Bone marrow-derived stem cells attenuate impaired contractility and enhance capillary density in a rabbit model of doxorubicin-induced failing hearts

Journal of Cardiac Surgery

Volumn 24, Issue 5, 2009, Pages 591-599

  Garbade, Jens ^a   Dhein, Stefan ^a   Lipinski, Catherin ^a   Aupperle, Heike ^a   Arsalan, Mani ^a   Borger, Michael A ^a   Barten, Markus J ^a   Lehmann, Sven ^a   Walther, Thomas ^a   Mohr, Friedrich Wilhelm ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTININ; COLLAGEN; CONNEXIN 43; DOXORUBICIN; TROPONIN I; ANTINEOPLASTIC ANTIBIOTIC;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CAPILLARY DENSITY; CONTROLLED STUDY; EXPERIMENTAL RABBIT; HEART EJECTION FRACTION; HEART FAILURE; HEART LEFT VENTRICLE; HEART MUSCLE CONTRACTILITY; HEART RIGHT VENTRICLE; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMODYNAMICS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; MORTALITY; NONHUMAN; ANIMAL; BONE MARROW; BONE MARROW TRANSPLANTATION; CAPILLARY; DISEASE MODEL; ECHOGRAPHY; RABBIT;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BONE MARROW; BONE MARROW TRANSPLANTATION; CAPILLARIES; DISEASE MODELS, ANIMAL; DOXORUBICIN; HEART FAILURE; HEMODYNAMICS; MALE; RABBITS;

EID: 70049110415     PISSN: 08860440     EISSN: 15408191     Source Type: Journal    
DOI: 10.1111/j.1540-8191.2009.00844.x     Document Type: Article

References (33)

