메뉴 건너뛰기




Volumn 63, Issue 7, 2014, Pages 737-747

Pilot study of a novel combination of two therapeutic vaccines in advanced non-small-cell lung cancer patients

Author keywords

Cancer vaccines; CIMT 2013; Combination; Epidermal growth factor; NGcGM3 ganglioside; NSCLC

Indexed keywords

CANCER VACCINE; CYCLOPHOSPHAMIDE; ERLOTINIB; IMMUNOMODULATING AGENT; IPILIMUMAB; MONTANIDE ISA 51; PLACEBO; RACOTUMOMAB; RECOMBINANT EPIDERMAL GROWTH FACTOR; UROKINASE;

EID: 84903817256     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-014-1552-9     Document Type: Review
Times cited : (7)

References (52)
  • 3
    • 84866058213 scopus 로고    scopus 로고
    • Immunoreactivity of the 14F7 Mab (Raised against N-Glycolyl GM3 Ganglioside) as a positive prognostic factor in non-small-cell lung cancer
    • Blanco R, Rengifo CE, Cedeño M, Frometa M, Rengifo E, Carr A (2012) Immunoreactivity of the 14F7 Mab (Raised against N-Glycolyl GM3 Ganglioside) as a positive prognostic factor in non-small-cell lung cancer. Pathol Res Int 2012:235418
    • (2012) Pathol Res Int , vol.2012 , pp. 235418
    • Blanco, R.1    Rengifo, C.E.2    Cedeño, M.3    Frometa, M.4    Rengifo, E.5    Carr, A.6
  • 4
    • 84872256078 scopus 로고    scopus 로고
    • Detection of N-glycolyated gangliosides in non-small-cell lung cancer using GMR8 monoclonal antibody
    • Hayashi N, Chiba H, Kuronuma K et al (2013) Detection of N-glycolyated gangliosides in non-small-cell lung cancer using GMR8 monoclonal antibody. Cancer Sci 104:43-47
    • (2013) Cancer Sci , vol.104 , pp. 43-47
    • Hayashi, N.1    Chiba, H.2    Kuronuma, K.3
  • 5
    • 30444446808 scopus 로고    scopus 로고
    • Role of tumour-associated N-glycolyated variant of GM3 ganglioside in cancer progression: Effect over CD4 expression on T cells
    • de Leon J, Fernández A, Mesa C, Clavel M, Fernández LE (2006) Role of tumour-associated N-glycolyated variant of GM3 ganglioside in cancer progression: effect over CD4 expression on T cells. Cancer Immunol Immunother 55:443-450
    • (2006) Cancer Immunol Immunother , vol.55 , pp. 443-450
    • De Leon, J.1    Fernández, A.2    Mesa, C.3    Clavel, M.4    Fernández, L.E.5
  • 6
    • 0015956495 scopus 로고
    • Towards a network theory of the immune system
    • Jerne NK (1974) Towards a network theory of the immune system. Ann Immunol (Paris) 125C:373-389
    • (1974) Ann Immunol (Paris) , vol.125 C , pp. 373-389
    • Jerne, N.K.1
  • 7
    • 0041664883 scopus 로고    scopus 로고
    • Vaccinating against GD3 ganglioside using BEC2 anti-idiotypic monoclonal antibody
    • Chapman PB (2003) Vaccinating against GD3 ganglioside using BEC2 anti-idiotypic monoclonal antibody. Curr Opin Investig Drugs 4:710-715
    • (2003) Curr Opin Investig Drugs , vol.4 , pp. 710-715
    • Chapman, P.B.1
  • 10
    • 84876529191 scopus 로고    scopus 로고
    • Abagovomab as maintenance therapy in patients with epithelial ovarian cancer: A phase III trial of the AGO OVAR, COGI, GINECO, and GEICO - The MIMOSA study
    • Sabbatini P, Harter P, Scambia G et al (2013) Abagovomab as maintenance therapy in patients with epithelial ovarian cancer: a phase III trial of the AGO OVAR, COGI, GINECO, and GEICO-the MIMOSA study. J Clin Oncol 31:1554-1561
    • (2013) J Clin Oncol , vol.31 , pp. 1554-1561
    • Sabbatini, P.1    Harter, P.2    Scambia, G.3
  • 11
    • 27244446896 scopus 로고    scopus 로고
    • Phase III study of adjuvant vaccination with Bec2/bacille Calmette-Guerin in responding patients with limited-disease small-cell lung cancer (European Organisation for Research and Treatment of Cancer 08971-08971B; Silva Study)
