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Volumn 9, Issue 7, 2014, Pages 1387-1396

The discovery of potent nonstructural protein 5A (NS5A) inhibitors with a unique resistance profile - Part 2

(30) Wakenhut, Florian a Tran, Thien Duc a Pickford, Chris a Shaw, Stephen a Westby, Mike a Smith Burchnell, Caroline a Watson, Lesa a Paradowski, Michael a Milbank, Jared a Stonehouse, David b Cheung, Kathy b Wybrow, Robert b Daverio, Felice b Crook, Samuel c Statham, Keith c Leese, David c Stead, Darren c Adam, Fiona a Hay, Duncan a Roberts, Lee R a more..

a PFIZER GLOBAL RESEARCH AND DEVELOPMENT (United Kingdom)

b Peakdale Chemistry Services Discovery Park House (United Kingdom)

c CXR Biosciences Ltd (United Kingdom)

d PFIZER INC (United States)

Author keywords

antiviral agents; drug resistance; HCV; hepatitis C virus; NS5A; viral RNA replication

Indexed keywords

ANTIVIRUS AGENT; DACLATASVIR; FUNCTIONAL GROUP; HYDROGEN; NONSTRUCTURAL PROTEIN 5A; PROLINE DERIVATIVE; PROTEIN INHIBITOR; NS-5 PROTEIN, HEPATITIS C VIRUS; PROTEINASE INHIBITOR; VIRAL PROTEIN;

ANIMAL CELL; ARTICLE; DRUG CYTOTOXICITY; DRUG POTENCY; HEPATITIS C VIRUS; HYDROGEN BOND; IC 50; MALE; MEMBRANE PERMEABILITY; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; SUPERCRITICAL FLUID; SUPERCRITICAL FLUID CHROMATOGRAPHY; VIRUS RESISTANCE; ANIMAL; ANTAGONISTS AND INHIBITORS; ANTIVIRAL RESISTANCE; CELL LINE; CELL MEMBRANE PERMEABILITY; CELL PROLIFERATION; CHEMISTRY; DOG; DRUG EFFECTS; HEPACIVIRUS; HUMAN; METABOLISM; PRECLINICAL STUDY; SYNTHESIS; VIRUS REPLICATION;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; CELL MEMBRANE PERMEABILITY; CELL PROLIFERATION; DOGS; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, VIRAL; HEPACIVIRUS; HUMANS; HYDROGEN BONDING; PROTEASE INHIBITORS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 84903819948 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201400046 Document Type: Article

Times cited : (14)

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