS; MUTATION; ORPHAN NUCLEAR RECEPTORS;

MUS;

EID: 80051820277     PISSN: 15687864     EISSN: 15687856     Source Type: Journal    
DOI: 10.1016/j.dnarep.2011.07.005     Document Type: Article

References (38)

1. Hoeijmakers J.H. Genome maintenance mechanisms for preventing cancer. Nature 2001, 411:366-374.
2. Sijbers A.M., de Laat W.L., Ariza R.R., Biggerstaff M., Wei Y.F., Moggs J.G., Carter K.C., Shell B.K., Evans E., de Jong M.C., Rademakers S., de Rooij J., Jaspers N.G., Hoeijmakers J.H., Wood R.D. Xeroderma pigmentosum group F caused by a defect in a structure-specific DNA repair endonuclease. Cell 1996, 86:811-822.
3. Enzlin J.H., Scharer O.D. The active site of the DNA repair endonuclease XPF-ERCC1 forms a highly conserved nuclease motif. EMBO J. 2002, 21:2045-2053.
4. Tsodikov O.V., Enzlin J.H., Scharer O.D., Ellenberger T. Crystal structure and DNA binding functions of ERCC1, a subunit of the DNA structure-specific endonuclease XPF-ERCC1. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:11236-11241.
5. Gaillard P.H., Wood R.D. Activity of individual ERCC1 and XPF subunits in DNA nucleotide excision repair. Nucleic Acids Res. 2001, 29:872-879.
6. Niedernhofer L.J., Odijk H., Budzowska M., van Drunen E., Maas A., Theil A.F., de Wit J., Jaspers N.G., Beverloo H.B., Hoeijmakers J.H., Kanaar R. The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks. Mol. Cell. Biol. 2004, 24:5776-5787.
7. Al-Minawi A.Z., Saleh-Gohari N., Helleday T. The ERCC1/XPF endonuclease is required for efficient single-strand annealing and gene conversion in mammalian cells. Nucleic Acids Res. 2008, 36:1-9.
8. Westerveld A., Hoeijmakers J.H., van Duin M., de Wit J., Odijk H., Pastink A., Wood R.D., Bootsma D. Molecular cloning of a human DNA repair gene. Nature 1984, 310:425-429.
9. van Duin M., de Wit J., Odijk H., Westerveld A., Yasui A., Koken M.H., Hoeijmakers J.H., Bootsma D. Molecular characterization of the human excision repair gene ERCC-1: cDNA cloning and amino acid homology with the yeast DNA repair gene RAD10. Cell 1986, 44:913-923.
10. Jaspers N.G., Raams A., Silengo M.C., Wijgers N., Niedernhofer L.J., Robinson A.R., Giglia-Mari G., Hoogstraten D., Kleijer W.J., Hoeijmakers J.H., Vermeulen W. First reported patient with human ERCC1 deficiency has cerebro-oculo-facio-skeletal syndrome with a mild defect in nucleotide excision repair and severe developmental failure. Am. J. Hum. Genet. 2007, 80:457-466.
11. Ahmad A., Enzlin J.H., Bhagwat N.R., Wijgers N., Raams A., Appledoorn E., Theil A.F., Hoeijmakers J.H.J., Vermeulen W., Jaspers N.G.J., Scharer O.D., Niedernhofer L.J. Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients. PLoS Genet. 2010, 6:e1000871.
12. Cleaver J.E., Lam E.T., Revet I. Disorders of nucleotide excision repair: the genetic and molecular basis of heterogeneity. Nat. Rev. Genet. 2009, 10:756-768.
13. Tian M., Shinkura R., Shinkura N., Alt F.W. Growth retardation, early death, and DNA repair defects in mice deficient for the nucleotide excision repair enzyme XPF. Mol. Cell. Biol. 2004, 24:1200-1205.
14. McWhir J., Selfridge J., Harrison D.J., Squires S., Melton D.W. Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning. Nat. Genet. 1993, 5:217-224.
15. Weeda G., Donker I., de Wit J., Morreau H., Janssens R., Vissers C.J., Nigg A., van Steeg H., Bootsma D., Hoeijmakers J.H. Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence. Curr. Biol. 1997, 7:427-439.
16. Prasher J.M., Lalai A.S., Heijmans-Antonissen C., Ploemacher R.E., Hoeijmakers J.H., Touw I.P., Niedernhofer L.J. Reduced hematopoietic reserves in DNA interstrand crosslink repair-deficient Ercc1-/- mice. EMBO J. 2005, 24:861-871.
17. Niedernhofer L.J., Garinis G.A., Raams A., Lalai A.S., Robinson A.R., Appeldoorn E., Odijk H., Oostendorp R., Ahmad A., van Leeuwen W., Theil A.F., Vermeulen W., van der Horst G.T., Meinecke P., Kleijer W.J., Vijg J., Jaspers N.G., Hoeijmakers J.H. A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature 2006, 444:1038-1043.