    • Giaccone G, Debruyne C, Felip E et al (2005) Phase III study of adjuvant vaccination with Bec2/bacille Calmette-Guerin in responding patients with limited-disease small-cell lung cancer (European Organisation for Research and Treatment of Cancer 08971-08971B; Silva Study). J Clin Oncol 23:6854-6864
    • (2005) J Clin Oncol , vol.23 , pp. 6854-6864
    • Giaccone, G.1    Debruyne, C.2    Felip, E.3
  • 12
    • 0032551747 scopus 로고    scopus 로고
    • CMP-N-acetylneuraminic acid hydroxylase is exclusively inactive in humans
    • DOI 10.1006/bbrc.1998.8946
    • Irie A, Suzuki A (1998) CMP-N-Acetylneuraminic acid hydroxylase is exclusively inactive in humans. Biochem Biophys Res Commun 248:330-333 (Pubitemid 28386421)
    • (1998) Biochemical and Biophysical Research Communications , vol.248 , Issue.2 , pp. 330-333
    • Irie, A.1    Suzuki, A.2
  • 14
    • 67650394884 scopus 로고    scopus 로고
    • Tissue micro array analysis of ganglioside N-glycolyl GM3 expression and signal transducer and activator of transcription (STAT)-3 activation in relation to dendritic cell infiltration and microvessel density in non-small cell lung cancer
    • van Cruijsen H, Ruiz MG, van der Valk P, de Gruijl TD, Giaccone G (2009) Tissue micro array analysis of ganglioside N-glycolyl GM3 expression and signal transducer and activator of transcription (STAT)-3 activation in relation to dendritic cell infiltration and microvessel density in non-small cell lung cancer. BMC Cancer 9:180
    • (2009) BMC Cancer , vol.9 , pp. 180
    • Van Cruijsen, H.1    Ruiz, M.G.2    Van Der Valk, P.3    De Gruijl, T.D.4    Giaccone, G.5
  • 15
    • 67349136455 scopus 로고    scopus 로고
    • Anti-ganglioside anti-idiotypic monoclonal antibody-based cancer vaccine induces apoptosis and antiangiogenic effect in a metastatic lung carcinoma
    • Díaz Y, González A, López A, Pérez R, Vázquez AM, Montero E (2009) Anti-ganglioside anti-idiotypic monoclonal antibody-based cancer vaccine induces apoptosis and antiangiogenic effect in a metastatic lung carcinoma. Cancer Immunol Immunother 58:1117-1128
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 1117-1128
    • Díaz, Y.1    González, A.2    López, A.3    Pérez, R.4    Vázquez, A.M.5    Montero, E.6
  • 16
    • 0036498936 scopus 로고    scopus 로고
    • An anti-idiotype vaccine elicits a specific response to N-glycolyl sialic acid residues of glycoconjugates in melanoma patients
    • Alfonso M, Díaz A, Hernández AM, Pérez A, Rodriguez E, Bitton R, Pérez R, Vázquez AM (2002) An anti-idiotype vaccine elicits a specific response to N-glycolyl sialic acid residues of glycoconjugates in melanoma patients. J Immunol 168:2523-2529 (Pubitemid 34171859)
    • (2002) Journal of Immunology , vol.168 , Issue.5 , pp. 2523-2529
    • Alfonso, M.1    Diaz, A.2    Hernandez, A.M.3    Perez, A.4    Rodriguez, E.5    Bitton, R.6    Perez, R.7    Vazquez, A.M.8
  • 17
  • 18
    • 33646768654 scopus 로고    scopus 로고
    • Cellular and humoral immune response to N-Glycolyl-GM3 elicited by prolonged immunotherapy with an anti-idiotypic vaccine in high-risk and metastatic breast cancer patients
    • Guthmann MD, Castro MA, Cinat G, Venier C, Koliren L, Bitton RJ, Vázquez AM, Fainboim L (2006) Cellular and humoral immune response to N-Glycolyl-GM3 elicited by prolonged immunotherapy with an anti-idiotypic vaccine in high-risk and metastatic breast cancer patients. J Immunother 29:215-223
    • (2006) J Immunother , vol.29 , pp. 215-223
    • Guthmann, M.D.1    Castro, M.A.2    Cinat, G.3    Venier, C.4    Koliren, L.5    Bitton, R.J.6    Vázquez, A.M.7    Fainboim, L.8
  • 19
    • 84879798525 scopus 로고    scopus 로고
    • Metronomic cyclophosphamide and methotrexate chemotherapy combined with 1E10 anti-idiotype vaccine in metastatic breast cancer
