메뉴 건너뛰기




Volumn 13, Issue 13, 2014, Pages 2101-2109

The anaphase-promoting complex/cyclosome is an E3 ubiquitin ligase for Mdm2

Author keywords

APC C; E3; Mdm2; P53; Ubiquitin

Indexed keywords

ANAPHASE PROMOTING COMPLEX SUBUNIT 2; PROTEASOME; PROTEIN MDM2; PROTEIN P53; RNA; MDM2 PROTEIN, HUMAN;

EID: 84903793859     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.29106     Document Type: Article
Times cited : (10)

References (29)
  • 1
    • 77955871461 scopus 로고    scopus 로고
    • The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor
    • PMID:20679392
    • Manfredi JJ. The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor. Genes Dev 2010; 24:1580-9; PMID:20679392; http://dx.doi.org/10.1101/gad.1941710
    • (2010) Genes Dev , vol.24 , pp. 1580-1589
    • Manfredi, J.J.1
  • 2
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • PMID:1535557
    • Momand J, Zambetti GP, Olson DC, George D, Levine AJ. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 1992; 69:1237-45; PMID:1535557; http://dx.doi.org/10.1016/ 0092-8674(92)90644-R
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 3
    • 0027325132 scopus 로고
    • Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
    • PMID:8479525
    • Oliner JD, Pietenpol JA, Thiagalingam S, Gyuris J, Kinzler KW, Vogelstein B. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Nature 1993; 362:857-60; PMID:8479525; http://dx.doi.org/10.1038/362857a0
    • (1993) Nature , vol.362 , pp. 857-860
    • Oliner, J.D.1    Pietenpol, J.A.2    Thiagalingam, S.3    Gyuris, J.4    Kinzler, K.W.5    Vogelstein, B.6
  • 4
    • 0031583962 scopus 로고    scopus 로고
    • Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
    • PMID:9450543
    • Honda R, Tanaka H, Yasuda H. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett 1997; 420:25-7; PMID:9450543; http://dx.doi.org/10.1016/S0014-5793(97)01480-4
    • (1997) FEBS Lett , vol.420 , pp. 25-27
    • Honda, R.1    Tanaka, H.2    Yasuda, H.3
  • 5
    • 0030965946 scopus 로고    scopus 로고
    • Regulation of p53 stability by Mdm2
    • PMID:9153396
    • Kubbutat MH, Jones SN, Vousden KH. Regulation of p53 stability by Mdm2. Nature 1997; 387:299-303; PMID:9153396; http://dx.doi.org/10.1038/387299a0
    • (1997) Nature , vol.387 , pp. 299-303
    • Kubbutat, M.H.1    Jones, S.N.2    Vousden, K.H.3
  • 6
    • 31544457877 scopus 로고    scopus 로고
    • p53 ubiquitination: Mdm2 and beyond
    • PMID:16455486
    • Brooks CL, Gu W. p53 ubiquitination: Mdm2 and beyond. Mol Cell 2006; 21:307-15; PMID:16455486; http://dx.doi.org/10.1016/j.molcel.2006.01.020
    • (2006) Mol Cell , vol.21 , pp. 307-315
    • Brooks, C.L.1    Gu, W.2
  • 7
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • PMID:9153395
    • Haupt Y, Maya R, Kazaz A, Oren M. Mdm2 promotes the rapid degradation of p53. Nature 1997; 387:296-9; PMID:9153395; http://dx.doi.org/10.1038/387296a0
    • (1997) Nature , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 8
    • 55949099028 scopus 로고    scopus 로고
    • Oscillations by the p53-Mdm2 feedback loop
    • PMID:18783169
