Synthesis and biological evaluation of new potent and selective HCV NS5A inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 10, 2012, Pages 3488-3491

  Shi, Junxing ^a   Zhou, Longhu ^b,c   Amblard, Franck ^b,c   Bobeck, Drew R ^a   Zhang, Hongwang ^b,c   Liu, Peng ^b,c   Bondada, Lavanya ^b,c   McBrayer, Tamara R ^a   Tharnish, Phillip M ^a   Whitaker, Tony ^a   Coats, Steven J ^a   Schinazi, Raymond F ^b,c  

^a RFS Pharma LLC   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ATLANTA VA MEDICAL CENTER   (United States)

Author keywords

Antiviral; HCV; NS5A inhibitor

Indexed keywords

DACLATASVIR; NONSTRUCTURAL PROTEIN 5A; NONSTRUCTURAL PROTEIN 5A INHIBITOR; PHENYL GROUP; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; GENOTYPE; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; NONHUMAN; REACTION ANALYSIS; REPLICON; STRUCTURE ANALYSIS;

ANTIVIRAL AGENTS; CELL LINE; HEPACIVIRUS; HUMANS; MICROBIAL SENSITIVITY TESTS; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 84860478649     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.03.089     Document Type: Article

References (18)

1. A. Wasley, and M.J. Alter Semin. Liver Dis. 20 2000 1
2. L.B. Seeff Hepatology 36 2002 S35
3. J.A. Cuthbert Clin. Microbiol. Rev. 7 1994 505
4. A.M. Di Bisceglie Hepatology 31 2000 1014
5. A.M. Di Bisceglie, J. McHutchison, and C.M. Rice Hepatology 35 2002 224
6. H. Fontaine, and S. Pol Clin. Res. Hepatol. Gastroenterol. 35 2011 S59
7. P. Ferenci, and K.R. Reddy Antivir. Ther. 16 2011 1187
8. U. Schmitz, and S.L. Tan Recent Patents Anti-Infect Drug Discov. 3 2008 77
9. T. Asselah, and P. Marcellin Liver Int. 31 2011 68
10. M. Gao, R.E. Nettles, M. Belema, L.B. Snyder, V.N. Nguyen, R.A. Fridell, M.H. Serrano-Wu, D.R. Langley, J.-H. Sun, D.R. O'Boyle II, J.A. Lemm, C. Wang, J.O. Knipe, C. Chien, R.J. Colonno, D.M. Grasela, N.A. Meanwell, and L.G. Hamann Nature 465 2010 96
11. J.A. Lemm, D. O'Boyle II, M. Liu, P.T. Nower, R. Colonno, M.S. Deshpande, L.B. Snyder, S.W. Martin, D.R.S. Laurent, M.H. Serrano-Wu, J.L. Romine, N.A. Meanwell, and M. Gao J. Virol. 84 2010 482
12. Bachand, C.; Belema, M.; Deon, D. H.; Good, A. C.; Goodrich, J.; James, C. A.; Lavoie, R.; Lopez, O. D.; Martel, A.; Meanwell, N. A.; N., N. V.; Romine, J. L.; Ruediger, E. H.; Snyder, L. B.; St. Laurent, D. R.; Yang, F.; Langley, D. R.; Wang, G.; Hamann, L. G. WO 2008/021927, 2008.
13. T. Ishiyama, M. Murata, and N. Miyaura J. Org. Chem. 60 1995 7508
14. H.C. Kolb, and K.B. Sharpless Drug Discovery Today 8 2003 1128
15. R. Chinchilla, and C. Nájera Chem. Rev. 107 2007 874
16. L.J. Stuyver, T. Whitaker, T.R. McBrayer, B.I. Hernandez-Santiago, S. Lostia, P.M. Tharnish, M. Ramesh, C.K. Chu, R. Jordan, J. Shi, S. Rachakonda, K.A. Watanabe, K.A. Watanabe, M.J. Otto, and R.F. Schinazi Antimicrob. Agents Chemother. 47 2003 244
17. R.F. Schinazi, J.P. Sommadossi, V. Saalmann, D.L. Cannon, M.-W. Xie, G.C. Hart, G.A. Smith, and E.F. Hahn Antimicrob. Agents Chemother. 34 1990 1061
18. L.J. Stuyver, S. Lostia, M. Adams, J. Mathew, B.S. Pai, J. Grier, P. Tharnish, Y. Choi, Y. Chong, H. Choo, C.K. Chu, M.J. Otto, and R.F. Schinazi Antimicrob. Agents Chemother. 46 2002 3854