    • Soriano JL, Batista N, Santiesteban E et al (2011) Metronomic cyclophosphamide and methotrexate chemotherapy combined with 1E10 anti-idiotype vaccine in metastatic breast cancer. Int J Breast Cancer 2011:710292
    • (2011) Int J Breast Cancer , vol.2011 , pp. 710292
    • Soriano, J.L.1    Batista, N.2    Santiesteban, E.3
  • 20
    • 33645532616 scopus 로고    scopus 로고
    • Hypoxic culture induces expression of sialin, a sialic acid transporter, and cancer-associated gangliosides containing non-human sialic acid on human cancer cells
    • Yin J, Hashimoto A, Izawa M et al (2006) Hypoxic culture induces expression of sialin, a sialic acid transporter, and cancer-associated gangliosides containing non-human sialic acid on human cancer cells. Cancer Res 66:2937-2945
    • (2006) Cancer Res , vol.66 , pp. 2937-2945
    • Yin, J.1    Hashimoto, A.2    Izawa, M.3
  • 22
    • 58149456558 scopus 로고    scopus 로고
    • Characterization of the antibody response against NeuGcGM3 ganglioside elicited in non-small cell lung cancer patients immunized with an anti-idiotype antibody
    • Hernández AM, Toledo D, Martínez D et al (2008) Characterization of the antibody response against NeuGcGM3 ganglioside elicited in non-small cell lung cancer patients immunized with an anti-idiotype antibody. J Immunol 181:6625-6634
    • (2008) J Immunol , vol.181 , pp. 6625-6634
    • Hernández, A.M.1    Toledo, D.2    Martínez, D.3
  • 23
    • 0027170357 scopus 로고
    • Evidence for a role of EGF receptor in the progression of human lung carcinoma
    • Pavelic K, Banjac Z, Pavelic J, Spaventi S (1993) Evidence for a role of EGF receptor in the progression of human lung carcinoma. Anticancer Res 13:1133-1137 (Pubitemid 23247476)
    • (1993) Anticancer Research , vol.13 , Issue.4 , pp. 1133-1137
    • Pavelic, K.1    Banjac, Z.2    Pavelic, J.3    Spaventi, S.4
  • 24
    • 55449123441 scopus 로고    scopus 로고
    • Clinical significance of pretreatment serum amphiregulin and transforming growth factor-alpha, and an epidermal growth factor receptor somatic mutation in patients with advanced non-squamous, non-small cell lung cancer
    • Masago K, Fujita S, Hatachi Y, Fukuhara A, Sakuma K, Ichikawa M, Kim YH, Mio T, Mishima M (2008) Clinical significance of pretreatment serum amphiregulin and transforming growth factor-alpha, and an epidermal growth factor receptor somatic mutation in patients with advanced non-squamous, non-small cell lung cancer. Cancer Sci 99:2295-2301
    • (2008) Cancer Sci , vol.99 , pp. 2295-2301
    • Masago, K.1    Fujita, S.2    Hatachi, Y.3    Fukuhara, A.4    Sakuma, K.5    Ichikawa, M.6    Kim, Y.H.7    Mio, T.8    Mishima, M.9
  • 25
    • 78650504769 scopus 로고    scopus 로고
    • Ligands of epidermal growth factor receptor and the insulin-like growth factor family as serum biomarkers for response to epidermal growth factor receptor inhibitors in patients with advanced non-small cell lung cancer
    • Vollebergh MA, Kappers I, Klomp HM, Buning-Kager JC, Korse CM, Hauptmann M, de Visser KE, van den Heuvel MM, Linn SC (2010) Ligands of epidermal growth factor receptor and the insulin-like growth factor family as serum biomarkers for response to epidermal growth factor receptor inhibitors in patients with advanced non-small cell lung cancer. J Thorac Oncol 5:1939-1948
    • (2010) J Thorac Oncol , vol.5 , pp. 1939-1948
    • Vollebergh, M.A.1    Kappers, I.2    Klomp, H.M.3    Buning-Kager, J.C.4    Korse, C.M.5    Hauptmann, M.6    De Visser, K.E.7    Van Den Heuvel, M.M.8    Linn, S.C.9
  • 26
    • 62649134382 scopus 로고    scopus 로고
    • Interaction of antibodies with ErbB receptor extracellular regions
    • Schmitz KR, Ferguson KM (2009) Interaction of antibodies with ErbB receptor extracellular regions. Exp Cell Res 315:659-670