    • Lahav G. Oscillations by the p53-Mdm2 feedback loop. Adv Exp Med Biol 2008; 641:28-38; PMID:18783169; http://dx.doi.org/10.1007/978-0-387-09794-7-2
    • (2008) Adv Exp Med Biol , vol.641 , pp. 28-38
    • Lahav, G.1
  • 9
    • 0027459198 scopus 로고
    • mdm2 expression is induced by wild-type p53 activity
    • PMID:8440237
    • Barak Y, Juven T, Haffner R, Oren M. mdm2 expression is induced by wild-type p53 activity. EMBO J 1993; 12:461-8; PMID:8440237
    • (1993) EMBO J , vol.12 , pp. 461-468
    • Barak, Y.1    Juven, T.2    Haffner, R.3    Oren, M.4
  • 10
    • 0027501841 scopus 로고
    • Wild-type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene
    • PMID:8247544
    • Juven T, Barak Y, Zauberman A, George DL, Oren M. Wild-type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene. Oncogene 1993; 8:3411-6; PMID:8247544
    • (1993) Oncogene , vol.8 , pp. 3411-3416
    • Juven, T.1    Barak, Y.2    Zauberman, A.3    George, D.L.4    Oren, M.5
  • 11
    • 0027143217 scopus 로고
    • The mdm-2 gene is induced in response to UV light in a p53-dependent manner
    • PMID:8265599
    • Perry ME, Piette J, Zawadzki JA, Harvey D, Levine AJ. The mdm-2 gene is induced in response to UV light in a p53-dependent manner. Proc Natl Acad Sci U S A 1993; 90:11623-7; PMID:8265599; http://dx.doi.org/10.1073/pnas.90.24.11623
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 11623-11627
    • Perry, M.E.1    Piette, J.2    Zawadzki, J.A.3    Harvey, D.4    Levine, A.J.5
  • 12
    • 0034708458 scopus 로고    scopus 로고
    • Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
    • PMID:10722742
    • Fang S, Jensen JP, Ludwig RL, Vousden KH, Weissman AM. Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J Biol Chem 2000; 275:8945-51; PMID:10722742; http://dx.doi.org/10.1074/jbc.275.12.8945
    • (2000) J Biol Chem , vol.275 , pp. 8945-8951
    • Fang, S.1    Jensen, J.P.2    Ludwig, R.L.3    Vousden, K.H.4    Weissman, A.M.5
  • 13
    • 0034624678 scopus 로고    scopus 로고
    • Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase
    • PMID:10723139
    • Honda R, Yasuda H. Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase. Oncogene 2000; 19:1473-6; PMID:10723139; http://dx.doi.org/10.1038/sj.onc.1203464
    • (2000) Oncogene , vol.19 , pp. 1473-1476
    • Honda, R.1    Yasuda, H.2
  • 14
    • 35148847384 scopus 로고    scopus 로고
    • Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation
    • PMID:17936560
    • Itahana K, Mao H, Jin A, Itahana Y, Clegg HV, Lindström MS, Bhat KP, Godfrey VL, Evan GI, Zhang Y. Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation. Cancer Cell 2007; 12:355-66; PMID:17936560; http://dx.doi.org/10. 1016/j.ccr.2007.09.007
    • (2007) Cancer Cell , vol.12 , pp. 355-366
    • Itahana, K.1    Mao, H.2    Jin, A.3    Itahana, Y.4    Clegg, H.V.5    Lindström, M.S.6    Bhat, K.P.7    Godfrey, V.L.8    Evan, G.I.9    Zhang, Y.10
  • 15
    • 40549099702 scopus 로고    scopus 로고
    • Unlocking the Mdm2-p53 loop: Ubiquitin is the key
    • PMID:18235222
    • Clegg HV, Itahana K, Zhang Y. Unlocking the Mdm2-p53 loop: ubiquitin is the key. Cell Cycle 2008; 7:287-92; PMID:18235222; http://dx.doi.org/10.4161/cc. 7.3.5358
