White matter integrity is associated with cerebrospinal fluid markers of Alzheimer's disease in normal adults

Neurobiology of Aging

Volumn 35, Issue 10, 2014, Pages 2263-2271

  Gold, Brian T ^a,b   Zhu, Zude ^a   Brown, Christopher A ^a   Andersen, Anders H ^a,b   LaDu, Mary Jo ^c   Tai, Leon ^c   Jicha, Greg A ^a   Kryscio, Richard J ^a,b   Estus, Steven ^a   Nelson, Peter T ^a,b   Scheff, Steve W ^a   Abner, Erin ^a,b   Schmitt, Frederick A ^a   Van Eldik, Linda J ^a   Smith, Charles D ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

CSF; DTI; Normal older adults; Preclinical AD; White matter

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; TAU PROTEIN; AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); BIOLOGICAL MARKER; PEPTIDE FRAGMENT;

AGED; ALZHEIMER DISEASE; ARCUATE FASCICULUS; ARTICLE; BRAIN FORNIX; BRAIN MAPPING; BRAIN SIZE; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; CORPUS CALLOSUM; DIFFUSION TENSOR IMAGING; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN EXPERIMENT; LUMBAR PUNCTURE; MALE; MEDIAL LONGITUDINAL FASCICULUS; MINI MENTAL STATE EXAMINATION; NEUROPSYCHOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; WHITE MATTER; AGING; CEREBROSPINAL FLUID; COGNITION; DIFFUSION WEIGHTED IMAGING; ORGAN SIZE; PATHOLOGY; PHYSIOLOGY; PSYCHOLOGY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; AGING; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; BIOLOGICAL MARKERS; COGNITION; DIFFUSION MAGNETIC RESONANCE IMAGING; FEMALE; FORNIX, BRAIN; HIPPOCAMPUS; HUMANS; MALE; ORGAN SIZE; PEPTIDE FRAGMENTS; TAU PROTEINS; WHITE MATTER;

EID: 84903816441     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2014.04.030     Document Type: Article

References (48)