1. Pelacho B, Aranguren XL, Mazo M, et al Plasticity and cardiovascular applications of multipotent adult progenitor cells. Nat Clin Pract Cardiovasc Med 2007 4 (Suppl 1 S15 S20. (Pubitemid 46151901)
2. Dimmeler S, Zeiher AM, Schneider MD : Unchain my heart: The scientific foundations of cardiac repair. J Clin Invest 2005 115 : 572 583.
3. Bartunek J, Dimmeler S, Drexler H, et al Task force of the European Society of Cardiology. The consensus of the task force of the European Society of Cardiology concerning the clinical investigation of the use of autologous adult stem cells for repair of the heart. Eur Heart J 2006 27 : 1338 1340.
4. Kocher AA, Schuster MD, Bonaros N, et al Myocardial homing and neovascularization by human bone marrow angioblasts is regulated by IL-8/Gro CXC chemokines. J Mol Cell Cardiol 2006 40 : 455 464.
5. Urbanek K, Torella D, Sheikh F, et al Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure. Proc Natl Acad Sci USA 2005 102 : 8692 8697.
6. Leor J, Patterson M, Quinones MJ, et al Transplantation of fetal myocardial tissue into the infarcted myocardium of rat: A potential method for repair of infarcted myocardium. Circulation 1996 94 (Suppl II II-332 336.
7. Li RK, Weisel RD, Mickle DAG, et al Autologous porcine heart cell transplantation improves heart function after myocardial infarction. J Thorac Cardiovasc Surg 2000 119 : 62 68.
8. Li RK, Jia ZQ, Weisel RD, et al Smooth muscle cell transplantation into myocardial scar tissue improves heart function. J Mol Cell Cardiol 1999 31 : 513 522.
9. Orlic D, Kajstura J, Chimenti S, et al Bone marrow cells regenerate infarcted myocardium. Nature 2001 410 : 702 705.
10. Tomita S, Li RK, Weisel RD, et al Autologous transplantation of bone marrow cells improves damaged heart function. Circulation 1999 100 (Suppl II II-247 256.
11. Wantanabe E, Smith DM Jr., Delcarpio JB, et al Cardiomyocyte transplantation in a porcine myocardial infaction model. Cell Transplant 1998 7 : 239 246.
12. Schachinger V, Erbs S, Elsasser A, et al REPAIR-AMI Investigators. Improved clinical outcome after intracoronary administration of bone-marrow-derived progenitor cells in acute myocardial infarction: Final 1-year results of the REPAIR-AMI trial. Eur Heart J 2006 27 : 2775 2783.
13. Balsam LB, Wagers AJ, Christensen JL, et al Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature 2004 428 : 664 668.
14. Murry CE, Soonpaa MH, Reinecke H, et al Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature 2004 428 : 668 673.
15. Linke A, Muller P, Nurzynska D, et al Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function. Proc Natl Acad Sci USA 2005 102 : 8966 8971. (Pubitemid 40881062)
16. Mangi AA, Noiseux N, Kong D, et al Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med 2003 9 : 1195 1201.
17. Kocher AA, Schuster MD, Szabolcs MJ, et al Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med 2001 7 : 430 436.
18. Simbre II VC, Adams MJ, Deshpande SS, et al Cardiomyopathy caused by antineoplastic therapies. Curr Treat Options Cardiovasc Med 2001 3 : 493 505.
19. Aupperle H, Garbade J, Schubert A, et al Effects of autologous stem cells on immunohisto-chemical patterns and gene expression of metalloproteinases and their tissue inhibitors in Doxorubicin cardiomyopathy in a rabbit model. Vet Pathol 2007 44 : 494 503.
20. Agbulut O, Menot ML, Li Z, et al Temporal patterns of bone marrow cell differentiation following transplantation in doxorubicin-induced cardiomyopathy. Cardiovasc Res 2003 58 : 451 459.
21. Nagaya N, Kangawa K, Itoh T, et al Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy. Circulation 2005 112 : 1128 1135.
22. Suzuki K, Murtuza B, Suzuki N, et al Intracoronary infusion of skeletal myoblasts improves cardiac function in doxorubicin-induced heart failure. Circulation 2001 104 (12 Suppl 1 I213 I217.
23. Lyngbaek S, Schneider M, Hansen JL, et al : Cardiac regeneration by resident stem and progenitor cells in the adult heart. Basic Res Cardiol 2007 102 : 101 114.
24. Garbade J, Schubert A, Scheffler A, et al : Transdifferentiation and cell-fusion are two different ways of bone marrow stromal cells to develop into cardiac lineage. Thorac Cardiovasc Surg 2005 53.
25. Müller-Ehmsen J : Survival of mononuclear bone marrow cells and mesenchymal stem cells after grafting into acute rat myocardial infarction - a quantitative TaqMan PCR analysis. Circ 2003 108 : IV-245/abstract1157.
26. Lu C, Arai M, Misao Y, et al Autologous bone marrow cell transplantation improves left ventricular function in rabbit hearts with cardiomyopathy via myocardial regeneration-unrelated mechanisms. Heart Vessels 2006 : 180 187.
27. Peterson JT, Hallak H, Johnson L, et al Matrix metalloproteinase inhibition attenuates left ventricular remodeling and dysfunction in a rat model of progressive heart failure. Circulation 2001 103 : 2303 2309.
28. Iwanaga Y, Aoyama T, Kihara Y, et al Excessive activation of matrix metalloproteinases coincides with left ventricular remodeling during transition from hypertrophy to heart failure in hypertensive rats. J Am Coll Cardiol 2002 39 : 1384 1391.
29. Gnecchi M, He H, Noiseux N, et al Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement. FASEB J 2006 20 : 661 669.
30. Fazel S, Cimini M, Chen L, et al Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines. J Clin Invest 2006 116 : 1865 1877.
31. Kinnaird T, Stabile E, Burnett MS, et al Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms. Circulation 2004 109 : 1543 1549.
32. Dhein S, Garbade J, Rouabah D, et al Effects of autologous bone marrow stem cell transplantation on beta-adrenoceptor density and electrical activation pattern in a rabbit model of non-ischemic heart failure. J Cardiothorac Surg 2006 26 : 1 17.
33. Garbade J, Schubert A, Barten MJ, et al Stem cell transplantation modulates mRNA gene expression profile in doxorubicin-induced cardiomyopathy. J Stem Cells 2008 3 : 235 244.