    • (2008) Cell Cycle , vol.7 , pp. 287-292
    • Clegg, H.V.1    Itahana, K.2    Zhang, Y.3
  • 16
    • 77955535107 scopus 로고    scopus 로고
    • Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase
    • PMID:20708156
    • Inuzuka H, Tseng A, Gao D, Zhai B, Zhang Q, Shaik S, Wan L, Ang XL, Mock C, Yin H, et al. Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. Cancer Cell 2010; 18:147-59; PMID:20708156; http://dx.doi.org/10.1016/j.ccr.2010.06.015
    • (2010) Cancer Cell , vol.18 , pp. 147-159
    • Inuzuka, H.1    Tseng, A.2    Gao, D.3    Zhai, B.4    Zhang, Q.5    Shaik, S.6    Wan, L.7    Ang, X.L.8    Mock, C.9    Yin, H.10
  • 17
    • 84891763776 scopus 로고    scopus 로고
    • Regulation of Mdm2 protein stability and the p53 response by NEDD4-1 E3 ligase
    • PMID:24413081
    • Xu C, Fan CD, Wang X. Regulation of Mdm2 protein stability and the p53 response by NEDD4-1 E3 ligase. Oncogene 2014; PMID:24413081; http://dx.doi.org/10.1038/onc.2013.557
    • (2014) Oncogene
    • Xu, C.1    Fan, C.D.2    Wang, X.3
  • 18
    • 33846193699 scopus 로고    scopus 로고
    • An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
    • PMID:17159902
    • Uldrijan S, Pannekoek WJ, Vousden KH. An essential function of the extreme C-terminus of MDM2 can be provided by MDMX. EMBO J 2007; 26:102-12; PMID:17159902; http://dx.doi.org/10.1038/sj.emboj.7601469
    • (2007) EMBO J , vol.26 , pp. 102-112
    • Uldrijan, S.1    Pannekoek, W.J.2    Vousden, K.H.3
  • 19
    • 33845611951 scopus 로고    scopus 로고
    • Modeling the therapeutic efficacy of p53 restoration in tumors
    • PMID:17182091
    • Martins CP, Brown-Swigart L, Evan GI. Modeling the therapeutic efficacy of p53 restoration in tumors. Cell 2006; 127:1323-34; PMID:17182091; http://dx.doi.org/10.1016/j.cell.2006.12.007
    • (2006) Cell , vol.127 , pp. 1323-1334
    • Martins, C.P.1    Brown-Swigart, L.2    Evan, G.I.3
  • 20
    • 67649964217 scopus 로고    scopus 로고
    • RING domain E3 ubiquitin ligases
    • PMID:19489725
    • Deshaies RJ, Joazeiro CA. RING domain E3 ubiquitin ligases. Annu Rev Biochem 2009; 78:399-434; PMID:19489725; http://dx.doi.org/10.1146/annurev. biochem.78.101807.093809
    • (2009) Annu Rev Biochem , vol.78 , pp. 399-434
    • Deshaies, R.J.1    Joazeiro, C.A.2
  • 21
    • 0038018467 scopus 로고    scopus 로고
    • The MDM2 RING finger is required for cell cycle-dependent regulation of its protein expression
    • PMID:12782320
    • Gu L, Ying H, Zheng H, Murray SA, Xiao ZX. The MDM2 RING finger is required for cell cycle-dependent regulation of its protein expression. FEBS Lett 2003; 544:218-22; PMID:12782320; http://dx.doi.org/10.1016/S0014-5793(03) 00502-7
    • (2003) FEBS Lett , vol.544 , pp. 218-222
    • Gu, L.1    Ying, H.2    Zheng, H.3    Murray, S.A.4    Xiao, Z.X.5
  • 22
    • 33747589184 scopus 로고    scopus 로고
    • The anaphase promoting complex/cyclosome: A machine designed to destroy
    • PMID:16896351
    • Peters JM. The anaphase promoting complex/cyclosome: a machine designed to destroy. Nat Rev Mol Cell Biol 2006; 7:644-56; PMID:16896351; http://dx.doi.org/10.1038/nrm1988