1. Acosta-Cabronero J., Williams G.B., Pengas G., Nestor P.J. Absolute diffusivities define the landscape of white matter degeneration in Alzheimer's disease. Brain 2010, 133:529-539.
2. Apostolova L.G., Mosconi L., Thompson P.M., Green A.E., Hwang K.S., Ramirez A., Mistur R., Tsui W.H., de Leon M.J. Subregional hippocampal atrophy predicts Alzheimer's dementia in the cognitively normal. Neurobiol. Aging 2010, 31:1077-1088.
3. Bartzokis G. Alzheimer's disease as homeostatic responses to age-related myelin breakdown. Neurobiol. Aging 2011, 32:1341-1371.
4. Basser P.J., Pajevic S., Pierpaoli C., Duda J., Aldroubi A. Invivo fiber tractography using DT-MRI data. Magn. Reson. Med. 2000, 44:625-632.
5. Beaulieu C. The basis of anisotropic water diffusion in the nervous system - a technical review. NMR Biomed. 2002, 15:435-455.
6. Bendlin B.B., Carlsson C.M., Johnson S.C., Zetterberg H., Blennow K., Willette A.A., Okonkwo O.C., Sodhi A., Ries M.L., Birdsill A.C., Alexander A.L., Rowley H.A., Puglielli L., Asthana S., Sager M.A. CSF T-Tau/Abeta42 predicts white matter microstructure in healthy adults at risk for Alzheimer's disease. PLoS One 2012, 7:e37720.
7. Bendlin B.B., Ries M.L., Canu E., Sodhi A., Lazar M., Alexander A.L., Carlsson C.M., Sager M.A., Asthana S., Johnson S.C. White matter is altered with parental family history of Alzheimer's disease. Alzheimers Dement. 2010, 6:394-403.
8. Bennett D.A., Schneider J.A., Arvanitakis Z., Kelly J.F., Aggarwal N.T., Shah R.C., Wilson R.S. Neuropathology of older persons without cognitive impairment from two community-based studies. Neurology 2006, 66:1837-1844.
9. Blacker D., Lee H., Muzikansky A., Martin E.C., Tanzi R., McArdle J.J., Moss M., Albert M. Neuropsychological measures in normal individuals that predict subsequent cognitive decline. Arch. Neurol. 2007, 64:862-871.
10. Brun A., Englund E. Awhite matter disorder in dementia of the Alzheimer type: a pathoanatomical study. Ann. Neurol. 1986, 19:253-262.
11. Chao L.L., Decarli C., Kriger S., Truran D., Zhang Y., Laxamana J., Villeneuve S., Jagust W.J., Sanossian N., Mack W.J., Chui H.C., Weiner M.W. Associations between white matter hyperintensities and beta amyloid on integrity of projection, association, and limbic fiber tracts measured with diffusion tensor MRI. PLoS One 2013, 8:e65175.
12. Convit A., De Leon M.J., Tarshish C., De Santi S., Tsui W., Rusinek H., George A. Specific hippocampal volume reductions in individuals at risk for Alzheimer's disease. Neurobiol. Aging 1997, 18:131-138.
13. Desikan R.S., Segonne F., Fischl B., Quinn B.T., Dickerson B.C., Blacker D., Buckner R.L., Dale A.M., Maguire R.P., Hyman B.T., Albert M.S., Killiany R.J. An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage 2006, 31:968-980.
14. Dickerson B.C., Sperling R.A., Hyman B.T., Albert M.S., Blacker D. Clinical prediction of Alzheimer disease dementia across the spectrum of mild cognitive impairment. Arch. Gen. Psychiatry 2007, 64:1443-1450.
15. Dickerson B.C., Wolk D.A. MRI cortical thickness biomarker predicts AD-like CSF and cognitive decline in normal adults. Neurology 2012, 78:84-90.
16. Englund E. Neuropathology of white matter changes in Alzheimer's disease and vascular dementia. Dement. Geriatr. Cogn. Disord. 1998, 9:6-12.
17. Fischl B., Salat D.H., Busa E., Albert M., Dieterich M., Haselgrove C., van der Kouwe A., Killiany R., Kennedy D., Klaveness S., Montillo A., Makris N., Rosen B., Dale A.M. Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 2002, 33:341-355.
18. Fischl B., van der Kouwe A., Destrieux C., Halgren E., Segonne F., Salat D.H., Busa E., Seidman L.J., Goldstein J., Kennedy D., Caviness V., Makris N., Rosen B., Dale A.M. Automatically parcellating the human cerebral cortex. Cereb. Cortex 2004, 14:11-22.
19. Fletcher E., Raman M., Huebner P., Liu A., Mungas D., Carmichael O., DeCarli C. Loss of fornix white matter volume as a predictor of cognitive impairment in cognitively normal elderly individuals. JAMA Neurol. 2013, 70:1389-1395.
20. Gold B.T., Johnson N.F., Powell D.K., Smith C.D. White matter integrity and vulnerability to Alzheimer's disease: preliminary findings and future directions. Biochim. Biophys. Acta 2012, 1822:416-422.
21. Gold B.T., Powell D.K., Andersen A.H., Smith C.D. Alterations in multiple measures of white matter integrity in normal women at high risk for Alzheimer's disease. Neuroimage 2010, 52:1487-1494.
22. Heise V., Filippini N., Ebmeier K.P., Mackay C.E. The APOE epsilon4 allele modulates brain white matter integrity in healthy adults. Mol. Psychiatry 2011, 16:908-916.
23. Ihara M., Polvikoski T.M., Hall R., Slade J.Y., Perry R.H., Oakley A.E., Englund E., O'Brien J.T., Ince P.G., Kalaria R.N. Quantification of myelin loss in frontal lobe white matter in vascular dementia, Alzheimer's disease, and dementia with Lewy bodies. Acta Neuropathol. 2010, 119:579-589.
24. Jack C.R., Knopman D.S., Jagust W.J., Petersen R.C., Weiner M.W., Aisen P.S., Shaw L.M., Vemuri P., Wiste H.J., Weigand S.D., Lesnick T.G., Pankratz V.S., Donohue M.C., Trojanowski J.Q. Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers. Lancet Neurol. 2013, 12:207-216.
25. Jack C.R., Knopman D.S., Jagust W.J., Shaw L.M., Aisen P.S., Weiner M.W., Petersen R.C., Trojanowski J.Q. Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol. 2010, 9:119-128.