    • (2009) Exp Cell Res , vol.315 , pp. 659-670
    • Schmitz, K.R.1    Ferguson, K.M.2
  • 28
    • 65349116059 scopus 로고    scopus 로고
    • Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): An open-label randomised phase III trial
    • Pirker R, Pereira JR, Szczesna A et al (2009) Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial. Lancet 373:1525-1531
    • (2009) Lancet , vol.373 , pp. 1525-1531
    • Pirker, R.1    Pereira, J.R.2    Szczesna, A.3
  • 29
    • 84867059528 scopus 로고    scopus 로고
    • Randomized, phase III study of gemcitabine or erlotinib maintenance therapy versus observation, with predefined second-line treatment, after cisplatin-gemcitabine induction chemotherapy in advanced non-small-cell lung cancer
    • Perol M, Chouaid C, Perol D et al (2012) Randomized, phase III study of gemcitabine or erlotinib maintenance therapy versus observation, with predefined second-line treatment, after cisplatin-gemcitabine induction chemotherapy in advanced non-small-cell lung cancer. J Clin Oncol 30:3516-3524
    • (2012) J Clin Oncol , vol.30 , pp. 3516-3524
    • Perol, M.1    Chouaid, C.2    Perol, D.3
  • 30
    • 84857502654 scopus 로고    scopus 로고
    • Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial
    • Rosell R, Carcereny E, Gervais R et al (2012) Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol 13:239-246
    • (2012) Lancet Oncol , vol.13 , pp. 239-246
    • Rosell, R.1    Carcereny, E.2    Gervais, R.3
  • 33
    • 77953541527 scopus 로고    scopus 로고
    • Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: A multicentre, randomised, placebo-controlled phase 3 study
    • Cappuzzo F, Ciuleanu T, Stelmakh L et al (2010) Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study. Lancet Oncol 11:521-529
    • (2010) Lancet Oncol , vol.11 , pp. 521-529
    • Cappuzzo, F.1    Ciuleanu, T.2    Stelmakh, L.3
  • 34
    • 0030497413 scopus 로고    scopus 로고
    • Induction of immune recognition of self epidermal growth factor (EGF): Effect on EGF-biodistribution and tumor growth
    • González SB, Suárez E, Beausoleil I, Perez O, Lastre M et al (1996) Induction of immune recognition of self-epidermal growth factor (EGF): effect on EGF biodistribution and tumor growth. Vac Res 5:233-244 (Pubitemid 27089202)
    • (1996) Vaccine Research , vol.5 , Issue.4 , pp. 233-244
    • Gonzalez, G.1    Sanchez, B.2    Suarez, E.3    Beausoleil, I.4    Perez, O.5    Lastre, M.6    Lage, L.7
  • 36
    • 34247860903 scopus 로고    scopus 로고
    • Cancer vaccines for hormone/growth factor immune deprivation: A feasible approach for cancer treatment
    • DOI 10.2174/156800907780618310
    • González G, Lage A (2007) Cancer vaccines for hormone/growth factor immune deprivation: a feasible approach for cancer treatment. Curr Cancer Drug Targets 7:229-241 (Pubitemid 46699074)
    • (2007) Current Cancer Drug Targets , vol.7 , Issue.3 , pp. 229-241
    • Gonzalez, G.1    Lage, A.2
  • 37
    • 49149127726 scopus 로고    scopus 로고
    • Increased EGFR gene copy number detected by fluorescent in situ hybridization predicts outcome in non-small-cell lung cancer patients treated with cetuximab and chemotherapy
    • Hirsch FR, Herbst RS, Olsen C et al (2008) Increased EGFR gene copy number detected by fluorescent in situ hybridization predicts outcome in non-small-cell lung cancer patients treated with cetuximab and chemotherapy. J Clin Oncol 26:3351-3357
    • (2008) J Clin Oncol , vol.26 , pp. 3351-3357
    • Hirsch, F.R.1    Herbst, R.S.2    Olsen, C.3
  • 38
    • 77649229271 scopus 로고    scopus 로고
    • Clinical development and perspectives of CIMAvax EGF, Cuban vaccine for non-small-cell lung cancer therapy