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 644-656
    • Peters, J.M.1
  • 24
    • 34250799719 scopus 로고    scopus 로고
    • Cdc20: A WD40 activator for a cell cycle degradation machine
    • PMID:17612486
    • Yu H. Cdc20: a WD40 activator for a cell cycle degradation machine. Mol Cell 2007; 27:3-16; PMID:17612486; http://dx.doi.org/10.1016/j.molcel.2007.06. 009
    • (2007) Mol Cell , vol.27 , pp. 3-16
    • Yu, H.1
  • 25
    • 0027956208 scopus 로고
    • Enhanced translation: A novel mechanism of mdm2 oncogene overexpression identified in human tumor cells
    • PMID:8058341
    • Landers JE, Haines DS, Strauss JF 3rd, George DL. Enhanced translation: a novel mechanism of mdm2 oncogene overexpression identified in human tumor cells. Oncogene 1994; 9:2745-50; PMID:8058341
    • (1994) Oncogene , vol.9 , pp. 2745-2750
    • Landers, J.E.1    Haines, D.S.2    Strauss III, J.F.3    George, D.L.4
  • 26
    • 40349098614 scopus 로고    scopus 로고
    • MDM2 gene amplification is correlated to tumor progression but not to the presence of SNP309 or TP53 mutational status in primary colorectal cancers
    • PMID:18314481
    • Forslund A, Zeng Z, Qin LX, Rosenberg S, Ndubuisi M, Pincas H, Gerald W, Notterman DA, Barany F, Paty PB. MDM2 gene amplification is correlated to tumor progression but not to the presence of SNP309 or TP53 mutational status in primary colorectal cancers. Mol Cancer Res 2008; 6:205-11; PMID:18314481; http://dx.doi.org/10.1158/1541-7786.MCR-07-0239
    • (2008) Mol Cancer Res , vol.6 , pp. 205-211
    • Forslund, A.1    Zeng, Z.2    Qin, L.X.3    Rosenberg, S.4    Ndubuisi, M.5    Pincas, H.6    Gerald, W.7    Notterman, D.A.8    Barany, F.9    Paty, P.B.10
  • 27
    • 16244414000 scopus 로고    scopus 로고
    • Docetaxel for treatment of solid tumours: A systematic review of clinical data
    • PMID:15811618
    • Montero A, Fossella F, Hortobagyi G, Valero V. Docetaxel for treatment of solid tumours: a systematic review of clinical data. Lancet Oncol 2005; 6:229-39; PMID:15811618; http://dx.doi.org/10.1016/S1470-2045(05)70094-2
    • (2005) Lancet Oncol , vol.6 , pp. 229-239
    • Montero, A.1    Fossella, F.2    Hortobagyi, G.3    Valero, V.4
  • 28
    • 77957947338 scopus 로고    scopus 로고
    • Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage
    • PMID:20951947
    • Zeng X, Sigoillot F, Gaur S, Choi S, Pfaff KL, Oh DC, Hathaway N, Dimova N, Cuny GD, King RW. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell 2010; 18:382-95; PMID:20951947; http://dx.doi.org/10.1016/j. ccr.2010.08.010
    • (2010) Cancer Cell , vol.18 , pp. 382-395
    • Zeng, X.1    Sigoillot, F.2    Gaur, S.3    Choi, S.4    Pfaff, K.L.5    Oh, D.C.6    Hathaway, N.7    Dimova, N.8    Cuny, G.D.9    King, R.W.10
  • 29
    • 65649144613 scopus 로고    scopus 로고
    • Calcium-phosphatemediated Transfection of Eukaryotic Cells with Plasmid DNAs
    • Sambrook J, Russell DW. Calcium-phosphatemediated Transfection of Eukaryotic Cells with Plasmid DNAs. CSH Protoc 2006; 2006.
    • (2006) CSH Protoc , vol.2006
    • Sambrook, J.1    Russell, D.W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.