26. Jack C.R., Petersen R.C., Xu Y.C., Waring S.C., O'Brien P.C., Tangalos E.G., Smith G.E., Ivnik R.J., Kokmen E. Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease. Neurology 1997, 49:786-794.
27. Johnson N.F., Kim C., Clasey J.L., Bailey A., Gold B.T. Cardiorespiratory fitness is positively correlated with cerebral white matter integrity in healthy seniors. Neuroimage 2012, 59:1514-1523.
28. Le Bihan D. Looking into the functional architecture of the brain with diffusion MRI. Nat. Rev. Neurosci. 2003, 4:469-480.
29. Martin S.B., Smith C.D., Collins H.R., Schmitt F.A., Gold B.T. Evidence that volume of anterior medial temporal lobe is reduced in seniors destined for mild cognitive impairment. Neurobiol. Aging 2010, 31:1099-1106.
30. McKhann G.M., Knopman D.S., Chertkow H., Hyman B.T., Jack C.R., Kawas C.H., Klunk W.E., Koroshetz W.J., Manly J.J., Mayeux R., Mohs R.C., Morris J.C., Rossor M.N., Scheltens P., Carrillo M.C., Thies B., Weintraub S., Phelps C.H. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011, 7:263-269.
31. Morris J.C., Storandt M., McKeel D.W., Rubin E.H., Price J.L., Grant E.A., Berg L. Cerebral amyloid deposition and diffuse plaques in "normal" aging: evidence for presymptomatic and very mild Alzheimer's disease. Neurology 1996, 46:707-719.
32. Morris J.C., Weintraub S., Chui H.C., Cummings J., Decarli C., Ferris S., Foster N.L., Galasko D., Graff-Radford N., Peskind E.R., Beekly D., Ramos E.M., Kukull W.A. The uniform data set (UDS): clinical and cognitive variables and descriptive data from Alzheimer Disease Centers. Alzheimer Dis. Assoc. Disord. 2006, 20:210-216.
33. Moseley M. Diffusion tensor imaging and aging - a review. NMR Biomed. 2002, 15:553-560.
34. Oishi K., Mielke M.M., Albert M., Lyketsos C.G., Mori S. The fornix sign: a potential sign for Alzheimer's disease based on diffusion tensor imaging. J.Neuroimaging 2012, 22:365-374.
35. Persson J., Lind J., Larsson A., Ingvar M., Cruts M., Van Broeckhoven C., Adolfsson R., Nilsson L.G., Nyberg L. Altered brain white matter integrity in healthy carriers of the APOE epsilon4 allele: a risk for AD?. Neurology 2006, 66:1029-1033.
36. Ringman J.M., O'Neill J., Geschwind D., Medina L., Apostolova L.G., Rodriguez Y., Schaffer B., Varpetian A., Tseng B., Ortiz F., Fitten J., Cummings J.L., Bartzokis G. Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer's disease mutations. Brain 2007, 130:1767-1776.
37. Roher A.E., Weiss N., Kokjohn T.A., Kuo Y.M., Kalback W., Anthony J., Watson D., Luehrs D.C., Sue L., Walker D., Emmerling M., Goux W., Beach T. Increased A beta peptides and reduced cholesterol and myelin proteins characterize white matter degeneration in Alzheimer's disease. Biochemistry 2002, 41:11080-11090.
38. Sachdev P.S., Zhuang L., Braidy N., Wen W. Is Alzheimer's a disease of the white matter?. Curr. Opin. Psychiatry 2013, 26:244-251.
39. Schmitt F.A., Nelson P.T., Abner E., Scheff S., Jicha G.A., Smith C., Cooper G., Mendiondo M., Danner D.D., Van Eldik L.J., Caban-Holt A., Lovell M.A., Kryscio R.J. University of Kentucky Sanders-Brown healthy brain aging volunteers: donor characteristics, procedures and neuropathology. Curr. Alzheimer Res. 2012, 9:724-733.
40. Shahani N., Brandt R. Functions and malfunctions of the tau proteins. Cell Mol. Life Sci. 2002, 59:1668-1680.
41. Sjogren M., Vanderstichele H., Agren H., Zachrisson O., Edsbagge M., Wikkelso C., Skoog I., Wallin A., Wahlund L.O., Marcusson J., Nagga K., Andreasen N., Davidsson P., Vanmechelen E., Blennow K. Tau and Abeta42 in cerebrospinal fluid from healthy adults 21-93 years of age: establishment of reference values. Clin. Chem. 2001, 47:1776-1781.
42. Smith C.D., Chebrolu H., Andersen A.H., Powell D.A., Lovell M.A., Xiong S., Gold B.T. White matter diffusion alterations in normal women at risk of Alzheimer's disease. Neurobiol. Aging 2010, 31:1122-1131.
43. Smith S.M., Jenkinson M., Johansen-Berg H., Rueckert D., Nichols T.E., Mackay C.E., Watkins K.E., Ciccarelli O., Cader M.Z., Matthews P.M., Behrens T.E. Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage 2006, 31:1487-1505.
44. Sperling R.A., Aisen P.S., Beckett L.A., Bennett D.A., Craft S., Fagan A.M., Iwatsubo T., Jack C.R., Kaye J., Montine T.J., Park D.C., Reiman E.M., Rowe C.C., Siemers E., Stern Y., Yaffe K., Carrillo M.C., Thies B., Morrison-Bogorad M., Wagster M.V., Phelps C.H. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 2011, 7:280-292.
45. Stebbins G.T., Murphy C.M. Diffusion tensor imaging in Alzheimer's disease and mild cognitive impairment. Behav. Neurol. 2009, 21:39-49.
46. Weintraub S., Salmon D., Mercaldo N., Ferris S., Graff-Radford N.R., Chui H., Cummings J., DeCarli C., Foster N.L., Galasko D., Peskind E., Dietrich W., Beekly D.L., Kukull W.A., Morris J.C. The Alzheimer's disease centers' uniform data set (UDS): the neuropsychologic test battery. Alzheimer Dis. Assoc. Disord. 2009, 23:91-101.
47. Xu J., Chen S., Ahmed S.H., Chen H., Ku G., Goldberg M.P., Hsu C.Y. Amyloid-beta peptides are cytotoxic to oligodendrocytes. J.Neurosci. 2001, 21:RC118.
48. Zhuang L., Sachdev P.S., Trollor J.N., Reppermund S., Kochan N.A., Brodaty H., Wen W. Microstructural white matter changes, not hippocampal atrophy, detect early amnestic mild cognitive impairment. PLoS One 2013, 8:e58887.