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Volumn 9, Issue 7, 2014, Pages 1546-1555
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Optimization of the antiviral potency and lipophilicity of halogenated 2,6-diarylpyridinamines as a novel class of HIV-1 NNRTIS
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Author keywords
anti HIV activity; antiviral agents; diarylpyridinamines; drug like properties; lipophilicity
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Indexed keywords
2,6 DIARYLPYRIDINAMINE DERIVATIVE;
6 (2'' BROMO 4'' CYANOVINYL 6'' METHOXY)PHENOXY N 2 (4' CYANOPHENYL)PYRIDIN 2,3 DIAMINE;
6 (4'' BROMO 2'',6'' DIFLUORO)PHENOXY N 2 (4' CYANOPHENYL)AMINO 3 NITROPYRIDINE;
6 (4'' CYANO 2'',6'' DIBROMO)PHENOXY N 2 (4' CYANOPHENYL)PYRIDIN 2,3 DIAMINE;
6 [4'' (2 CYANOETHYL) 2'',6'' DIFLUORO]PHENOXY N 2 (4' CYANOPHENYL)AMINOPYRIDIN 3 AMINE;
6 [4'' (3 AMINO 2 CYANO 3 OXOPROP 1 ENYL) 2'',6'' DIFLUORO]PHENOXY N 2 (4 CYANOPHENYL)PYRIDIN 2,3 DIAMINE;
ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;
DIAMINE DERIVATIVE;
N 2 (4 CYANOPHENYL)AMINO 6 (2'',6'' DIFLUORO 4'' PROPYLCARBMETHOXY)PHENOXYPYRIDIN 3 AMINE;
N 2 (4' CYANOPHENYL)AMINO 6 (2'' METHOXY 4'' CYANOVINYL)PHENOXYPYRIDIN 3 AMINE;
N 2 (4' CYANOPHENYL)AMINO 6 (2'',6'' DIFLUORO 4'' (HYDROXYIMINO) METHYL)PHENOXYPYRIDINE 3 AMINE;
N 2 (4' CYANOPHENYL)AMINO 6 (2'',6'' DIFLUORO 4'' ACETOXYMETHYL)PHENOXYPYRIDIN 3 AMINE;
N 2 (4' CYANOPHENYL)AMINO 6 (2'',6'' DIFLUORO 4'' CYANO)PHENOXYPYRIDIN 3 AMINE;
N 2 (4' CYANOPHENYL)AMINO 6 (2'',6'' DIFLUORO 4'' HYDROXYMETHYL)PHENOXYPYRIDINE 3 AMINE;
N 2 (4' CYANOPHENYL)AMINO 6 (4'' CYANOVINYL 2'' METHOXY)PHENOXY 3 NITROPYRIDINE;
N 2 (4' CYANOPHENYL)AMINO 6 (4'' CYANOVINYL 2'',6'' DIBROMO)PHENOXYPYRIDIN 3 DIAMINE;
N 2 (4' CYANOPHENYL)AMINO 6 (4'' CYANOVINYL 2'',6'' DICHLORO)PHENOXYPYRIDIN 3 AMINE;
N 2 (4' CYANOPHENYL)AMINO 6 (4'' CYANOVINYL 2'',6'' DIFLUORO)PHENOXYPYRIDIN 3 AMINE;
N 2 (4' CYANOPHENYL)AMINO 6 (4'' FORMYL 2'' METHOXY)PHENOXY 3 NITROPYRIDINE;
N 2 (4' CYANOPHENYL)AMINO 6 [2'',6'' DIFLUORO 4'' (2 CARBAMOYL)VINYL]PHENOXYPYRIDIN 3 AMINE;
N 2 (4' CYANOPHENYL)AMINO 6 [2'',6'' DIFLUORO 4'' (3 HYDROXYPROPYL)PHENOXY]PYRIDIN3 AMINE;
N 2 (4' CYANOPHENYL)AMINO 6 [2'',6'' DIFLUORO 4'' (3 OXOBUTYL)PHENOXY]PYRIDIN 3 AMINE;
N 2 (4' CYANOPHENYL)AMINO 6 [4'' (2 CYANO)PROPYLCARBAMOYL 2'',6'' DIFLUORO]PHENOXYPYRIDIN 3 AMINE;
N 2 (4'' CYANOPHENYL)AMINO 6 (2'',6'' DIFLUORO)PHENOXYPYRIDIN 3 AMINE;
NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR;
PYRIDINE DERIVATIVE;
UNCLASSIFIED DRUG;
AMINE;
PYRIMIDINE;
PYRIMIDINE DERIVATIVE;
RNA DIRECTED DNA POLYMERASE;
RNA DIRECTED DNA POLYMERASE INHIBITOR;
ANTIVIRAL ACTIVITY;
ARTICLE;
CONTROLLED STUDY;
DRUG HALF LIFE;
DRUG METABOLISM;
DRUG POTENCY;
DRUG STABILITY;
DRUG SYNTHESIS;
HALOGENATION;
HUMAN;
HUMAN CELL;
HUMAN IMMUNODEFICIENCY VIRUS 1;
HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION;
IC 50;
IN VITRO STUDY;
LIPOPHILICITY;
LIVER MICROSOME METABOLISM;
PRIORITY JOURNAL;
PROCESS OPTIMIZATION;
VIRUS MUTATION;
VIRUS RESISTANCE;
VIRUS STRAIN;
WILD TYPE;
ANTAGONISTS AND INHIBITORS;
CHEMISTRY;
DRUG DESIGN;
DRUG EFFECTS;
ENZYMOLOGY;
GENETICS;
HALF LIFE TIME;
LIVER MICROSOME;
METABOLISM;
MUTATION;
STRUCTURE ACTIVITY RELATION;
AMINES;
DRUG DESIGN;
HALF-LIFE;
HALOGENATION;
HIV REVERSE TRANSCRIPTASE;
HIV-1;
HUMANS;
MICROSOMES, LIVER;
MUTATION;
PYRIMIDINES;
REVERSE TRANSCRIPTASE INHIBITORS;
STRUCTURE-ACTIVITY RELATIONSHIP;
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EID: 84903820244
PISSN: 18607179
EISSN: 18607187
Source Type: Journal
DOI: 10.1002/cmdc.201400075 Document Type: Article |
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Times cited : (14)
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References (24)
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