    • Rodriguez PC, Rodriguez G, González G, Lage A (2010) Clinical development and perspectives of CIMAvax EGF, Cuban vaccine for non-small-cell lung cancer therapy. MEDICC Rev 12:17-23
    • (2010) MEDICC Rev , vol.12 , pp. 17-23
    • Rodriguez, P.C.1    Rodriguez, G.2    González, G.3    Lage, A.4
  • 39
    • 41149159650 scopus 로고    scopus 로고
    • Phase II randomized controlled trial of an epidermal growth factor vaccine in advanced non-small-cell lung cancer
    • Neninger Vinageras E, de la Torre A, Osorio Rodriguez M et al (2008) Phase II randomized controlled trial of an epidermal growth factor vaccine in advanced non-small-cell lung cancer. J Clin Oncol 26:1452-1458
    • (2008) J Clin Oncol , vol.26 , pp. 1452-1458
    • Neninger Vinageras, E.1    De La Torre, A.2    Osorio Rodriguez, M.3
  • 40
    • 38949193901 scopus 로고    scopus 로고
    • Effective inhibition of the epidermal growth factor/epidermal growth factor receptor binding by anti-epidermal growth factor antibodies is related to better survival in advanced non-small-cell lung cancer patients treated with the epidermal growth factor cancer vaccine
    • DOI 10.1158/1078-0432.CCR-07-1050
    • García B, Neninger E, de la Torre A et al (2008) Effective inhibition of the epidermal growth factor/epidermal growth factor receptor binding by anti-epidermal growth factor antibodies is related to better survival in advanced non-small-cell lung cancer patients treated with the epidermal growth factor cancer vaccine. Clin Cancer Res 14:840-846 (Pubitemid 351231168)
    • (2008) Clinical Cancer Research , vol.14 , Issue.3 , pp. 840-846
    • Garcia, V.B.1    Neninger, E.2    De La, T.A.3    Leonard, I.4    Martinez, R.5    Viada, C.6    Gonzalez, G.7    Mazorra, Z.8    Lage, A.9    Crombet, T.10
  • 41
    • 79951826832 scopus 로고    scopus 로고
    • Tumor regression and growth rates determined in five intramural NCI prostate cancer trials: The growth rate constant as an indicator of therapeutic efficacy
    • Stein WD, Gulley JL, Schlom J et al (2011) Tumor regression and growth rates determined in five intramural NCI prostate cancer trials: the growth rate constant as an indicator of therapeutic efficacy. Clin Cancer Res 17:907-917
    • (2011) Clin Cancer Res , vol.17 , pp. 907-917
    • Stein, W.D.1    Gulley, J.L.2    Schlom, J.3
  • 42
    • 0033517152 scopus 로고    scopus 로고
    • Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony- stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation
    • DOI 10.1084/jem.190.3.355
    • van Elsas A, Hurwitz A, Allison JP (1999) Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation. J Exp Med 190:355-366 (Pubitemid 29374833)
    • (1999) Journal of Experimental Medicine , vol.190 , Issue.3 , pp. 355-366
    • Van Elsas, A.1    Hurwitz, A.A.2    Allison, J.P.3
  • 43
    • 33644659256 scopus 로고    scopus 로고
    • Principles and use of anti-CTLA4 antibody in human cancer immunotherapy
    • DOI 10.1016/j.coi.2006.01.011, PII S0952791506000148, Lymphocyte Development / Tumor Immunology
    • Peggs KS, Quezada SA, Korman AJ, Allison JP (2006) Principles and use of anti-CTLA4 antibody in human cancer immunotherapy. Curr Opin Immunol 18:206-213 (Pubitemid 43327304)
    • (2006) Current Opinion in Immunology , vol.18 , Issue.2 , pp. 206-213
    • Peggs, K.S.1    Quezada, S.A.2    Korman, A.J.3    Allison, J.P.4
  • 44
    • 36849035139 scopus 로고    scopus 로고
    • Targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4): A novel strategy for the treatment of melanoma and other malignancies
    • DOI 10.1002/cncr.23086
    • O'Day SJ, Hamid O, Urba WJ (2007) Targeting cytotoxic T-lymphocyte antigen-4 (CTLA-4): a novel strategy for the treatment of melanoma and other malignancies. Cancer 110:2614-2627 (Pubitemid 350250330)