18. Chipchase M.D., O'Neill M., Melton D.W. Characterization of premature liver polyploidy in DNA repair (Ercc1)-deficient mice. Hepatology (Baltimor, MD) 2003, 38:958-966.
19. Nunez F., Chipchase M.D., Clarke A.R., Melton D.W. Nucleotide excision repair gene (ERCC1) deficiency causes G(2) arrest in hepatocytes and a reduction in liver binucleation: the role of p53 and p21. FASEB J. 2000, 14:1073-1082.
20. Selfridge J., Hsia K.T., Redhead N.J., Melton D.W. Correction of liver dysfunction in DNA repair-deficient mice with an ERCC1 transgene. Nucleic Acids Res. 2001, 29:4541-4550.
21. Kirschner K., Singh R., Prost S., Melton D.W. Characterisation of Ercc1 deficiency in the liver and in conditional Ercc1-deficient primary hepatocytes in vitro. DNA Repair 2007, 6:304-316.
22. Fautrel A., Andrieux L., Musso O., Boudjema K., Guillouzo A., Langouet S. Overexpression of the two nucleotide excision repair genes ERCC1 and XPC in human hepatocellular carcinoma. J. Hepatol. 2005, 43:288-293.
23. Andrieux L.O., Fautrel A., Bessard A., Guillouzo A., Baffet G., Langouet S. GATA-1 is essential in EGF-mediated induction of nucleotide excision repair activity and ERCC1 expression through ERK2 in human hepatoma cells. Cancer Res. 2007, 67:2114-2123.
24. Kanda T., Sullivan K.F., Wahl G.M. Histone-GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells. Curr. Biol. 1998, 8:377-385.
25. Ame J.C., Fouquerel E., Gauthier L.R., Biard D., Boussin F.D., Dantzer F., de Murcia G., Schreiber V. Radiation-induced mitotic catastrophe in PARG-deficient cells. J. Cell Sci. 2009, 122:1990-2002.
26. Arora S., Kothandapani A., Tillison K., Kalman-Maltese V., Patrick S.M. Downregulation of XPF-ERCC1 enhances cisplatin efficacy in cancer cells. DNA Repair 2010, 9:745-753.
27. Kozutsumi Y., Kanazawa T., Sun Y., Yamaji T., Yamamoto H., Takematsu H. Sphingolipids involved in the induction of multinuclear cell formation. Biochim. Biophys. Acta 2002, 1582:138-143.
28. Ariizumi T., Ogose A., Kawashima H., Hotta T., Umezu H., Endo N. Multinucleation followed by an acytokinetic cell division in myxofibrosarcoma with giant cell proliferation. J. Exp. Clin. Cancer Res. 2009, 28:44.
29. Shankar H., Michal A., Kern R.C., Kang D.S., Gurevich V.V., Benovic J.L. Non-visual arrestins are constitutively associated with the centrosome and regulate centrosome function. J. Biol. Chem. 2010, 285:8316-8329.
30. Colnaghi R., Wheatley S.P. Liaisons between survivin and Plk1 during cell division and cell death. J. Biol. Chem. 2010, 285:22592-22604.
31. Manchinelly S.A., Miller J.A., Su L., Miyake T., Palmer L., Mikawa M., Parsons S.J. Mitotic down-regulation of p190RhoGAP is required for the successful completion of cytokinesis. J. Biol. Chem. 2010, 285:26923-26932.
32. Naim V., Rosselli F. The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities. Nat. Cell Biol. 2009, 11:761-768.
33. Biggerstaff M., Szymkowski D.E., Wood R.D. Co-correction of the ERCC1, ERCC4 and xeroderma pigmentosum group F DNA repair defects in vitro. EMBO J. 1993, 12:3685-3692.
34. de Laat W.L., Sijbers A.M., Odijk H., Jaspers N.G., Hoeijmakers J.H. Mapping of interaction domains between human repair proteins ERCC1 and XPF. Nucleic Acids Res. 1998, 26:4146-4152.
35. Yagi T., Wood R.D., Takebe H. A low content of ERCC1 and a 120kDa protein is a frequent feature of group F xeroderma pigmentosum fibroblast cells. Mutagenesis 1997, 12:41-44.
36. Kirschner K., Melton D.W. Multiple roles of the ERCC1-XPF endonuclease in DNA repair and resistance to anticancer drugs. Anticancer Res. 2010, 30:3223-3232.
37. Zhu X.D., Niedernhofer L., Kuster B., Mann M., Hoeijmakers J.H., de Lange T. ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes. Mol. Cell 2003, 12:1489-1498.
38. Wu Y., Mitchell T.R., Zhu X.D. Human XPF controls TRF2 and telomere length maintenance through distinctive mechanisms. Mech. Ageing Dev. 2008, 129:602-610.