    • (2007) Cancer , vol.110 , Issue.12 , pp. 2614-2627
    • O'Day, S.J.1    Hamid, O.2    Urba, W.J.3
  • 46
    • 0037449805 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-dependent and -independent cell-signaling pathways originating from the urokinase receptor
    • DOI 10.1074/jbc.M210877200
    • Jo M, Thomas KS, O'Donnell DM, Gonias SL (2003) Epidermal growth factor receptor-dependent and -independent cell-signaling pathways originating from the urokinase receptor. J Biol Chem 278:1642-1646 (Pubitemid 36801395)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.3 , pp. 1642-1646
    • Jo, M.1    Thomas, K.S.2    O'Donnell, D.M.3    Gonias, S.L.4
  • 47
  • 48
    • 33751115183 scopus 로고    scopus 로고
    • Ganglioside GM3 promotes carcinoma cell proliferation via urokinase plasminogen activator-induced extracellular signal-regulated kinase-independent p70S6 kinase signaling
    • DOI 10.1038/sj.jid.5700469, PII 5700469
    • Wang XQ, Sun P, Go L, Koti V, Fliman M, Paller AS (2006) Ganglioside GM3 promotes carcinoma cell proliferation via urokinase plasminogen activator-induced extracellular signal-regulated kinase-independent p70S6 kinase signaling. J Invest Dermatol 126:2687-2696 (Pubitemid 44764053)
    • (2006) Journal of Investigative Dermatology , vol.126 , Issue.12 , pp. 2687-2696
    • Wang, X.-Q.1    Sun, P.2    Go, L.3    Koti, V.4    Fliman, M.5    Paller, A.S.6
  • 49
    • 41149148210 scopus 로고    scopus 로고
    • + regulatory T cells function
    • DOI 10.1093/intimm/dxn018
    • de Leon J, Fernández A, Clavell M, Labrada M, Bebelagua Y, Mesa C, Fernández LE (2008) Differential influence of the tumour-specific non-human sialic acid containing GM3 ganglioside on CD4 + CD25- effector and naturally occurring CD4 + CD25 + regulatory T cells function. Int Immunol 20:591-600 (Pubitemid 351426051)
    • (2008) International Immunology , vol.20 , Issue.4 , pp. 591-600
    • De Leon, J.1    Fernandez, A.2    Clavell, M.3    Labrada, M.4    Bebelagua, Y.5    Mesa, C.6    Fernandez, L.E.7
  • 50
    • 84863154124 scopus 로고    scopus 로고
    • Trafficking of high avidity HER-2/neu-specific T cells into HER-2/neu-expressing tumors after depletion of effector/memory-like regulatory T cells
    • Weiss VL, Lee TH, Song H, Kouo TS, Black CM, Sgouros G, Jaffee EM, Armstrong TD (2012) Trafficking of high avidity HER-2/neu-specific T cells into HER-2/neu-expressing tumors after depletion of effector/memory-like regulatory T cells. PLoS ONE 7:e31962
    • (2012) PLoS ONE , vol.7
    • Weiss, V.L.1    Lee, T.H.2    Song, H.3    Kouo, T.S.4    Black, C.M.5    Sgouros, G.6    Jaffee, E.M.7    Armstrong, T.D.8
  • 51
    • 15944410592 scopus 로고    scopus 로고
    • + T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide
    • DOI 10.1182/blood-2004-06-2410
    • Lutsiak ME, Semnani RT, De Pascalis R, Kashmiri SV, Schlom J, Sabzevari H (2005) Inhibition of CD4(+)25 + T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide. Blood 105:2862-2868 (Pubitemid 40446280)
    • (2005) Blood , vol.105 , Issue.7 , pp. 2862-2868
    • Lutsiak, M.E.C.1    Semnani, R.T.2    De Pascalis, R.3    Kashmiri, S.V.S.4    Schlom, J.5    Sabzevari, H.6
  • 52
    • 41949141343 scopus 로고    scopus 로고
    • Immune-potentiating effects of the chemotherapeutic drug cyclophosphamide
    • Brode S, Cooke A (2008) Immune-potentiating effects of the chemotherapeutic drug cyclophosphamide. Crit Rev Immunol 28:109-126 (Pubitemid 351507425)
    • (2008) Critical Reviews in Immunology , vol.28 , Issue.2 , pp. 109-126
    • Brode, S.1    Cooke, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.